Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

23087

Name

TRIM35

Synonymous

tripartite motif containing 35;TRIM35;tripartite motif containing 35

Definition

hemopoietic lineage switch protein 5|tripartite motif-containing 35|tripartite motif-containing protein 35

Position

8p21.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.03.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1092_1093insG; p.L365fs*18; 8:27287939-27287940

 large_intestinecarcinoma; adenocarcinomaInsertion - Frameshift

c.969C>T; p.S323S; 8:27288063-27288063

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.398G>A; p.R133H; 8:27310838-27310838

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.969C>T; p.S323S; 8:27288063-27288063

 ovaryother; neoplasmSubstitution - coding silent

c.86G>A; p.R29H; 8:27311150-27311150

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1301G>A; p.C434Y; 8:27287731-27287731

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.598G>C; p.V200L; 8:27294244-27294244

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.466C>T; p.R156W; 8:27298529-27298529

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.850C>A; p.L284M; 8:27289216-27289216

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1405G>A; p.A469T; 8:27287627-27287627

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1045C>T; p.R349C; 8:27287987-27287987

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1436G>A; p.R479H; 8:27287596-27287596

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.958G>A; p.D320N; 8:27288074-27288074

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.8G>A; p.R3Q; 8:27311228-27311228

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.45C>G; p.F15L; 8:27311191-27311191

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1239G>A; p.S413S; 8:27287793-27287793

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1312G>A; p.E438K; 8:27287720-27287720

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1478G>A; p.G493D; 8:27287554-27287554

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1336C>T; p.R446C; 8:27287696-27287696

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1254G>A; p.S418S; 8:27287778-27287778

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1254G>A; p.S418S; 8:27287778-27287778

 central_nervous_system; braingliomaSubstitution - coding silent

c.1254G>A; p.S418S; 8:27287778-27287778

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.557G>A; p.R186Q; 8:27294285-27294285

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1263C>T; p.V421V; 8:27287769-27287769

 skinmalignant_melanomaSubstitution - coding silent

c.1446C>T; p.P482P; 8:27287586-27287586

 skinmalignant_melanomaSubstitution - coding silent

c.988C>T; p.R330C; 8:27288044-27288044

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.988C>T; p.R330C; 8:27288044-27288044

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.583C>T; p.R195C; 8:27294259-27294259

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.583C>T; p.R195C; 8:27294259-27294259

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.583C>T; p.R195C; 8:27294259-27294259

 skinmalignant_melanomaSubstitution - Missense

c.1363G>A; p.A455T; 8:27287669-27287669

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.822C>T; p.P274P; 8:27289244-27289244

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.822C>T; p.P274P; 8:27289244-27289244

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.822C>T; p.P274P; 8:27289244-27289244

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.273C>T; p.R91R; 8:27310963-27310963

 livercarcinoma; hepatocellular_carcinomaSubstitution - coding silent

c.35C>T; p.S12F; 8:27311201-27311201

 kidneyother; neoplasmSubstitution - Missense

c.1251G>T; p.T417T; 8:27287781-27287781

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.784C>T; p.R262*; 8:27290157-27290157

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1280G>A; p.R427H; 8:27287752-27287752

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.868C>T; p.R290C; 8:27289198-27289198

 skinmalignant_melanomaSubstitution - Missense

c.266G>A; p.G89D; 8:27310970-27310970

 skinmalignant_melanomaSubstitution - Missense

c.495G>A; p.M165I; 8:27298500-27298500

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1140C>T; p.G380G; 8:27287892-27287892

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.500G>A; p.R167H; 8:27298495-27298495

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.719G>A; p.R240Q; 8:27294123-27294123

 breastcarcinomaSubstitution - Missense

c.1023G>A; p.S341S; 8:27288009-27288009

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.938G>A; p.G313D; 8:27288094-27288094

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.938G>A; p.G313D; 8:27288094-27288094

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.231C>T; p.N77N; 8:27311005-27311005

 skinmalignant_melanomaSubstitution - coding silent

c.780delA; p.K260fs*152; 8:27290161-27290161

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.263A>T; p.E88V; 8:27310973-27310973

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.862C>T; p.Q288*; 8:27289204-27289204

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.328C>A; p.L110I; 8:27310908-27310908

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.1027C>A; p.P343T; 8:27288005-27288005

 upper_aerodigestive_tract; pharynxcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.655C>T; p.L219L; 8:27294187-27294187

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.835G>A; p.D279N; 8:27289231-27289231

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.947C>A; p.S316Y; 8:27288085-27288085

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.517G>A; p.A173T; 8:27298478-27298478

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.517G>A; p.A173T; 8:27298478-27298478

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.964A>T; p.T322S; 8:27288068-27288068

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.1092delG; p.L365fs*47; 8:27287940-27287940

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.1348C>T; p.L450L; 8:27287684-27287684

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1224C>G; p.D408E; 8:27287808-27287808

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1311C>T; p.G437G; 8:27287721-27287721

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1073G>A; p.W358*; 8:27287959-27287959

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.1435C>T; p.R479C; 8:27287597-27287597

 bone; tibiaEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.1362C>T; p.H454H; 8:27287670-27287670

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.923C>T; p.P308L; 8:27288109-27288109

 skinmalignant_melanomaSubstitution - Missense

c.633G>T; p.E211D; 8:27294209-27294209

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.634G>C; p.E212Q; 8:27294208-27294208

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.107G>A; p.C36Y; 8:27311129-27311129

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.748G>A; p.V250I; 8:27294094-27294094

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.748G>A; p.V250I; 8:27294094-27294094

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.522G>A; p.K174K; 8:27298473-27298473

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.569A>G; p.E190G; 8:27294273-27294273

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.970G>A; p.V324I; 8:27288062-27288062

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.1212C>T; p.G404G; 8:27287820-27287820

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.692C>T; p.T231M; 8:27294150-27294150

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.556C>T; p.R186W; 8:27294286-27294286

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1368C>G; p.R456R; 8:27287664-27287664

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.199G>A; p.A67T; 8:27311037-27311037

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.511G>A; p.A171T; 8:27298484-27298484

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1113C>T; p.G371G; 8:27287919-27287919

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.558G>T; p.R186R; 8:27294284-27294284

 lung; middle_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.1113C>T; p.G371G; 8:27287919-27287919

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.558G>T; p.R186R; 8:27294284-27294284

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.871G>A; p.V291I; 8:27289195-27289195

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.591C>T; p.F197F; 8:27294251-27294251

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1318T>C; p.S440P; 8:27287714-27287714

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1318T>A; p.S440T; 8:27287714-27287714

 kidneyother; neoplasmSubstitution - Missense

c.745G>A; p.D249N; 8:27294097-27294097

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.308T>G; p.L103R; 8:27310928-27310928

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1206G>A; p.T402T; 8:27287826-27287826

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.296G>T; p.R99L; 8:27310940-27310940

 lungcarcinoma; adenocarcinomaSubstitution - Missense

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