Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

3400

Name

ID4

Synonymous

inhibitor of DNA binding 4, dominant negative helix-loop-helix protein;ID4;inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

Definition

DNA-binding protein inhibitor ID-4|class B basic helix-loop-helix protein 27|inhibitor of differentiation 4

Position

6p22.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.455A>G; p.N152S; 6:19838597-19838597

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.456C>T; p.N152N; 6:19838598-19838598

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.381G>T; p.P127P; 6:19838135-19838135

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.320C>T; p.A107V; 6:19838074-19838074

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.234G>T; p.L78L; 6:19837988-19837988

 thyroidother; neoplasmSubstitution - coding silent

c.465C>T; p.G155G; 6:19838607-19838607

 pancreascarcinomaSubstitution - coding silent

c.340C>T; p.L114L; 6:19838094-19838094

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.316C>T; p.L106L; 6:19838070-19838070

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.407C>T; p.P136L; 6:19838161-19838161

 livercarcinomaSubstitution - Missense

c.407C>T; p.P136L; 6:19838161-19838161

 livercarcinomaSubstitution - Missense

c.137C>A; p.A46E; 6:19837891-19837891

 thyroidother; neoplasmSubstitution - Missense

c.466G>A; p.D156N; 6:19838608-19838608

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.221G>T; p.R74L; 6:19837975-19837975

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.225G>A; p.L75L; 6:19837979-19837979

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.474T>G; p.I158M; 6:19838616-19838616

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

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