| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 347252 |
Name | IGFBPL1 |
Synonymous | insulin-like growth factor binding protein-like 1;IGFBPL1;insulin-like growth factor binding protein-like 1 |
Definition | IGFBP-related protein 10|insulin-like growth factor binding protein related protein 4|insulin-like growth factor-binding protein-like 1|insulin-like growth factor-binding-related protein 4 |
Position | 9p13.1 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.20. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.525C>A; p.S175S; 9:38414139-38414139 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.712G>A; p.E238K; 9:38411525-38411525 |
breast | carcinoma | Substitution - Missense |
c.582C>T; p.S194S; 9:38413342-38413342 |
skin | malignant_melanoma | Substitution - coding silent |
c.646C>T; p.R216*; 9:38413278-38413278 |
oesophagus; lower_third | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |
c.646C>T; p.R216*; 9:38413278-38413278 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.646C>T; p.R216*; 9:38413278-38413278 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.646C>T; p.R216*; 9:38413278-38413278 |
large_intestine; colon | carcinoma | Substitution - Nonsense |
c.646C>T; p.R216*; 9:38413278-38413278 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.646C>T; p.R216*; 9:38413278-38413278 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.646C>T; p.R216*; 9:38413278-38413278 |
pancreas | carcinoma | Substitution - Nonsense |
c.498C>T; p.N166N; 9:38414166-38414166 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.667G>C; p.E223Q; 9:38413257-38413257 |
skin | malignant_melanoma | Substitution - Missense |
c.506G>T; p.G169V; 9:38414158-38414158 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.800G>A; p.R267K; 9:38411437-38411437 |
skin | malignant_melanoma | Substitution - Missense |
c.647G>T; p.R216L; 9:38413277-38413277 |
biliary_tract; bile_duct | carcinoma; adenocarcinoma | Substitution - Missense |
c.44T>G; p.L15R; 9:38424381-38424381 |
thyroid | other; neoplasm | Substitution - Missense |
c.692A>G; p.N231S; 9:38411545-38411545 |
upper_aerodigestive_tract; pharynx | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.514G>A; p.V172M; 9:38414150-38414150 |
skin | malignant_melanoma | Substitution - Missense |
c.464C>T; p.P155L; 9:38414200-38414200 |
skin | malignant_melanoma | Substitution - Missense |
c.531A>C; p.E177D; 9:38414133-38414133 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.734C>T; p.A245V; 9:38411503-38411503 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.696C>T; p.P232P; 9:38411541-38411541 |
skin | malignant_melanoma | Substitution - coding silent |
c.499G>A; p.V167I; 9:38414165-38414165 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.613C>T; p.P205S; 9:38413311-38413311 |
liver | carcinoma | Substitution - Missense |
c.613C>T; p.P205S; 9:38413311-38413311 |
liver | carcinoma | Substitution - Missense |
c.738C>T; p.A246A; 9:38411499-38411499 |
skin | malignant_melanoma | Substitution - coding silent |
c.78T>C; p.L26L; 9:38424347-38424347 |
thyroid | other; neoplasm | Substitution - coding silent |
c.583C>T; p.P195S; 9:38413341-38413341 |
skin | malignant_melanoma | Substitution - Missense |
c.224C>A; p.A75E; 9:38424201-38424201 |
liver | carcinoma | Substitution - Missense |
c.224C>A; p.A75E; 9:38424201-38424201 |
liver | carcinoma | Substitution - Missense |