Entrez Gene

Basic Information
Gene ID	167465
Name	ZNF366
Synonymous	zinc finger protein 366;ZNF366;zinc finger protein 366
Definition	-
Position	5q13.2\|5q13.2
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.09.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.58A>G; p.K20E; 5:72461439-72461439	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.58A>G; p.K20E; 5:72461439-72461439	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.58A>G; p.K20E; 5:72461439-72461439	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.58A>G; p.K20E; 5:72461439-72461439	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.479T>C; p.V160A; 5:72461018-72461018	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.217G>A; p.G73R; 5:72461280-72461280	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.325C>T; p.L109F; 5:72461172-72461172	skin	malignant_melanoma	Substitution - Missense
c.1187C>T; p.S396F; 5:72460310-72460310	skin	malignant_melanoma	Substitution - Missense
c.1187C>T; p.S396F; 5:72460310-72460310	skin	malignant_melanoma	Substitution - Missense
c.1066G>A; p.E356K; 5:72460431-72460431	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.494C>T; p.T165M; 5:72461003-72461003	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.1077C>T; p.H359H; 5:72460420-72460420	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.666C>T; p.S222S; 5:72460831-72460831	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.858C>T; p.C286C; 5:72460639-72460639	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1690C>T; p.H564Y; 5:72447252-72447252	skin	malignant_melanoma	Substitution - Missense
c.1822G>A; p.G608R; 5:72444169-72444169	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1886A>C; p.E629A; 5:72444105-72444105	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2072G>A; p.R691K; 5:72443919-72443919	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.654G>A; p.E218E; 5:72460843-72460843	thyroid	other; neoplasm	Substitution - coding silent
c.976C>T; p.R326C; 5:72460521-72460521	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.652G>A; p.E218K; 5:72460845-72460845	breast	carcinoma	Substitution - Missense
c.1963G>A; p.A655T; 5:72444028-72444028	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1229A>G; p.N410S; 5:72460268-72460268	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2017G>A; p.G673R; 5:72443974-72443974	skin	malignant_melanoma	Substitution - Missense
c.38T>G; p.V13G; 5:72461459-72461459	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.1909C>T; p.P637S; 5:72444082-72444082	skin	malignant_melanoma	Substitution - Missense
c.1418A>C; p.N473T; 5:72456510-72456510	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.52G>C; p.A18P; 5:72461445-72461445	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1878C>G; p.Y626*; 5:72444113-72444113	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Nonsense
c.24C>G; p.I8M; 5:72461473-72461473	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1878C>T; p.Y626Y; 5:72444113-72444113	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.381G>A; p.Q127Q; 5:72461116-72461116	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.582G>A; p.S194S; 5:72460915-72460915	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1830T>G; p.S610R; 5:72444161-72444161	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1993G>C; p.E665Q; 5:72443998-72443998	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.110A>G; p.K37R; 5:72461387-72461387	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1995G>T; p.E665D; 5:72443996-72443996	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.576G>A; p.S192S; 5:72460921-72460921	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1519T>A; p.C507S; 5:72456409-72456409	breast	carcinoma	Substitution - Missense
c.45C>T; p.F15F; 5:72461452-72461452	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.45C>T; p.F15F; 5:72461452-72461452	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1488G>A; p.M496I; 5:72456440-72456440	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.805G>T; p.V269F; 5:72460692-72460692	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.983T>C; p.M328T; 5:72460514-72460514	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.46G>A; p.D16N; 5:72461451-72461451	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2198G>A; p.R733K; 5:72443793-72443793	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.714C>T; p.I238I; 5:72460783-72460783	skin	malignant_melanoma	Substitution - coding silent
c.1189G>A; p.E397K; 5:72460308-72460308	skin	malignant_melanoma	Substitution - Missense
c.1125C>A; p.P375P; 5:72460372-72460372	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1921C>G; p.Q641E; 5:72444070-72444070	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.400G>A; p.V134M; 5:72461097-72461097	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.400G>A; p.V134M; 5:72461097-72461097	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1699+8C>T; p.?; 5:72447235-72447235	liver	carcinoma	Unknown
c.1699+8C>T; p.?; 5:72447235-72447235	liver	carcinoma	Unknown
c.1916G>A; p.S639N; 5:72444075-72444075	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.304G>C; p.E102Q; 5:72461193-72461193	ovary	other; neoplasm	Substitution - Missense
c.500C>A; p.T167N; 5:72460997-72460997	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1356G>A; p.G452G; 5:72456572-72456572	skin	malignant_melanoma	Substitution - coding silent
c.2132G>A; p.G711D; 5:72443859-72443859	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1157C>T; p.T386M; 5:72460340-72460340	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1028G>A; p.G343D; 5:72460469-72460469	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1134C>T; p.A378A; 5:72460363-72460363	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1878C>A; p.Y626*; 5:72444113-72444113	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.512C>T; p.P171L; 5:72460985-72460985	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.419G>A; p.R140H; 5:72461078-72461078	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.958C>T; p.Q320*; 5:72460539-72460539	skin	malignant_melanoma	Substitution - Nonsense
c.419G>A; p.R140H; 5:72461078-72461078	breast	carcinoma	Substitution - Missense
c.129C>T; p.P43P; 5:72461368-72461368	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1402G>A; p.V468M; 5:72456526-72456526	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.478G>A; p.V160M; 5:72461019-72461019	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.541C>T; p.H181Y; 5:72460956-72460956	skin	malignant_melanoma	Substitution - Missense
c.1648C>T; p.R550C; 5:72447294-72447294	liver	carcinoma	Substitution - Missense
c.1648C>T; p.R550C; 5:72447294-72447294	liver	carcinoma	Substitution - Missense
c.422G>A; p.S141N; 5:72461075-72461075	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.384G>A; p.M128I; 5:72461113-72461113	breast	carcinoma	Substitution - Missense
c.422G>A; p.S141N; 5:72461075-72461075	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1110C>T; p.C370C; 5:72460387-72460387	skin	malignant_melanoma	Substitution - coding silent
c.510G>T; p.L170L; 5:72460987-72460987	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1206C>T; p.F402F; 5:72460291-72460291	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1710G>A; p.R570R; 5:72444281-72444281	skin	malignant_melanoma	Substitution - coding silent
c.1838G>A; p.G613D; 5:72444153-72444153	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2138C>A; p.S713Y; 5:72443853-72443853	breast	carcinoma	Substitution - Missense
c.851C>T; p.T284M; 5:72460646-72460646	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.867C>T; p.L289L; 5:72460630-72460630	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.851C>T; p.T284M; 5:72460646-72460646	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1102G>A; p.V368M; 5:72460395-72460395	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1858G>A; p.E620K; 5:72444133-72444133	skin	malignant_melanoma	Substitution - Missense
c.1480G>A; p.A494T; 5:72456448-72456448	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1376C>T; p.T459I; 5:72456552-72456552	skin	malignant_melanoma	Substitution - Missense
c.461C>T; p.P154L; 5:72461036-72461036	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1480G>A; p.A494T; 5:72456448-72456448	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1812C>T; p.F604F; 5:72444179-72444179	skin	malignant_melanoma	Substitution - coding silent
c.1302C>A; p.H434Q; 5:72460195-72460195	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1811T>C; p.F604S; 5:72444180-72444180	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1748G>A; p.R583K; 5:72444243-72444243	skin; arm	malignant_melanoma	Substitution - Missense
c.1680G>A; p.E560E; 5:72447262-72447262	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.976C>A; p.R326S; 5:72460521-72460521	breast	carcinoma	Substitution - Missense
c.976C>A; p.R326S; 5:72460521-72460521	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.1806G>T; p.P602P; 5:72444185-72444185	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.526T>C; p.Y176H; 5:72460971-72460971	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.695T>C; p.V232A; 5:72460802-72460802	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1919A>T; p.Q640L; 5:72444072-72444072	breast	carcinoma	Substitution - Missense
c.1222C>T; p.L408L; 5:72460275-72460275	prostate	adenoma	Substitution - coding silent
c.839C>T; p.P280L; 5:72460658-72460658	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.698A>G; p.D233G; 5:72460799-72460799	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1918C>T; p.Q640*; 5:72444073-72444073	skin	malignant_melanoma	Substitution - Nonsense
c.686T>C; p.V229A; 5:72460811-72460811	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.214G>A; p.E72K; 5:72461283-72461283	skin	malignant_melanoma	Substitution - Missense
c.1124C>G; p.P375R; 5:72460373-72460373	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.1297C>A; p.P433T; 5:72460200-72460200	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1856A>G; p.E619G; 5:72444135-72444135	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.111G>T; p.K37N; 5:72461386-72461386	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1410C>A; p.I470I; 5:72456518-72456518	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1947C>T; p.S649S; 5:72444044-72444044	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.723C>T; p.S241S; 5:72460774-72460774	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1793G>A; p.R598Q; 5:72444198-72444198	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.887T>C; p.L296P; 5:72460610-72460610	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1459G>A; p.V487M; 5:72456469-72456469	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.888G>A; p.L296L; 5:72460609-72460609	pancreas	carcinoma	Substitution - coding silent
c.10G>A; p.E4K; 5:72461487-72461487	skin	malignant_melanoma	Substitution - Missense
c.1018C>T; p.R340C; 5:72460479-72460479	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.866T>C; p.L289P; 5:72460631-72460631	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.866T>C; p.L289P; 5:72460631-72460631	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.775G>A; p.E259K; 5:72460722-72460722	breast	carcinoma	Substitution - Missense
c.309G>T; p.E103D; 5:72461188-72461188	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1164G>A; p.R388R; 5:72460333-72460333	skin	malignant_melanoma	Substitution - coding silent
c.1231C>A; p.H411N; 5:72460266-72460266	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1051G>A; p.E351K; 5:72460446-72460446	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2143delT; p.S715fs*13; 5:72443848-72443848	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.543C>T; p.H181H; 5:72460954-72460954	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.471C>A; p.P157P; 5:72461026-72461026	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.443A>T; p.K148M; 5:72461054-72461054	thyroid	other; neoplasm	Substitution - Missense
c.447C>T; p.P149P; 5:72461050-72461050	prostate	carcinoma	Substitution - coding silent
c.57G>A; p.V19V; 5:72461440-72461440	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.389A>G; p.D130G; 5:72461108-72461108	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1738G>T; p.G580C; 5:72444253-72444253	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1367G>A; p.R456Q; 5:72456561-72456561	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1938G>T; p.E646D; 5:72444053-72444053	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1367G>A; p.R456Q; 5:72456561-72456561	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1367G>A; p.R456Q; 5:72456561-72456561	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.206G>T; p.G69V; 5:72461291-72461291	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1670G>T; p.G557V; 5:72447272-72447272	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.1515C>G; p.F505L; 5:72456413-72456413	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1920G>A; p.Q640Q; 5:72444071-72444071	breast	carcinoma	Substitution - coding silent
c.977G>A; p.R326H; 5:72460520-72460520	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.860G>A; p.G287E; 5:72460637-72460637	skin; trunk	malignant_melanoma	Substitution - Missense
c.977G>A; p.R326H; 5:72460520-72460520	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.68C>T; p.P23L; 5:72461429-72461429	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.700G>A; p.V234M; 5:72460797-72460797	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.515C>T; p.T172M; 5:72460982-72460982	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1299G>A; p.P433P; 5:72460198-72460198	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.796T>A; p.Y266N; 5:72460701-72460701	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.748C>T; p.Q250*; 5:72460749-72460749	parathyroid	adenoma	Substitution - Nonsense
c.210C>T; p.V70V; 5:72461287-72461287	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1681C>T; p.R561W; 5:72447261-72447261	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2130G>A; p.R710R; 5:72443861-72443861	skin	malignant_melanoma	Substitution - coding silent
c.182C>T; p.P61L; 5:72461315-72461315	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.776A>G; p.E259G; 5:72460721-72460721	liver	carcinoma	Substitution - Missense
c.776A>G; p.E259G; 5:72460721-72460721	liver	carcinoma	Substitution - Missense
c.2170G>T; p.D724Y; 5:72443821-72443821	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.28G>A; p.D10N; 5:72461469-72461469	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.436G>T; p.G146W; 5:72461061-72461061	skin	malignant_melanoma	Substitution - Missense
c.1426G>A; p.A476T; 5:72456502-72456502	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.746C>T; p.S249L; 5:72460751-72460751	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1158G>A; p.T386T; 5:72460339-72460339	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.821G>A; p.G274D; 5:72460676-72460676	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.793A>G; p.K265E; 5:72460704-72460704	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.692G>A; p.R231K; 5:72460805-72460805	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.903G>A; p.L301L; 5:72460594-72460594	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.840G>A; p.P280P; 5:72460657-72460657	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.840G>A; p.P280P; 5:72460657-72460657	oesophagus	carcinoma	Substitution - coding silent
c.1723C>A; p.L575M; 5:72444268-72444268	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.265A>C; p.N89H; 5:72461232-72461232	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.152C>T; p.P51L; 5:72461345-72461345	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1046C>T; p.P349L; 5:72460451-72460451	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1341G>T; p.K447N; 5:72456587-72456587	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1189G>T; p.E397*; 5:72460308-72460308	liver	carcinoma	Substitution - Nonsense
c.1189G>T; p.E397*; 5:72460308-72460308	liver	carcinoma	Substitution - Nonsense
c.1599C>G; p.F533L; 5:72447343-72447343	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1396C>T; p.R466*; 5:72456532-72456532	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.532C>T; p.P178S; 5:72460965-72460965	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1847G>A; p.C616Y; 5:72444144-72444144	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1594C>A; p.P532T; 5:72447348-72447348	pancreas	carcinoma	Substitution - Missense
c.231G>A; p.R77R; 5:72461266-72461266	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.846G>A; p.A282A; 5:72460651-72460651	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.538G>T; p.V180F; 5:72460959-72460959	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.591_592insA; p.F198fs*43; 5:72460905-72460906	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1723C>T; p.L575L; 5:72444268-72444268	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1923G>A; p.Q641Q; 5:72444068-72444068	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.837G>C; p.K279N; 5:72460660-72460660	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1785G>T; p.Q595H; 5:72444206-72444206	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.651C>T; p.A217A; 5:72460846-72460846	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1174C>T; p.Q392*; 5:72460323-72460323	skin	malignant_melanoma	Substitution - Nonsense
c.1907C>T; p.A636V; 5:72444084-72444084	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1890C>T; p.P630P; 5:72444101-72444101	liver	carcinoma	Substitution - coding silent
c.1140G>A; p.L380L; 5:72460357-72460357	skin	malignant_melanoma	Substitution - coding silent
c.1890C>T; p.P630P; 5:72444101-72444101	liver	carcinoma	Substitution - coding silent
c.2185G>T; p.E729*; 5:72443806-72443806	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1879G>T; p.E627*; 5:72444112-72444112	liver	carcinoma	Substitution - Nonsense
c.1103T>C; p.V368A; 5:72460394-72460394	central_nervous_system; brain	glioma	Substitution - Missense
c.567C>T; p.F189F; 5:72460930-72460930	skin	malignant_melanoma	Substitution - coding silent
c.567C>T; p.F189F; 5:72460930-72460930	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1503C>T; p.D501D; 5:72456425-72456425	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2034G>A; p.R678R; 5:72443957-72443957	prostate	carcinoma	Substitution - coding silent
c.715G>A; p.D239N; 5:72460782-72460782	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.1089C>T; p.R363R; 5:72460408-72460408	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2109G>A; p.R703R; 5:72443882-72443882	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.2047C>A; p.L683I; 5:72443944-72443944	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.359C>T; p.P120L; 5:72461138-72461138	liver	carcinoma	Substitution - Missense
c.359C>T; p.P120L; 5:72461138-72461138	skin	malignant_melanoma	Substitution - Missense
c.359C>T; p.P120L; 5:72461138-72461138	liver	carcinoma	Substitution - Missense
c.1086G>A; p.G362G; 5:72460411-72460411	skin	malignant_melanoma	Substitution - coding silent
c.348C>T; p.F116F; 5:72461149-72461149	skin	malignant_melanoma	Substitution - coding silent
c.1491C>T; p.I497I; 5:72456437-72456437	skin	malignant_melanoma	Substitution - coding silent
c.446C>T; p.P149L; 5:72461051-72461051	skin	malignant_melanoma	Substitution - Missense
c.322G>A; p.G108S; 5:72461175-72461175	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1533G>A; p.G511G; 5:72447409-72447409	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.9G>C; p.K3N; 5:72461488-72461488	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.510G>C; p.L170L; 5:72460987-72460987	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.117C>A; p.P39P; 5:72461380-72461380	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2139T>G; p.S713S; 5:72443852-72443852	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.619C>A; p.Q207K; 5:72460878-72460878	central_nervous_system; medulla	glioma; astrocytoma_Grade_III	Substitution - Missense
c.437G>A; p.G146E; 5:72461060-72461060	skin	malignant_melanoma	Substitution - Missense
c.1889C>T; p.P630L; 5:72444102-72444102	skin	malignant_melanoma	Substitution - Missense
c.859G>T; p.G287W; 5:72460638-72460638	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1298C>T; p.P433L; 5:72460199-72460199	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2148T>G; p.D716E; 5:72443843-72443843	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1883T>C; p.V628A; 5:72444108-72444108	liver	carcinoma	Substitution - Missense
c.167G>A; p.R56Q; 5:72461330-72461330	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1883T>C; p.V628A; 5:72444108-72444108	liver	carcinoma	Substitution - Missense
c.246G>A; p.M82I; 5:72461251-72461251	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2040G>A; p.K680K; 5:72443951-72443951	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.298C>T; p.H100Y; 5:72461199-72461199	skin	malignant_melanoma	Substitution - Missense
c.524C>T; p.P175L; 5:72460973-72460973	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.889C>T; p.H297Y; 5:72460608-72460608	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]