Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1852

Name

DUSP9

Synonymous

dual specificity phosphatase 9;DUSP9;dual specificity phosphatase 9

Definition

dual specificity protein phosphatase 9|map kinase phosphatase 4|mitogen-activated protein kinase phosphatase 4|serine/threonine specific protein phosphatase

Position

Xq28

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.15.

The copy number variations for various cancers

Top

There is no record for DUSP9

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.38G>A; p.R13Q; 23:153647991-153647991

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1103C>A; p.S368Y; 23:153650253-153650253

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.659C>T; p.A220V; 23:153649517-153649517

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1063G>A; p.G355S; 23:153650213-153650213

 prostatecarcinomaSubstitution - Missense

c.885C>T; p.S295S; 23:153650035-153650035

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.572G>A; p.G191D; 23:153649430-153649430

 skinmalignant_melanomaSubstitution - Missense

c.1046G>A; p.R349H; 23:153650196-153650196

 livercarcinomaSubstitution - Missense

c.475G>A; p.V159M; 23:153649333-153649333

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.727T>G; p.F243V; 23:153649585-153649585

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.727T>G; p.F243V; 23:153649585-153649585

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.597G>A; p.L199L; 23:153649455-153649455

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.918G>A; p.M306I; 23:153650068-153650068

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.1131C>T; p.G377G; 23:153650281-153650281

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.798G>A; p.S266S; 23:153649656-153649656

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1069delG; p.Q359fs*>26; 23:153650219-153650219

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.539G>A; p.R180H; 23:153649397-153649397

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.977A>G; p.N326S; 23:153650127-153650127

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.977A>G; p.N326S; 23:153650127-153650127

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.649C>A; p.R217R; 23:153649507-153649507

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.977A>G; p.N326S; 23:153650127-153650127

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.523G>A; p.E175K; 23:153649381-153649381

 skinmalignant_melanomaSubstitution - Missense

c.774C>T; p.S258S; 23:153649632-153649632

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.774C>T; p.S258S; 23:153649632-153649632

 pancreascarcinomaSubstitution - coding silent

c.907G>T; p.A303S; 23:153650057-153650057

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.732C>T; p.F244F; 23:153649590-153649590

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.732C>T; p.F244F; 23:153649590-153649590

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.732C>T; p.F244F; 23:153649590-153649590

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.732C>T; p.F244F; 23:153649590-153649590

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.732C>T; p.F244F; 23:153649590-153649590

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.775G>A; p.D259N; 23:153649633-153649633

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1137C>A; p.F379L; 23:153650287-153650287

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1068_1069insG; p.Q359fs*18; 23:153650218-153650219

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.985C>T; p.P329S; 23:153650135-153650135

 skinmalignant_melanomaSubstitution - Missense

c.976A>T; p.N326Y; 23:153650126-153650126

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1098G>A; p.P366P; 23:153650248-153650248

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.1098G>A; p.P366P; 23:153650248-153650248

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.452C>T; p.A151V; 23:153649310-153649310

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.521C>T; p.A174V; 23:153649379-153649379

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.521C>T; p.A174V; 23:153649379-153649379

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.995A>T; p.N332I; 23:153650145-153650145

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.756C>A; p.Y252*; 23:153649614-153649614

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.756C>A; p.Y252*; 23:153649614-153649614

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.541G>A; p.D181N; 23:153649399-153649399

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.538C>T; p.R180C; 23:153649396-153649396

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.1096C>A; p.P366T; 23:153650246-153650246

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.667G>T; p.E223*; 23:153649525-153649525

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Nonsense

c.528C>T; p.S176S; 23:153649386-153649386

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.950A>G; p.Y317C; 23:153650100-153650100

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1154A>T; p.*385L; 23:153650304-153650304

 large_intestine; rectumcarcinoma; adenocarcinomaNonstop extension

c.1028G>C; p.S343T; 23:153650178-153650178

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1074G>T; p.G358G; 23:153650224-153650224

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1067G>T; p.S356I; 23:153650217-153650217

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.995A>G; p.N332S; 23:153650145-153650145

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.878G>T; p.G293V; 23:153650028-153650028

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.710delC; p.N239fs*>146; 23:153649568-153649568

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.996C>T; p.N332N; 23:153650146-153650146

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.455C>T; p.P152L; 23:153649313-153649313

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1039G>T; p.E347*; 23:153650189-153650189

 breastcarcinomaSubstitution - Nonsense

c.580C>A; p.P194T; 23:153649438-153649438

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.978C>T; p.N326N; 23:153650128-153650128

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.997T>A; p.F333I; 23:153650147-153650147

 breastcarcinomaSubstitution - Missense

c.473C>T; p.P158L; 23:153649331-153649331

 skinmalignant_melanomaSubstitution - Missense

c.155G>A; p.R52H; 23:153648108-153648108

 livercarcinomaSubstitution - Missense

c.433C>T; p.R145C; 23:153649291-153649291

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.566C>T; p.S189L; 23:153649424-153649424

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.155G>A; p.R52H; 23:153648108-153648108

 livercarcinomaSubstitution - Missense

c.669G>T; p.E223D; 23:153649527-153649527

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.527C>A; p.S176Y; 23:153649385-153649385

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

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