Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

2878

Name

GPX3

Synonymous

glutathione peroxidase 3;GPX3;glutathione peroxidase 3

Definition

GPx-3|extracellular glutathione peroxidase|glutathione peroxidase 3 (plasma)|plasma glutathione peroxidase

Position

5q33.1

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.608C>T; p.T203M; 5:151028057-151028057

 pancreascarcinomaSubstitution - Missense

c.634C>A; p.L212M; 5:151028083-151028083

 kidneyother; neoplasmSubstitution - Missense

c.539G>A; p.R180H; 5:151027988-151027988

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.566G>T; p.G189V; 5:151028015-151028015

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.592T>G; p.W198G; 5:151028041-151028041

 livercarcinomaSubstitution - Missense

c.631A>G; p.I211V; 5:151028080-151028080

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.277G>A; p.G93S; 5:151026935-151026935

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.314G>A; p.G105E; 5:151026972-151026972

 breastcarcinomaSubstitution - Missense

c.406G>C; p.E136Q; 5:151027478-151027478

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.451T>G; p.F151V; 5:151027523-151027523

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.131G>A; p.G44E; 5:151025383-151025383

 skinmalignant_melanomaSubstitution - Missense

c.205G>A; p.V69M; 5:151025457-151025457

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.258G>A; p.Q86Q; 5:151026916-151026916

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.124G>A; p.E42K; 5:151025376-151025376

 skinmalignant_melanomaSubstitution - Missense

c.522G>A; p.M174I; 5:151027971-151027971

 skinmalignant_melanomaSubstitution - Missense

c.367C>G; p.R123G; 5:151027439-151027439

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.83C>T; p.S28L; 5:151020737-151020737

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.538C>T; p.R180C; 5:151027987-151027987

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.294C>T; p.G98G; 5:151026952-151026952

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.367C>T; p.R123*; 5:151027439-151027439

 urinary_tract; bladdercarcinomaSubstitution - Nonsense

c.538C>A; p.R180S; 5:151027987-151027987

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.649C>T; p.R217W; 5:151028098-151028098

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.424G>A; p.G142R; 5:151027496-151027496

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.24C>T; p.S8S; 5:151020678-151020678

 livercarcinoma; hepatocellular_carcinomaSubstitution - coding silent

c.579A>G; p.I193M; 5:151028028-151028028

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.575G>A; p.G192D; 5:151028024-151028024

 skin; trunkmalignant_melanomaSubstitution - Missense

c.659C>T; p.A220V; 5:151028108-151028108

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.659C>T; p.A220V; 5:151028108-151028108

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

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