| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 1958 |
Name | EGR1 |
Synonymous | early growth response 1;EGR1;early growth response 1 |
Definition | EGR-1|early growth response protein 1|nerve growth factor-induced protein A|transcription factor ETR103|transcription factor Zif268|zinc finger protein 225|zinc finger protein Krox-24 |
Position | 5q31.1 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.33. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.108G>A; p.E36E; 5:138465870-138465870 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma | Substitution - coding silent |
c.450G>A; p.W150*; 5:138466899-138466899 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.959G>A; p.R320H; 5:138467408-138467408 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.1123C>T; p.R375C; 5:138467572-138467572 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1626T>C; p.I542I; 5:138468075-138468075 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1440G>A; p.S480S; 5:138467889-138467889 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |