Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

26260

Name

FBXO25

Synonymous

F-box protein 25;FBXO25;F-box protein 25

Definition

F-box only protein 25|F-box protein Fbx25

Position

8p23.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.14.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.465C>T; p.I155I; 8:450073-450073

 skinmalignant_melanomaSubstitution - coding silent

c.507C>G; p.I169M; 8:451300-451300

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.357C>A; p.I119I; 8:435683-435683

 breastcarcinomaSubstitution - coding silent

c.961C>T; p.R321W; 8:463124-463124

 breastcarcinomaSubstitution - Missense

c.735C>T; p.D245D; 8:458443-458443

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.547C>T; p.L183F; 8:451340-451340

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1040C>A; p.A347D; 8:468740-468740

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.121_122delAT; p.I41fs*8; 8:413200-413201

 pancreascarcinoma; adenocarcinomaDeletion - Frameshift

c.338C>G; p.S113*; 8:435664-435664

 urinary_tract; bladdercarcinomaSubstitution - Nonsense

c.570T>C; p.S190S; 8:451363-451363

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.138C>G; p.I46M; 8:431344-431344

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.138C>G; p.I46M; 8:431344-431344

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.497C>A; p.P166H; 8:451290-451290

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.469C>G; p.Q157E; 8:450077-450077

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.657T>A; p.T219T; 8:451450-451450

 prostatecarcinomaSubstitution - coding silent

c.1031G>A; p.C344Y; 8:468731-468731

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.357C>T; p.I119I; 8:435683-435683

 skinmalignant_melanomaSubstitution - coding silent

c.892T>G; p.L298V; 8:463055-463055

 livercarcinomaSubstitution - Missense

c.624C>T; p.A208A; 8:451417-451417

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.568T>C; p.S190P; 8:451361-451361

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.438G>T; p.K146N; 8:450046-450046

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.616A>G; p.I206V; 8:451409-451409

 breastcarcinomaSubstitution - Missense

c.939C>T; p.Y313Y; 8:463102-463102

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.426C>T; p.G142G; 8:450034-450034

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1060A>G; p.T354A; 8:468760-468760

 livercarcinomaSubstitution - Missense

c.597G>A; p.W199*; 8:451390-451390

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.15T>C; p.G5G; 8:413094-413094

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - coding silent

c.239-1G>T; p.?; 8:432885-432885

 large_intestine; rectumcarcinoma; adenocarcinomaUnknown

c.603C>T; p.C201C; 8:451396-451396

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.427G>A; p.V143M; 8:450035-450035

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.988G>T; p.D330Y; 8:467720-467720

 breastcarcinomaSubstitution - Missense

c.193delA; p.R67fs*44; 8:431399-431399

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.604C>T; p.R202*; 8:451397-451397

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.193delA; p.R67fs*44; 8:431399-431399

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.315A>G; p.E105E; 8:435641-435641

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.570T>A; p.S190S; 8:451363-451363

 lungcarcinoma; non_small_cell_carcinomaSubstitution - coding silent

c.1072C>A; p.P358T; 8:468772-468772

 adrenal_gland; adrenal_glandadrenal_cortical_carcinoma; functioningSubstitution - Missense

c.1072C>T; p.P358S; 8:468772-468772

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.470delA; p.K158fs*11; 8:450078-450078

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.399delA; p.K134fs*4; 8:450007-450007

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.399delA; p.K134fs*4; 8:450007-450007

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1015-2A>G; p.?; 8:468713-468713

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaUnknown

c.784C>T; p.L262F; 8:458492-458492

 haematopoietic_and_lymphoid_tissue; central_nervous_systemlymphoid_neoplasm; primary_central_nervous_system_lymphomaSubstitution - Missense

c.833C>A; p.A278D; 8:458541-458541

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.533C>T; p.S178F; 8:451326-451326

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.113G>A; p.R38H; 8:413192-413192

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1087G>A; p.D363N; 8:468787-468787

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.113G>A; p.R38H; 8:413192-413192

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.349C>T; p.Q117*; 8:435675-435675

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.436A>C; p.K146Q; 8:450044-450044

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.517C>G; p.L173V; 8:451310-451310

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.75T>C; p.C25C; 8:413154-413154

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

')