Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

387496

Name

RASL11A

Synonymous

RAS-like, family 11, member A;RASL11A;RAS-like, family 11, member A

Definition

ras-like protein family member 11A

Position

13q12.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.17.

The copy number variations for various cancers

Top

There is no record for RASL11A

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.202G>T; p.V68F; 13:27271659-27271659

 prostatecarcinomaSubstitution - Missense

c.318C>T; p.A106A; 13:27273083-27273083

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.312G>A; p.Q104Q; 13:27273077-27273077

 endometriumcarcinoma; serous_carcinomaSubstitution - coding silent

c.331C>T; p.L111L; 13:27273096-27273096

 breastcarcinomaSubstitution - coding silent

c.677G>A; p.R226H; 13:27273442-27273442

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.677G>A; p.R226H; 13:27273442-27273442

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.543C>G; p.N181K; 13:27273308-27273308

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.631A>T; p.I211F; 13:27273396-27273396

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.176A>C; p.N59T; 13:27271535-27271535

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.241G>A; p.D81N; 13:27271698-27271698

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.697C>T; p.P233S; 13:27273462-27273462

 skinmalignant_melanomaSubstitution - Missense

c.676C>T; p.R226C; 13:27273441-27273441

 breastcarcinoma; ER-PR-positive_carcinomaSubstitution - Missense

c.276delC; p.Q94fs*72; 13:27273041-27273041

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.419C>T; p.A140V; 13:27273184-27273184

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.174G>A; p.P58P; 13:27271533-27271533

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.463C>T; p.R155W; 13:27273228-27273228

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.710C>A; p.A237D; 13:27273475-27273475

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.169G>A; p.E57K; 13:27271528-27271528

 breastcarcinomaSubstitution - Missense

c.634A>T; p.I212F; 13:27273399-27273399

 livercarcinomaSubstitution - Missense

c.634A>T; p.I212F; 13:27273399-27273399

 livercarcinomaSubstitution - Missense

c.667C>A; p.L223M; 13:27273432-27273432

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.136C>T; p.R46C; 13:27271495-27271495

 ovaryother; neoplasmSubstitution - Missense

c.378C>T; p.P126P; 13:27273143-27273143

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.385C>T; p.Q129*; 13:27273150-27273150

 skinmalignant_melanomaSubstitution - Nonsense

c.262-1G>T; p.?; 13:27273026-27273026

 lungcarcinoma; adenocarcinomaUnknown

c.182-6C>A; p.?; 13:27271633-27271633

 breastcarcinomaUnknown

c.466_477del12; p.V157_Q160delVQTQ; 13:27273231-27273242

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaDeletion - In frame

c.5G>C; p.R2P; 13:27270949-27270949

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.520C>T; p.L174F; 13:27273285-27273285

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.372C>T; p.I124I; 13:27273137-27273137

 skinmalignant_melanomaSubstitution - coding silent

c.600C>T; p.H200H; 13:27273365-27273365

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.460G>A; p.A154T; 13:27273225-27273225

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.404A>C; p.H135P; 13:27273169-27273169

 breastcarcinomaSubstitution - Missense

c.181+5G>A; p.?; 13:27271545-27271545

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaUnknown

c.646C>T; p.R216C; 13:27273411-27273411

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.483C>T; p.D161D; 13:27273248-27273248

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.530C>T; p.S177F; 13:27273295-27273295

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.373C>T; p.R125*; 13:27273138-27273138

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Nonsense

c.373C>T; p.R125*; 13:27273138-27273138

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Nonsense

c.546C>T; p.Y182Y; 13:27273311-27273311

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.450C>T; p.D150D; 13:27273215-27273215

 skinmalignant_melanomaSubstitution - coding silent

c.254G>C; p.G85A; 13:27271711-27271711

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.521T>C; p.L174P; 13:27273286-27273286

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; polycythaemia_veraSubstitution - Missense

c.276C>T; p.L92L; 13:27273041-27273041

 skinmalignant_melanomaSubstitution - coding silent

c.583G>T; p.E195*; 13:27273348-27273348

 oesophaguscarcinomaSubstitution - Nonsense

c.515T>G; p.L172R; 13:27273280-27273280

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.182G>A; p.G61D; 13:27271639-27271639

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.538G>A; p.E180K; 13:27273303-27273303

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.428T>C; p.I143T; 13:27273193-27273193

 salivary_gland; parotidcarcinoma; adenoid_cystic_carcinomaSubstitution - Missense

c.547G>A; p.E183K; 13:27273312-27273312

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.256G>A; p.V86I; 13:27271713-27271713

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.647G>A; p.R216H; 13:27273412-27273412

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.107G>T; p.G36V; 13:27271051-27271051

 lungcarcinoma; adenocarcinomaSubstitution - Missense

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