| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 123920 |
Name | CMTM3 |
Synonymous | CKLF-like MARVEL transmembrane domain containing 3;CMTM3;CKLF-like MARVEL transmembrane domain containing 3 |
Definition | CKLF-like MARVEL transmembrane domain-containing protein 3|chemokine-like factor superfamily member 3 |
Position | 16q21 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
 |
The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
 |
 |
Loss of Function mutations compare to missense mutations | Top |
 |
| The ratio of the loss-of-function mutations over missense mutations is 0.10. |
The copy number variations for various cancers | Top |
 |
The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.304-2A>G; p.?; 16:66609433-66609433 |
endometrium | carcinoma; endometrioid_carcinoma | Unknown |
c.457G>A; p.D153N; 16:66609940-66609940 |
skin | malignant_melanoma | Substitution - Missense |
c.375G>A; p.S125S; 16:66609506-66609506 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.174C>A; p.C58*; 16:66608335-66608335 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.363C>T; p.I121I; 16:66609494-66609494 |
bone | Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour | Substitution - coding silent |
c.364G>A; p.A122T; 16:66609495-66609495 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.313C>T; p.R105C; 16:66609444-66609444 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.423C>A; p.I141I; 16:66609906-66609906 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.336C>T; p.I112I; 16:66609467-66609467 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - coding silent |
c.176A>T; p.Y59F; 16:66608337-66608337 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.472C>T; p.L158F; 16:66609955-66609955 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.190G>A; p.A64T; 16:66608351-66608351 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.190G>A; p.A64T; 16:66608351-66608351 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.460G>A; p.V154M; 16:66609943-66609943 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.182C>T; p.A61V; 16:66608343-66608343 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.96G>A; p.P32P; 16:66604901-66604901 |
thyroid | other; neoplasm | Substitution - coding silent |
c.517G>C; p.E173Q; 16:66610000-66610000 |
breast | carcinoma | Substitution - Missense |
c.167T>G; p.F56C; 16:66608328-66608328 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.486delC; p.S163fs*>20; 16:66609969-66609969 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Deletion - Frameshift |