Entrez Gene

Basic Information
Gene ID	1803
Name	DPP4
Synonymous	dipeptidyl-peptidase 4;DPP4;dipeptidyl-peptidase 4
Definition	ADCP-2\|DPP IV\|T-cell activation antigen CD26\|adenosine deaminase complexing protein 2\|dipeptidyl peptidase 4\|dipeptidyl peptidase IV\|dipeptidylpeptidase 4\|dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
Position	2q24.3
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.12.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.349G>T; p.E117*; 2:162045549-162045549	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.555C>A; p.I185I; 2:162038360-162038360	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.555C>A; p.I185I; 2:162038360-162038360	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1859A>G; p.D620G; 2:162009269-162009269	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.663T>C; p.T221T; 2:162035275-162035275	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1023+3G>A; p.?; 2:162024801-162024801	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.365A>C; p.K122T; 2:162045533-162045533	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.916G>A; p.A306T; 2:162024911-162024911	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1469-1_1469GG>AA; p.?; 2:162016866-162016867	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.360C>T; p.Y120Y; 2:162045538-162045538	pancreas	carcinoma	Substitution - coding silent
c.360C>T; p.Y120Y; 2:162045538-162045538	pancreas	carcinoma	Substitution - coding silent
c.1780A>G; p.I594V; 2:162011845-162011845	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.67G>A; p.V23M; 2:162073426-162073426	breast	carcinoma	Substitution - Missense
c.1061T>G; p.V354G; 2:162022762-162022762	thyroid	other; neoplasm	Substitution - Missense
c.2113G>A; p.G705R; 2:161995312-161995312	skin	malignant_melanoma	Substitution - Missense
c.1868G>A; p.R623Q; 2:162009260-162009260	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1868G>A; p.R623Q; 2:162009260-162009260	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1868G>A; p.R623Q; 2:162009260-162009260	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1868G>A; p.R623Q; 2:162009260-162009260	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1394C>T; p.A465V; 2:162018755-162018755	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1731C>A; p.S577R; 2:162011894-162011894	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1394C>T; p.A465V; 2:162018755-162018755	breast	carcinoma	Substitution - Missense
c.1926G>A; p.S642S; 2:162008623-162008623	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1215C>T; p.I405I; 2:162020258-162020258	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.688G>A; p.D230N; 2:162035250-162035250	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1360T>A; p.C454S; 2:162018789-162018789	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.319A>G; p.I107V; 2:162045579-162045579	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.27G>T; p.L9L; 2:162073466-162073466	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2269C>T; p.H757Y; 2:161993315-161993315	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.875C>T; p.S292F; 2:162033553-162033553	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1994T>C; p.V665A; 2:162005803-162005803	liver	carcinoma	Substitution - Missense
c.2053-1G>T; p.?; 2:161995373-161995373	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1863C>T; p.N621N; 2:162009265-162009265	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.658G>A; p.G220S; 2:162035280-162035280	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.658G>A; p.G220S; 2:162035280-162035280	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1456G>A; p.V486M; 2:162017120-162017120	breast	carcinoma	Substitution - Missense
c.1610C>T; p.S537F; 2:162014423-162014423	skin	malignant_melanoma	Substitution - Missense
c.1333C>T; p.L445F; 2:162018816-162018816	skin	malignant_melanoma	Substitution - Missense
c.2239G>T; p.A747S; 2:161993345-161993345	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.917C>T; p.A306V; 2:162024910-162024910	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1395G>A; p.A465A; 2:162018754-162018754	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1395G>A; p.A465A; 2:162018754-162018754	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1947T>C; p.C649C; 2:162008602-162008602	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1395G>A; p.A465A; 2:162018754-162018754	skin	malignant_melanoma	Substitution - coding silent
c.1395G>A; p.A465A; 2:162018754-162018754	pancreas	carcinoma	Substitution - coding silent
c.1395G>A; p.A465A; 2:162018754-162018754	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1459A>C; p.N487H; 2:162017117-162017117	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1299-1G>T; p.?; 2:162018851-162018851	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1468+1G>A; p.?; 2:162017107-162017107	skin	malignant_melanoma	Unknown
c.878T>C; p.M293T; 2:162033550-162033550	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.878T>C; p.M293T; 2:162033550-162033550	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.250G>A; p.G84R; 2:162046950-162046950	skin	malignant_melanoma	Substitution - Missense
c.2221G>A; p.G741R; 2:161993363-161993363	skin	malignant_melanoma	Substitution - Missense
c.1377_1378delGT; p.S460fs*3; 2:162018771-162018772	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1498T>C; p.L500L; 2:162016837-162016837	skin	malignant_melanoma	Substitution - coding silent
c.2298T>G; p.P766P; 2:161993286-161993286	skin	malignant_melanoma	Substitution - coding silent
c.564G>A; p.T188T; 2:162038351-162038351	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1189A>G; p.I397V; 2:162020284-162020284	liver	carcinoma	Substitution - Missense
c.867T>C; p.A289A; 2:162033561-162033561	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2097G>A; p.E699E; 2:161995328-161995328	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.980T>C; p.I327T; 2:162024847-162024847	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.165G>T; p.L55L; 2:162047431-162047431	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1067G>A; p.R356K; 2:162022756-162022756	breast	carcinoma	Substitution - Missense
c.868C>T; p.P290S; 2:162033560-162033560	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.286-1G>A; p.?; 2:162045613-162045613	lung	carcinoma; adenocarcinoma	Unknown
c.1050T>C; p.T350T; 2:162022773-162022773	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.940C>T; p.Q314*; 2:162024887-162024887	central_nervous_system; brain	glioma; oligodendroglioma_Grade_III	Substitution - Nonsense
c.1770C>T; p.I590I; 2:162011855-162011855	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1717A>G; p.I573V; 2:162011908-162011908	liver	carcinoma	Substitution - Missense
c.1271G>A; p.G424E; 2:162019250-162019250	skin	malignant_melanoma	Substitution - Missense
c.1717A>G; p.I573V; 2:162011908-162011908	liver	carcinoma	Substitution - Missense
c.889G>A; p.D297N; 2:162024938-162024938	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2002G>A; p.E668K; 2:162005795-162005795	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.632A>G; p.Y211C; 2:162035306-162035306	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1903G>A; p.V635I; 2:162008646-162008646	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.888G>A; p.G296G; 2:162024939-162024939	skin	malignant_melanoma	Substitution - coding silent
c.361G>A; p.V121M; 2:162045537-162045537	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.193+5G>T; p.?; 2:162047398-162047398	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.929G>T; p.R310I; 2:162024898-162024898	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.517T>C; p.Y173H; 2:162038398-162038398	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.699C>T; p.V233V; 2:162035239-162035239	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1633G>T; p.D545Y; 2:162014400-162014400	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.342T>G; p.I114M; 2:162045556-162045556	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1046G>A; p.S349N; 2:162022777-162022777	liver	carcinoma	Substitution - Missense
c.194-1G>T; p.?; 2:162047007-162047007	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1046G>A; p.S349N; 2:162022777-162022777	liver	carcinoma	Substitution - Missense
c.1630T>G; p.L544V; 2:162014403-162014403	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.869C>T; p.P290L; 2:162033559-162033559	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.943T>G; p.W315G; 2:162024884-162024884	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.217G>T; p.E73*; 2:162046983-162046983	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.288T>C; p.D96D; 2:162045610-162045610	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2072G>T; p.R691I; 2:161995353-161995353	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1462G>A; p.D488N; 2:162017114-162017114	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.360C>A; p.Y120*; 2:162045538-162045538	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.896A>T; p.Y299F; 2:162024931-162024931	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.458A>T; p.Q153L; 2:162038983-162038983	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.926A>G; p.E309G; 2:162024901-162024901	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.542C>T; p.P181L; 2:162038373-162038373	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1745G>A; p.G582E; 2:162011880-162011880	skin	malignant_melanoma	Substitution - Missense
c.1014C>A; p.N338K; 2:162024813-162024813	ovary	other; neoplasm	Substitution - Missense
c.536A>G; p.N179S; 2:162038379-162038379	skin	malignant_melanoma	Substitution - Missense
c.1014C>A; p.N338K; 2:162024813-162024813	ovary	other; neoplasm	Substitution - Missense
c.1753T>C; p.Y585H; 2:162011872-162011872	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.16A>G; p.K6E; 2:162073477-162073477	skin	malignant_melanoma	Substitution - Missense
c.687C>T; p.N229N; 2:162035251-162035251	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1180T>A; p.C394S; 2:162020293-162020293	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1730G>C; p.S577T; 2:162011895-162011895	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1078T>C; p.S360P; 2:162020679-162020679	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1458G>A; p.V486V; 2:162017118-162017118	skin	malignant_melanoma	Substitution - coding silent
c.1617A>C; p.K539N; 2:162014416-162014416	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1947T>A; p.C649*; 2:162008602-162008602	pancreas	carcinoma	Substitution - Nonsense
c.1947T>A; p.C649*; 2:162008602-162008602	pancreas	carcinoma	Substitution - Nonsense
c.535A>G; p.N179D; 2:162038380-162038380	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.935C>A; p.S312Y; 2:162024892-162024892	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.935C>A; p.S312Y; 2:162024892-162024892	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.935C>A; p.S312Y; 2:162024892-162024892	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1567+3A>G; p.?; 2:162016765-162016765	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.2092G>T; p.V698F; 2:161995333-161995333	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.515T>G; p.I172S; 2:162038400-162038400	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1928G>A; p.G643E; 2:162008621-162008621	skin	malignant_melanoma	Substitution - Missense
c.1245-5C>T; p.?; 2:162019281-162019281	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.24T>C; p.L8L; 2:162073469-162073469	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2176G>A; p.V726I; 2:161994984-161994984	central_nervous_system; brain	glioma	Substitution - Missense
c.888G>T; p.G296G; 2:162024939-162024939	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2222G>A; p.G741E; 2:161993362-161993362	breast	carcinoma	Substitution - Missense
c.1029G>A; p.R343R; 2:162022794-162022794	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1366T>C; p.Y456H; 2:162018783-162018783	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1023+10A>G; p.?; 2:162024794-162024794	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1084C>T; p.P362S; 2:162020673-162020673	skin; subungual	malignant_melanoma; acral_lentiginous	Substitution - Missense
c.1084C>T; p.P362S; 2:162020673-162020673	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.1309_1322del14; p.Y439fs*5; 2:162018827-162018840	prostate	carcinoma	Deletion - Frameshift
c.237C>T; p.F79F; 2:162046963-162046963	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1869A>G; p.R623R; 2:162009259-162009259	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.46G>T; p.A16S; 2:162073447-162073447	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1059G>A; p.W353*; 2:162022764-162022764	NS	malignant_melanoma	Substitution - Nonsense
c.1059G>A; p.W353*; 2:162022764-162022764	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Nonsense
c.1059G>A; p.W353*; 2:162022764-162022764	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Nonsense
c.2173G>A; p.D725N; 2:161994987-161994987	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2073A>G; p.R691R; 2:161995352-161995352	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2199+1G>A; p.?; 2:161994960-161994960	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1921G>A; p.G641R; 2:162008628-162008628	skin	malignant_melanoma	Substitution - Missense
c.481G>T; p.G161C; 2:162038960-162038960	central_nervous_system; brain	glioma	Substitution - Missense
c.1760G>A; p.G587E; 2:162011865-162011865	skin	malignant_melanoma	Substitution - Missense
c.1475G>C; p.R492T; 2:162016860-162016860	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.960G>C; p.Q320H; 2:162024867-162024867	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1961C>T; p.A654V; 2:162008588-162008588	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2278A>C; p.K760Q; 2:161993306-161993306	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1351C>T; p.P451S; 2:162018798-162018798	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1940T>C; p.F647S; 2:162008609-162008609	urinary_tract; bladder	carcinoma	Substitution - Missense
c.326C>T; p.P109L; 2:162045572-162045572	skin	malignant_melanoma	Substitution - Missense
c.119G>A; p.R40H; 2:162047477-162047477	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.779G>C; p.G260A; 2:162033649-162033649	breast	carcinoma	Substitution - Missense
c.1051A>G; p.T351A; 2:162022772-162022772	breast	carcinoma	Substitution - Missense
c.2199G>A; p.M733I; 2:161994961-161994961	skin	malignant_melanoma	Substitution - Missense
c.1493C>T; p.S498L; 2:162016842-162016842	breast	carcinoma	Substitution - Missense
c.1462G>T; p.D488Y; 2:162017114-162017114	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.928A>G; p.R310G; 2:162024899-162024899	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2241A>T; p.A747A; 2:161993343-161993343	pancreas	carcinoma	Substitution - coding silent
c.1421G>A; p.G474D; 2:162017155-162017155	pancreas	carcinoma	Substitution - Missense
c.1539delA; p.K513fs*7; 2:162016796-162016796	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2001A>T; p.T667T; 2:162005796-162005796	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1972C>T; p.R658W; 2:162008577-162008577	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1011G>T; p.W337C; 2:162024816-162024816	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1857G>T; p.V619V; 2:162009271-162009271	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent

Mutation summary in protein domains

Top

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

Loss of Function mutations compare to missense mutations

Top

The copy number variations for various cancers

Top

COSMIC somatic mutation [Top]