Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

2619

Name

GAS1

Synonymous

growth arrest-specific 1;GAS1;growth arrest-specific 1

Definition

GAS-1|Growth arrest-specific gene-1|growth arrest-specific protein 1

Position

9q21.3-q22

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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There is no record for GAS1

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.862G>C; p.D288H; 9:86945918-86945918

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.831C>T; p.G277G; 9:86945949-86945949

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.623A>G; p.E208G; 9:86946157-86946157

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.834G>A; p.A278A; 9:86945946-86945946

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.608G>T; p.C203F; 9:86946172-86946172

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.866G>A; p.G289D; 9:86945914-86945914

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.584A>G; p.N195S; 9:86946196-86946196

 skin; trunkmalignant_melanomaSubstitution - Missense

c.672C>T; p.C224C; 9:86946108-86946108

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.796G>A; p.D266N; 9:86945984-86945984

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.737C>G; p.A246G; 9:86946043-86946043

 thyroidcarcinomaSubstitution - Missense

c.682G>C; p.E228Q; 9:86946098-86946098

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.600G>A; p.T200T; 9:86946180-86946180

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.961G>T; p.G321C; 9:86945819-86945819

 thyroidother; neoplasmSubstitution - Missense

c.750C>T; p.N250N; 9:86946030-86946030

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.685C>T; p.R229W; 9:86946095-86946095

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.662A>T; p.D221V; 9:86946118-86946118

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.685C>A; p.R229R; 9:86946095-86946095

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.608G>A; p.C203Y; 9:86946172-86946172

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.755C>A; p.P252H; 9:86946025-86946025

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.622G>A; p.E208K; 9:86946158-86946158

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.353A>C; p.H118P; 9:86946427-86946427

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.705C>G; p.V235V; 9:86946075-86946075

 breastcarcinomaSubstitution - coding silent

c.788A>G; p.D263G; 9:86945992-86945992

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.318G>C; p.P106P; 9:86946462-86946462

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.560T>A; p.L187Q; 9:86946220-86946220

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.848C>T; p.P283L; 9:86945932-86945932

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.865G>T; p.G289C; 9:86945915-86945915

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

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