Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

22954

Name

TRIM32

Synonymous

tripartite motif containing 32;TRIM32;tripartite motif containing 32

Definition

72 kDa Tat-interacting protein|E3 ubiquitin-protein ligase TRIM32|TAT-interactive protein, 72-KD|tripartite motif-containing 32|tripartite motif-containing protein 32|zinc finger protein HT2A|zinc-finger protein HT2A

Position

9q33.1

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.13.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1610T>A; p.L537Q; 9:116699352-116699352

kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.1129C>T; p.L377F; 9:116698871-116698871

urinary_tract; bladdercarcinomaSubstitution - Missense

c.1129C>T; p.L377F; 9:116698871-116698871

urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.1677G>T; p.G559G; 9:116699419-116699419

lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1578C>A; p.T526T; 9:116699320-116699320

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.876A>G; p.G292G; 9:116698618-116698618

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.876A>G; p.G292G; 9:116698618-116698618

endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.395G>A; p.G132D; 9:116698137-116698137

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1853G>A; p.C618Y; 9:116699595-116699595

urinary_tract; bladdercarcinomaSubstitution - Missense

c.1498C>T; p.R500*; 9:116699240-116699240

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.52C>A; p.L18I; 9:116697794-116697794

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.960T>C; p.V320V; 9:116698702-116698702

kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1754C>T; p.A585V; 9:116699496-116699496

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.968G>C; p.R323T; 9:116698710-116698710

skinmalignant_melanomaSubstitution - Missense

c.553C>A; p.L185I; 9:116698295-116698295

endometriumcarcinoma; serous_carcinomaSubstitution - Missense

c.1656T>C; p.I552I; 9:116699398-116699398

ovaryother; neoplasmSubstitution - coding silent

c.1618C>T; p.R540W; 9:116699360-116699360

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.666G>T; p.E222D; 9:116698408-116698408

skin; facecarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.762G>A; p.L254L; 9:116698504-116698504

stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1798C>A; p.L600I; 9:116699540-116699540

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1632C>T; p.H544H; 9:116699374-116699374

oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - coding silent

c.1072C>A; p.L358I; 9:116698814-116698814

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.302G>A; p.R101Q; 9:116698044-116698044

urinary_tract; bladdercarcinomaSubstitution - Missense

c.1808C>A; p.P603H; 9:116699550-116699550

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1576A>G; p.T526A; 9:116699318-116699318

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1273G>T; p.D425Y; 9:116699015-116699015

pancreascarcinomaSubstitution - Missense

c.97C>T; p.R33C; 9:116697839-116697839

pancreascarcinomaSubstitution - Missense

c.97C>T; p.R33C; 9:116697839-116697839

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.551T>A; p.V184D; 9:116698293-116698293

breastcarcinomaSubstitution - Missense

c.574G>A; p.E192K; 9:116698316-116698316

thyroidother; neoplasmSubstitution - Missense

c.1640A>C; p.E547A; 9:116699382-116699382

kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1578C>T; p.T526T; 9:116699320-116699320

central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.1578C>T; p.T526T; 9:116699320-116699320

central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.11C>T; p.A4V; 9:116697753-116697753

skinmalignant_melanomaSubstitution - Missense

c.1354C>T; p.L452F; 9:116699096-116699096

boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.1031G>A; p.R344Q; 9:116698773-116698773

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1735G>C; p.A579P; 9:116699477-116699477

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1709C>A; p.S570*; 9:116699451-116699451

pancreascarcinomaSubstitution - Nonsense

c.12A>C; p.A4A; 9:116697754-116697754

stomachadenocarcinomaSubstitution - coding silent

c.1417T>C; p.W473R; 9:116699159-116699159

pancreascarcinomaSubstitution - Missense

c.234C>G; p.D78E; 9:116697976-116697976

breastcarcinomaSubstitution - Missense

c.923C>T; p.A308V; 9:116698665-116698665

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1285C>A; p.L429I; 9:116699027-116699027

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.277G>T; p.E93*; 9:116698019-116698019

lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.99T>C; p.R33R; 9:116697841-116697841

upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.721T>C; p.Y241H; 9:116698463-116698463

kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1124T>G; p.V375G; 9:116698866-116698866

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.147G>A; p.E49E; 9:116697889-116697889

endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1816G>T; p.G606W; 9:116699558-116699558

lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.938C>T; p.A313V; 9:116698680-116698680

bone; vertebraeEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.938C>T; p.A313V; 9:116698680-116698680

bone; vertebraeEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.1654A>T; p.I552F; 9:116699396-116699396

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.576G>A; p.E192E; 9:116698318-116698318

endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1787G>A; p.R596H; 9:116699529-116699529

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.464G>A; p.R155H; 9:116698206-116698206

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1292C>T; p.P431L; 9:116699034-116699034

skinmalignant_melanomaSubstitution - Missense

c.1923G>C; p.K641N; 9:116699665-116699665

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.252G>A; p.K84K; 9:116697994-116697994

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1606A>G; p.N536D; 9:116699348-116699348

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1924A>G; p.I642V; 9:116699666-116699666

livercarcinomaSubstitution - Missense

c.1924A>G; p.I642V; 9:116699666-116699666

livercarcinomaSubstitution - Missense

c.556C>T; p.Q186*; 9:116698298-116698298

breastcarcinomaSubstitution - Nonsense

c.797C>T; p.T266I; 9:116698539-116698539

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1254G>A; p.V418V; 9:116698996-116698996

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.608G>A; p.R203Q; 9:116698350-116698350

pancreascarcinomaSubstitution - Missense

c.178C>T; p.R60C; 9:116697920-116697920

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.244G>A; p.V82M; 9:116697986-116697986

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.273C>T; p.L91L; 9:116698015-116698015

thyroidcarcinomaSubstitution - coding silent

c.112C>A; p.H38N; 9:116697854-116697854

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1222C>A; p.R408S; 9:116698964-116698964

skinmalignant_melanomaSubstitution - Missense

c.655C>T; p.Q219*; 9:116698397-116698397

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.615C>A; p.F205L; 9:116698357-116698357

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1125C>T; p.V375V; 9:116698867-116698867

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1223G>A; p.R408H; 9:116698965-116698965

central_nervous_system; braingliomaSubstitution - Missense

c.1770C>T; p.I590I; 9:116699512-116699512

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1770C>T; p.I590I; 9:116699512-116699512

skinmalignant_melanomaSubstitution - coding silent

c.1384G>A; p.V462M; 9:116699126-116699126

oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.1243G>T; p.D415Y; 9:116698985-116698985

pancreaspancreatic_intraepithelial_neoplasia_(PanIN)Substitution - Missense

c.1243G>T; p.D415Y; 9:116698985-116698985

pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.206G>A; p.R69H; 9:116697948-116697948

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.572A>C; p.E191A; 9:116698314-116698314

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1088C>T; p.A363V; 9:116698830-116698830

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1088C>T; p.A363V; 9:116698830-116698830

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1088C>T; p.A363V; 9:116698830-116698830

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1577C>T; p.T526I; 9:116699319-116699319

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.172G>T; p.G58C; 9:116697914-116697914

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.211A>G; p.T71A; 9:116697953-116697953

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1045G>T; p.A349S; 9:116698787-116698787

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1147G>T; p.G383C; 9:116698889-116698889

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1526G>A; p.C509Y; 9:116699268-116699268

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.46G>A; p.E16K; 9:116697788-116697788

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1526G>A; p.C509Y; 9:116699268-116699268

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1537G>T; p.A513S; 9:116699279-116699279

prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1397G>T; p.R466M; 9:116699139-116699139

lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.292C>A; p.L98I; 9:116698034-116698034

kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.593A>G; p.E198G; 9:116698335-116698335

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1271C>T; p.A424V; 9:116699013-116699013

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.812G>A; p.R271Q; 9:116698554-116698554

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_leukaemiaSubstitution - Missense

c.1640A>G; p.E547G; 9:116699382-116699382

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1640A>G; p.E547G; 9:116699382-116699382

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.812G>A; p.R271Q; 9:116698554-116698554

lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.660G>C; p.V220V; 9:116698402-116698402

haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.1161C>T; p.V387V; 9:116698903-116698903

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.61C>T; p.P21S; 9:116697803-116697803

skin; facecarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1745G>A; p.C582Y; 9:116699487-116699487

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.499A>T; p.K167*; 9:116698241-116698241

livercarcinoma; hepatocellular_carcinomaSubstitution - Nonsense

c.1926C>T; p.I642I; 9:116699668-116699668

breastcarcinomaSubstitution - coding silent

c.518T>C; p.V173A; 9:116698260-116698260

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1639G>T; p.E547*; 9:116699381-116699381

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1030C>T; p.R344W; 9:116698772-116698772

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.90G>A; p.E30E; 9:116697832-116697832

bone; extraskeletalEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.1030C>T; p.R344W; 9:116698772-116698772

prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1323G>A; p.L441L; 9:116699065-116699065

urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1961_1962insT; p.*654fs?; 9:116699703-116699704

large_intestine; caecumcarcinoma; adenocarcinomaInsertion - Frameshift

c.605C>T; p.S202F; 9:116698347-116698347

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.714C>T; p.R238R; 9:116698456-116698456

ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.972G>T; p.E324D; 9:116698714-116698714

autonomic_ganglianeuroblastomaSubstitution - Missense

c.682C>T; p.L228F; 9:116698424-116698424

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.379G>A; p.D127N; 9:116698121-116698121

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.284T>G; p.V95G; 9:116698026-116698026

stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.327G>C; p.R109R; 9:116698069-116698069

lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.205C>T; p.R69C; 9:116697947-116697947

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1792G>A; p.E598K; 9:116699534-116699534

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.247C>T; p.L83L; 9:116697989-116697989

upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent


')