Entrez Gene

Basic Information
Gene ID	23095
Name	KIF1B
Synonymous	kinesin family member 1B;KIF1B;kinesin family member 1B
Definition	kinesin superfamily protein KIF1B\|kinesin-like protein KIF1B
Position	1p36.2
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.06.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.3180G>A; p.E1060E; 1:10337429-10337429	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1422A>G; p.G474G; 1:10292092-10292092	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.3318G>A; p.T1106T; 1:10339802-10339802	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.4011G>T; p.M1337I; 1:10361022-10361022	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2352_2364del13; p.D785fs*17; 1:10324015-10324027	oesophagus	carcinoma; adenocarcinoma	Deletion - Frameshift
c.3185G>A; p.G1062D; 1:10337434-10337434	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.253G>A; p.A85T; 1:10258562-10258562	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.253G>A; p.A85T; 1:10258562-10258562	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3698C>A; p.P1233H; 1:10347799-10347799	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.873G>T; p.K291N; 1:10275436-10275436	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.186C>T; p.P62P; 1:10258495-10258495	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1296G>A; p.K432K; 1:10282533-10282533	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.4448C>T; p.S1483L; 1:10365482-10365482	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3995G>T; p.G1332V; 1:10361006-10361006	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3820C>T; p.R1274W; 1:10352639-10352639	breast	carcinoma	Substitution - Missense
c.3820C>T; p.R1274W; 1:10352639-10352639	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.3820C>T; p.R1274W; 1:10352639-10352639	breast	carcinoma	Substitution - Missense
c.1640-2A>T; p.?; 1:10296580-10296580	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.1640-2A>T; p.?; 1:10296580-10296580	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.1694G>A; p.R565K; 1:10296636-10296636	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2691C>T; p.A897A; 1:10326264-10326264	skin	malignant_melanoma	Substitution - coding silent
c.1855G>A; p.E619K; 1:10297028-10297028	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.833T>G; p.L278W; 1:10272275-10272275	skin	malignant_melanoma	Substitution - Missense
c.326G>T; p.G109V; 1:10258635-10258635	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3908A>G; p.N1303S; 1:10352727-10352727	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2489G>A; p.G830D; 1:10324847-10324847	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3737G>A; p.R1246Q; 1:10348659-10348659	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.5298C>G; p.S1766R; 1:10376572-10376572	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.895C>T; p.P299S; 1:10275458-10275458	skin	malignant_melanoma	Substitution - Missense
c.895C>T; p.P299S; 1:10275458-10275458	skin	malignant_melanoma	Substitution - Missense
c.1639+10C>T; p.?; 1:10295776-10295776	stomach	carcinoma; adenocarcinoma	Unknown
c.4711C>T; p.R1571W; 1:10371165-10371165	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.4252A>T; p.I1418F; 1:10365123-10365123	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.88A>G; p.M30V; 1:10232416-10232416	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2327G>A; p.R776H; 1:10323990-10323990	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3911C>G; p.S1304C; 1:10352730-10352730	breast	carcinoma	Substitution - Missense
c.3918-1G>T; p.?; 1:10360928-10360928	stomach	carcinoma; adenocarcinoma	Unknown
c.920G>A; p.W307*; 1:10275483-10275483	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1880A>G; p.D627G; 1:10297053-10297053	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2992-10delT; p.?; 1:10337064-10337064	skin	malignant_melanoma	Unknown
c.2297delA; p.T768fs*12; 1:10323960-10323960	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2881C>T; p.R961C; 1:10334614-10334614	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.4144G>A; p.G1382S; 1:10361803-10361803	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2638G>A; p.E880K; 1:10326211-10326211	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2638G>A; p.E880K; 1:10326211-10326211	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1298A>C; p.E433A; 1:10291083-10291083	skin; arm	malignant_melanoma	Substitution - Missense
c.4691C>T; p.S1564F; 1:10371145-10371145	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.4117C>T; p.R1373C; 1:10361776-10361776	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.206C>T; p.S69F; 1:10258515-10258515	breast	carcinoma	Substitution - Missense
c.3505C>T; p.P1169S; 1:10343242-10343242	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2024G>A; p.R675Q; 1:10320089-10320089	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3514C>T; p.R1172*; 1:10343251-10343251	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.2024G>A; p.R675Q; 1:10320089-10320089	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.865-1G>C; p.?; 1:10275427-10275427	urinary_tract; bladder	carcinoma	Unknown
c.3372G>A; p.Q1124Q; 1:10339856-10339856	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3372G>A; p.Q1124Q; 1:10339856-10339856	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2593C>T; p.P865S; 1:10326166-10326166	skin	malignant_melanoma	Substitution - Missense
c.3944G>T; p.W1315L; 1:10360955-10360955	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.4842C>A; p.P1614P; 1:10374349-10374349	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.4671C>T; p.S1557S; 1:10368523-10368523	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.123G>T; p.K41N; 1:10256263-10256263	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3507G>A; p.P1169P; 1:10343244-10343244	liver	carcinoma	Substitution - coding silent
c.3507G>A; p.P1169P; 1:10343244-10343244	liver	carcinoma	Substitution - coding silent
c.3292C>T; p.H1098Y; 1:10339776-10339776	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3040G>A; p.E1014K; 1:10337122-10337122	breast	carcinoma	Substitution - Missense
c.701C>A; p.T234N; 1:10268244-10268244	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3146A>G; p.D1049G; 1:10337395-10337395	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.983C>T; p.A328V; 1:10276363-10276363	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1086G>T; p.L362L; 1:10278052-10278052	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.5051T>A; p.V1684D; 1:10374946-10374946	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.285C>G; p.A95A; 1:10258594-10258594	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.285C>G; p.A95A; 1:10258594-10258594	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.5051T>A; p.V1684D; 1:10374946-10374946	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.285C>G; p.A95A; 1:10258594-10258594	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.139C>T; p.P47S; 1:10256279-10256279	skin	malignant_melanoma	Substitution - Missense
c.719A>T; p.K240M; 1:10268262-10268262	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.1888C>G; p.Q630E; 1:10297061-10297061	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1542A>G; p.Q514Q; 1:10295669-10295669	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; polycythaemia_vera	Substitution - coding silent
c.1819C>T; p.P607S; 1:10296992-10296992	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.85C>T; p.Q29*; 1:10232413-10232413	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.2848G>A; p.V950I; 1:10334581-10334581	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3712delT; p.L1239fs*12; 1:10347813-10347813	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.4666G>A; p.G1556S; 1:10368518-10368518	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1297G>A; p.E433K; 1:10291082-10291082	skin; arm	malignant_melanoma	Substitution - Missense
c.96C>T; p.G32G; 1:10232424-10232424	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.3002C>T; p.S1001L; 1:10337084-10337084	skin	malignant_melanoma	Substitution - Missense
c.3396A>C; p.E1132D; 1:10342070-10342070	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1830T>C; p.P610P; 1:10297003-10297003	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.5271-4A>C; p.?; 1:10376541-10376541	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.3002C>T; p.S1001L; 1:10337084-10337084	skin	malignant_melanoma	Substitution - Missense
c.4575C>T; p.I1525I; 1:10365609-10365609	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.5271-4A>C; p.?; 1:10376541-10376541	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1191A>G; p.P397P; 1:10282428-10282428	thyroid	other; neoplasm	Substitution - coding silent
c.1711C>G; p.Q571E; 1:10296653-10296653	breast	carcinoma	Substitution - Missense
c.4525G>C; p.E1509Q; 1:10365559-10365559	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.3107G>A; p.R1036Q; 1:10337189-10337189	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3107G>A; p.R1036Q; 1:10337189-10337189	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3317C>T; p.T1106M; 1:10339801-10339801	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2384C>A; p.S795Y; 1:10324047-10324047	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1713G>A; p.Q571Q; 1:10296655-10296655	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.220T>A; p.Y74N; 1:10258529-10258529	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2710G>T; p.E904*; 1:10326283-10326283	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.3010G>T; p.A1004S; 1:10337092-10337092	thyroid	other; neoplasm	Substitution - Missense
c.4233G>A; p.M1411I; 1:10365104-10365104	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4167G>T; p.S1389S; 1:10363283-10363283	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.5285G>A; p.R1762H; 1:10376559-10376559	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.3285C>T; p.N1095N; 1:10339769-10339769	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.3285C>T; p.N1095N; 1:10339769-10339769	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.5285G>A; p.R1762H; 1:10376559-10376559	stomach	adenocarcinoma	Substitution - Missense
c.227A>G; p.D76G; 1:10258536-10258536	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.306A>G; p.G102G; 1:10258615-10258615	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2701G>A; p.A901T; 1:10326274-10326274	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.227A>G; p.D76G; 1:10258536-10258536	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2680G>A; p.V894M; 1:10326253-10326253	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1223T>C; p.L408S; 1:10282460-10282460	liver	carcinoma	Substitution - Missense
c.1198T>A; p.C400S; 1:10282435-10282435	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.3350C>T; p.P1117L; 1:10339834-10339834	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4020G>A; p.S1340S; 1:10361031-10361031	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.4020G>A; p.S1340S; 1:10361031-10361031	prostate	carcinoma	Substitution - coding silent
c.654C>T; p.H218H; 1:10268197-10268197	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.3399A>G; p.S1133S; 1:10342073-10342073	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.980C>T; p.P327L; 1:10276360-10276360	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2149C>T; p.R717W; 1:10321786-10321786	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.146C>T; p.S49F; 1:10256286-10256286	skin	malignant_melanoma	Substitution - Missense
c.5304G>A; p.S1768S; 1:10376578-10376578	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.146C>T; p.S49F; 1:10256286-10256286	skin	malignant_melanoma	Substitution - Missense
c.2464G>T; p.D822Y; 1:10324822-10324822	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.4600G>A; p.E1534K; 1:10365634-10365634	skin	malignant_melanoma	Substitution - Missense
c.4313G>T; p.R1438L; 1:10365184-10365184	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.226G>T; p.D76Y; 1:10258535-10258535	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.4759T>C; p.S1587P; 1:10371213-10371213	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.5227G>A; p.D1743N; 1:10375330-10375330	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4672G>A; p.V1558I; 1:10368524-10368524	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3410A>G; p.Y1137C; 1:10342084-10342084	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.3812-1G>A; p.?; 1:10352630-10352630	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelofibrosis	Unknown
c.997G>A; p.D333N; 1:10276377-10276377	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3551-2A>C; p.?; 1:10345843-10345843	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Unknown
c.339A>C; p.E113D; 1:10258648-10258648	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2494G>A; p.D832N; 1:10324852-10324852	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2689G>A; p.A897T; 1:10326262-10326262	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4313G>A; p.R1438H; 1:10365184-10365184	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.2558G>T; p.C853F; 1:10326131-10326131	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2558G>T; p.C853F; 1:10326131-10326131	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2510G>A; p.R837Q; 1:10324868-10324868	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4548G>C; p.E1516D; 1:10365582-10365582	breast	carcinoma	Substitution - Missense
c.127C>T; p.P43S; 1:10256267-10256267	skin	malignant_melanoma	Substitution - Missense
c.4236G>A; p.Q1412Q; 1:10365107-10365107	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2902G>A; p.A968T; 1:10334635-10334635	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.4525G>A; p.E1509K; 1:10365559-10365559	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3697C>T; p.P1233S; 1:10347798-10347798	NS	malignant_melanoma	Substitution - Missense
c.5206C>A; p.L1736I; 1:10375309-10375309	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4166C>T; p.S1389L; 1:10361825-10361825	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1055C>T; p.A352V; 1:10278021-10278021	breast	carcinoma	Substitution - Missense
c.3773G>C; p.S1258T; 1:10348695-10348695	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5266A>G; p.I1756V; 1:10375369-10375369	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1569A>T; p.I523I; 1:10295696-10295696	breast	carcinoma	Substitution - coding silent
c.2344G>A; p.E782K; 1:10324007-10324007	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.4561G>A; p.D1521N; 1:10365595-10365595	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3013A>G; p.M1005V; 1:10337095-10337095	thyroid	carcinoma	Substitution - Missense
c.2322C>T; p.F774F; 1:10323985-10323985	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.709T>C; p.S237P; 1:10268252-10268252	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.2179C>T; p.L727L; 1:10321816-10321816	skin	malignant_melanoma	Substitution - coding silent
c.2754C>T; p.Y918Y; 1:10326327-10326327	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1995G>A; p.L665L; 1:10320060-10320060	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.3902C>T; p.S1301F; 1:10352721-10352721	skin	malignant_melanoma	Substitution - Missense
c.4055C>T; p.A1352V; 1:10361714-10361714	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3599G>A; p.S1200N; 1:10345893-10345893	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1899G>T; p.E633D; 1:10297072-10297072	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1398G>A; p.M466I; 1:10292068-10292068	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.5272T>G; p.S1758A; 1:10376546-10376546	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.5272T>G; p.S1758A; 1:10376546-10376546	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.4176C>A; p.V1392V; 1:10363292-10363292	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3618C>T; p.L1206L; 1:10345912-10345912	skin	malignant_melanoma	Substitution - coding silent
c.4531G>A; p.A1511T; 1:10365565-10365565	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2920C>T; p.P974S; 1:10336671-10336671	skin	malignant_melanoma	Substitution - Missense
c.1187C>T; p.S396F; 1:10282424-10282424	skin	malignant_melanoma	Substitution - Missense
c.3774C>T; p.S1258S; 1:10348696-10348696	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3774C>T; p.S1258S; 1:10348696-10348696	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.987T>C; p.D329D; 1:10276367-10276367	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1308G>A; p.K436K; 1:10291093-10291093	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.5269C>T; p.R1757W; 1:10375372-10375372	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.5269C>T; p.R1757W; 1:10375372-10375372	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1308G>A; p.K436K; 1:10291093-10291093	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.2569C>T; p.R857C; 1:10326142-10326142	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3934G>C; p.E1312Q; 1:10360945-10360945	breast	carcinoma	Substitution - Missense
c.2569C>T; p.R857C; 1:10326142-10326142	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2569C>T; p.R857C; 1:10326142-10326142	large_intestine	adenoma	Substitution - Missense
c.2060A>C; p.E687A; 1:10320125-10320125	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3308C>A; p.A1103E; 1:10339792-10339792	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1771C>T; p.P591S; 1:10296944-10296944	skin	malignant_melanoma	Substitution - Missense
c.1568T>C; p.I523T; 1:10295695-10295695	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.419A>G; p.Y140C; 1:10261960-10261960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1568T>C; p.I523T; 1:10295695-10295695	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.5136G>A; p.Q1712Q; 1:10375031-10375031	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.656C>T; p.A219V; 1:10268199-10268199	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.816T>C; p.N272N; 1:10272258-10272258	breast	carcinoma	Substitution - coding silent
c.2079G>T; p.W693C; 1:10321716-10321716	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2251A>G; p.T751A; 1:10323914-10323914	skin	malignant_melanoma	Substitution - Missense
c.4959-7delT; p.?; 1:10374847-10374847	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.2172C>T; p.A724A; 1:10321809-10321809	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1475A>G; p.N492S; 1:10295108-10295108	liver	carcinoma	Substitution - Missense
c.4945G>T; p.E1649*; 1:10374452-10374452	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.4475delC; p.L1493fs*101; 1:10365509-10365509	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.4161A>G; p.P1387P; 1:10361820-10361820	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1034C>T; p.A345V; 1:10278000-10278000	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2890G>A; p.V964I; 1:10334623-10334623	thyroid	carcinoma	Substitution - Missense
c.4280G>A; p.R1427Q; 1:10365151-10365151	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.2866G>A; p.V956M; 1:10334599-10334599	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.4219G>T; p.G1407C; 1:10363335-10363335	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2623A>G; p.T875A; 1:10326196-10326196	breast	carcinoma	Substitution - Missense
c.3502C>T; p.Q1168*; 1:10343239-10343239	skin	malignant_melanoma	Substitution - Nonsense
c.4714G>T; p.D1572Y; 1:10371168-10371168	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.5163C>A; p.T1721T; 1:10375266-10375266	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2923G>A; p.D975N; 1:10336674-10336674	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.4663C>T; p.H1555Y; 1:10368515-10368515	large_intestine; colon	adenoma	Substitution - Missense
c.5163C>A; p.T1721T; 1:10375266-10375266	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.5163C>A; p.T1721T; 1:10375266-10375266	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.3167G>T; p.G1056V; 1:10337416-10337416	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.125A>T; p.N42I; 1:10256265-10256265	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.953G>C; p.R318P; 1:10276333-10276333	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.4123C>G; p.L1375V; 1:10361782-10361782	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1579G>T; p.G527W; 1:10295706-10295706	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.4440G>A; p.L1480L; 1:10365474-10365474	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2709G>T; p.T903T; 1:10326282-10326282	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3841G>A; p.E1281K; 1:10352660-10352660	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.4769C>T; p.P1590L; 1:10371223-10371223	skin	malignant_melanoma	Substitution - Missense
c.4440G>A; p.L1480L; 1:10365474-10365474	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.4784C>G; p.S1595C; 1:10371238-10371238	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5295G>A; p.P1765P; 1:10376569-10376569	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.458G>C; p.R153T; 1:10267408-10267408	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1239T>C; p.S413S; 1:10282476-10282476	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.4384A>C; p.T1462P; 1:10365418-10365418	thyroid	other; neoplasm	Substitution - Missense
c.2044A>G; p.T682A; 1:10320109-10320109	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3726G>A; p.Q1242Q; 1:10347827-10347827	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2871G>A; p.R957R; 1:10334604-10334604	skin	malignant_melanoma	Substitution - coding silent
c.5241C>T; p.A1747A; 1:10375344-10375344	skin	malignant_melanoma	Substitution - coding silent
c.4191A>G; p.E1397E; 1:10363307-10363307	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.4406G>A; p.R1469H; 1:10365440-10365440	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2349C>G; p.V783V; 1:10324012-10324012	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.3721C>T; p.H1241Y; 1:10347822-10347822	thyroid	other; neoplasm	Substitution - Missense
c.4464C>T; p.L1488L; 1:10365498-10365498	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.4942G>C; p.E1648Q; 1:10374449-10374449	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.338A>C; p.E113A; 1:10258647-10258647	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.504G>A; p.V168V; 1:10267454-10267454	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1910A>T; p.Q637L; 1:10297179-10297179	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.504G>A; p.V168V; 1:10267454-10267454	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3050T>C; p.I1017T; 1:10337132-10337132	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.5037_5038CC>TT; p.R1680C; 1:10374932-10374933	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.380T>G; p.F127C; 1:10261921-10261921	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.617C>A; p.A206E; 1:10268160-10268160	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.4826C>T; p.S1609F; 1:10374333-10374333	skin	malignant_melanoma	Substitution - Missense
c.93A>G; p.Q31Q; 1:10232421-10232421	liver	carcinoma	Substitution - coding silent
c.350G>A; p.G117D; 1:10258659-10258659	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2116C>T; p.R706W; 1:10321753-10321753	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.4113A>T; p.P1371P; 1:10361772-10361772	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.416C>G; p.S139C; 1:10261957-10261957	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.4753C>A; p.P1585T; 1:10371207-10371207	skin	malignant_melanoma	Substitution - Missense
c.2854G>C; p.E952Q; 1:10334587-10334587	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2747C>T; p.P916L; 1:10326320-10326320	skin	malignant_melanoma	Substitution - Missense
c.3189C>T; p.N1063N; 1:10337438-10337438	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.5152-2A>C; p.?; 1:10375253-10375253	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.3608A>C; p.K1203T; 1:10345902-10345902	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2748G>A; p.P916P; 1:10326321-10326321	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.3296G>A; p.R1099H; 1:10339780-10339780	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3094G>A; p.E1032K; 1:10337176-10337176	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.970G>T; p.A324S; 1:10276350-10276350	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2420G>A; p.R807Q; 1:10324778-10324778	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.984G>T; p.A328A; 1:10276364-10276364	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.499C>T; p.R167C; 1:10267449-10267449	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.622A>G; p.T208A; 1:10268165-10268165	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4039C>T; p.H1347Y; 1:10361698-10361698	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2747C>G; p.P916R; 1:10326320-10326320	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - Missense
c.2374C>T; p.H792Y; 1:10324037-10324037	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.4957A>C; p.S1653R; 1:10374464-10374464	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.4387C>A; p.R1463S; 1:10365421-10365421	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2272C>T; p.P758S; 1:10323935-10323935	skin	malignant_melanoma	Substitution - Missense
c.2737G>A; p.G913R; 1:10326310-10326310	pancreas	carcinoma	Substitution - Missense
c.2610C>T; p.A870A; 1:10326183-10326183	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2737G>A; p.G913R; 1:10326310-10326310	pancreas	carcinoma	Substitution - Missense
c.4374+2T>C; p.?; 1:10365247-10365247	ovary	carcinoma; serous_carcinoma	Unknown
c.3814C>T; p.R1272C; 1:10352633-10352633	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.4439T>C; p.L1480P; 1:10365473-10365473	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2821G>A; p.V941M; 1:10334554-10334554	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3830C>A; p.P1277H; 1:10352649-10352649	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.4189G>A; p.E1397K; 1:10363305-10363305	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3376-5T>A; p.?; 1:10342045-10342045	liver	carcinoma	Unknown
c.3376-5T>A; p.?; 1:10342045-10342045	liver	carcinoma	Unknown
c.4189G>A; p.E1397K; 1:10363305-10363305	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2733_2741delTGACGGGCA; p.G913_D915delGHD; 1:10326306-10326314	pancreas	carcinoma; ductal_carcinoma	Deletion - In frame
c.924C>T; p.L308L; 1:10275487-10275487	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3542C>A; p.S1181Y; 1:10343279-10343279	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2616C>T; p.S872S; 1:10326189-10326189	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.5042G>T; p.R1681L; 1:10374937-10374937	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1730G>A; p.R577H; 1:10296903-10296903	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3327C>T; p.L1109L; 1:10339811-10339811	skin	malignant_melanoma	Substitution - coding silent
c.2606C>T; p.T869M; 1:10326179-10326179	central_nervous_system; brain	glioma	Substitution - Missense
c.4567G>C; p.G1523R; 1:10365601-10365601	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2316G>T; p.R772S; 1:10323979-10323979	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2606C>T; p.T869M; 1:10326179-10326179	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1644C>T; p.I548I; 1:10296586-10296586	skin	malignant_melanoma	Substitution - coding silent
c.4242G>A; p.R1414R; 1:10365113-10365113	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1838G>T; p.W613L; 1:10297011-10297011	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.45C>T; p.F15F; 1:10232373-10232373	pancreas	carcinoma	Substitution - coding silent
c.5303C>T; p.S1768L; 1:10376577-10376577	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1652T>G; p.L551*; 1:10296594-10296594	prostate	carcinoma	Substitution - Nonsense
c.190G>A; p.D64N; 1:10258499-10258499	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2727C>G; p.L909L; 1:10326300-10326300	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.4984C>A; p.L1662I; 1:10374879-10374879	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3623T>C; p.V1208A; 1:10345917-10345917	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2472C>T; p.S824S; 1:10324830-10324830	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1259C>G; p.S420C; 1:10282496-10282496	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.552G>A; p.L184L; 1:10267502-10267502	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.4275T>A; p.Y1425*; 1:10365146-10365146	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]