Entrez Gene

Basic Information
Gene ID	27302
Name	BMP10
Synonymous	bone morphogenetic protein 10;BMP10;bone morphogenetic protein 10
Definition	-
Position	2p13.3
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.

The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.08.

The copy number variations for various cancers

Top

There is no record for BMP10

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.344C>T; p.S115F; 2:68866562-68866562	skin	malignant_melanoma	Substitution - Missense
c.344C>T; p.S115F; 2:68866562-68866562	skin; neck	malignant_melanoma	Substitution - Missense
c.522A>T; p.K174N; 2:68866384-68866384	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.272A>C; p.K91T; 2:68871087-68871087	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.998A>G; p.K333R; 2:68865908-68865908	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.371G>A; p.R124Q; 2:68866535-68866535	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.371G>A; p.R124Q; 2:68866535-68866535	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.300C>T; p.P100P; 2:68871059-68871059	skin	malignant_melanoma	Substitution - coding silent
c.1120G>A; p.A374T; 2:68865786-68865786	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.441A>G; p.L147L; 2:68866465-68866465	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.953C>A; p.A318D; 2:68865953-68865953	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.824C>A; p.S275Y; 2:68866082-68866082	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.486C>A; p.D162E; 2:68866420-68866420	kidney	other; neoplasm	Substitution - Missense
c.1134C>G; p.L378L; 2:68865772-68865772	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1183G>A; p.E395K; 2:68865723-68865723	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.563C>A; p.S188Y; 2:68866343-68866343	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.990C>T; p.I330I; 2:68865916-68865916	pancreas	carcinoma	Substitution - coding silent
c.1027G>A; p.A343T; 2:68865879-68865879	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.966C>T; p.Y322Y; 2:68865940-68865940	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.91C>T; p.P31S; 2:68871268-68871268	skin	malignant_melanoma	Substitution - Missense
c.665T>C; p.V222A; 2:68866241-68866241	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.151T>C; p.F51L; 2:68871208-68871208	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1218C>T; p.V406V; 2:68865688-68865688	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.538G>T; p.E180*; 2:68866368-68866368	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Nonsense
c.227C>G; p.S76*; 2:68871132-68871132	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.738G>T; p.Q246H; 2:68866168-68866168	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1108G>A; p.A370T; 2:68865798-68865798	breast	carcinoma	Substitution - Missense
c.1017C>A; p.S339S; 2:68865889-68865889	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.765G>A; p.V255V; 2:68866141-68866141	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.798G>A; p.R266R; 2:68866108-68866108	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.798G>A; p.R266R; 2:68866108-68866108	skin	malignant_melanoma	Substitution - coding silent
c.245C>A; p.P82Q; 2:68871114-68871114	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1173C>A; p.P391P; 2:68865733-68865733	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1186C>T; p.P396S; 2:68865720-68865720	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.521A>G; p.K174R; 2:68866385-68866385	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.521A>G; p.K174R; 2:68866385-68866385	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.521A>G; p.K174R; 2:68866385-68866385	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.521A>G; p.K174R; 2:68866385-68866385	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.521A>G; p.K174R; 2:68866385-68866385	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.410A>G; p.H137R; 2:68866496-68866496	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.497C>T; p.T166I; 2:68866409-68866409	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.370C>T; p.R124*; 2:68866536-68866536	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.503T>G; p.F168C; 2:68866403-68866403	skin	malignant_melanoma	Substitution - Missense
c.763G>A; p.V255M; 2:68866143-68866143	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.951C>T; p.N317N; 2:68865955-68865955	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.550C>A; p.L184M; 2:68866356-68866356	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.430G>A; p.E144K; 2:68866476-68866476	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.878G>A; p.G293E; 2:68866028-68866028	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.580A>G; p.T194A; 2:68866326-68866326	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1011G>A; p.W337*; 2:68865895-68865895	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.1078delC; p.L360fs*35; 2:68865828-68865828	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1188C>T; p.P396P; 2:68865718-68865718	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.684C>T; p.H228H; 2:68866222-68866222	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.684C>T; p.H228H; 2:68866222-68866222	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.814G>A; p.E272K; 2:68866092-68866092	skin	malignant_melanoma	Substitution - Missense
c.129C>A; p.F43L; 2:68871230-68871230	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1034C>A; p.P345H; 2:68865872-68865872	large_intestine; colon	NS	Substitution - Missense
c.885G>A; p.G295G; 2:68866021-68866021	skin	malignant_melanoma	Substitution - coding silent
c.1262G>A; p.C421Y; 2:68865644-68865644	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.647C>T; p.S216F; 2:68866259-68866259	skin	malignant_melanoma	Substitution - Missense
c.805G>A; p.E269K; 2:68866101-68866101	skin	malignant_melanoma	Substitution - Missense
c.378C>T; p.Y126Y; 2:68866528-68866528	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.667C>T; p.H223Y; 2:68866239-68866239	skin	malignant_melanoma	Substitution - Missense
c.477T>A; p.D159E; 2:68866429-68866429	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.802G>A; p.E268K; 2:68866104-68866104	skin	malignant_melanoma	Substitution - Missense
c.475G>A; p.D159N; 2:68866431-68866431	skin	malignant_melanoma	Substitution - Missense
c.755T>C; p.L252S; 2:68866151-68866151	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1041C>T; p.Y347Y; 2:68865865-68865865	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.862G>A; p.D288N; 2:68866044-68866044	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.235G>A; p.V79M; 2:68871124-68871124	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.312C>T; p.I104I; 2:68871047-68871047	skin	malignant_melanoma	Substitution - coding silent
c.542G>T; p.R181I; 2:68866364-68866364	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.867C>G; p.S289R; 2:68866039-68866039	kidney	other; neoplasm	Substitution - Missense
c.571A>G; p.I191V; 2:68866335-68866335	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.712C>T; p.R238W; 2:68866194-68866194	oesophagus	carcinoma	Substitution - Missense
c.488G>A; p.R163Q; 2:68866418-68866418	skin	malignant_melanoma	Substitution - Missense
c.1030_1031CC>TT; p.P344L; 2:68865875-68865876	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.488G>A; p.R163Q; 2:68866418-68866418	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.673G>T; p.E225*; 2:68866233-68866233	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.237G>T; p.V79V; 2:68871122-68871122	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.29C>T; p.A10V; 2:68871330-68871330	skin	malignant_melanoma	Substitution - Missense
c.552G>T; p.L184L; 2:68866354-68866354	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.63C>T; p.G21G; 2:68871296-68871296	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.89C>T; p.S30F; 2:68871270-68871270	skin	malignant_melanoma	Substitution - Missense
c.89C>T; p.S30F; 2:68871270-68871270	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.219G>A; p.T73T; 2:68871140-68871140	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1232T>A; p.F411Y; 2:68865674-68865674	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.241C>A; p.P81T; 2:68871118-68871118	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.346C>A; p.Q116K; 2:68866560-68866560	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.714G>A; p.R238R; 2:68866192-68866192	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.367C>G; p.L123V; 2:68866539-68866539	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.338T>G; p.L113R; 2:68866568-68866568	skin	malignant_melanoma	Substitution - Missense
c.703A>T; p.S235C; 2:68866203-68866203	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.522A>G; p.K174K; 2:68866384-68866384	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1251C>T; p.A417A; 2:68865655-68865655	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.522A>G; p.K174K; 2:68866384-68866384	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.711A>G; p.G237G; 2:68866195-68866195	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.522A>G; p.K174K; 2:68866384-68866384	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.522A>G; p.K174K; 2:68866384-68866384	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.522A>G; p.K174K; 2:68866384-68866384	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1251C>T; p.A417A; 2:68865655-68865655	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1187C>T; p.P396L; 2:68865719-68865719	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.215C>A; p.P72H; 2:68871144-68871144	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.112C>T; p.L38F; 2:68871247-68871247	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.148G>A; p.D50N; 2:68871211-68871211	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.148G>A; p.D50N; 2:68871211-68871211	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.801G>A; p.K267K; 2:68866105-68866105	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.427G>A; p.A143T; 2:68866479-68866479	skin	malignant_melanoma	Substitution - Missense
c.390C>T; p.F130F; 2:68866516-68866516	skin	malignant_melanoma	Substitution - coding silent
c.1252G>A; p.V418I; 2:68865654-68865654	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1252G>A; p.V418I; 2:68865654-68865654	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.762C>T; p.I254I; 2:68866144-68866144	skin	malignant_melanoma	Substitution - coding silent
c.139G>A; p.D47N; 2:68871220-68871220	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.762C>T; p.I254I; 2:68866144-68866144	pancreas	carcinoma	Substitution - coding silent
c.577G>A; p.G193R; 2:68866329-68866329	skin	malignant_melanoma	Substitution - Missense
c.577G>A; p.G193R; 2:68866329-68866329	skin	malignant_melanoma	Substitution - Missense
c.577G>A; p.G193R; 2:68866329-68866329	skin	malignant_melanoma	Substitution - Missense
c.958G>A; p.G320R; 2:68865948-68865948	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.487C>T; p.R163W; 2:68866419-68866419	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1142C>T; p.S381F; 2:68865764-68865764	skin	malignant_melanoma	Substitution - Missense
c.1137G>T; p.K379N; 2:68865769-68865769	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1209C>A; p.D403E; 2:68865697-68865697	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1209C>A; p.D403E; 2:68865697-68865697	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.50A>T; p.Y17F; 2:68871309-68871309	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.350C>T; p.P117L; 2:68866556-68866556	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.350C>T; p.P117L; 2:68866556-68866556	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Mutation summary in protein domains

Top

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

Loss of Function mutations compare to missense mutations

Top

The copy number variations for various cancers

Top

COSMIC somatic mutation [Top]