Entrez Gene

Basic Information
Gene ID	4163
Name	MCC
Synonymous	mutated in colorectal cancers;MCC;mutated in colorectal cancers
Definition	colorectal mutant cancer protein
Position	5q21
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.08.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.2260C>T; p.R754*; 5:113028983-113028983	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.172-1G>A; p.?; 5:113143361-113143361	skin	malignant_melanoma	Unknown
c.2260C>T; p.R754*; 5:113028983-113028983	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.160G>T; p.A54S; 5:113151320-113151320	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1695C>T; p.D565D; 5:113053908-113053908	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1469C>T; p.S490L; 5:113064158-113064158	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2476G>C; p.E826Q; 5:113027316-113027316	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.552C>T; p.S184S; 5:113104261-113104261	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.552C>T; p.S184S; 5:113104261-113104261	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.739G>A; p.A247T; 5:113101828-113101828	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2422C>T; p.L808F; 5:113027370-113027370	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.552C>A; p.S184S; 5:113104261-113104261	central_nervous_system; brain	glioma	Substitution - coding silent
c.2141G>T; p.C714F; 5:113043575-113043575	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1304T>G; p.V435G; 5:113071145-113071145	breast	carcinoma	Substitution - Missense
c.2385G>A; p.M795I; 5:113027407-113027407	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1239A>G; p.Q413Q; 5:113071210-113071210	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1423G>A; p.G475R; 5:113068116-113068116	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2250C>T; p.S750S; 5:113028993-113028993	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1313A>G; p.Y438C; 5:113071136-113071136	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2483C>T; p.S828L; 5:113027309-113027309	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1378G>A; p.E460K; 5:113068161-113068161	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2085+9G>A; p.?; 5:113049084-113049084	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.911C>T; p.P304L; 5:113085228-113085228	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2108C>A; p.P703Q; 5:113043608-113043608	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.858C>T; p.S286S; 5:113085281-113085281	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.703C>T; p.L235L; 5:113101864-113101864	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.386G>A; p.R129Q; 5:113122755-113122755	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.386G>A; p.R129Q; 5:113122755-113122755	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1581C>T; p.A527A; 5:113064046-113064046	skin	malignant_melanoma	Substitution - coding silent
c.1016C>T; p.S339L; 5:113084150-113084150	skin	malignant_melanoma	Substitution - Missense
c.988G>A; p.V330M; 5:113084178-113084178	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.988G>A; p.V330M; 5:113084178-113084178	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1016C>T; p.S339L; 5:113084150-113084150	skin	malignant_melanoma	Substitution - Missense
c.988G>A; p.V330M; 5:113084178-113084178	large_intestine; colon	carcinoma	Substitution - Missense
c.2227G>T; p.A743S; 5:113029016-113029016	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.988G>A; p.V330M; 5:113084178-113084178	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.86A>G; p.K29R; 5:113151394-113151394	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.975+4A>G; p.?; 5:113085160-113085160	pancreas	other; adenoma	Unknown
c.1568G>A; p.S523N; 5:113064059-113064059	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.302G>T; p.G101V; 5:113143230-113143230	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.815G>A; p.R272Q; 5:113101752-113101752	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1232A>G; p.K411R; 5:113071217-113071217	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.907C>T; p.R303C; 5:113085232-113085232	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1745C>T; p.A582V; 5:113053858-113053858	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2367G>C; p.K789N; 5:113027425-113027425	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1266G>T; p.E422D; 5:113071183-113071183	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.522C>T; p.C174C; 5:113104291-113104291	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.984G>A; p.E328E; 5:113084182-113084182	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.984G>A; p.E328E; 5:113084182-113084182	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.984G>A; p.E328E; 5:113084182-113084182	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.42G>A; p.S14S; 5:113294344-113294344	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.558C>T; p.A186A; 5:113104255-113104255	stomach	adenocarcinoma	Substitution - coding silent
c.393_394GG>AA; p.M131_D132>IN; 5:113122747-113122748	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Complex - compound substitution
c.208G>A; p.V70I; 5:113143324-113143324	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.691T>G; p.W231G; 5:113101876-113101876	breast	carcinoma	Substitution - Missense
c.204G>A; p.E68E; 5:113143328-113143328	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1487C>A; p.T496N; 5:113064140-113064140	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.262G>A; p.V88I; 5:113143270-113143270	prostate	carcinoma	Substitution - Missense
c.262G>A; p.V88I; 5:113143270-113143270	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.347A>C; p.E116A; 5:113122794-113122794	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.745C>T; p.L249L; 5:113101822-113101822	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2476G>A; p.E826K; 5:113027316-113027316	breast	carcinoma	Substitution - Missense
c.534G>A; p.K178K; 5:113104279-113104279	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1066-1G>C; p.?; 5:113083009-113083009	lung	carcinoma; adenocarcinoma	Unknown
c.744G>A; p.M248I; 5:113101823-113101823	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2148G>T; p.E716D; 5:113043568-113043568	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.458-1G>T; p.?; 5:113104356-113104356	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.458-1G>T; p.?; 5:113104356-113104356	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.1588G>A; p.V530M; 5:113064039-113064039	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.86A>T; p.K29M; 5:113151394-113151394	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.113G>A; p.R38H; 5:113151367-113151367	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.113G>A; p.R38H; 5:113151367-113151367	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.113G>A; p.R38H; 5:113151367-113151367	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.969C>G; p.I323M; 5:113085170-113085170	breast	carcinoma	Substitution - Missense
c.507G>A; p.L169L; 5:113104306-113104306	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.124A>G; p.T42A; 5:113151356-113151356	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1870G>A; p.A624T; 5:113053733-113053733	skin	malignant_melanoma	Substitution - Missense
c.1694A>G; p.D565G; 5:113053909-113053909	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.318G>A; p.E106E; 5:113122823-113122823	skin	malignant_melanoma	Substitution - coding silent
c.1957C>T; p.R653W; 5:113049221-113049221	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.424G>A; p.E142K; 5:113122717-113122717	large_intestine; colon	NS	Substitution - Missense
c.424G>A; p.E142K; 5:113122717-113122717	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2145C>T; p.S715S; 5:113043571-113043571	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.270G>A; p.A90A; 5:113143262-113143262	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2145C>T; p.S715S; 5:113043571-113043571	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2095G>C; p.D699H; 5:113043621-113043621	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2283C>A; p.F761L; 5:113028960-113028960	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1084G>A; p.E362K; 5:113082990-113082990	urinary_tract; bladder	carcinoma	Substitution - Missense
c.373A>T; p.N125Y; 5:113122768-113122768	breast	carcinoma	Substitution - Missense
c.9C>T; p.S3S; 5:113294377-113294377	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2406G>T; p.E802D; 5:113027386-113027386	pancreas	carcinoma	Substitution - Missense
c.1107G>C; p.Q369H; 5:113082967-113082967	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2406G>T; p.E802D; 5:113027386-113027386	pancreas	carcinoma	Substitution - Missense
c.2361G>A; p.L787L; 5:113027431-113027431	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1751A>G; p.K584R; 5:113053852-113053852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2068A>T; p.K690*; 5:113049110-113049110	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1070C>G; p.S357C; 5:113083004-113083004	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1853T>C; p.L618P; 5:113053750-113053750	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.835G>A; p.E279K; 5:113085304-113085304	urinary_tract; bladder	carcinoma	Substitution - Missense
c.57G>A; p.E19E; 5:113294329-113294329	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1184A>T; p.E395V; 5:113082890-113082890	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1392G>A; p.A464A; 5:113068147-113068147	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1433G>A; p.R478Q; 5:113068106-113068106	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.771C>G; p.N257K; 5:113101796-113101796	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1285G>A; p.E429K; 5:113071164-113071164	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1285G>A; p.E429K; 5:113071164-113071164	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.473T>G; p.L158R; 5:113104340-113104340	skin	malignant_melanoma	Substitution - Missense
c.221C>T; p.T74M; 5:113143311-113143311	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.221C>T; p.T74M; 5:113143311-113143311	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1786G>A; p.D596N; 5:113053817-113053817	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1671C>T; p.C557C; 5:113053932-113053932	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1693G>A; p.D565N; 5:113053910-113053910	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1082C>G; p.A361G; 5:113082992-113082992	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1671C>T; p.C557C; 5:113053932-113053932	prostate	carcinoma	Substitution - coding silent
c.805G>T; p.E269*; 5:113101762-113101762	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1561G>A; p.D521N; 5:113064066-113064066	skin	malignant_melanoma	Substitution - Missense
c.545G>C; p.S182T; 5:113104268-113104268	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2375C>T; p.S792L; 5:113027417-113027417	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.863A>G; p.Q288R; 5:113085276-113085276	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2375C>T; p.S792L; 5:113027417-113027417	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2375C>T; p.S792L; 5:113027417-113027417	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.646C>T; p.L216F; 5:113101921-113101921	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1068A>G; p.V356V; 5:113083006-113083006	pancreas	carcinoma	Substitution - coding silent
c.1032G>T; p.R344R; 5:113084134-113084134	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.293G>A; p.R98H; 5:113143239-113143239	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1331C>T; p.A444V; 5:113071118-113071118	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.964C>T; p.P322S; 5:113085175-113085175	thyroid	carcinoma	Substitution - Missense
c.1031G>A; p.R344Q; 5:113084135-113084135	stomach	adenocarcinoma	Substitution - Missense
c.1315G>A; p.E439K; 5:113071134-113071134	skin	malignant_melanoma	Substitution - Missense
c.847C>T; p.R283*; 5:113085292-113085292	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1779C>G; p.I593M; 5:113053824-113053824	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1284C>T; p.A428A; 5:113071165-113071165	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1284C>T; p.A428A; 5:113071165-113071165	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1284C>T; p.A428A; 5:113071165-113071165	thyroid	other; neoplasm	Substitution - coding silent
c.1357G>A; p.E453K; 5:113068182-113068182	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.252G>A; p.E84E; 5:113143280-113143280	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1888G>T; p.A630S; 5:113049290-113049290	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2376G>A; p.S792S; 5:113027416-113027416	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1134C>T; p.F378F; 5:113082940-113082940	skin	malignant_melanoma	Substitution - coding silent
c.1391delC; p.A464fs*55; 5:113068148-113068148	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2205C>T; p.A735A; 5:113029038-113029038	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1502G>A; p.R501Q; 5:113064125-113064125	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1955C>T; p.T652M; 5:113049223-113049223	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1955C>T; p.T652M; 5:113049223-113049223	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1789C>T; p.P597S; 5:113053814-113053814	skin	malignant_melanoma	Substitution - Missense
c.1355+5_1355+6ins14; p.?; 5:113071088-113071089	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.140A>G; p.D47G; 5:113151340-113151340	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.805G>A; p.E269K; 5:113101762-113101762	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2170A>G; p.T724A; 5:113043546-113043546	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.229C>T; p.R77C; 5:113143303-113143303	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.325G>A; p.E109K; 5:113122816-113122816	urinary_tract; bladder	carcinoma	Substitution - Missense
c.580C>A; p.Q194K; 5:113104233-113104233	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1254C>T; p.T418T; 5:113071195-113071195	skin	malignant_melanoma	Substitution - coding silent
c.1438G>T; p.A480S; 5:113068101-113068101	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.58-5C>T; p.?; 5:113151427-113151427	liver	carcinoma	Unknown
c.58-5C>T; p.?; 5:113151427-113151427	liver	carcinoma	Unknown
c.2283C>T; p.F761F; 5:113028960-113028960	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2283C>T; p.F761F; 5:113028960-113028960	breast	carcinoma	Substitution - coding silent
c.410C>T; p.S137F; 5:113122731-113122731	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2283C>T; p.F761F; 5:113028960-113028960	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2283C>T; p.F761F; 5:113028960-113028960	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2283C>T; p.F761F; 5:113028960-113028960	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1444G>A; p.V482M; 5:113068095-113068095	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1444G>A; p.V482M; 5:113068095-113068095	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.827G>A; p.R276K; 5:113101740-113101740	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.435T>A; p.S145S; 5:113122706-113122706	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.489G>C; p.Q163H; 5:113104324-113104324	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1283C>T; p.A428V; 5:113071166-113071166	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2289delT; p.N763fs*3; 5:113028954-113028954	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.875C>T; p.P292L; 5:113085264-113085264	skin	malignant_melanoma	Substitution - Missense
c.2073C>T; p.D691D; 5:113049105-113049105	thyroid	other; neoplasm	Substitution - coding silent
c.241C>T; p.R81C; 5:113143291-113143291	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.376G>A; p.E126K; 5:113122765-113122765	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1384C>T; p.L462F; 5:113068155-113068155	skin	malignant_melanoma	Substitution - Missense
c.241C>T; p.R81C; 5:113143291-113143291	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.241C>T; p.R81C; 5:113143291-113143291	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.65C>A; p.S22*; 5:113151415-113151415	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2006C>T; p.S669F; 5:113049172-113049172	skin	malignant_melanoma	Substitution - Missense
c.1592C>T; p.A531V; 5:113064035-113064035	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2228C>T; p.A743V; 5:113029015-113029015	small_intestine	carcinoid-endocrine_tumour	Substitution - Missense
c.813C>A; p.D271E; 5:113101754-113101754	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1521G>T; p.K507N; 5:113064106-113064106	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]