Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

122953

Name

JDP2

Synonymous

Jun dimerization protein 2;JDP2;Jun dimerization protein 2

Definition

jun dimerization protein 2|progesterone receptor co-activator

Position

14q24.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.348C>A; p.T116T; 14:75469331-75469331

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.306G>A; p.R102R; 14:75461530-75461530

 skinmalignant_melanomaSubstitution - coding silent

c.440A>T; p.K147M; 14:75469423-75469423

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.156C>T; p.F52F; 14:75438076-75438076

 skinmalignant_melanomaSubstitution - coding silent

c.202C>G; p.L68V; 14:75461426-75461426

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.122G>A; p.R41H; 14:75438042-75438042

 breastcarcinomaSubstitution - Missense

c.317G>A; p.R106Q; 14:75469300-75469300

 livercarcinomaSubstitution - Missense

c.317G>A; p.R106Q; 14:75469300-75469300

 livercarcinomaSubstitution - Missense

c.317G>A; p.R106Q; 14:75469300-75469300

 livercarcinomaSubstitution - Missense

c.406C>T; p.R136C; 14:75469389-75469389

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.37A>G; p.T13A; 14:75437957-75437957

 thyroidother; neoplasmSubstitution - Missense

c.112G>A; p.A38T; 14:75438032-75438032

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.233G>A; p.R78H; 14:75461457-75461457

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.6G>A; p.M2I; 14:75437926-75437926

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.172G>T; p.G58C; 14:75438092-75438092

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.92C>T; p.T31I; 14:75438012-75438012

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.262C>T; p.R88*; 14:75461486-75461486

 skinmalignant_melanomaSubstitution - Nonsense

c.236G>A; p.R79Q; 14:75461460-75461460

 skinmalignant_melanomaSubstitution - Missense

c.192G>T; p.V64V; 14:75438112-75438112

 skinmalignant_melanomaSubstitution - coding silent

')