Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

3248

Name

HPGD

Synonymous

hydroxyprostaglandin dehydrogenase 15-(NAD);HPGD;hydroxyprostaglandin dehydrogenase 15-(NAD)

Definition

15-hydroxyprostaglandin dehydrogenase [NAD(+)]|NAD+-dependent 15-hydroxyprostaglandin dehydrogenase|prostaglandin dehydrogenase 1|short chain dehydrogenase/reductase family 36C member 1|short chain dehydrogenase/reductase family 36C, member 1

Position

4q34-q35

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.462A>G; p.S154S; 4:174495584-174495584

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.442C>A; p.Q148K; 4:174495604-174495604

 ovaryother; neoplasmSubstitution - Missense

c.222T>G; p.T74T; 4:174518073-174518073

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.494C>T; p.A165V; 4:174495552-174495552

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; NK-T_cell_lymphomaSubstitution - Missense

c.275C>A; p.A92D; 4:174518020-174518020

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.60C>G; p.A20A; 4:174522392-174522392

 prostatecarcinomaSubstitution - coding silent

c.402C>T; p.I134I; 4:174508715-174508715

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.748G>A; p.G250R; 4:174492009-174492009

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.672G>A; p.L224L; 4:174492085-174492085

 skinmalignant_melanomaSubstitution - coding silent

c.526G>A; p.V176M; 4:174493287-174493287

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.157T>G; p.F53V; 4:174522004-174522004

 skinmalignant_melanomaSubstitution - Missense

c.156G>A; p.Q52Q; 4:174522005-174522005

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.207A>G; p.Q69Q; 4:174521954-174521954

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.156G>C; p.Q52H; 4:174522005-174522005

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.706G>C; p.D236H; 4:174492051-174492051

 soft_tissue; blood_vesselangiosarcomaSubstitution - Missense

c.283A>T; p.N95Y; 4:174518012-174518012

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.743C>A; p.S248Y; 4:174492014-174492014

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.497C>T; p.A166V; 4:174495549-174495549

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.788C>G; p.A263G; 4:174491969-174491969

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.512T>G; p.L171R; 4:174493301-174493301

 haematopoietic_and_lymphoid_tissue; spleenlymphoid_neoplasm; marginal_zone_lymphomaSubstitution - Missense

c.498+1G>A; p.?; 4:174495547-174495547

 skin; head_neckcarcinoma; squamous_cell_carcinomaUnknown

c.625C>A; p.H209N; 4:174493188-174493188

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.493G>T; p.A165S; 4:174495553-174495553

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.718G>T; p.G240C; 4:174492039-174492039

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.498G>T; p.A166A; 4:174495548-174495548

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.746A>G; p.K249R; 4:174492011-174492011

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.645A>G; p.K215K; 4:174493168-174493168

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.682G>A; p.G228R; 4:174492075-174492075

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.94-1G>T; p.?; 4:174522068-174522068

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.391G>A; p.G131S; 4:174508726-174508726

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.694C>T; p.L232F; 4:174492063-174492063

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.487C>T; p.R163C; 4:174495559-174495559

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

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