| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 4335 |
Name | MNT |
Synonymous | MAX network transcriptional repressor;MNT;MAX network transcriptional repressor |
Definition | MAX binding protein|MNT, MAX dimerization protein|Max-interacting protein|class D basic helix-loop-helix protein 3|max-binding protein MNT|myc antagonist MNT |
Position | 17p13.3 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
 |
The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
 |
 |
Loss of Function mutations compare to missense mutations | Top |
 |
| The ratio of the loss-of-function mutations over missense mutations is 0.26. |
The copy number variations for various cancers | Top |
 |
The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.378C>T; p.A126A; 17:2395150-2395150 |
oesophagus; lower_third | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.1695T>C; p.P565P; 17:2386955-2386955 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1695T>C; p.P565P; 17:2386955-2386955 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.565delC; p.Q189fs*11; 17:2394963-2394963 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.1696G>A; p.V566M; 17:2386954-2386954 |
pancreas | carcinoma | Substitution - Missense |
c.653+1delG; p.?; 17:2394874-2394874 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Unknown |
c.321G>T; p.L107F; 17:2395207-2395207 |
thyroid | other; neoplasm | Substitution - Missense |
c.1600G>T; p.G534C; 17:2387050-2387050 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.771T>C; p.N257N; 17:2394079-2394079 |
lung; right_lower_lobe | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1499A>G; p.H500R; 17:2387151-2387151 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.409delC; p.L137fs*38; 17:2395119-2395119 |
oesophagus; lower_third | carcinoma; squamous_cell_carcinoma | Deletion - Frameshift |
c.2T>C; p.M1T; 17:2400711-2400711 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.560C>G; p.A187G; 17:2394968-2394968 |
skin | malignant_melanoma | Substitution - Missense |
c.1542C>A; p.P514P; 17:2387108-2387108 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.767C>T; p.S256F; 17:2394083-2394083 |
skin; nipple | malignant_melanoma | Substitution - Missense |
c.1445C>T; p.A482V; 17:2387205-2387205 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1667A>C; p.Q556P; 17:2386983-2386983 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.375C>T; p.G125G; 17:2395153-2395153 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1175C>T; p.P392L; 17:2387475-2387475 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1686delG; p.L563fs*4; 17:2386964-2386964 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma | Deletion - Frameshift |
c.616G>T; p.E206*; 17:2394912-2394912 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.1238C>T; p.P413L; 17:2387412-2387412 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.186G>A; p.A62A; 17:2395342-2395342 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.1238C>T; p.P413L; 17:2387412-2387412 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.1308T>G; p.G436G; 17:2387342-2387342 |
urinary_tract; bladder | carcinoma; transitional_cell_carcinoma | Substitution - coding silent |
c.1405C>A; p.H469N; 17:2387245-2387245 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.1040G>T; p.R347L; 17:2387610-2387610 |
prostate | carcinoma; adenocarcinoma | Substitution - Missense |
c.1247C>T; p.P416L; 17:2387403-2387403 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1391G>A; p.G464D; 17:2387259-2387259 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.481G>T; p.G161C; 17:2395047-2395047 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.325G>A; p.A109T; 17:2395203-2395203 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.325G>A; p.A109T; 17:2395203-2395203 |
thyroid | other; neoplasm | Substitution - Missense |
c.1138C>T; p.P380S; 17:2387512-2387512 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1574C>A; p.S525*; 17:2387076-2387076 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.1367A>G; p.N456S; 17:2387283-2387283 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.176G>T; p.R59L; 17:2395352-2395352 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1307delG; p.G436fs*20; 17:2387343-2387343 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.513G>A; p.T171T; 17:2395015-2395015 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.255_256insC; p.L86fs*47; 17:2395272-2395273 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Insertion - Frameshift |
c.1678C>T; p.Q560*; 17:2386972-2386972 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.865A>G; p.K289E; 17:2387992-2387992 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.225A>C; p.A75A; 17:2395303-2395303 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.99G>T; p.E33D; 17:2395429-2395429 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.847G>C; p.E283Q; 17:2388010-2388010 |
breast | carcinoma | Substitution - Missense |
c.1A>T; p.M1L; 17:2400712-2400712 |
large_intestine; colon | carcinoma | Substitution - Missense |
c.1361C>T; p.T454I; 17:2387289-2387289 |
skin | malignant_melanoma | Substitution - Missense |
c.1460_1461CC>TT; p.P487L; 17:2387189-2387190 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.189A>C; p.P63P; 17:2395339-2395339 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1371C>T; p.H457H; 17:2387279-2387279 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.647_648CC>TT; p.P216L; 17:2394880-2394881 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1180G>C; p.A394P; 17:2387470-2387470 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.565_566insC; p.Q189fs*17; 17:2394962-2394963 |
autonomic_ganglia | neuroblastoma | Insertion - Frameshift |
c.1333G>A; p.A445T; 17:2387317-2387317 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1433C>T; p.A478V; 17:2387217-2387217 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.1434G>A; p.A478A; 17:2387216-2387216 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.1541C>T; p.P514L; 17:2387109-2387109 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1410C>T; p.I470I; 17:2387240-2387240 |
oesophagus | carcinoma; adenocarcinoma | Substitution - coding silent |
c.453G>A; p.P151P; 17:2395075-2395075 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1411G>A; p.A471T; 17:2387239-2387239 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1517C>T; p.S506F; 17:2387133-2387133 |
breast | carcinoma | Substitution - Missense |
c.1053C>A; p.G351G; 17:2387597-2387597 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.1005T>C; p.G335G; 17:2387645-2387645 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.295C>T; p.Q99*; 17:2395233-2395233 |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |
c.207A>G; p.P69P; 17:2395321-2395321 |
thyroid | other; neoplasm | Substitution - coding silent |
c.207A>G; p.P69P; 17:2395321-2395321 |
thyroid | other; neoplasm | Substitution - coding silent |
c.207A>G; p.P69P; 17:2395321-2395321 |
thyroid | other; neoplasm | Substitution - coding silent |
c.1113delC; p.S372fs*84; 17:2387537-2387537 |
large_intestine | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.1575G>A; p.S525S; 17:2387075-2387075 |
oesophagus | carcinoma | Substitution - coding silent |
c.1575G>A; p.S525S; 17:2387075-2387075 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1081C>T; p.P361S; 17:2387569-2387569 |
skin | malignant_melanoma | Substitution - Missense |
c.1746T>G; p.A582A; 17:2386904-2386904 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.530C>T; p.A177V; 17:2394998-2394998 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.572C>T; p.P191L; 17:2394956-2394956 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.690G>C; p.K230N; 17:2394310-2394310 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1561G>A; p.A521T; 17:2387089-2387089 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1561G>A; p.A521T; 17:2387089-2387089 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.942C>T; p.R314R; 17:2387915-2387915 |
bone | Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour | Substitution - coding silent |
c.1172T>C; p.L391P; 17:2387478-2387478 |
skin | malignant_melanoma | Substitution - Missense |
c.1661A>G; p.H554R; 17:2386989-2386989 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1402G>A; p.A468T; 17:2387248-2387248 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1402G>A; p.A468T; 17:2387248-2387248 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.191C>T; p.P64L; 17:2395337-2395337 |
skin | malignant_melanoma | Substitution - Missense |
c.175C>T; p.R59C; 17:2395353-2395353 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |