Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

247

Name

ALOX15B

Synonymous

arachidonate 15-lipoxygenase, type B;ALOX15B;arachidonate 15-lipoxygenase, type B

Definition

15-LOX-B|15S-lipoxygenase|arachidonate 15-lipoxygenase 2|arachidonate 15-lipoxygenase B|arachidonate 15-lipoxygenase type II|arachidonate 15-lipoxygenase, second type|arachidonate omega(6) lipoxygenase|linoleate 13-lipoxygenase 15-LOb

Position

17p13.1

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.02.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.572C>T; p.A191V; 17:8042491-8042491

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.572C>T; p.A191V; 17:8042491-8042491

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1135C>A; p.L379M; 17:8045621-8045621

 prostatecarcinomaSubstitution - Missense

c.499G>T; p.V167L; 17:8042418-8042418

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.258C>T; p.A86A; 17:8039496-8039496

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.857C>T; p.S286F; 17:8045245-8045245

 skinmalignant_melanomaSubstitution - Missense

c.1953C>T; p.I651I; 17:8048487-8048487

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.767A>G; p.Y256C; 17:8044919-8044919

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.589A>G; p.I197V; 17:8042797-8042797

 skinmalignant_melanomaSubstitution - Missense

c.1788T>C; p.P596P; 17:8047852-8047852

 breastcarcinomaSubstitution - coding silent

c.1206G>A; p.L402L; 17:8046673-8046673

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.932C>T; p.A311V; 17:8045320-8045320

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1830G>A; p.L610L; 17:8047894-8047894

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1371T>C; p.P457P; 17:8046990-8046990

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1178C>T; p.P393L; 17:8045664-8045664

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.129G>A; p.K43K; 17:8039284-8039284

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.129G>A; p.K43K; 17:8039284-8039284

 skinmalignant_melanomaSubstitution - coding silent

c.6C>T; p.A2A; 17:8039161-8039161

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.1732C>T; p.P578S; 17:8047796-8047796

 breastcarcinomaSubstitution - Missense

c.1656G>A; p.K552K; 17:8047640-8047640

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; plasma_cell_myelomaSubstitution - coding silent

c.720C>T; p.S240S; 17:8044872-8044872

 skinmalignant_melanomaSubstitution - coding silent

c.368-2A>T; p.?; 17:8039900-8039900

 skinmalignant_melanomaUnknown

c.670G>A; p.A224T; 17:8042878-8042878

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1115C>T; p.T372M; 17:8045601-8045601

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1948G>A; p.G650S; 17:8048482-8048482

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.927C>A; p.F309L; 17:8045315-8045315

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.777G>T; p.K259N; 17:8044929-8044929

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.753C>T; p.I251I; 17:8044905-8044905

 skinmalignant_melanomaSubstitution - coding silent

c.645G>A; p.R215R; 17:8042853-8042853

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1381C>T; p.R461W; 17:8047000-8047000

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1323G>A; p.L441L; 17:8046942-8046942

 skinmalignant_melanomaSubstitution - coding silent

c.711C>A; p.F237L; 17:8044863-8044863

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1101C>T; p.F367F; 17:8045587-8045587

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.125_126GC>TT; p.G42V; 17:8039280-8039281

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1525C>T; p.Q509*; 17:8047325-8047325

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemiaSubstitution - Nonsense

c.1437G>A; p.Q479Q; 17:8047056-8047056

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1759T>A; p.C587S; 17:8047823-8047823

 stomachcarcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiableSubstitution - Missense

c.1169G>A; p.R390H; 17:8045655-8045655

 prostatecarcinomaSubstitution - Missense

c.1466C>G; p.S489C; 17:8047266-8047266

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.123C>T; p.L41L; 17:8039278-8039278

 NSmalignant_melanomaSubstitution - coding silent

c.123C>T; p.L41L; 17:8039278-8039278

 NSmalignant_melanomaSubstitution - coding silent

c.2011G>A; p.E671K; 17:8048545-8048545

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.572+6G>A; p.?; 17:8042497-8042497

 skin; head_neckmalignant_melanoma; superficial_spreadingUnknown

c.740A>T; p.N247I; 17:8044892-8044892

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.929C>A; p.S310Y; 17:8045317-8045317

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.547A>G; p.N183D; 17:8042466-8042466

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.393C>A; p.H131Q; 17:8039927-8039927

 ovaryother; neoplasmSubstitution - Missense

c.547A>G; p.N183D; 17:8042466-8042466

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1032C>T; p.F344F; 17:8045518-8045518

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1314C>A; p.F438L; 17:8046933-8046933

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.714C>A; p.F238L; 17:8044866-8044866

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.170T>C; p.L57P; 17:8039408-8039408

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; plasma_cell_myelomaSubstitution - Missense

c.1097C>T; p.S366F; 17:8045583-8045583

 skin; trunkmalignant_melanomaSubstitution - Missense

c.876C>T; p.H292H; 17:8045264-8045264

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1605G>T; p.R535R; 17:8047589-8047589

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.865T>G; p.L289V; 17:8045253-8045253

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2028C>G; p.I676M; 17:8048562-8048562

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.506A>G; p.D169G; 17:8042425-8042425

 bone; pelvisEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.1334A>G; p.N445S; 17:8046953-8046953

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.72C>T; p.V24V; 17:8039227-8039227

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.2026A>G; p.I676V; 17:8048560-8048560

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.2026A>G; p.I676V; 17:8048560-8048560

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2026A>G; p.I676V; 17:8048560-8048560

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2026A>G; p.I676V; 17:8048560-8048560

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.569C>T; p.S190F; 17:8042488-8042488

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.345C>G; p.T115T; 17:8039583-8039583

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.345C>G; p.T115T; 17:8039583-8039583

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.446A>G; p.Y149C; 17:8039980-8039980

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.345C>G; p.T115T; 17:8039583-8039583

 thyroidother; neoplasmSubstitution - coding silent

c.345C>G; p.T115T; 17:8039583-8039583

 thyroidother; neoplasmSubstitution - coding silent

c.345C>G; p.T115T; 17:8039583-8039583

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.345C>G; p.T115T; 17:8039583-8039583

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.345C>G; p.T115T; 17:8039583-8039583

 thyroidother; neoplasmSubstitution - coding silent

c.345C>G; p.T115T; 17:8039583-8039583

 livercarcinoma; hepatocellular_carcinomaSubstitution - coding silent

c.479A>T; p.H160L; 17:8042398-8042398

 thyroidother; neoplasmSubstitution - Missense

c.1457G>T; p.R486L; 17:8047076-8047076

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1804G>A; p.D602N; 17:8047868-8047868

 skin; scalpmalignant_melanomaSubstitution - Missense

c.1426G>A; p.D476N; 17:8047045-8047045

 skinmalignant_melanomaSubstitution - Missense

c.28A>G; p.T10A; 17:8039183-8039183

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1089C>T; p.A363A; 17:8045575-8045575

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1001G>T; p.S334I; 17:8045487-8045487

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.927C>T; p.F309F; 17:8045315-8045315

 skinmalignant_melanomaSubstitution - coding silent

c.1650C>A; p.S550S; 17:8047634-8047634

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1650C>A; p.S550S; 17:8047634-8047634

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; plasma_cell_myelomaSubstitution - coding silent

c.535G>T; p.A179S; 17:8042454-8042454

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1900C>T; p.R634W; 17:8048434-8048434

 ovaryother; neoplasmSubstitution - Missense

c.613G>T; p.G205W; 17:8042821-8042821

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.516C>T; p.L172L; 17:8042435-8042435

 skinmalignant_melanomaSubstitution - coding silent

c.205G>A; p.V69M; 17:8039443-8039443

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.204C>T; p.R68R; 17:8039442-8039442

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.750G>T; p.L250L; 17:8044902-8044902

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1375G>A; p.D459N; 17:8046994-8046994

 skinmalignant_melanomaSubstitution - Missense

c.706G>A; p.A236T; 17:8044858-8044858

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1355C>T; p.S452F; 17:8046974-8046974

 skinmalignant_melanomaSubstitution - Missense

c.1355C>T; p.S452F; 17:8046974-8046974

 NSmalignant_melanomaSubstitution - Missense

c.969C>T; p.C323C; 17:8045357-8045357

 ovaryother; neoplasmSubstitution - coding silent

c.435G>A; p.R145R; 17:8039969-8039969

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.969C>T; p.C323C; 17:8045357-8045357

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.506A>T; p.D169V; 17:8042425-8042425

 breastcarcinomaSubstitution - Missense

c.1649C>T; p.S550F; 17:8047633-8047633

 skinmalignant_melanomaSubstitution - Missense

c.829A>G; p.S277G; 17:8044981-8044981

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.50G>A; p.G17D; 17:8039205-8039205

 breastcarcinomaSubstitution - Missense

c.1888G>A; p.E630K; 17:8048422-8048422

 skinmalignant_melanomaSubstitution - Missense

c.1888G>A; p.E630K; 17:8048422-8048422

 skinmalignant_melanomaSubstitution - Missense

c.786C>A; p.P262P; 17:8044938-8044938

 prostateadenomaSubstitution - coding silent

c.614G>A; p.G205E; 17:8042822-8042822

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.754C>T; p.R252C; 17:8044906-8044906

 skinmalignant_melanomaSubstitution - Missense

c.292C>T; p.R98W; 17:8039530-8039530

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1961G>A; p.R654Q; 17:8048495-8048495

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1088C>T; p.A363V; 17:8045574-8045574

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1767C>T; p.G589G; 17:8047831-8047831

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1655A>C; p.K552T; 17:8047639-8047639

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1456C>T; p.R486C; 17:8047075-8047075

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.99delC; p.P35fs*21; 17:8039254-8039254

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.974C>T; p.P325L; 17:8045362-8045362

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1135C>G; p.L379V; 17:8045621-8045621

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.84G>A; p.G28G; 17:8039239-8039239

 skinmalignant_melanomaSubstitution - coding silent

c.84G>A; p.G28G; 17:8039239-8039239

 skinmalignant_melanomaSubstitution - coding silent

c.894C>T; p.I298I; 17:8045282-8045282

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.121C>T; p.L41F; 17:8039276-8039276

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.875delA; p.H292fs*23; 17:8045263-8045263

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.705C>T; p.D235D; 17:8044857-8044857

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.16G>A; p.V6I; 17:8039171-8039171

 skinmalignant_melanomaSubstitution - Missense

c.705C>T; p.D235D; 17:8044857-8044857

 thyroidother; neoplasmSubstitution - coding silent

c.1783C>T; p.P595S; 17:8047847-8047847

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1081C>T; p.R361C; 17:8045567-8045567

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1477G>A; p.G493S; 17:8047277-8047277

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1227C>T; p.T409T; 17:8046694-8046694

 skinmalignant_melanomaSubstitution - coding silent

c.1921C>T; p.Q641*; 17:8048455-8048455

 skinmalignant_melanomaSubstitution - Nonsense

c.715G>A; p.A239T; 17:8044867-8044867

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.715G>A; p.A239T; 17:8044867-8044867

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.150G>T; p.E50D; 17:8039388-8039388

 breastcarcinomaSubstitution - Missense

c.150G>T; p.E50D; 17:8039388-8039388

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1090G>A; p.E364K; 17:8045576-8045576

 lungcarcinoma; adenocarcinomaSubstitution - Missense

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