Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

255877

Name

BCL6B

Synonymous

B-cell CLL/lymphoma 6, member B;BCL6B;B-cell CLL/lymphoma 6, member B

Definition

B-cell CLL/lymphoma 6 member B protein|B-cell CLL/lymphoma 6, member B (zinc finger protein)|bcl6-associated zinc finger protein|zinc finger protein 62

Position

17p13.1

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.05.

The copy number variations for various cancers

Top

There is no record for BCL6B

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.488G>A; p.R163H; 17:7024487-7024487

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1131C>T; p.I377I; 17:7026781-7026781

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1328A>C; p.D443A; 17:7027507-7027507

 thyroidother; neoplasmSubstitution - Missense

c.87C>T; p.N29N; 17:7023758-7023758

 breastcarcinomaSubstitution - coding silent

c.393C>A; p.I131I; 17:7024296-7024296

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.393C>A; p.I131I; 17:7024296-7024296

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - coding silent

c.524G>A; p.R175Q; 17:7024523-7024523

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.550C>T; p.P184S; 17:7024549-7024549

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1203G>A; p.A401A; 17:7026967-7026967

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.633C>T; p.S211S; 17:7024632-7024632

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1139G>T; p.G380V; 17:7026789-7026789

 breastcarcinomaSubstitution - Missense

c.1367G>A; p.R456Q; 17:7027546-7027546

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.427C>T; p.R143C; 17:7024426-7024426

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.630G>A; p.G210G; 17:7024629-7024629

 skinmalignant_melanomaSubstitution - coding silent

c.337G>T; p.A113S; 17:7024240-7024240

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.135C>T; p.G45G; 17:7023806-7023806

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.366C>T; p.H122H; 17:7024269-7024269

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.301C>A; p.L101M; 17:7024204-7024204

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.887C>A; p.P296Q; 17:7025198-7025198

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.888G>A; p.P296P; 17:7025199-7025199

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.212C>T; p.A71V; 17:7024115-7024115

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.404A>G; p.Y135C; 17:7024403-7024403

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.493G>A; p.E165K; 17:7024492-7024492

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.967G>T; p.D323Y; 17:7026534-7026534

 breastcarcinomaSubstitution - Missense

c.1227G>A; p.E409E; 17:7026991-7026991

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.961C>T; p.P321S; 17:7026528-7026528

 skinmalignant_melanomaSubstitution - Missense

c.28G>C; p.A10P; 17:7023699-7023699

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1221C>T; p.T407T; 17:7026985-7026985

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.297G>A; p.S99S; 17:7024200-7024200

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.970G>A; p.E324K; 17:7026537-7026537

 skinmalignant_melanomaSubstitution - Missense

c.428G>A; p.R143H; 17:7024427-7024427

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1001G>A; p.R334Q; 17:7026568-7026568

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.1124G>A; p.S375N; 17:7026774-7026774

 skinmalignant_melanomaSubstitution - Missense

c.607A>T; p.N203Y; 17:7024606-7024606

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.871C>T; p.R291W; 17:7025182-7025182

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.268G>A; p.A90T; 17:7024171-7024171

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1074C>T; p.C358C; 17:7026724-7026724

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.252C>T; p.P84P; 17:7024155-7024155

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.13G>T; p.A5S; 17:7023684-7023684

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.1090C>T; p.R364C; 17:7026740-7026740

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.538_539insC; p.G180fs*9; 17:7024537-7024538

 large_intestinecarcinoma; adenocarcinomaInsertion - Frameshift

c.1326C>T; p.C442C; 17:7027505-7027505

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1313A>G; p.K438R; 17:7027077-7027077

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.960T>C; p.V320V; 17:7026527-7026527

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.877C>T; p.R293C; 17:7025188-7025188

 skinmalignant_melanomaSubstitution - Missense

c.877C>T; p.R293C; 17:7025188-7025188

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.877C>T; p.R293C; 17:7025188-7025188

 skinmalignant_melanomaSubstitution - Missense

c.1218C>T; p.H406H; 17:7026982-7026982

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1366C>T; p.R456W; 17:7027545-7027545

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.647G>A; p.R216K; 17:7024646-7024646

 skinmalignant_melanomaSubstitution - Missense

c.909C>T; p.C303C; 17:7026476-7026476

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1039C>T; p.R347C; 17:7026606-7026606

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.473C>T; p.P158L; 17:7024472-7024472

 skinmalignant_melanomaSubstitution - Missense

c.1229A>C; p.K410T; 17:7026993-7026993

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.953C>T; p.S318F; 17:7026520-7026520

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1258C>T; p.R420C; 17:7027022-7027022

 skinmalignant_melanomaSubstitution - Missense

c.540C>A; p.G180G; 17:7024539-7024539

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.540C>A; p.G180G; 17:7024539-7024539

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - coding silent

c.1100G>A; p.R367Q; 17:7026750-7026750

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.539_540insC; p.S183fs*6; 17:7024538-7024539

 breastcarcinomaInsertion - Frameshift

c.224T>G; p.V75G; 17:7024127-7024127

 ovaryother; neoplasmSubstitution - Missense

c.1000C>T; p.R334W; 17:7026567-7026567

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.267C>T; p.F89F; 17:7024170-7024170

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 endometriumcarcinoma; endometrioid_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 breastcarcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 endometriumcarcinoma; endometrioid_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 endometriumcarcinoma; endometrioid_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 breastcarcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 breastcarcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 breastcarcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 breastcarcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 breastcarcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 endometriumcarcinoma; endometrioid_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 endometriumcarcinoma; endometrioid_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.1102C>G; p.P368A; 17:7026752-7026752

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.701_702insCAG; p.S244_E245insS; 17:7024700-7024701

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - In frame

c.726_727insAAG; p.S242_S243insK; 17:7024725-7024726

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; mantle_cell_lymphomaInsertion - In frame

c.842C>A; p.A281D; 17:7025153-7025153

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.600C>T; p.I200I; 17:7024599-7024599

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.600C>T; p.I200I; 17:7024599-7024599

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.194C>T; p.S65L; 17:7024097-7024097

 ovaryother; neoplasmSubstitution - Missense

c.257C>T; p.A86V; 17:7024160-7024160

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1207G>A; p.V403M; 17:7026971-7026971

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.1290C>T; p.H430H; 17:7027054-7027054

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.511C>T; p.P171S; 17:7024510-7024510

 skinmalignant_melanomaSubstitution - Missense

c.1083C>T; p.C361C; 17:7026733-7026733

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1314G>A; p.K438K; 17:7027078-7027078

 skinmalignant_melanomaSubstitution - coding silent

c.1327G>A; p.D443N; 17:7027506-7027506

 skinmalignant_melanomaSubstitution - Missense

c.115G>A; p.D39N; 17:7023786-7023786

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.115G>A; p.D39N; 17:7023786-7023786

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.540delC; p.S183fs*20; 17:7024539-7024539

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.1251C>T; p.C417C; 17:7027015-7027015

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.525A>G; p.R175R; 17:7024524-7024524

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.861A>C; p.S287S; 17:7025172-7025172

 breastcarcinomaSubstitution - coding silent

c.1040G>A; p.R347H; 17:7026607-7026607

 pancreascarcinomaSubstitution - Missense

c.248G>A; p.G83D; 17:7024151-7024151

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1434G>A; p.G478G; 17:7027613-7027613

 skinmalignant_melanomaSubstitution - coding silent

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