| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 29959 |
Name | NRBP1 |
Synonymous | nuclear receptor binding protein 1;NRBP1;nuclear receptor binding protein 1 |
Definition | multiple domain putative nuclear protein|myeloid leukemia factor 1 adaptor molecule|nuclear receptor-binding protein |
Position | 2p23 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.11. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.976G>C; p.A326P; 2:27439838-27439838 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.516G>C; p.M172I; 2:27434551-27434551 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.512C>T; p.T171M; 2:27434547-27434547 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.542G>T; p.C181F; 2:27434738-27434738 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.6G>A; p.S2S; 2:27433279-27433279 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1012G>A; p.A338T; 2:27439874-27439874 |
liver | carcinoma | Substitution - Missense |
c.1383+1G>A; p.?; 2:27441181-27441181 |
large_intestine; colon | carcinoma; adenocarcinoma | Unknown |
c.1114G>A; p.G372R; 2:27440480-27440480 |
liver | carcinoma | Substitution - Missense |
c.1114G>A; p.G372R; 2:27440480-27440480 |
liver | carcinoma | Substitution - Missense |
c.1350C>T; p.N450N; 2:27441147-27441147 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.854A>T; p.Q285L; 2:27437311-27437311 |
kidney | carcinoma; papillary_renal_cell_carcinoma | Substitution - Missense |
c.661G>A; p.V221M; 2:27435227-27435227 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; NK-T_cell_lymphoma | Substitution - Missense |
c.305C>G; p.S102C; 2:27433767-27433767 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.344G>A; p.R115H; 2:27433999-27433999 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.921C>T; p.C307C; 2:27439783-27439783 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.133_135delGAA; p.E48delE; 2:27433406-27433408 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - In frame |
c.1554C>T; p.F518F; 2:27441758-27441758 |
breast | carcinoma | Substitution - coding silent |
c.1554C>T; p.F518F; 2:27441758-27441758 |
large_intestine; rectum | NS | Substitution - coding silent |
c.1029A>G; p.G343G; 2:27439891-27439891 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.612C>T; p.T204T; 2:27435178-27435178 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.1037-1G>A; p.?; 2:27440402-27440402 |
endometrium | carcinoma; endometrioid_carcinoma | Unknown |
c.1036C>A; p.H346N; 2:27439898-27439898 |
skin; extremity | malignant_melanoma | Substitution - Missense |
c.1092C>A; p.A364A; 2:27440458-27440458 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.89T>C; p.V30A; 2:27433362-27433362 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1271T>C; p.V424A; 2:27440882-27440882 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1248G>A; p.Q416Q; 2:27440859-27440859 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.392A>C; p.K131T; 2:27434047-27434047 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.32G>A; p.S11N; 2:27433305-27433305 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1295C>T; p.P432L; 2:27440906-27440906 |
ovary | carcinoma; mucinous_carcinoma | Substitution - Missense |
c.1295C>T; p.P432L; 2:27440906-27440906 |
ovary | carcinoma; mucinous_carcinoma | Substitution - Missense |
c.162G>T; p.E54D; 2:27433435-27433435 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.21G>A; p.Q7Q; 2:27433294-27433294 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1232G>A; p.R411Q; 2:27440843-27440843 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.770T>C; p.V257A; 2:27437071-27437071 |
liver | carcinoma | Substitution - Missense |
c.22A>T; p.T8S; 2:27433295-27433295 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.537T>C; p.R179R; 2:27434733-27434733 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.17C>T; p.S6F; 2:27433290-27433290 |
pancreas | carcinoma | Substitution - Missense |
c.1177T>G; p.F393V; 2:27440686-27440686 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.944G>A; p.R315K; 2:27439806-27439806 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1331T>G; p.V444G; 2:27441128-27441128 |
breast | carcinoma | Substitution - Missense |
c.217C>T; p.Q73*; 2:27433679-27433679 |
lung | carcinoma; non_small_cell_carcinoma | Substitution - Nonsense |
c.217C>T; p.Q73*; 2:27433679-27433679 |
lung | carcinoma; non_small_cell_carcinoma | Substitution - Nonsense |
c.1452G>T; p.E484D; 2:27441571-27441571 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.127C>T; p.P43S; 2:27433400-27433400 |
skin | malignant_melanoma | Substitution - Missense |
c.1562C>T; p.A521V; 2:27441766-27441766 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.274G>A; p.V92I; 2:27433736-27433736 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.567-1G>A; p.?; 2:27435132-27435132 |
breast | carcinoma | Unknown |
c.703G>T; p.E235*; 2:27436794-27436794 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |
c.1239G>T; p.Q413H; 2:27440850-27440850 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.211G>T; p.V71L; 2:27433673-27433673 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1092C>T; p.A364A; 2:27440458-27440458 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - coding silent |
c.1517G>A; p.R506Q; 2:27441721-27441721 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1517G>A; p.R506Q; 2:27441721-27441721 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1517G>A; p.R506Q; 2:27441721-27441721 |
kidney | carcinoma; papillary_renal_cell_carcinoma | Substitution - Missense |
c.357T>C; p.D119D; 2:27434012-27434012 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - coding silent |
c.1383C>T; p.H461H; 2:27441180-27441180 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.643C>T; p.L215F; 2:27435209-27435209 |
pancreas | carcinoma | Substitution - Missense |
c.813G>A; p.V271V; 2:27437270-27437270 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.496delA; p.K167fs*6; 2:27434531-27434531 |
stomach | adenocarcinoma | Deletion - Frameshift |
c.494C>T; p.T165I; 2:27434529-27434529 |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma | Substitution - Missense |
c.429delG; p.A144fs*15; 2:27434084-27434084 |
breast | carcinoma | Deletion - Frameshift |
c.1447+2T>C; p.?; 2:27441332-27441332 |
stomach | carcinoma; adenocarcinoma | Unknown |
c.1447+2T>C; p.?; 2:27441332-27441332 |
oesophagus; lower_third | carcinoma; adenocarcinoma | Unknown |
c.585delC; p.I198fs*6; 2:27435151-27435151 |
large_intestine | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.585delC; p.I198fs*6; 2:27435151-27435151 |
large_intestine | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.224A>G; p.N75S; 2:27433686-27433686 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.218A>G; p.Q73R; 2:27433680-27433680 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1261A>G; p.T421A; 2:27440872-27440872 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.472C>G; p.L158V; 2:27434507-27434507 |
breast | carcinoma | Substitution - Missense |
c.1561G>A; p.A521T; 2:27441765-27441765 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1183G>C; p.E395Q; 2:27440692-27440692 |
breast | carcinoma | Substitution - Missense |
c.341T>G; p.V114G; 2:27433996-27433996 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1262C>T; p.T421I; 2:27440873-27440873 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.1601C>T; p.S534F; 2:27441805-27441805 |
skin | malignant_melanoma | Substitution - Missense |
c.1359G>A; p.S453S; 2:27441156-27441156 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.892C>G; p.P298A; 2:27437349-27437349 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1268C>A; p.P423H; 2:27440879-27440879 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.501G>C; p.K167N; 2:27434536-27434536 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1228C>T; p.P410S; 2:27440839-27440839 |
upper_aerodigestive_tract; larynx | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.738G>T; p.E246D; 2:27436829-27436829 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |