Entrez Gene

Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)

General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information
Gene ID	4502
Name	MT2A
Synonymous	metallothionein 2A;MT2A;metallothionein 2A
Definition	MT-2\|MT-II\|metallothionein-2\|metallothionein-2A\|metallothionein-II
Position	16q13
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.

The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.

The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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There is no record for MT2A

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.125C>T; p.A42V; 16:56609293-56609293	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.125C>T; p.A42V; 16:56609293-56609293	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.19T>G; p.C7G; 16:56608674-56608674	pancreas	carcinoma	Substitution - Missense
c.140G>A; p.G47D; 16:56609308-56609308	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.140G>A; p.G47D; 16:56609308-56609308	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.140G>A; p.G47D; 16:56609308-56609308	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.41C>T; p.T14I; 16:56609004-56609004	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.28G>T; p.G10C; 16:56608683-56608683	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.97T>C; p.C33R; 16:56609265-56609265	skin	malignant_melanoma	Substitution - Missense
c.17C>A; p.S6Y; 16:56608672-56608672	skin	malignant_melanoma	Substitution - Missense
c.169T>C; p.C57R; 16:56609337-56609337	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.185G>A; p.62; 16:56609353-56609353	breast	carcinoma	Substitution - coding silent

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