Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

284406

Name

ZFP82

Synonymous

ZFP82 zinc finger protein;ZFP82;ZFP82 zinc finger protein

Definition

zfp-82|zinc finger protein 545|zinc finger protein 82 homolog|zinc finger protein 85

Position

19q13.12

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.05.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.944G>A; p.C315Y; 19:36393396-36393396

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1176A>G; p.K392K; 19:36393164-36393164

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.636C>T; p.H212H; 19:36393704-36393704

 skinmalignant_melanomaSubstitution - coding silent

c.1191G>A; p.K397K; 19:36393149-36393149

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1493G>T; p.R498I; 19:36392847-36392847

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1191G>A; p.K397K; 19:36393149-36393149

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.985C>T; p.H329Y; 19:36393355-36393355

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1330C>A; p.H444N; 19:36393010-36393010

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1418C>A; p.T473N; 19:36392922-36392922

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1019G>A; p.C340Y; 19:36393321-36393321

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.1434_1435insT; p.E479fs*1; 19:36392905-36392906

 livercarcinomaInsertion - Frameshift

c.1345C>A; p.P449T; 19:36392995-36392995

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.793G>A; p.V265I; 19:36393547-36393547

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.793G>A; p.V265I; 19:36393547-36393547

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.554T>G; p.L185R; 19:36393786-36393786

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.713G>A; p.G238D; 19:36393627-36393627

 breastcarcinomaSubstitution - Missense

c.1360G>A; p.E454K; 19:36392980-36392980

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1A>T; p.M1L; 19:36409789-36409789

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1053A>C; p.Q351H; 19:36393287-36393287

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.886C>T; p.H296Y; 19:36393454-36393454

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.450T>C; p.S150S; 19:36393890-36393890

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.635A>G; p.H212R; 19:36393705-36393705

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.973C>G; p.L325V; 19:36393367-36393367

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.664G>A; p.G222S; 19:36393676-36393676

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.524G>A; p.C175Y; 19:36393816-36393816

 pancreascarcinomaSubstitution - Missense

c.187G>T; p.E63*; 19:36405622-36405622

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.187G>T; p.E63*; 19:36405622-36405622

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.842C>G; p.P281R; 19:36393498-36393498

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.321T>G; p.I107M; 19:36394019-36394019

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.321T>G; p.I107M; 19:36394019-36394019

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.211G>A; p.G71R; 19:36405598-36405598

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.406G>A; p.G136R; 19:36393934-36393934

 skin; facecarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.508T>A; p.Y170N; 19:36393832-36393832

 skin; mucosalmalignant_melanomaSubstitution - Missense

c.429G>A; p.M143I; 19:36393911-36393911

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.850T>G; p.C284G; 19:36393490-36393490

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1105A>G; p.K369E; 19:36393235-36393235

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1299A>C; p.L433L; 19:36393041-36393041

 skinmalignant_melanomaSubstitution - coding silent

c.739_740insA; p.M247fs*5; 19:36393600-36393601

 large_intestinecarcinoma; adenocarcinomaInsertion - Frameshift

c.128T>G; p.V43G; 19:36407895-36407895

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1476C>T; p.S492S; 19:36392864-36392864

 skinmalignant_melanomaSubstitution - coding silent

c.376A>C; p.K126Q; 19:36393964-36393964

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.391G>A; p.E131K; 19:36393949-36393949

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.358G>T; p.D120Y; 19:36393982-36393982

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1500T>G; p.H500Q; 19:36392840-36392840

 prostatecarcinomaSubstitution - Missense

c.1214G>A; p.R405H; 19:36393126-36393126

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.883G>A; p.A295T; 19:36393457-36393457

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.136+5G>A; p.?; 19:36407882-36407882

 livercarcinomaUnknown

c.47C>A; p.S16Y; 19:36407976-36407976

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.428T>A; p.M143K; 19:36393912-36393912

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.616G>T; p.A206S; 19:36393724-36393724

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.428T>A; p.M143K; 19:36393912-36393912

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1276G>A; p.E426K; 19:36393064-36393064

 livercarcinomaSubstitution - Missense

c.1276G>A; p.E426K; 19:36393064-36393064

 livercarcinomaSubstitution - Missense

c.1334T>A; p.I445N; 19:36393006-36393006

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.811C>T; p.L271L; 19:36393529-36393529

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.511G>A; p.E171K; 19:36393829-36393829

 skinmalignant_melanomaSubstitution - Missense

c.434C>G; p.S145C; 19:36393906-36393906

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.1456G>A; p.A486T; 19:36392884-36392884

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1187G>A; p.C396Y; 19:36393153-36393153

 central_nervous_system; brainglioma; astrocytoma_Grade_IIISubstitution - Missense

c.829A>G; p.T277A; 19:36393511-36393511

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.434C>G; p.S145C; 19:36393906-36393906

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1384C>T; p.R462C; 19:36392956-36392956

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.460C>A; p.R154S; 19:36393880-36393880

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.699A>T; p.E233D; 19:36393641-36393641

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1577A>G; p.K526R; 19:36392763-36392763

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; hairy_cell_leukaemiaSubstitution - Missense

c.1582C>T; p.H528Y; 19:36392758-36392758

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.929A>G; p.Y310C; 19:36393411-36393411

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.275A>G; p.D92G; 19:36394065-36394065

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1493G>A; p.R498K; 19:36392847-36392847

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.407G>A; p.G136E; 19:36393933-36393933

 skinmalignant_melanomaSubstitution - Missense

c.109G>A; p.E37K; 19:36407914-36407914

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1554T>C; p.H518H; 19:36392786-36392786

 breastcarcinomaSubstitution - coding silent

c.1334T>C; p.I445T; 19:36393006-36393006

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.574C>T; p.H192Y; 19:36393766-36393766

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.461G>A; p.R154H; 19:36393879-36393879

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1178C>T; p.P393L; 19:36393162-36393162

 livercarcinomaSubstitution - Missense

c.1178C>T; p.P393L; 19:36393162-36393162

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1283G>T; p.G428V; 19:36393057-36393057

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.9+2T>C; p.?; 19:36409779-36409779

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.1281C>T; p.C427C; 19:36393059-36393059

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1138C>T; p.H380Y; 19:36393202-36393202

 skinmalignant_melanomaSubstitution - Missense

c.1281C>T; p.C427C; 19:36393059-36393059

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1345C>T; p.P449S; 19:36392995-36392995

 skin; upper_armmalignant_melanomaSubstitution - Missense

c.1513C>T; p.P505S; 19:36392827-36392827

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.1367G>A; p.G456D; 19:36392973-36392973

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1385G>A; p.R462H; 19:36392955-36392955

 oesophaguscarcinomaSubstitution - Missense

c.588delA; p.K196fs*102; 19:36393752-36393752

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.888C>A; p.H296Q; 19:36393452-36393452

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1413T>A; p.I471I; 19:36392927-36392927

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.380T>C; p.I127T; 19:36393960-36393960

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.986A>G; p.H329R; 19:36393354-36393354

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.986A>G; p.H329R; 19:36393354-36393354

 stomachadenocarcinomaSubstitution - Missense

c.1519G>A; p.E507K; 19:36392821-36392821

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.558T>G; p.T186T; 19:36393782-36393782

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.1182C>T; p.Y394Y; 19:36393158-36393158

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1182C>T; p.Y394Y; 19:36393158-36393158

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.917C>T; p.A306V; 19:36393423-36393423

 stomachadenocarcinomaSubstitution - Missense

c.917C>T; p.A306V; 19:36393423-36393423

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.936C>T; p.C312C; 19:36393404-36393404

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.527G>A; p.G176E; 19:36393813-36393813

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.406G>T; p.G136*; 19:36393934-36393934

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.688G>T; p.E230*; 19:36393652-36393652

 lung; middle_lobecarcinoma; adenocarcinomaSubstitution - Nonsense

c.190C>A; p.P64T; 19:36405619-36405619

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1422C>T; p.G474G; 19:36392918-36392918

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.1422C>T; p.G474G; 19:36392918-36392918

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.562C>T; p.H188Y; 19:36393778-36393778

 skinmalignant_melanomaSubstitution - Missense

c.131C>T; p.S44L; 19:36407892-36407892

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1149C>T; p.L383L; 19:36393191-36393191

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1576A>C; p.K526Q; 19:36392764-36392764

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.680A>T; p.E227V; 19:36393660-36393660

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1065C>T; p.L355L; 19:36393275-36393275

 skinmalignant_melanomaSubstitution - coding silent

c.882C>T; p.Y294Y; 19:36393458-36393458

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.229G>A; p.D77N; 19:36405580-36405580

 livercarcinomaSubstitution - Missense

c.592T>C; p.Y198H; 19:36393748-36393748

 breastcarcinomaSubstitution - Missense

c.170C>T; p.S57L; 19:36405639-36405639

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.149C>A; p.S50Y; 19:36405660-36405660

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.526G>T; p.G176W; 19:36393814-36393814

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.694G>C; p.G232R; 19:36393646-36393646

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.694G>C; p.G232R; 19:36393646-36393646

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.694G>C; p.G232R; 19:36393646-36393646

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.694G>C; p.G232R; 19:36393646-36393646

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1027T>C; p.C343R; 19:36393313-36393313

 lung; middle_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.672A>T; p.K224N; 19:36393668-36393668

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1157G>T; p.R386I; 19:36393183-36393183

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1157G>T; p.R386I; 19:36393183-36393183

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1423G>A; p.E475K; 19:36392917-36392917

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.137-4G>A; p.?; 19:36405676-36405676

 pancreascarcinoma; adenocarcinomaUnknown

c.1165A>T; p.T389S; 19:36393175-36393175

 prostatecarcinomaSubstitution - Missense

c.475_476CC>TA; p.P159>?; 19:36393864-36393865

 lungcarcinoma; adenocarcinomaComplex

c.875G>T; p.R292I; 19:36393465-36393465

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.875G>T; p.R292I; 19:36393465-36393465

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1029C>T; p.C343C; 19:36393311-36393311

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1186T>G; p.C396G; 19:36393154-36393154

 livercarcinomaSubstitution - Missense

c.1029C>T; p.C343C; 19:36393311-36393311

 breastcarcinomaSubstitution - coding silent

c.1031G>T; p.G344V; 19:36393309-36393309

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.776G>A; p.C259Y; 19:36393564-36393564

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1526A>G; p.K509R; 19:36392814-36392814

 pancreascarcinomaSubstitution - Missense

c.1526A>G; p.K509R; 19:36392814-36392814

 pancreascarcinomaSubstitution - Missense

c.840A>C; p.K280N; 19:36393500-36393500

 pancreascarcinomaSubstitution - Missense

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