Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

126520

Name

PLK5

Synonymous

polo-like kinase 5;PLK5;polo-like kinase 5

Definition

inactive serine/threonine-protein kinase PLK5|polo-like kinase 5, pseudogene

Position

19p13.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.508C>T; p.R170W; 19:1529764-1529764

 pancreascarcinomaSubstitution - Missense

c.967G>C; p.G323R; 19:1535206-1535206

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.967G>C; p.G323R; 19:1535206-1535206

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.967G>C; p.G323R; 19:1535206-1535206

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.967G>C; p.G323R; 19:1535206-1535206

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.967G>C; p.G323R; 19:1535206-1535206

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.967G>C; p.G323R; 19:1535206-1535206

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.967G>C; p.G323R; 19:1535206-1535206

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.967G>C; p.G323R; 19:1535206-1535206

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.967G>C; p.G323R; 19:1535206-1535206

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.967G>C; p.G323R; 19:1535206-1535206

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.967G>C; p.G323R; 19:1535206-1535206

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.967G>C; p.G323R; 19:1535206-1535206

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.956_958delCCC; p.P320delP; 19:1535195-1535197

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaDeletion - In frame

c.956_958delCCC; p.P320delP; 19:1535195-1535197

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaDeletion - In frame

c.956_958delCCC; p.P320delP; 19:1535195-1535197

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaDeletion - In frame

c.956_958delCCC; p.P320delP; 19:1535195-1535197

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaDeletion - In frame

c.956_958delCCC; p.P320delP; 19:1535195-1535197

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaDeletion - In frame

c.956_958delCCC; p.P320delP; 19:1535195-1535197

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaDeletion - In frame

c.956_958delCCC; p.P320delP; 19:1535195-1535197

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaDeletion - In frame

c.956_958delCCC; p.P320delP; 19:1535195-1535197

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaDeletion - In frame

c.956_958delCCC; p.P320delP; 19:1535195-1535197

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaDeletion - In frame

c.956_958delCCC; p.P320delP; 19:1535195-1535197

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaDeletion - In frame

c.956_958delCCC; p.P320delP; 19:1535195-1535197

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaDeletion - In frame

c.941G>A; p.R314Q; 19:1535180-1535180

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.941G>A; p.R314Q; 19:1535180-1535180

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.941G>A; p.R314Q; 19:1535180-1535180

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.941G>A; p.R314Q; 19:1535180-1535180

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.941G>A; p.R314Q; 19:1535180-1535180

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.941G>A; p.R314Q; 19:1535180-1535180

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.941G>A; p.R314Q; 19:1535180-1535180

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.941G>A; p.R314Q; 19:1535180-1535180

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.941G>A; p.R314Q; 19:1535180-1535180

 thyroidother; neoplasmSubstitution - Missense

c.941G>A; p.R314Q; 19:1535180-1535180

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.941G>A; p.R314Q; 19:1535180-1535180

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.941G>A; p.R314Q; 19:1535180-1535180

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.941G>A; p.R314Q; 19:1535180-1535180

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.703A>C; p.T235P; 19:1531872-1531872

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.703A>C; p.T235P; 19:1531872-1531872

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.703A>C; p.T235P; 19:1531872-1531872

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.703A>C; p.T235P; 19:1531872-1531872

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.703A>C; p.T235P; 19:1531872-1531872

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.703A>C; p.T235P; 19:1531872-1531872

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.703A>C; p.T235P; 19:1531872-1531872

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.703A>C; p.T235P; 19:1531872-1531872

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.703A>C; p.T235P; 19:1531872-1531872

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.703A>C; p.T235P; 19:1531872-1531872

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.703A>C; p.T235P; 19:1531872-1531872

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.339G>T; p.T113T; 19:1528908-1528908

 thyroidother; neoplasmSubstitution - coding silent

c.319C>T; p.R107W; 19:1528419-1528419

 biliary_tract; gallbladdercarcinoma; adenocarcinomaSubstitution - Missense

c.709C>T; p.R237W; 19:1531878-1531878

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.701C>T; p.A234V; 19:1531870-1531870

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.701C>T; p.A234V; 19:1531870-1531870

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.701C>T; p.A234V; 19:1531870-1531870

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.673C>T; p.R225C; 19:1531842-1531842

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.757C>G; p.L253V; 19:1533973-1533973

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.757C>G; p.L253V; 19:1533973-1533973

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.757C>G; p.L253V; 19:1533973-1533973

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.757C>G; p.L253V; 19:1533973-1533973

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.757C>G; p.L253V; 19:1533973-1533973

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.757C>G; p.L253V; 19:1533973-1533973

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.757C>G; p.L253V; 19:1533973-1533973

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.757C>G; p.L253V; 19:1533973-1533973

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.757C>G; p.L253V; 19:1533973-1533973

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.757C>G; p.L253V; 19:1533973-1533973

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.757C>G; p.L253V; 19:1533973-1533973

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.984C>T; p.H328H; 19:1535223-1535223

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.261A>C; p.I87I; 19:1528361-1528361

 thyroidother; neoplasmSubstitution - coding silent

c.38C>A; p.A13D; 19:1527971-1527971

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.38C>A; p.A13D; 19:1527971-1527971

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - Missense

c.905G>T; p.G302V; 19:1535144-1535144

 pancreascarcinomaSubstitution - Missense

c.846G>A; p.P282P; 19:1535085-1535085

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.846G>A; p.P282P; 19:1535085-1535085

 breastcarcinomaSubstitution - coding silent

c.255C>T; p.F85F; 19:1528355-1528355

 pancreascarcinomaSubstitution - coding silent

c.266C>T; p.P89L; 19:1528366-1528366

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

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