Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

3622

Name

ING2

Synonymous

inhibitor of growth family, member 2;ING2;inhibitor of growth family, member 2

Definition

ING1Lp|inhibitor of growth 1-like protein|inhibitor of growth protein 2|p32

Position

4q35.1

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.20.

The copy number variations for various cancers

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There is no record for ING2

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.457C>A; p.R153S; 4:183510566-183510566

 large_intestine; coloncarcinomaSubstitution - Missense

c.457C>A; p.R153S; 4:183510566-183510566

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.759G>C; p.W253C; 4:183510868-183510868

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.786T>A; p.N262K; 4:183510895-183510895

 skinmalignant_melanomaSubstitution - Missense

c.445T>C; p.S149P; 4:183510554-183510554

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.515A>C; p.D172A; 4:183510624-183510624

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.325G>T; p.E109*; 4:183510434-183510434

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.278G>C; p.S93T; 4:183510387-183510387

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.340C>T; p.R114W; 4:183510449-183510449

 skinmalignant_melanomaSubstitution - Missense

c.39C>T; p.A13A; 4:183505234-183505234

 breastcarcinomaSubstitution - coding silent

c.39C>T; p.A13A; 4:183505234-183505234

 thyroidother; neoplasmSubstitution - coding silent

c.398G>A; p.R133Q; 4:183510507-183510507

 oesophaguscarcinomaSubstitution - Missense

c.819delA; p.K275fs*>6; 4:183510928-183510928

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.514G>T; p.D172Y; 4:183510623-183510623

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.642C>G; p.Y214*; 4:183510751-183510751

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Nonsense

c.759G>T; p.W253C; 4:183510868-183510868

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.266C>T; p.A89V; 4:183510375-183510375

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.475G>A; p.E159K; 4:183510584-183510584

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.202G>A; p.E68K; 4:183510311-183510311

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.202G>A; p.E68K; 4:183510311-183510311

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.200A>G; p.Y67C; 4:183510309-183510309

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.758G>A; p.W253*; 4:183510867-183510867

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.758G>A; p.W253*; 4:183510867-183510867

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.760T>C; p.Y254H; 4:183510869-183510869

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.605C>T; p.P202L; 4:183510714-183510714

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.309T>A; p.I103I; 4:183510418-183510418

 skinmalignant_melanomaSubstitution - coding silent

c.245T>C; p.L82P; 4:183510354-183510354

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.749A>G; p.K250R; 4:183510858-183510858

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.116_117CC>TT; p.P39L; 4:183505311-183505312

 skinmalignant_melanomaSubstitution - Missense

c.412G>C; p.A138P; 4:183510521-183510521

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.679G>A; p.G227R; 4:183510788-183510788

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.467G>C; p.R156P; 4:183510576-183510576

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.120C>G; p.H40Q; 4:183505315-183505315

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; mantle_cell_lymphomaSubstitution - Missense

c.120C>G; p.H40Q; 4:183505315-183505315

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; mantle_cell_lymphomaSubstitution - Missense

c.745C>T; p.P249S; 4:183510854-183510854

 skinmalignant_melanomaSubstitution - Missense

c.602C>T; p.S201L; 4:183510711-183510711

 breastcarcinomaSubstitution - Missense

c.54G>A; p.G18G; 4:183505249-183505249

 pancreascarcinomaSubstitution - coding silent

c.610G>C; p.E204Q; 4:183510719-183510719

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.469A>T; p.T157S; 4:183510578-183510578

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.778G>T; p.G260*; 4:183510887-183510887

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

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