Entrez Gene

Basic Information
Gene ID	4485
Name	MST1
Synonymous	macrophage stimulating 1;MST1;macrophage stimulating 1
Definition	hepatocyte growth factor-like protein\|hepatocyte growth factor-like protein homolog\|macrophage stimulating 1 (hepatocyte growth factor-like)\|macrophage-stimulating protein
Position	3p21
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.09.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.2165T>C; p.M722T; 3:49684041-49684041	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1565G>C; p.G522A; 3:49685069-49685069	skin	malignant_melanoma	Substitution - Missense
c.1731G>A; p.G577G; 3:49684776-49684776	skin	malignant_melanoma	Substitution - coding silent
c.1565G>C; p.G522A; 3:49685069-49685069	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1565G>C; p.G522A; 3:49685069-49685069	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1565G>C; p.G522A; 3:49685069-49685069	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1162G>A; p.A388T; 3:49685948-49685948	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	thyroid	other; neoplasm	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	breast	carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	breast	carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.55C>T; p.P19S; 3:49688637-49688637	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2178G>C; p.*726Y; 3:49684028-49684028	eye; uveal_tract	malignant_melanoma; spindle	Nonstop extension
c.1209C>T; p.V403V; 3:49685901-49685901	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2007G>A; p.G669G; 3:49684323-49684323	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.866G>A; p.R289H; 3:49686463-49686463	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.162G>A; p.A54A; 3:49687830-49687830	thyroid	other; neoplasm	Substitution - coding silent
c.1092G>A; p.M364I; 3:49686117-49686117	liver	carcinoma	Substitution - Missense
c.1092G>A; p.M364I; 3:49686117-49686117	liver	carcinoma	Substitution - Missense
c.1046C>T; p.P349L; 3:49686163-49686163	skin; trunk	malignant_melanoma	Substitution - Missense
c.1046C>T; p.P349L; 3:49686163-49686163	skin; extremity	malignant_melanoma	Substitution - Missense
c.1046C>T; p.P349L; 3:49686163-49686163	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1046C>T; p.P349L; 3:49686163-49686163	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1046C>T; p.P349L; 3:49686163-49686163	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1046C>T; p.P349L; 3:49686163-49686163	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1046C>T; p.P349L; 3:49686163-49686163	central_nervous_system; brain	glioma	Substitution - Missense
c.1100C>G; p.A367G; 3:49686109-49686109	central_nervous_system; brain	glioma	Substitution - Missense
c.1863G>T; p.W621C; 3:49684563-49684563	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1863G>T; p.W621C; 3:49684563-49684563	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1099G>A; p.A367T; 3:49686110-49686110	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1637C>T; p.T546M; 3:49684870-49684870	breast	carcinoma	Substitution - Missense
c.1637C>T; p.T546M; 3:49684870-49684870	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.310A>T; p.T104S; 3:49687601-49687601	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.310A>T; p.T104S; 3:49687601-49687601	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.310A>T; p.T104S; 3:49687601-49687601	urinary_tract; bladder	carcinoma	Substitution - Missense
c.310A>T; p.T104S; 3:49687601-49687601	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.1603C>G; p.R535G; 3:49685031-49685031	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1603C>G; p.R535G; 3:49685031-49685031	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1603C>G; p.R535G; 3:49685031-49685031	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1342A>G; p.M448V; 3:49685641-49685641	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1778C>T; p.T593I; 3:49684648-49684648	pancreas	carcinoma	Substitution - Missense
c.1118G>A; p.R373Q; 3:49686091-49686091	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1853T>C; p.I618T; 3:49684573-49684573	liver	carcinoma	Substitution - Missense
c.2119G>A; p.V707I; 3:49684087-49684087	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2119G>A; p.V707I; 3:49684087-49684087	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.319C>T; p.R107W; 3:49687592-49687592	skin	malignant_melanoma	Substitution - Missense
c.319C>T; p.R107W; 3:49687592-49687592	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1097C>T; p.A366V; 3:49686112-49686112	central_nervous_system; brain	glioma	Substitution - Missense
c.1239G>T; p.P413P; 3:49685871-49685871	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1657G>A; p.G553S; 3:49684850-49684850	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.781G>C; p.E261Q; 3:49686750-49686750	thyroid	other; neoplasm	Substitution - Missense
c.781G>C; p.E261Q; 3:49686750-49686750	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.781G>C; p.E261Q; 3:49686750-49686750	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.781G>C; p.E261Q; 3:49686750-49686750	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.781G>C; p.E261Q; 3:49686750-49686750	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.781G>C; p.E261Q; 3:49686750-49686750	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.781G>C; p.E261Q; 3:49686750-49686750	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.781G>C; p.E261Q; 3:49686750-49686750	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.781G>C; p.E261Q; 3:49686750-49686750	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.781G>C; p.E261Q; 3:49686750-49686750	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.781G>C; p.E261Q; 3:49686750-49686750	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.781G>C; p.E261Q; 3:49686750-49686750	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.781G>C; p.E261Q; 3:49686750-49686750	urinary_tract; bladder	carcinoma	Substitution - Missense
c.781G>C; p.E261Q; 3:49686750-49686750	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.781G>C; p.E261Q; 3:49686750-49686750	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1790G>A; p.R597H; 3:49684636-49684636	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.41G>A; p.R14K; 3:49688651-49688651	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.540T>C; p.G180G; 3:49687216-49687216	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1012T>C; p.C338R; 3:49686317-49686317	thyroid	other; neoplasm	Substitution - Missense
c.1012T>C; p.C338R; 3:49686317-49686317	thyroid	other; neoplasm	Substitution - Missense
c.1012T>C; p.C338R; 3:49686317-49686317	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.227C>T; p.P76L; 3:49687765-49687765	skin; trunk	malignant_melanoma	Substitution - Missense
c.1855G>A; p.A619T; 3:49684571-49684571	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.671G>A; p.R224H; 3:49687004-49687004	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.305_306CC>TT; p.P102L; 3:49687605-49687606	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.462T>C; p.N154N; 3:49687372-49687372	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.783G>C; p.E261D; 3:49686748-49686748	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.792G>A; p.W264*; 3:49686739-49686739	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.792G>A; p.W264*; 3:49686739-49686739	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.263G>A; p.S88N; 3:49687648-49687648	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.579G>C; p.Q193H; 3:49687177-49687177	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1251-2A>C; p.?; 3:49685734-49685734	autonomic_ganglia	neuroblastoma	Unknown
c.1120C>T; p.R374C; 3:49686089-49686089	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1120C>T; p.R374C; 3:49686089-49686089	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1812C>G; p.P604P; 3:49684614-49684614	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1120C>T; p.R374C; 3:49686089-49686089	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.767A>G; p.N256S; 3:49686764-49686764	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.767A>G; p.N256S; 3:49686764-49686764	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1039C>T; p.R347W; 3:49686170-49686170	skin; trunk	malignant_melanoma	Substitution - Missense
c.767A>G; p.N256S; 3:49686764-49686764	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.767A>G; p.N256S; 3:49686764-49686764	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1039C>T; p.R347W; 3:49686170-49686170	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.767A>G; p.N256S; 3:49686764-49686764	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1039C>T; p.R347W; 3:49686170-49686170	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.767A>G; p.N256S; 3:49686764-49686764	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1116C>A; p.I372I; 3:49686093-49686093	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1039C>T; p.R347W; 3:49686170-49686170	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.767A>G; p.N256S; 3:49686764-49686764	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.767A>G; p.N256S; 3:49686764-49686764	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.767A>G; p.N256S; 3:49686764-49686764	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.767A>G; p.N256S; 3:49686764-49686764	urinary_tract; bladder	carcinoma	Substitution - Missense
c.767A>G; p.N256S; 3:49686764-49686764	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1039C>T; p.R347W; 3:49686170-49686170	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1039C>T; p.R347W; 3:49686170-49686170	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.767A>G; p.N256S; 3:49686764-49686764	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.767A>G; p.N256S; 3:49686764-49686764	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1247C>T; p.P416L; 3:49685863-49685863	skin; trunk	malignant_melanoma	Substitution - Missense
c.1247C>T; p.P416L; 3:49685863-49685863	NS	malignant_melanoma	Substitution - Missense
c.123A>G; p.Q41Q; 3:49687869-49687869	thyroid	other; neoplasm	Substitution - coding silent
c.1247C>T; p.P416L; 3:49685863-49685863	NS	malignant_melanoma	Substitution - Missense
c.365G>T; p.R122L; 3:49687469-49687469	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.204A>C; p.E68D; 3:49687788-49687788	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1161C>T; p.G387G; 3:49685949-49685949	skin	malignant_melanoma	Substitution - coding silent
c.483T>C; p.T161T; 3:49687273-49687273	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.939T>C; p.T313T; 3:49686390-49686390	thyroid	other; neoplasm	Substitution - coding silent
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.356A>G; p.D119G; 3:49687478-49687478	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2017G>A; p.G673S; 3:49684189-49684189	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2017G>A; p.G673S; 3:49684189-49684189	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1978T>C; p.C660R; 3:49684352-49684352	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2017G>A; p.G673S; 3:49684189-49684189	breast	carcinoma	Substitution - Missense
c.939T>C; p.T313T; 3:49686390-49686390	breast	carcinoma	Substitution - coding silent
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.939T>C; p.T313T; 3:49686390-49686390	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.171C>T; p.P57P; 3:49687821-49687821	thyroid	other; neoplasm	Substitution - coding silent
c.610G>A; p.A204T; 3:49687065-49687065	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.660G>T; p.T220T; 3:49687015-49687015	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.414G>C; p.T138T; 3:49687420-49687420	skin	malignant_melanoma	Substitution - coding silent
c.1121G>A; p.R374H; 3:49686088-49686088	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.410C>T; p.A137V; 3:49687424-49687424	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.320G>A; p.R107Q; 3:49687591-49687591	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1093C>T; p.R365C; 3:49686116-49686116	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.978G>T; p.P326P; 3:49686351-49686351	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.978G>T; p.P326P; 3:49686351-49686351	thyroid	other; neoplasm	Substitution - coding silent
c.978G>T; p.P326P; 3:49686351-49686351	thyroid	other; neoplasm	Substitution - coding silent
c.1239G>A; p.P413P; 3:49685871-49685871	central_nervous_system; brain	glioma	Substitution - coding silent
c.1239G>A; p.P413P; 3:49685871-49685871	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1239G>A; p.P413P; 3:49685871-49685871	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1348C>A; p.P450T; 3:49685635-49685635	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.492T>A; p.N164K; 3:49687264-49687264	urinary_tract; bladder	carcinoma	Substitution - Missense
c.258C>T; p.N86N; 3:49687653-49687653	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.550T>C; p.Y184H; 3:49687206-49687206	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1296C>T; p.F432F; 3:49685687-49685687	skin	malignant_melanoma	Substitution - coding silent
c.458C>G; p.P153R; 3:49687376-49687376	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1091T>C; p.M364T; 3:49686118-49686118	skin; trunk	malignant_melanoma	Substitution - Missense
c.1091T>C; p.M364T; 3:49686118-49686118	NS	malignant_melanoma	Substitution - Missense
c.1091T>C; p.M364T; 3:49686118-49686118	NS	malignant_melanoma	Substitution - Missense
c.1091T>C; p.M364T; 3:49686118-49686118	central_nervous_system; cerebellum	glioma; ependymoma	Substitution - Missense
c.146_150delAGCAC; p.Q49fs*18; 3:49687842-49687846	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2033C>T; p.P678L; 3:49684173-49684173	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1689G>A; p.E563E; 3:49684818-49684818	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1401G>A; p.P467P; 3:49685493-49685493	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.848-2A>C; p.?; 3:49686483-49686483	breast	carcinoma	Unknown
c.848-2A>C; p.?; 3:49686483-49686483	oesophagus	carcinoma; adenocarcinoma	Unknown
c.848-2A>C; p.?; 3:49686483-49686483	pancreas	carcinoma	Unknown
c.848-2A>C; p.?; 3:49686483-49686483	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.848-2A>C; p.?; 3:49686483-49686483	breast	carcinoma	Unknown
c.848-2A>C; p.?; 3:49686483-49686483	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.612G>T; p.A204A; 3:49687063-49687063	pancreas	carcinoma	Substitution - coding silent
c.1647_1648delGG; p.E549fs*57; 3:49684859-49684860	prostate	carcinoma	Deletion - Frameshift
c.906T>G; p.G302G; 3:49686423-49686423	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.241C>T; p.R81W; 3:49687751-49687751	skin; trunk	malignant_melanoma	Substitution - Missense
c.323G>A; p.R108H; 3:49687588-49687588	pancreas	carcinoma	Substitution - Missense
c.1008C>T; p.Y336Y; 3:49686321-49686321	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1304delA; p.N435fs*91; 3:49685679-49685679	breast	carcinoma	Deletion - Frameshift
c.1304delA; p.N435fs*91; 3:49685679-49685679	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.54C>T; p.L18L; 3:49688638-49688638	skin	malignant_melanoma	Substitution - coding silent
c.77A>T; p.Q26L; 3:49688615-49688615	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1861T>C; p.W621R; 3:49684565-49684565	prostate	carcinoma	Substitution - Missense
c.1861T>C; p.W621R; 3:49684565-49684565	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1861T>C; p.W621R; 3:49684565-49684565	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.259G>A; p.V87M; 3:49687652-49687652	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.708G>A; p.Q236Q; 3:49686967-49686967	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1065C>T; p.P355P; 3:49686144-49686144	skin	malignant_melanoma	Substitution - coding silent
c.1772C>A; p.S591Y; 3:49684654-49684654	urinary_tract; bladder	carcinoma	Substitution - Missense
c.881C>G; p.T294S; 3:49686448-49686448	skin; extremity	malignant_melanoma	Substitution - Missense
c.881C>G; p.T294S; 3:49686448-49686448	urinary_tract; bladder	carcinoma	Substitution - Missense
c.881C>G; p.T294S; 3:49686448-49686448	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1565G>A; p.G522E; 3:49685069-49685069	ovary	other; neoplasm	Substitution - Missense
c.463G>T; p.D155Y; 3:49687371-49687371	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.430C>T; p.P144S; 3:49687404-49687404	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1131C>T; p.D377D; 3:49686078-49686078	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.523G>T; p.D175Y; 3:49687233-49687233	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1954G>T; p.G652*; 3:49684376-49684376	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2094A>G; p.V698V; 3:49684112-49684112	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.364C>T; p.R122W; 3:49687470-49687470	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2107C>T; p.R703C; 3:49684099-49684099	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1231G>T; p.E411*; 3:49685879-49685879	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2107C>T; p.R703C; 3:49684099-49684099	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2107C>T; p.R703C; 3:49684099-49684099	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2107C>T; p.R703C; 3:49684099-49684099	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2107C>T; p.R703C; 3:49684099-49684099	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2107C>T; p.R703C; 3:49684099-49684099	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.724G>C; p.G242R; 3:49686951-49686951	thyroid	carcinoma	Substitution - Missense
c.1117C>T; p.R373W; 3:49686092-49686092	central_nervous_system; brain	glioma	Substitution - Missense
c.1216_1221delCAGCGC; p.Q406_R407delQR; 3:49685889-49685894	skin	malignant_melanoma	Deletion - In frame
c.1919T>C; p.V640A; 3:49684411-49684411	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.591C>G; p.I197M; 3:49687165-49687165	breast	carcinoma	Substitution - Missense
c.735C>A; p.L245L; 3:49686796-49686796	thyroid	carcinoma	Substitution - coding silent
c.1789C>T; p.R597C; 3:49684637-49684637	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1164A>G; p.A388A; 3:49685946-49685946	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.306C>G; p.P102P; 3:49687605-49687605	urinary_tract; bladder	carcinoma	Substitution - coding silent

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]