Entrez Gene

Basic Information
Gene ID	29119
Name	CTNNA3
Synonymous	catenin (cadherin-associated protein), alpha 3;CTNNA3;catenin (cadherin-associated protein), alpha 3
Definition	alpha-T-catenin\|alpha-catenin-like protein\|catenin alpha-3
Position	10q22.2
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.13.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1896A>G; p.E632E; 10:66103238-66103238	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.616G>A; p.G206R; 10:67219834-67219834	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2160-2A>G; p.?; 10:65988799-65988799	stomach	carcinoma; adenocarcinoma	Unknown
c.1839C>A; p.I613I; 10:66280515-66280515	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2546G>C; p.R849T; 10:65920472-65920472	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1582C>A; p.Q528K; 10:66379302-66379302	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1382A>G; p.N461S; 10:66520766-66520766	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.687T>C; p.S229S; 10:67219763-67219763	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1443G>T; p.M481I; 10:66520705-66520705	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2249G>A; p.R750Q; 10:65988708-65988708	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2546G>C; p.R849T; 10:65920472-65920472	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1813C>T; p.Q605*; 10:66280541-66280541	skin; upper_arm	malignant_melanoma	Substitution - Nonsense
c.129C>T; p.N43N; 10:67607020-67607020	skin	malignant_melanoma	Substitution - coding silent
c.778C>T; p.Q260*; 10:67219672-67219672	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.2487A>C; p.S829S; 10:65920531-65920531	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.82G>A; p.E28K; 10:67647432-67647432	skin	malignant_melanoma	Substitution - Missense
c.2153T>C; p.F718S; 10:66069314-66069314	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1000G>A; p.A334T; 10:67180364-67180364	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1390C>A; p.L464I; 10:66520758-66520758	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1000G>A; p.A334T; 10:67180364-67180364	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.991G>A; p.E331K; 10:67180373-67180373	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1775C>A; p.A592D; 10:66280579-66280579	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1222G>A; p.E408K; 10:66766323-66766323	skin	malignant_melanoma	Substitution - Missense
c.950C>T; p.S317F; 10:67180414-67180414	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.34G>A; p.D12N; 10:67647480-67647480	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1007G>A; p.R336H; 10:67180357-67180357	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.182C>T; p.S61F; 10:67606967-67606967	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1222G>A; p.E408K; 10:66766323-66766323	skin	malignant_melanoma	Substitution - Missense
c.2520G>A; p.G840G; 10:65920498-65920498	stomach	adenocarcinoma	Substitution - coding silent
c.2520G>A; p.G840G; 10:65920498-65920498	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2569C>A; p.P857T; 10:65920449-65920449	oesophagus	carcinoma	Substitution - Missense
c.650T>A; p.L217H; 10:67219800-67219800	breast	carcinoma	Substitution - Missense
c.582C>A; p.D194E; 10:67219868-67219868	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1604G>A; p.R535H; 10:66379280-66379280	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1333G>A; p.V445I; 10:66621733-66621733	skin	malignant_melanoma	Substitution - Missense
c.2565A>C; p.K855N; 10:65920453-65920453	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.64A>C; p.T22P; 10:67647450-67647450	breast	carcinoma	Substitution - Missense
c.1033G>A; p.E345K; 10:67180331-67180331	skin	malignant_melanoma	Substitution - Missense
c.1451G>A; p.R484H; 10:66520697-66520697	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.105C>G; p.T35T; 10:67607044-67607044	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1451G>A; p.R484H; 10:66520697-66520697	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.437G>T; p.C146F; 10:67539525-67539525	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1528T>A; p.S510T; 10:66520620-66520620	fallopian_tube	carcinoma; serous_carcinoma	Substitution - Missense
c.1964G>A; p.G655E; 10:66103170-66103170	skin	malignant_melanoma	Substitution - Missense
c.1848A>G; p.T616T; 10:66280506-66280506	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2337G>A; p.L779L; 10:65966675-65966675	skin	malignant_melanoma	Substitution - coding silent
c.1964G>A; p.G655E; 10:66103170-66103170	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1964G>A; p.G655E; 10:66103170-66103170	skin	malignant_melanoma	Substitution - Missense
c.2435A>C; p.K812T; 10:65920583-65920583	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1989T>C; p.T663T; 10:66069478-66069478	oesophagus	carcinoma	Substitution - coding silent
c.1585G>A; p.D529N; 10:66379299-66379299	skin	malignant_melanoma	Substitution - Missense
c.2490delC; p.K831fs*16; 10:65920528-65920528	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2435A>C; p.K812T; 10:65920583-65920583	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1021G>A; p.D341N; 10:67180343-67180343	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.686C>T; p.S229F; 10:67219764-67219764	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1360A>C; p.T454P; 10:66621706-66621706	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.2472G>T; p.M824I; 10:65920546-65920546	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.161G>A; p.R54K; 10:67606988-67606988	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2378G>A; p.G793E; 10:65966634-65966634	skin	malignant_melanoma	Substitution - Missense
c.2399C>T; p.A800V; 10:65966613-65966613	skin; trunk	malignant_melanoma	Substitution - Missense
c.1930G>A; p.E644K; 10:66103204-66103204	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.346C>T; p.P116S; 10:67539616-67539616	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1183C>A; p.P395T; 10:66766362-66766362	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.544G>A; p.E182K; 10:67521877-67521877	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.346C>T; p.P116S; 10:67539616-67539616	skin	malignant_melanoma	Substitution - Missense
c.1930G>A; p.E644K; 10:66103204-66103204	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1639G>C; p.V547L; 10:66379245-66379245	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1885-1G>A; p.?; 10:66103250-66103250	oesophagus	carcinoma; squamous_cell_carcinoma	Unknown
c.1995G>T; p.L665L; 10:66069472-66069472	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1412A>T; p.K471I; 10:66520736-66520736	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1028T>C; p.L343P; 10:67180336-67180336	skin	malignant_melanoma	Substitution - Missense
c.1885-1G>A; p.?; 10:66103250-66103250	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.2136G>T; p.M712I; 10:66069331-66069331	breast	carcinoma	Substitution - Missense
c.468G>A; p.R156R; 10:67521953-67521953	skin	malignant_melanoma	Substitution - coding silent
c.1064G>T; p.R355M; 10:66775508-66775508	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2525G>T; p.R842L; 10:65920493-65920493	large_intestine	adenoma	Substitution - Missense
c.1518C>T; p.F506F; 10:66520630-66520630	skin	malignant_melanoma	Substitution - coding silent
c.2501G>A; p.R834Q; 10:65920517-65920517	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1655C>T; p.T552M; 10:66379229-66379229	pancreas	carcinoma	Substitution - Missense
c.1271G>T; p.R424M; 10:66766274-66766274	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2386C>A; p.L796I; 10:65966626-65966626	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2608G>T; p.A870S; 10:65920410-65920410	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2501G>A; p.R834Q; 10:65920517-65920517	skin	malignant_melanoma	Substitution - Missense
c.1655C>T; p.T552M; 10:66379229-66379229	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1902G>A; p.E634E; 10:66103232-66103232	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; polycythaemia_vera	Substitution - coding silent
c.807G>T; p.Q269H; 10:67219643-67219643	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2097C>T; p.N699N; 10:66069370-66069370	prostate	carcinoma	Substitution - coding silent
c.892C>T; p.P298S; 10:67180472-67180472	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2133C>T; p.I711I; 10:66069334-66069334	skin	malignant_melanoma	Substitution - coding silent
c.1161C>A; p.D387E; 10:66766384-66766384	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1161C>A; p.D387E; 10:66766384-66766384	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.2133C>T; p.I711I; 10:66069334-66069334	skin	malignant_melanoma	Substitution - coding silent
c.828C>T; p.A276A; 10:67219622-67219622	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1402G>T; p.A468S; 10:66520746-66520746	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2615G>T; p.R872I; 10:65920403-65920403	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1265C>T; p.T422I; 10:66766280-66766280	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1170G>T; p.L390L; 10:66766375-66766375	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.876T>C; p.T292T; 10:67180488-67180488	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1706G>A; p.R569K; 10:66379178-66379178	stomach	adenocarcinoma	Substitution - Missense
c.835G>T; p.E279*; 10:67219615-67219615	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.563C>T; p.A188V; 10:67521858-67521858	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.174T>C; p.L58L; 10:67606975-67606975	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1542C>A; p.I514I; 10:66379342-66379342	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1591G>A; p.D531N; 10:66379293-66379293	skin	malignant_melanoma	Substitution - Missense
c.1594A>G; p.N532D; 10:66379290-66379290	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.960G>A; p.T320T; 10:67180404-67180404	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.960G>A; p.T320T; 10:67180404-67180404	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2600C>A; p.T867K; 10:65920418-65920418	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1059delA; p.E354fs*6; 10:66775513-66775513	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.973C>T; p.R325*; 10:67180391-67180391	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2115C>A; p.A705A; 10:66069352-66069352	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1059delA; p.E354fs*6; 10:66775513-66775513	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1059delA; p.E354fs*6; 10:66775513-66775513	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.973C>T; p.R325*; 10:67180391-67180391	pancreas	carcinoma	Substitution - Nonsense
c.2276C>T; p.P759L; 10:65966736-65966736	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1175C>T; p.T392M; 10:66766370-66766370	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.1175C>T; p.T392M; 10:66766370-66766370	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2205G>A; p.A735A; 10:65988752-65988752	skin	malignant_melanoma	Substitution - coding silent
c.2205G>A; p.A735A; 10:65988752-65988752	liver	carcinoma	Substitution - coding silent
c.38C>T; p.P13L; 10:67647476-67647476	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1963G>A; p.G655R; 10:66103171-66103171	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2205G>A; p.A735A; 10:65988752-65988752	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1997C>A; p.P666H; 10:66069470-66069470	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1094A>G; p.N365S; 10:66775478-66775478	breast	carcinoma	Substitution - Missense
c.1465C>G; p.H489D; 10:66520683-66520683	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.37C>T; p.P13S; 10:67647477-67647477	skin	malignant_melanoma	Substitution - Missense
c.2148A>C; p.T716T; 10:66069319-66069319	skin	malignant_melanoma	Substitution - coding silent
c.2596G>A; p.E866K; 10:65920422-65920422	skin	malignant_melanoma	Substitution - Missense
c.1918G>T; p.E640*; 10:66103216-66103216	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Nonsense
c.1789T>C; p.S597P; 10:66280565-66280565	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2167G>T; p.G723*; 10:65988790-65988790	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1523C>T; p.A508V; 10:66520625-66520625	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.474T>G; p.F158L; 10:67521947-67521947	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.66C>T; p.T22T; 10:67647448-67647448	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1129-8C>A; p.?; 10:66766424-66766424	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Unknown
c.2265G>A; p.Q755Q; 10:65988692-65988692	skin	malignant_melanoma	Substitution - coding silent
c.2550G>A; p.M850I; 10:65920468-65920468	skin	malignant_melanoma	Substitution - Missense
c.586A>G; p.K196E; 10:67219864-67219864	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2125T>C; p.C709R; 10:66069342-66069342	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2364G>A; p.E788E; 10:65966648-65966648	skin	malignant_melanoma	Substitution - coding silent
c.1982A>C; p.K661T; 10:66069485-66069485	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2574G>T; p.L858F; 10:65920444-65920444	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1982A>C; p.K661T; 10:66069485-66069485	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2380G>A; p.G794R; 10:65966632-65966632	skin	malignant_melanoma	Substitution - Missense
c.2031T>A; p.V677V; 10:66069436-66069436	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.398C>T; p.T133M; 10:67539564-67539564	pancreas	carcinoma	Substitution - Missense
c.411C>T; p.I137I; 10:67539551-67539551	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1958C>A; p.T653N; 10:66103176-66103176	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.539A>T; p.E180V; 10:67521882-67521882	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1848A>C; p.T616T; 10:66280506-66280506	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1126C>T; p.Q376*; 10:66775446-66775446	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.284G>A; p.R95H; 10:67606865-67606865	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.284G>A; p.R95H; 10:67606865-67606865	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1538A>G; p.H513R; 10:66379346-66379346	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.284G>A; p.R95H; 10:67606865-67606865	large_intestine; colon	carcinoma	Substitution - Missense
c.284G>A; p.R95H; 10:67606865-67606865	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1126C>T; p.Q376*; 10:66775446-66775446	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Nonsense
c.1089A>T; p.L363F; 10:66775483-66775483	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1374+2T>A; p.?; 10:66621690-66621690	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Unknown
c.768A>C; p.S256S; 10:67219682-67219682	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1807G>A; p.D603N; 10:66280547-66280547	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2167G>A; p.G723R; 10:65988790-65988790	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.200G>A; p.W67*; 10:67606949-67606949	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2500C>T; p.R834*; 10:65920518-65920518	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1272G>T; p.R424S; 10:66766273-66766273	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.156G>A; p.S52S; 10:67606993-67606993	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.156G>A; p.S52S; 10:67606993-67606993	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2006A>T; p.E669V; 10:66069461-66069461	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2059C>G; p.L687V; 10:66069408-66069408	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2040C>T; p.F680F; 10:66069427-66069427	skin	malignant_melanoma	Substitution - coding silent
c.924C>T; p.I308I; 10:67180440-67180440	skin	malignant_melanoma	Substitution - coding silent
c.924C>T; p.I308I; 10:67180440-67180440	skin	malignant_melanoma	Substitution - coding silent
c.2246C>T; p.A749V; 10:65988711-65988711	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1345G>A; p.A449T; 10:66621721-66621721	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1052G>A; p.G351E; 10:66775520-66775520	skin	malignant_melanoma	Substitution - Missense
c.999C>T; p.N333N; 10:67180365-67180365	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1650C>T; p.I550I; 10:66379234-66379234	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.312A>T; p.S104S; 10:67539650-67539650	breast	carcinoma	Substitution - coding silent
c.1766C>G; p.A589G; 10:66280588-66280588	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1692_1693GG>TA; p.T564>?; 10:66379191-66379192	lung	carcinoma; adenocarcinoma	Complex
c.1451G>T; p.R484L; 10:66520697-66520697	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1965G>A; p.G655G; 10:66103169-66103169	skin	malignant_melanoma	Substitution - coding silent
c.1965G>A; p.G655G; 10:66103169-66103169	skin	malignant_melanoma	Substitution - coding silent
c.1775C>T; p.A592V; 10:66280579-66280579	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1024C>A; p.L342M; 10:67180340-67180340	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1628G>A; p.R543Q; 10:66379256-66379256	breast	carcinoma	Substitution - Missense
c.1797T>G; p.N599K; 10:66280557-66280557	central_nervous_system; brain	glioma	Substitution - Missense
c.1628G>A; p.R543Q; 10:66379256-66379256	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1885-2A>C; p.?; 10:66103251-66103251	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1822G>T; p.D608Y; 10:66280532-66280532	thyroid	other; neoplasm	Substitution - Missense
c.2531C>A; p.P844Q; 10:65920487-65920487	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2114C>A; p.A705D; 10:66069353-66069353	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.67G>A; p.V23M; 10:67647447-67647447	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.67G>A; p.V23M; 10:67647447-67647447	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.67G>A; p.V23M; 10:67647447-67647447	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1052G>C; p.G351A; 10:66775520-66775520	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.889C>T; p.R297*; 10:67180475-67180475	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.889C>T; p.R297*; 10:67180475-67180475	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.883G>A; p.E295K; 10:67180481-67180481	skin	malignant_melanoma	Substitution - Missense
c.1421C>T; p.A474V; 10:66520727-66520727	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1186C>T; p.L396F; 10:66766359-66766359	skin	malignant_melanoma	Substitution - Missense
c.1482T>C; p.T494T; 10:66520666-66520666	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.417G>A; p.A139A; 10:67539545-67539545	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.974G>A; p.R325Q; 10:67180390-67180390	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2575A>T; p.I859F; 10:65920443-65920443	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.974G>A; p.R325Q; 10:67180390-67180390	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1616C>T; p.A539V; 10:66379268-66379268	skin; mucosal	malignant_melanoma	Substitution - Missense
c.974G>A; p.R325Q; 10:67180390-67180390	skin	malignant_melanoma	Substitution - Missense
c.2074G>A; p.E692K; 10:66069393-66069393	skin	malignant_melanoma	Substitution - Missense
c.1978G>T; p.A660S; 10:66069489-66069489	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.483C>G; p.L161L; 10:67521938-67521938	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.842A>G; p.E281G; 10:67219608-67219608	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.38C>A; p.P13H; 10:67647476-67647476	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1237G>C; p.E413Q; 10:66766308-66766308	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.842A>G; p.E281G; 10:67219608-67219608	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2543G>A; p.W848*; 10:65920475-65920475	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.842A>G; p.E281G; 10:67219608-67219608	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2266-10T>G; p.?; 10:65966756-65966756	stomach	carcinoma; adenocarcinoma	Unknown
c.2266-10T>G; p.?; 10:65966756-65966756	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1241A>G; p.Y414C; 10:66766304-66766304	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2266-10T>G; p.?; 10:65966756-65966756	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1375-2A>G; p.?; 10:66520775-66520775	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.509T>G; p.L170R; 10:67521912-67521912	skin	malignant_melanoma	Substitution - Missense
c.263C>T; p.T88M; 10:67606886-67606886	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1348A>C; p.N450H; 10:66621718-66621718	prostate	carcinoma	Substitution - Missense
c.993A>T; p.E331D; 10:67180371-67180371	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1733-6T>C; p.?; 10:66280627-66280627	skin; head_neck	malignant_melanoma; superficial_spreading	Unknown
c.1159G>A; p.D387N; 10:66766386-66766386	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1434C>T; p.T478T; 10:66520714-66520714	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1875G>C; p.M625I; 10:66280479-66280479	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.729A>T; p.E243D; 10:67219721-67219721	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.2307G>A; p.L769L; 10:65966705-65966705	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2345G>A; p.C782Y; 10:65966667-65966667	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.2266-1G>T; p.?; 10:65966747-65966747	lung	carcinoma; adenocarcinoma	Unknown
c.2198A>T; p.Y733F; 10:65988759-65988759	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1167C>T; p.F389F; 10:66766378-66766378	skin	malignant_melanoma	Substitution - coding silent
c.394G>A; p.V132M; 10:67539568-67539568	skin	malignant_melanoma	Substitution - Missense
c.42G>T; p.Q14H; 10:67647472-67647472	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.987C>T; p.I329I; 10:67180377-67180377	skin	malignant_melanoma	Substitution - coding silent
c.2500C>G; p.R834G; 10:65920518-65920518	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.2447A>G; p.N816S; 10:65920571-65920571	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.2500C>G; p.R834G; 10:65920518-65920518	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.2500C>G; p.R834G; 10:65920518-65920518	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.1664T>C; p.M555T; 10:66379220-66379220	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2658G>T; p.M886I; 10:65920360-65920360	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.2658G>T; p.M886I; 10:65920360-65920360	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1954C>T; p.Q652*; 10:66103180-66103180	skin	malignant_melanoma	Substitution - Nonsense
c.165C>T; p.A55A; 10:67606984-67606984	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1894G>A; p.E632K; 10:66103240-66103240	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1536C>T; p.S512S; 10:66379348-66379348	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1999G>A; p.E667K; 10:66069468-66069468	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2654T>A; p.V885D; 10:65920364-65920364	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2598A>G; p.E866E; 10:65920420-65920420	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2598A>G; p.E866E; 10:65920420-65920420	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1018C>T; p.Q340*; 10:67180346-67180346	skin	malignant_melanoma	Substitution - Nonsense
c.640A>T; p.N214Y; 10:67219810-67219810	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1248G>A; p.A416A; 10:66766297-66766297	skin	malignant_melanoma	Substitution - coding silent
c.1248G>A; p.A416A; 10:66766297-66766297	skin	malignant_melanoma	Substitution - coding silent
c.1430delA; p.N477fs*21; 10:66520718-66520718	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2329C>T; p.H777Y; 10:65966683-65966683	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.849A>G; p.L283L; 10:67180515-67180515	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1060G>T; p.E354*; 10:66775512-66775512	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1060G>T; p.E354*; 10:66775512-66775512	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1956G>C; p.Q652H; 10:66103178-66103178	breast	carcinoma	Substitution - Missense
c.553G>A; p.D185N; 10:67521868-67521868	skin	malignant_melanoma	Substitution - Missense
c.2641C>T; p.H881Y; 10:65920377-65920377	skin; mucosal	malignant_melanoma	Substitution - Missense
c.980G>A; p.R327Q; 10:67180384-67180384	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1243G>A; p.A415T; 10:66766302-66766302	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.980G>A; p.R327Q; 10:67180384-67180384	skin; mucosal	malignant_melanoma	Substitution - Missense
c.2400+1G>T; p.?; 10:65966611-65966611	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.218G>A; p.G73E; 10:67606931-67606931	skin; shoulder	malignant_melanoma	Substitution - Missense
c.841G>T; p.E281*; 10:67219609-67219609	lung	carcinoma; non_small_cell_carcinoma	Substitution - Nonsense
c.511C>T; p.Q171*; 10:67521910-67521910	skin	malignant_melanoma	Substitution - Nonsense
c.2282G>T; p.C761F; 10:65966730-65966730	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2383G>A; p.E795K; 10:65966629-65966629	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.82delG; p.E28fs*4; 10:67647432-67647432	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1107G>T; p.K369N; 10:66775465-66775465	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.477G>T; p.E159D; 10:67521944-67521944	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1247C>T; p.A416V; 10:66766298-66766298	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1247C>T; p.A416V; 10:66766298-66766298	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1247C>T; p.A416V; 10:66766298-66766298	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1375A>G; p.I459V; 10:66520773-66520773	liver	carcinoma	Substitution - Missense
c.1133G>A; p.R378H; 10:66766412-66766412	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1375A>G; p.I459V; 10:66520773-66520773	liver	carcinoma	Substitution - Missense
c.141G>A; p.R47R; 10:67607008-67607008	skin	malignant_melanoma	Substitution - coding silent
c.1771G>A; p.E591K; 10:66280583-66280583	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.141G>A; p.R47R; 10:67607008-67607008	skin	malignant_melanoma	Substitution - coding silent
c.1281G>T; p.E427D; 10:66766264-66766264	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1281G>T; p.E427D; 10:66766264-66766264	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.84G>A; p.E28E; 10:67647430-67647430	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.141G>A; p.R47R; 10:67607008-67607008	skin	malignant_melanoma	Substitution - coding silent
c.1281G>T; p.E427D; 10:66766264-66766264	large_intestine; colon	carcinoma	Substitution - Missense
c.1281G>T; p.E427D; 10:66766264-66766264	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.67G>T; p.V23L; 10:67647447-67647447	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1301C>T; p.S434F; 10:66621765-66621765	skin	malignant_melanoma	Substitution - Missense
c.2567_2568insA; p.P857fs*4; 10:65920450-65920451	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2567_2568insA; p.P857fs*4; 10:65920450-65920451	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.567C>T; p.F189F; 10:67521854-67521854	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.567C>T; p.F189F; 10:67521854-67521854	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1891G>C; p.E631Q; 10:66103243-66103243	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.331G>A; p.D111N; 10:67539631-67539631	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1047+1G>A; p.?; 10:67180316-67180316	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.2464G>T; p.V822L; 10:65920554-65920554	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1236delA; p.E413fs*14; 10:66766309-66766309	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.822A>T; p.G274G; 10:67219628-67219628	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2449G>A; p.A817T; 10:65920569-65920569	liver	carcinoma	Substitution - Missense
c.1369C>T; p.P457S; 10:66621697-66621697	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2563A>G; p.K855E; 10:65920455-65920455	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1195C>T; p.L399F; 10:66766350-66766350	skin	malignant_melanoma	Substitution - Missense
c.2449G>A; p.A817T; 10:65920569-65920569	liver	carcinoma	Substitution - Missense
c.2563A>G; p.K855E; 10:65920455-65920455	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.2563A>G; p.K855E; 10:65920455-65920455	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.847T>C; p.L283L; 10:67180517-67180517	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.847T>C; p.L283L; 10:67180517-67180517	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1339A>G; p.I447V; 10:66621727-66621727	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1406G>C; p.R469T; 10:66520742-66520742	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.891A>G; p.R297R; 10:67180473-67180473	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2613C>T; p.V871V; 10:65920405-65920405	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1406G>C; p.R469T; 10:66520742-66520742	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1465C>T; p.H489Y; 10:66520683-66520683	skin	malignant_melanoma	Substitution - Missense
c.747C>T; p.L249L; 10:67219703-67219703	skin	malignant_melanoma	Substitution - coding silent
c.279A>C; p.E93D; 10:67606870-67606870	skin	malignant_melanoma	Substitution - Missense
c.546A>C; p.E182D; 10:67521875-67521875	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1433C>A; p.T478N; 10:66520715-66520715	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.946G>A; p.D316N; 10:67180418-67180418	skin	malignant_melanoma	Substitution - Missense
c.580-1G>A; p.?; 10:67219871-67219871	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.2016G>T; p.K672N; 10:66069451-66069451	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.277G>A; p.E93K; 10:67606872-67606872	skin; neck	malignant_melanoma	Substitution - Missense
c.1309A>G; p.T437A; 10:66621757-66621757	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1881T>A; p.I627I; 10:66280473-66280473	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1627C>T; p.R543W; 10:66379257-66379257	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.148G>A; p.G50R; 10:67607001-67607001	skin	malignant_melanoma	Substitution - Missense
c.1302C>T; p.S434S; 10:66621764-66621764	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1220G>T; p.R407L; 10:66766325-66766325	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1190T>G; p.L397W; 10:66766355-66766355	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2520G>T; p.G840G; 10:65920498-65920498	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1977G>T; p.R659S; 10:66103157-66103157	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2376_2377insA; p.G793fs*68; 10:65966635-65966636	breast	carcinoma	Insertion - Frameshift
c.2398G>T; p.A800S; 10:65966614-65966614	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2470A>T; p.M824L; 10:65920548-65920548	liver	carcinoma	Substitution - Missense
c.819G>T; p.L273L; 10:67219631-67219631	skin; upper_leg	malignant_melanoma	Substitution - coding silent
c.753A>C; p.V251V; 10:67219697-67219697	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1935C>T; p.V645V; 10:66103199-66103199	skin	malignant_melanoma	Substitution - coding silent
c.1145T>C; p.I382T; 10:66766400-66766400	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.412C>T; p.L138F; 10:67539550-67539550	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.956G>A; p.C319Y; 10:67180408-67180408	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.675T>C; p.C225C; 10:67219775-67219775	skin	malignant_melanoma	Substitution - coding silent
c.1488C>T; p.A496A; 10:66520660-66520660	skin	malignant_melanoma	Substitution - coding silent
c.1645C>T; p.H549Y; 10:66379239-66379239	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1488C>T; p.A496A; 10:66520660-66520660	breast	carcinoma	Substitution - coding silent
c.1758G>T; p.V586V; 10:66280596-66280596	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1187T>G; p.L396R; 10:66766358-66766358	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.721G>A; p.V241I; 10:67219729-67219729	skin	malignant_melanoma	Substitution - Missense
c.1386T>C; p.A462A; 10:66520762-66520762	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.721G>A; p.V241I; 10:67219729-67219729	skin	malignant_melanoma	Substitution - Missense
c.1483G>A; p.E495K; 10:66520665-66520665	skin	malignant_melanoma	Substitution - Missense
c.1002C>T; p.A334A; 10:67180362-67180362	skin	malignant_melanoma	Substitution - coding silent
c.1656G>T; p.T552T; 10:66379228-66379228	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1914C>T; p.D638D; 10:66103220-66103220	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2569C>T; p.P857S; 10:65920449-65920449	skin	malignant_melanoma	Substitution - Missense
c.1750A>G; p.T584A; 10:66280604-66280604	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1107G>A; p.K369K; 10:66775465-66775465	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2205G>T; p.A735A; 10:65988752-65988752	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2568delA; p.K856fs*3; 10:65920450-65920450	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1794G>A; p.L598L; 10:66280560-66280560	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2568delA; p.K856fs*3; 10:65920450-65920450	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2568delA; p.K856fs*3; 10:65920450-65920450	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2568delA; p.K856fs*3; 10:65920450-65920450	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2568_2569insA; p.P857fs*4; 10:65920449-65920450	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2568_2569insA; p.P857fs*4; 10:65920449-65920450	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.521A>G; p.Y174C; 10:67521900-67521900	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2568_2569insA; p.P857fs*4; 10:65920449-65920450	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2568_2569insA; p.P857fs*4; 10:65920449-65920450	liver	carcinoma; hepatocellular_carcinoma	Insertion - Frameshift
c.2568_2569insA; p.P857fs*4; 10:65920449-65920450	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1144A>T; p.I382L; 10:66766401-66766401	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1471C>T; p.H491Y; 10:66520677-66520677	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1060_1061insA; p.R355fs*3; 10:66775511-66775512	skin; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.2672G>A; p.G891E; 10:65920346-65920346	skin	malignant_melanoma	Substitution - Missense
c.1228G>A; p.E410K; 10:66766317-66766317	skin	malignant_melanoma	Substitution - Missense
c.326C>A; p.T109K; 10:67539636-67539636	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1006C>T; p.R336C; 10:67180358-67180358	skin	malignant_melanoma	Substitution - Missense
c.1006C>T; p.R336C; 10:67180358-67180358	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1006C>T; p.R336C; 10:67180358-67180358	breast	carcinoma	Substitution - Missense
c.843G>A; p.E281E; 10:67219607-67219607	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1006C>T; p.R336C; 10:67180358-67180358	skin	malignant_melanoma	Substitution - Missense
c.1006C>T; p.R336C; 10:67180358-67180358	skin	malignant_melanoma	Substitution - Missense
c.327A>G; p.T109T; 10:67539635-67539635	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.715G>A; p.D239N; 10:67219735-67219735	skin	malignant_melanoma	Substitution - Missense
c.503C>T; p.S168F; 10:67521918-67521918	skin	malignant_melanoma	Substitution - Missense
c.1519C>A; p.L507I; 10:66520629-66520629	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1674C>T; p.Y558Y; 10:66379210-66379210	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1112G>A; p.R371K; 10:66775460-66775460	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1674C>T; p.Y558Y; 10:66379210-66379210	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.945G>A; p.A315A; 10:67180419-67180419	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1606G>T; p.A536S; 10:66379278-66379278	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.793C>A; p.P265T; 10:67219657-67219657	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.789A>T; p.T263T; 10:67219661-67219661	ovary	other; neoplasm	Substitution - coding silent
c.2374C>A; p.L792M; 10:65966638-65966638	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2374C>A; p.L792M; 10:65966638-65966638	breast	carcinoma	Substitution - Missense
c.228T>A; p.I76I; 10:67606921-67606921	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.217G>A; p.G73R; 10:67606932-67606932	skin	malignant_melanoma	Substitution - Missense
c.1865G>A; p.C622Y; 10:66280489-66280489	central_nervous_system; brain	glioma; astrocytoma_Grade_II	Substitution - Missense
c.2653G>T; p.V885F; 10:65920365-65920365	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1846A>C; p.T616P; 10:66280508-66280508	pancreas	NS	Substitution - Missense
c.841G>A; p.E281K; 10:67219609-67219609	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2067T>G; p.A689A; 10:66069400-66069400	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.841G>A; p.E281K; 10:67219609-67219609	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.293G>T; p.S98I; 10:67539669-67539669	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1603C>T; p.R535C; 10:66379281-66379281	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.607G>A; p.E203K; 10:67219843-67219843	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2160-1G>T; p.?; 10:65988798-65988798	lung	carcinoma; squamous_cell_carcinoma	Unknown

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]