Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1613

Name

DAPK3

Synonymous

death-associated protein kinase 3;DAPK3;death-associated protein kinase 3

Definition

DAP kinase 3|DAP-like kinase|MYPT1 kinase|ZIP-kinase|zipper-interacting protein kinase

Position

19p13.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.07.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.92G>A; p.R31Q; 19:3964962-3964962

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.265G>A; p.V89M; 19:3964789-3964789

 skin; trunkmalignant_melanomaSubstitution - Missense

c.155G>T; p.S52I; 19:3964899-3964899

 bone; femurchondrosarcomaSubstitution - Missense

c.769G>A; p.V257I; 19:3961022-3961022

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.155G>T; p.S52I; 19:3964899-3964899

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1300G>A; p.V434M; 19:3959166-3959166

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.899C>T; p.T300M; 19:3959567-3959567

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1144C>T; p.R382W; 19:3959322-3959322

 skinmalignant_melanomaSubstitution - Missense

c.1286C>T; p.S429F; 19:3959180-3959180

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1216A>T; p.T406S; 19:3959250-3959250

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasmSubstitution - Missense

c.850C>T; p.R284C; 19:3959616-3959616

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.129C>T; p.F43F; 19:3964925-3964925

 skinmalignant_melanomaSubstitution - coding silent

c.509C>T; p.A170V; 19:3964288-3964288

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.774A>C; p.K258N; 19:3961017-3961017

 large_intestine; coloncarcinomaSubstitution - Missense

c.1020C>T; p.R340R; 19:3959446-3959446

 thyroidother; neoplasmSubstitution - coding silent

c.486C>T; p.F162F; 19:3964311-3964311

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.34C>T; p.H12Y; 19:3969702-3969702

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.544G>A; p.E182K; 19:3964253-3964253

 skinmalignant_melanomaSubstitution - Missense

c.495G>A; p.A165A; 19:3964302-3964302

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.528C>G; p.N176K; 19:3964269-3964269

 central_nervous_system; braingliomaSubstitution - Missense

c.646C>T; p.P216S; 19:3961145-3961145

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.646C>T; p.P216S; 19:3961145-3961145

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.646C>T; p.P216S; 19:3961145-3961145

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.646C>T; p.P216S; 19:3961145-3961145

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.1169C>A; p.A390E; 19:3959297-3959297

 thyroidother; neoplasmSubstitution - Missense

c.250G>A; p.E84K; 19:3964804-3964804

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.498C>T; p.H166H; 19:3964299-3964299

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.636C>T; p.S212S; 19:3961155-3961155

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.582G>A; p.L194L; 19:3963891-3963891

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.1035C>A; p.S345R; 19:3959431-3959431

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.900G>A; p.T300T; 19:3959566-3959566

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.406G>A; p.A136T; 19:3964648-3964648

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.117C>T; p.Y39Y; 19:3964937-3964937

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.785G>A; p.R262Q; 19:3960102-3960102

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.795C>G; p.T265T; 19:3960092-3960092

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1330G>A; p.E444K; 19:3959136-3959136

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.510G>A; p.A170A; 19:3964287-3964287

 breastcarcinomaSubstitution - coding silent

c.775G>T; p.D259Y; 19:3961016-3961016

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.517G>T; p.E173*; 19:3964280-3964280

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.375C>T; p.D125D; 19:3964679-3964679

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.313C>A; p.L105M; 19:3964741-3964741

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.445G>A; p.D149N; 19:3964352-3964352

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.140G>A; p.R47H; 19:3964914-3964914

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.493G>A; p.A165T; 19:3964304-3964304

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.335C>T; p.T112M; 19:3964719-3964719

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.335C>T; p.T112M; 19:3964719-3964719

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1355G>T; p.G452V; 19:3959111-3959111

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1227C>T; p.L409L; 19:3959239-3959239

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.517G>A; p.E173K; 19:3964280-3964280

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.336G>A; p.T112T; 19:3964718-3964718

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.336G>A; p.T112T; 19:3964718-3964718

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.336G>A; p.T112T; 19:3964718-3964718

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.336G>A; p.T112T; 19:3964718-3964718

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.336G>A; p.T112T; 19:3964718-3964718

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.731C>T; p.T244I; 19:3961060-3961060

 skin; extremitymalignant_melanomaSubstitution - Missense

c.753C>G; p.F251L; 19:3961038-3961038

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.392A>G; p.H131R; 19:3964662-3964662

 skinmalignant_melanomaSubstitution - Missense

c.757C>T; p.R253C; 19:3961034-3961034

 skinmalignant_melanomaSubstitution - Missense

c.57G>A; p.L19L; 19:3969679-3969679

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.330G>A; p.S110S; 19:3964724-3964724

 central_nervous_system; braingliomaSubstitution - coding silent

c.330G>A; p.S110S; 19:3964724-3964724

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.482A>G; p.D161G; 19:3964315-3964315

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.143G>T; p.R48L; 19:3964911-3964911

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.348C>T; p.A116A; 19:3964706-3964706

 skinmalignant_melanomaSubstitution - coding silent

c.480C>T; p.I160I; 19:3964317-3964317

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1360C>T; p.R454C; 19:3959106-3959106

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.59G>A; p.G20D; 19:3969677-3969677

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.264C>T; p.D88D; 19:3964790-3964790

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.512G>C; p.G171A; 19:3964285-3964285

 livercarcinomaSubstitution - Missense

c.512G>C; p.G171A; 19:3964285-3964285

 livercarcinomaSubstitution - Missense

c.1111A>G; p.S371G; 19:3959355-3959355

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.377G>A; p.G126D; 19:3964677-3964677

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.884G>T; p.R295L; 19:3959582-3959582

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.170G>C; p.S57T; 19:3964884-3964884

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.78C>T; p.I26I; 19:3964976-3964976

 skinmalignant_melanomaSubstitution - coding silent

c.122C>A; p.A41D; 19:3964932-3964932

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.786G>A; p.R262R; 19:3960101-3960101

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.249C>T; p.F83F; 19:3964805-3964805

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.811G>C; p.E271Q; 19:3960076-3960076

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1128G>A; p.Q376Q; 19:3959338-3959338

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasmSubstitution - coding silent

c.886C>T; p.R296C; 19:3959580-3959580

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.404T>C; p.I135T; 19:3964650-3964650

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.100G>T; p.G34C; 19:3964954-3964954

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.647C>T; p.P216L; 19:3961144-3961144

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.230_232delTCA; p.I77delI; 19:3964822-3964824

 breastcarcinomaDeletion - In frame

c.481G>A; p.D161N; 19:3964316-3964316

 ovarycarcinoma; mucinous_carcinomaSubstitution - Missense

c.481G>A; p.D161N; 19:3964316-3964316

 ovarycarcinoma; mucinous_carcinomaSubstitution - Missense

c.481G>A; p.D161N; 19:3964316-3964316

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.427G>T; p.E143*; 19:3964370-3964370

 livercarcinoma; hepatocellular_carcinomaSubstitution - Nonsense

c.837G>A; p.R279R; 19:3959629-3959629

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.1316G>A; p.R439H; 19:3959150-3959150

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1317C>T; p.R439R; 19:3959149-3959149

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.435C>T; p.I145I; 19:3964362-3964362

 skinmalignant_melanomaSubstitution - coding silent

c.463C>A; p.P155T; 19:3964334-3964334

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.146T>C; p.L49P; 19:3964908-3964908

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1205C>T; p.A402V; 19:3959261-3959261

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.594G>A; p.A198A; 19:3963879-3963879

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.594G>A; p.A198A; 19:3963879-3963879

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.405C>T; p.I135I; 19:3964649-3964649

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.228C>T; p.I76I; 19:3964826-3964826

 skinmalignant_melanomaSubstitution - coding silent

c.228C>T; p.I76I; 19:3964826-3964826

 skinmalignant_melanomaSubstitution - coding silent

c.91C>T; p.R31W; 19:3964963-3964963

 soft_tissue; fibrous_tissue_and_uncertain_ogastrointestinal_stromal_tumourSubstitution - Missense

c.914A>G; p.Y305C; 19:3959552-3959552

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.914A>G; p.Y305C; 19:3959552-3959552

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.580C>A; p.L194M; 19:3963893-3963893

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1203C>T; p.G401G; 19:3959263-3959263

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

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