Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

23604

Name

DAPK2

Synonymous

death-associated protein kinase 2;DAPK2;death-associated protein kinase 2

Definition

DAP kinase 2|DAP-kinase-related protein 1 beta isoform

Position

15q22.31

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.04.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.122G>A; p.R41Q; 15:63983725-63983725

 skinmalignant_melanomaSubstitution - Missense

c.242T>G; p.V81G; 15:63983605-63983605

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1058A>G; p.E353G; 15:63908575-63908575

 breastcarcinomaSubstitution - Missense

c.235C>T; p.R79W; 15:63983612-63983612

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.742G>T; p.E248*; 15:63926011-63926011

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Nonsense

c.633-1G>A; p.?; 15:63929578-63929578

 oesophaguscarcinoma; adenocarcinomaUnknown

c.633-1G>A; p.?; 15:63929578-63929578

 oesophaguscarcinoma; adenocarcinomaUnknown

c.529G>A; p.E177K; 15:63939286-63939286

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.54G>C; p.K18N; 15:64040208-64040208

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.203G>T; p.R68L; 15:63983644-63983644

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; hairy_cell_leukaemiaSubstitution - Missense

c.12C>A; p.A4A; 15:64040250-64040250

 livercarcinomaSubstitution - coding silent

c.14C>G; p.S5*; 15:64040248-64040248

 urinary_tract; bladdercarcinomaSubstitution - Nonsense

c.693G>A; p.T231T; 15:63926060-63926060

 skinmalignant_melanomaSubstitution - coding silent

c.702A>G; p.E234E; 15:63926051-63926051

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.286C>A; p.R96S; 15:63983561-63983561

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.152C>G; p.A51G; 15:63983695-63983695

 ovaryother; neoplasmSubstitution - Missense

c.826A>G; p.I276V; 15:63924848-63924848

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.935G>A; p.R312H; 15:63912121-63912121

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.63C>T; p.D21D; 15:64040199-64040199

 central_nervous_system; braingliomaSubstitution - coding silent

c.63C>T; p.D21D; 15:64040199-64040199

 central_nervous_system; braingliomaSubstitution - coding silent

c.939G>C; p.R313S; 15:63912117-63912117

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.36G>A; p.E12E; 15:64040226-64040226

 breastcarcinomaSubstitution - coding silent

c.788G>A; p.R263Q; 15:63925965-63925965

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.633-2A>G; p.?; 15:63929579-63929579

 pancreascarcinomaUnknown

c.75C>T; p.I25I; 15:64040187-64040187

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.165G>A; p.K55K; 15:63983682-63983682

 skinmalignant_melanomaSubstitution - coding silent

c.37C>T; p.P13S; 15:64040225-64040225

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.287G>A; p.R96H; 15:63983560-63983560

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.633-9A>G; p.?; 15:63929586-63929586

 livercarcinoma; hepatocellular_carcinomaUnknown

c.337G>A; p.D113N; 15:63971539-63971539

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.439C>T; p.H147Y; 15:63971437-63971437

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.691A>G; p.T231A; 15:63926062-63926062

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; mantle_cell_lymphomaSubstitution - Missense

c.497A>C; p.H166P; 15:63939318-63939318

 skinmalignant_melanomaSubstitution - Missense

c.1014G>A; p.L338L; 15:63911926-63911926

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1014G>A; p.L338L; 15:63911926-63911926

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - coding silent

c.60G>A; p.E20E; 15:64040202-64040202

 skinmalignant_melanomaSubstitution - coding silent

c.682C>T; p.L228L; 15:63926071-63926071

 skinmalignant_melanomaSubstitution - coding silent

c.1034G>T; p.R345M; 15:63908599-63908599

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.604G>A; p.E202K; 15:63930435-63930435

 skinmalignant_melanomaSubstitution - Missense

c.1092G>A; p.R364R; 15:63908541-63908541

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.677C>T; p.P226L; 15:63926076-63926076

 skin; scalpcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.336C>T; p.F112F; 15:63971540-63971540

 skinmalignant_melanomaSubstitution - coding silent

c.899T>A; p.V300E; 15:63912157-63912157

 breastcarcinomaSubstitution - Missense

c.1065C>T; p.I355I; 15:63908568-63908568

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.726G>A; p.V242V; 15:63926027-63926027

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.872A>T; p.Q291L; 15:63912184-63912184

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.207G>A; p.E69E; 15:63983640-63983640

 skinmalignant_melanomaSubstitution - coding silent

c.508A>T; p.I170F; 15:63939307-63939307

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.62A>G; p.D21G; 15:64040200-64040200

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1104C>A; p.S368R; 15:63908529-63908529

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.292G>T; p.D98Y; 15:63983555-63983555

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.569C>T; p.T190M; 15:63939246-63939246

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.1097G>A; p.R366K; 15:63908536-63908536

 skinmalignant_melanomaSubstitution - Missense

c.1097G>A; p.R366K; 15:63908536-63908536

 skinmalignant_melanomaSubstitution - Missense

c.271G>A; p.D91N; 15:63983576-63983576

 skinmalignant_melanomaSubstitution - Missense

c.1033-4C>A; p.?; 15:63908604-63908604

 livercarcinomaUnknown

c.1087C>T; p.P363S; 15:63908546-63908546

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.930T>C; p.Y310Y; 15:63912126-63912126

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.182C>G; p.A61G; 15:63983665-63983665

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.245T>C; p.L82P; 15:63983602-63983602

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.766G>A; p.E256K; 15:63925987-63925987

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.297G>A; p.V99V; 15:63983550-63983550

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.297G>A; p.V99V; 15:63983550-63983550

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.570G>A; p.T190T; 15:63939245-63939245

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.203G>A; p.R68Q; 15:63983644-63983644

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.315-2_315-1insA; p.?; 15:63971562-63971563

 livercarcinomaUnknown

c.198G>A; p.V66V; 15:63983649-63983649

 skinmalignant_melanomaSubstitution - coding silent

c.204G>A; p.R68R; 15:63983643-63983643

 skinmalignant_melanomaSubstitution - coding silent

c.171G>A; p.R57R; 15:63983676-63983676

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.421C>T; p.H141Y; 15:63971455-63971455

 skinmalignant_melanomaSubstitution - Missense

c.528C>G; p.H176Q; 15:63939287-63939287

 stomachcarcinomaSubstitution - Missense

c.658C>A; p.L220I; 15:63929552-63929552

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.134C>G; p.T45R; 15:63983713-63983713

 ovaryother; neoplasmSubstitution - Missense

')