Entrez Gene

Basic Information
Gene ID	140690
Name	CTCFL
Synonymous	CCCTC-binding factor (zinc finger protein)-like;CTCFL;CCCTC-binding factor (zinc finger protein)-like
Definition	BORIS-like protein\|CTCF paralog\|CTCF-like protein\|HMG-1L1\|brother of the regulator of imprinted sites\|cancer/testis antigen 27\|putative high mobility group protein 1-like 1\|putative high mobility group protein B1-like 1\|transcriptional repressor CTCFL\|zin
Position	20q13.31
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.15.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1570C>T; p.R524*; 20:57508710-57508710	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.121C>A; p.H41N; 20:57524085-57524085	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1800G>A; p.K600K; 20:57503476-57503476	skin	malignant_melanoma	Substitution - coding silent
c.1472G>A; p.C491Y; 20:57512611-57512611	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1054G>T; p.V352L; 20:57518763-57518763	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1069T>C; p.L357L; 20:57515825-57515825	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.942G>A; p.K314K; 20:57518875-57518875	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.671T>A; p.V224E; 20:57523151-57523151	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.97G>T; p.D33Y; 20:57524109-57524109	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.822T>C; p.R274R; 20:57519310-57519310	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.822T>C; p.R274R; 20:57519310-57519310	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.764G>A; p.G255E; 20:57519368-57519368	skin	malignant_melanoma	Substitution - Missense
c.1316G>A; p.R439Q; 20:57514606-57514606	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.706G>A; p.A236T; 20:57523116-57523116	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.135T>G; p.S45R; 20:57524071-57524071	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.949G>A; p.D317N; 20:57518868-57518868	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.949G>A; p.D317N; 20:57518868-57518868	skin; back	malignant_melanoma	Substitution - Missense
c.949G>A; p.D317N; 20:57518868-57518868	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.640G>A; p.E214K; 20:57523182-57523182	skin	malignant_melanoma	Substitution - Missense
c.1344C>G; p.R448R; 20:57512739-57512739	breast	carcinoma	Substitution - coding silent
c.1084C>A; p.R362R; 20:57515810-57515810	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.219G>T; p.E73D; 20:57523987-57523987	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.322G>A; p.V108M; 20:57523884-57523884	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1835G>A; p.G612E; 20:57503441-57503441	skin	malignant_melanoma	Substitution - Missense
c.1097G>A; p.G366E; 20:57515797-57515797	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.916A>G; p.T306A; 20:57519216-57519216	NS	NS	Substitution - Missense
c.988C>T; p.R330*; 20:57518829-57518829	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.335T>A; p.V112E; 20:57523871-57523871	breast	carcinoma	Substitution - Missense
c.1304C>T; p.T435I; 20:57514618-57514618	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1516C>T; p.R506C; 20:57508764-57508764	skin	malignant_melanoma	Substitution - Missense
c.1871A>T; p.K624M; 20:57498671-57498671	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1267G>A; p.E423K; 20:57514655-57514655	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1267G>A; p.E423K; 20:57514655-57514655	skin	malignant_melanoma	Substitution - Missense
c.1267G>A; p.E423K; 20:57514655-57514655	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1267G>A; p.E423K; 20:57514655-57514655	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1143T>G; p.D381E; 20:57515751-57515751	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.145G>T; p.A49S; 20:57524061-57524061	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1533G>C; p.E511D; 20:57508747-57508747	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1339A>G; p.M447V; 20:57512744-57512744	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1071G>C; p.L357F; 20:57515823-57515823	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1343G>A; p.R448H; 20:57512740-57512740	ovary	other; neoplasm	Substitution - Missense
c.1313C>T; p.A438V; 20:57514609-57514609	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.69G>A; p.P23P; 20:57524137-57524137	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.873G>A; p.L291L; 20:57519259-57519259	skin	malignant_melanoma	Substitution - coding silent
c.1936G>C; p.E646Q; 20:57498606-57498606	breast	carcinoma	Substitution - Missense
c.1936G>C; p.E646Q; 20:57498606-57498606	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.564G>A; p.K188K; 20:57523258-57523258	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.998G>A; p.R333H; 20:57518819-57518819	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.738_739insA; p.Q247fs*14; 20:57523083-57523084	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.300G>A; p.L100L; 20:57523906-57523906	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.216G>C; p.S72S; 20:57523990-57523990	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1723T>C; p.S575P; 20:57503553-57503553	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1237A>G; p.M413V; 20:57514685-57514685	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.646G>C; p.V216L; 20:57523176-57523176	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1573C>G; p.Q525E; 20:57508707-57508707	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.75delA; p.G26fs*2; 20:57524131-57524131	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.75delA; p.G26fs*2; 20:57524131-57524131	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.75delA; p.G26fs*2; 20:57524131-57524131	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Deletion - Frameshift
c.96delA; p.D33fs*48; 20:57524110-57524110	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.173A>G; p.D58G; 20:57524033-57524033	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.173A>G; p.D58G; 20:57524033-57524033	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1805C>T; p.A602V; 20:57503471-57503471	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1612G>A; p.D538N; 20:57508668-57508668	skin	malignant_melanoma	Substitution - Missense
c.1113G>C; p.Q371H; 20:57515781-57515781	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.173A>G; p.D58G; 20:57524033-57524033	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1144A>C; p.T382P; 20:57515750-57515750	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.320_332del13; p.V108fs*45; 20:57523874-57523886	kidney	carcinoma; renal_cell_carcinoma	Deletion - Frameshift
c.403G>A; p.A135T; 20:57523803-57523803	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1972C>A; p.L658I; 20:57498570-57498570	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.251C>T; p.T84M; 20:57523955-57523955	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.227A>T; p.E76V; 20:57523979-57523979	breast	carcinoma	Substitution - Missense
c.139T>C; p.L47L; 20:57524067-57524067	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.212C>T; p.P71L; 20:57523994-57523994	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.174C>A; p.D58E; 20:57524032-57524032	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.169C>T; p.Q57*; 20:57524037-57524037	large_intestine; colon	carcinoma	Substitution - Nonsense
c.169C>T; p.Q57*; 20:57524037-57524037	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.152G>A; p.R51H; 20:57524054-57524054	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.415C>A; p.Q139K; 20:57523791-57523791	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1840G>A; p.E614K; 20:57503436-57503436	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1840G>A; p.E614K; 20:57503436-57503436	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1247A>G; p.H416R; 20:57514675-57514675	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1124G>A; p.C375Y; 20:57515770-57515770	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1034C>T; p.S345F; 20:57518783-57518783	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.1628C>T; p.P543L; 20:57508652-57508652	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1359C>A; p.Y453*; 20:57512724-57512724	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.725A>C; p.K242T; 20:57523097-57523097	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.93A>T; p.E31D; 20:57524113-57524113	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1173G>A; p.T391T; 20:57515721-57515721	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.820C>T; p.R274C; 20:57519312-57519312	skin	malignant_melanoma	Substitution - Missense
c.820C>T; p.R274C; 20:57519312-57519312	skin	malignant_melanoma	Substitution - Missense
c.1173G>A; p.T391T; 20:57515721-57515721	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.767C>T; p.T256I; 20:57519365-57519365	skin	malignant_melanoma	Substitution - Missense
c.692C>T; p.P231L; 20:57523130-57523130	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1676T>A; p.I559N; 20:57503600-57503600	skin	malignant_melanoma	Substitution - Missense
c.1529G>C; p.G510A; 20:57508751-57508751	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.148G>A; p.E50K; 20:57524058-57524058	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1959C>A; p.T653T; 20:57498583-57498583	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1953C>T; p.G651G; 20:57498589-57498589	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1542C>T; p.F514F; 20:57508738-57508738	skin	malignant_melanoma	Substitution - coding silent
c.1840G>T; p.E614*; 20:57503436-57503436	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1141G>C; p.D381H; 20:57515753-57515753	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1758G>A; p.K586K; 20:57503518-57503518	skin	malignant_melanoma	Substitution - coding silent
c.529A>G; p.T177A; 20:57523677-57523677	thyroid	other; neoplasm	Substitution - Missense
c.40A>G; p.T14A; 20:57524166-57524166	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.901C>T; p.R301W; 20:57519231-57519231	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.901C>T; p.R301W; 20:57519231-57519231	breast	carcinoma	Substitution - Missense
c.1408C>T; p.R470C; 20:57512675-57512675	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.140T>G; p.L47W; 20:57524066-57524066	skin	malignant_melanoma	Substitution - Missense
c.168C>T; p.F56F; 20:57524038-57524038	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1408C>T; p.R470C; 20:57512675-57512675	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.754+1G>A; p.?; 20:57523067-57523067	stomach	carcinoma; adenocarcinoma	Unknown
c.762A>C; p.K254N; 20:57519370-57519370	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1772T>C; p.I591T; 20:57503504-57503504	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.379C>T; p.R127W; 20:57523827-57523827	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1409G>C; p.R470P; 20:57512674-57512674	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.525A>T; p.E175D; 20:57523681-57523681	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1694C>T; p.S565L; 20:57503582-57503582	skin	malignant_melanoma	Substitution - Missense
c.1792G>A; p.G598S; 20:57503484-57503484	skin	malignant_melanoma	Substitution - Missense
c.1822G>A; p.E608K; 20:57503454-57503454	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.397T>C; p.C133R; 20:57523809-57523809	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1822G>A; p.E608K; 20:57503454-57503454	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.81G>A; p.L27L; 20:57524125-57524125	breast	carcinoma	Substitution - coding silent
c.1075C>T; p.R359C; 20:57515819-57515819	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1323C>T; p.S441S; 20:57514599-57514599	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1015G>A; p.E339K; 20:57518802-57518802	skin	malignant_melanoma	Substitution - Missense
c.569A>C; p.Q190P; 20:57523253-57523253	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1216C>T; p.R406C; 20:57514706-57514706	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.697G>A; p.A233T; 20:57523125-57523125	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1479T>A; p.Y493*; 20:57512604-57512604	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.763G>T; p.G255*; 20:57519369-57519369	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1216C>T; p.R406C; 20:57514706-57514706	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.310C>T; p.Q104*; 20:57523896-57523896	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1230C>T; p.S410S; 20:57514692-57514692	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1230C>T; p.S410S; 20:57514692-57514692	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1833C>T; p.N611N; 20:57503443-57503443	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1230C>T; p.S410S; 20:57514692-57514692	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.266C>T; p.S89F; 20:57523940-57523940	skin	malignant_melanoma	Substitution - Missense
c.728C>G; p.S243C; 20:57523094-57523094	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.52G>T; p.E18*; 20:57524154-57524154	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1263C>T; p.H421H; 20:57514659-57514659	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.320G>T; p.G107V; 20:57523886-57523886	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.888G>A; p.T296T; 20:57519244-57519244	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.990A>T; p.R330R; 20:57518827-57518827	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1329A>G; p.L443L; 20:57514593-57514593	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1227G>C; p.Q409H; 20:57514695-57514695	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.642A>C; p.E214D; 20:57523180-57523180	liver	carcinoma	Substitution - Missense
c.1706G>A; p.G569E; 20:57503570-57503570	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.357G>T; p.L119F; 20:57523849-57523849	breast	carcinoma	Substitution - Missense
c.1076G>A; p.R359H; 20:57515818-57515818	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1143T>C; p.D381D; 20:57515751-57515751	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.148G>C; p.E50Q; 20:57524058-57524058	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.148G>C; p.E50Q; 20:57524058-57524058	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.83A>G; p.K28R; 20:57524123-57524123	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.178G>A; p.V60I; 20:57524028-57524028	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.178G>A; p.V60I; 20:57524028-57524028	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.690delA; p.Q230fs*47; 20:57523132-57523132	bone; ilium	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Deletion - Frameshift
c.67C>T; p.P23S; 20:57524139-57524139	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.225C>T; p.S75S; 20:57523981-57523981	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.67C>T; p.P23S; 20:57524139-57524139	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.789G>A; p.M263I; 20:57519343-57519343	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1495C>T; p.R499C; 20:57508785-57508785	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1405G>A; p.E469K; 20:57512678-57512678	skin	malignant_melanoma	Substitution - Missense
c.1830G>A; p.A610A; 20:57503446-57503446	skin	malignant_melanoma	Substitution - coding silent
c.592G>A; p.E198K; 20:57523230-57523230	skin; extremity	malignant_melanoma	Substitution - Missense
c.755G>A; p.G252E; 20:57519377-57519377	skin	malignant_melanoma	Substitution - Missense
c.384G>A; p.Q128Q; 20:57523822-57523822	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1828G>A; p.A610T; 20:57503448-57503448	central_nervous_system; brain	glioma	Substitution - Missense
c.391C>A; p.Q131K; 20:57523815-57523815	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.31G>T; p.E11*; 20:57524175-57524175	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.319G>A; p.G107R; 20:57523887-57523887	breast	carcinoma	Substitution - Missense
c.1517G>A; p.R506H; 20:57508763-57508763	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.984C>A; p.L328L; 20:57518833-57518833	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.112G>C; p.E38Q; 20:57524094-57524094	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.690A>G; p.Q230Q; 20:57523132-57523132	skin	malignant_melanoma	Substitution - coding silent
c.1317G>C; p.R439R; 20:57514605-57514605	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1180G>T; p.G394C; 20:57515714-57515714	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1084C>T; p.R362*; 20:57515810-57515810	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1084C>T; p.R362*; 20:57515810-57515810	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1627C>T; p.P543S; 20:57508653-57508653	skin	malignant_melanoma	Substitution - Missense
c.1618A>G; p.N540D; 20:57508662-57508662	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1084C>T; p.R362*; 20:57515810-57515810	skin	malignant_melanoma	Substitution - Nonsense
c.600C>A; p.L200L; 20:57523222-57523222	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1103G>A; p.R368H; 20:57515791-57515791	liver	carcinoma	Substitution - Missense
c.1103G>A; p.R368H; 20:57515791-57515791	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.855C>T; p.H285H; 20:57519277-57519277	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.344_345delCT; p.P115fs*8; 20:57523861-57523862	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.215C>T; p.S72L; 20:57523991-57523991	stomach	carcinoma; adenocarcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]