| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 373863 |
Name | DND1 |
Synonymous | DND microRNA-mediated repression inhibitor 1;DND1;DND microRNA-mediated repression inhibitor 1 |
Definition | RNA-binding motif, single-stranded-interacting protein 4|dead end homolog 1|dead end protein homolog 1 |
Position | 5q31.3 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.17. |
The copy number variations for various cancers | Top |
There is no record for DND1 |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.407A>G; p.E136G; 5:140672642-140672642 |
adrenal_gland; adrenal_gland | adrenal_cortical_carcinoma; functioning | Substitution - Missense |
c.1033G>A; p.A345T; 5:140671322-140671322 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.117G>A; p.Q39Q; 5:140673296-140673296 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.314A>G; p.Y105C; 5:140672735-140672735 |
liver | carcinoma | Substitution - Missense |
c.314A>G; p.Y105C; 5:140672735-140672735 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.349delA; p.T117fs*24; 5:140672700-140672700 |
adrenal_gland; adrenal_gland | adrenal_cortical_carcinoma; functioning | Deletion - Frameshift |
c.349delA; p.T117fs*24; 5:140672700-140672700 |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma | Deletion - Frameshift |
c.135A>C; p.P45P; 5:140673278-140673278 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.535G>T; p.G179W; 5:140672514-140672514 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma | Substitution - Missense |
c.1045A>G; p.T349A; 5:140671310-140671310 |
pancreas | carcinoma; ductal_carcinoma | Substitution - Missense |
c.1014C>T; p.N338N; 5:140671341-140671341 |
prostate | carcinoma; adenocarcinoma | Substitution - coding silent |
c.879G>A; p.V293V; 5:140671476-140671476 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.827A>C; p.K276T; 5:140671528-140671528 |
pancreas | carcinoma | Substitution - Missense |
c.204C>A; p.D68E; 5:140672845-140672845 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.204C>A; p.D68E; 5:140672845-140672845 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.204C>A; p.D68E; 5:140672845-140672845 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.204C>A; p.D68E; 5:140672845-140672845 |
thyroid | other; neoplasm | Substitution - Missense |
c.204C>A; p.D68E; 5:140672845-140672845 |
thyroid | other; neoplasm | Substitution - Missense |
c.204C>A; p.D68E; 5:140672845-140672845 |
stomach | carcinoma; diffuse_adenocarcinoma | Substitution - Missense |
c.673C>T; p.R225C; 5:140671682-140671682 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.673C>T; p.R225C; 5:140671682-140671682 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.227C>T; p.P76L; 5:140672822-140672822 |
prostate | carcinoma; adenocarcinoma | Substitution - Missense |
c.227C>T; p.P76L; 5:140672822-140672822 |
thyroid | other; neoplasm | Substitution - Missense |
c.647T>A; p.L216H; 5:140671708-140671708 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.647T>A; p.L216H; 5:140671708-140671708 |
liver | carcinoma | Substitution - Missense |
c.210C>T; p.Y70Y; 5:140672839-140672839 |
thyroid | other; neoplasm | Substitution - coding silent |
c.210C>T; p.Y70Y; 5:140672839-140672839 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.210C>T; p.Y70Y; 5:140672839-140672839 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.210C>T; p.Y70Y; 5:140672839-140672839 |
thyroid | other; neoplasm | Substitution - coding silent |
c.210C>T; p.Y70Y; 5:140672839-140672839 |
thyroid | other; neoplasm | Substitution - coding silent |
c.854G>A; p.W285*; 5:140671501-140671501 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Nonsense |
c.854G>A; p.W285*; 5:140671501-140671501 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Nonsense |
c.508C>T; p.L170L; 5:140672541-140672541 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.301G>A; p.A101T; 5:140672748-140672748 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.303C>A; p.A101A; 5:140672746-140672746 |
prostate | carcinoma; adenocarcinoma | Substitution - coding silent |
c.303C>A; p.A101A; 5:140672746-140672746 |
liver | carcinoma | Substitution - coding silent |
c.303C>A; p.A101A; 5:140672746-140672746 |
liver | carcinoma | Substitution - coding silent |
c.303C>A; p.A101A; 5:140672746-140672746 |
liver | carcinoma | Substitution - coding silent |
c.766C>T; p.R256W; 5:140671589-140671589 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.111C>T; p.N37N; 5:140673302-140673302 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.228G>A; p.P76P; 5:140672821-140672821 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.764C>T; p.A255V; 5:140671591-140671591 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1000G>A; p.E334K; 5:140671355-140671355 |
pancreas | pancreatic_intraepithelial_neoplasia_(PanIN) | Substitution - Missense |
c.1000G>A; p.E334K; 5:140671355-140671355 |
pancreas | carcinoma; ductal_carcinoma | Substitution - Missense |
c.1000G>A; p.E334K; 5:140671355-140671355 |
pancreas | pancreatic_intraepithelial_neoplasia_(PanIN) | Substitution - Missense |
c.1000G>A; p.E334K; 5:140671355-140671355 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1000G>A; p.E334K; 5:140671355-140671355 |
breast | carcinoma | Substitution - Missense |
c.264C>T; p.R88R; 5:140672785-140672785 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - coding silent |
c.15G>A; p.R5R; 5:140673528-140673528 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.363T>C; p.H121H; 5:140672686-140672686 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.363T>C; p.H121H; 5:140672686-140672686 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.363T>C; p.H121H; 5:140672686-140672686 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.363T>C; p.H121H; 5:140672686-140672686 |
thyroid | other; neoplasm | Substitution - coding silent |
c.363T>C; p.H121H; 5:140672686-140672686 |
thyroid | other; neoplasm | Substitution - coding silent |
c.322A>C; p.R108R; 5:140672727-140672727 |
prostate | carcinoma; adenocarcinoma | Substitution - coding silent |
c.390C>T; p.L130L; 5:140672659-140672659 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |