Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

116071

Name

BATF2

Synonymous

basic leucine zipper transcription factor, ATF-like 2;BATF2;basic leucine zipper transcription factor, ATF-like 2

Definition

B-ATF-2|basic leucine zipper transcriptional factor ATF-like 2|suppressor of AP-1 regulated by IFN

Position

11q13.1

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.19.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.582C>A; p.A194A; 11:64989372-64989372

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.702T>A; p.R234R; 11:64989252-64989252

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.668C>T; p.P223L; 11:64989286-64989286

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.604C>A; p.Q202K; 11:64989350-64989350

 kidneyother; neoplasmSubstitution - Missense

c.98G>A; p.R33Q; 11:64994491-64994491

 skinmalignant_melanomaSubstitution - Missense

c.570T>C; p.S190S; 11:64989384-64989384

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.478C>T; p.P160S; 11:64989476-64989476

 skin; extremitymalignant_melanomaSubstitution - Missense

c.643A>G; p.T215A; 11:64989311-64989311

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.794C>A; p.P265H; 11:64989160-64989160

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.52C>T; p.Q18*; 11:64994537-64994537

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.559G>A; p.G187R; 11:64989395-64989395

 skinmalignant_melanomaSubstitution - Missense

c.548C>T; p.S183F; 11:64989406-64989406

 skinmalignant_melanomaSubstitution - Missense

c.577A>G; p.S193G; 11:64989377-64989377

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.233A>G; p.H78R; 11:64989721-64989721

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1A>C; p.M1L; 11:64996914-64996914

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.793C>T; p.P265S; 11:64989161-64989161

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.354G>T; p.R118R; 11:64989600-64989600

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.354G>T; p.R118R; 11:64989600-64989600

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.481G>A; p.A161T; 11:64989473-64989473

 ovaryother; neoplasmSubstitution - Missense

c.225G>A; p.R75R; 11:64989729-64989729

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.619C>T; p.Q207*; 11:64989335-64989335

 breastcarcinomaSubstitution - Nonsense

c.235G>A; p.V79M; 11:64989719-64989719

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.195C>T; p.S65S; 11:64989759-64989759

 skinmalignant_melanomaSubstitution - coding silent

c.751G>T; p.G251W; 11:64989203-64989203

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.306G>A; p.Q102Q; 11:64989648-64989648

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.701G>A; p.R234H; 11:64989253-64989253

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.636G>T; p.E212D; 11:64989318-64989318

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.634G>A; p.E212K; 11:64989320-64989320

 skinmalignant_melanomaSubstitution - Missense

c.617C>T; p.P206L; 11:64989337-64989337

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.205G>A; p.E69K; 11:64989749-64989749

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastomaSubstitution - Missense

c.205G>A; p.E69K; 11:64989749-64989749

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastomaSubstitution - Missense

c.553C>A; p.L185M; 11:64989401-64989401

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.537G>A; p.S179S; 11:64989417-64989417

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.194C>T; p.S65F; 11:64989760-64989760

 skinmalignant_melanomaSubstitution - Missense

c.641C>T; p.P214L; 11:64989313-64989313

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.172G>A; p.A58T; 11:64989782-64989782

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.487G>A; p.V163I; 11:64989467-64989467

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.638_639insGCA; p.E212_H213insQ; 11:64989315-64989316

 oesophaguscarcinoma; adenocarcinomaInsertion - In frame

c.97C>T; p.R33*; 11:64994492-64994492

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.405G>A; p.P135P; 11:64989549-64989549

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.250T>C; p.C84R; 11:64989704-64989704

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.98_99insG; p.S34fs*48; 11:64994490-64994491

 endometriumcarcinoma; endometrioid_carcinomaInsertion - Frameshift

c.249G>A; p.L83L; 11:64989705-64989705

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.627C>T; p.L209L; 11:64989327-64989327

 skinmalignant_melanomaSubstitution - coding silent

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