Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

467

Name

ATF3

Synonymous

activating transcription factor 3;ATF3;activating transcription factor 3

Definition

cAMP-dependent transcription factor ATF-3|cyclic AMP-dependent transcription factor ATF-3

Position

1q32.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.259G>A; p.E87K; 1:212618145-212618145

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.275G>A; p.R92Q; 1:212618161-212618161

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.183G>A; p.A61A; 1:212615204-212615204

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.218G>A; p.G73E; 1:212615239-212615239

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.498G>C; p.E166D; 1:212619507-212619507

 breastcarcinomaSubstitution - Missense

c.216C>T; p.L72L; 1:212615237-212615237

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.371T>C; p.V124A; 1:212619380-212619380

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.377C>T; p.A126V; 1:212619386-212619386

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.448C>T; p.R150W; 1:212619457-212619457

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.258T>C; p.D86D; 1:212618144-212618144

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.73C>T; p.P25S; 1:212615094-212615094

 skinmalignant_melanomaSubstitution - Missense

c.284G>T; p.R95I; 1:212618170-212618170

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.3G>T; p.M1I; 1:212615024-212615024

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.3G>T; p.M1I; 1:212615024-212615024

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.467G>A; p.R156Q; 1:212619476-212619476

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.206A>G; p.D69G; 1:212615227-212615227

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.505C>A; p.L169I; 1:212619514-212619514

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.24G>T; p.Q8H; 1:212615045-212615045

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.148C>A; p.Q50K; 1:212615169-212615169

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.305A>G; p.K102R; 1:212618191-212618191

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.62C>G; p.P21R; 1:212615083-212615083

 breastcarcinomaSubstitution - Missense

c.412G>A; p.E138K; 1:212619421-212619421

 skinmalignant_melanomaSubstitution - Missense

c.316_318delAAG; p.K108delK; 1:212618202-212618204

 large_intestinecarcinoma; adenocarcinomaDeletion - In frame

c.36_37GG>AA; p.E13K; 1:212615057-212615058

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.333G>A; p.T111T; 1:212618219-212618219

 breastcarcinomaSubstitution - coding silent

c.262A>G; p.R88G; 1:212618148-212618148

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.171G>A; p.R57R; 1:212615192-212615192

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.396T>C; p.I132I; 1:212619405-212619405

 livercarcinomaSubstitution - coding silent

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