Entrez Gene

Basic Information
Gene ID	4920
Name	ROR2
Synonymous	receptor tyrosine kinase-like orphan receptor 2;ROR2;receptor tyrosine kinase-like orphan receptor 2
Definition	neurotrophic tyrosine kinase receptor-related 2\|tyrosine-protein kinase transmembrane receptor ROR2
Position	9q22
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.06.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.356G>A; p.R119Q; 9:91757379-91757379	skin	malignant_melanoma	Substitution - Missense
c.1735G>A; p.D579N; 9:91724759-91724759	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.947G>A; p.C316Y; 9:91731146-91731146	skin	malignant_melanoma	Substitution - Missense
c.1814A>C; p.Y605S; 9:91724680-91724680	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1436T>C; p.L479P; 9:91725058-91725058	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.947G>A; p.C316Y; 9:91731146-91731146	skin	malignant_melanoma	Substitution - Missense
c.1814A>C; p.Y605S; 9:91724680-91724680	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1556A>G; p.E519G; 9:91724938-91724938	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2029T>C; p.S677P; 9:91724465-91724465	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1155C>G; p.R385R; 9:91730938-91730938	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1797C>T; p.I599I; 9:91724697-91724697	skin	malignant_melanoma	Substitution - coding silent
c.995A>T; p.K332M; 9:91731098-91731098	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1843G>A; p.D615N; 9:91724651-91724651	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1843G>A; p.D615N; 9:91724651-91724651	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.322C>T; p.R108W; 9:91757413-91757413	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.555C>T; p.F185F; 9:91737458-91737458	skin	malignant_melanoma	Substitution - coding silent
c.2770G>A; p.E924K; 9:91723724-91723724	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.1048C>A; p.L350M; 9:91731045-91731045	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1949G>T; p.G650V; 9:91724545-91724545	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2321G>A; p.S774N; 9:91724173-91724173	liver	carcinoma	Substitution - Missense
c.799G>A; p.E267K; 9:91733260-91733260	skin	malignant_melanoma	Substitution - Missense
c.799G>A; p.E267K; 9:91733260-91733260	central_nervous_system; brain	glioma	Substitution - Missense
c.1095C>G; p.C365W; 9:91730998-91730998	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.233C>T; p.T78M; 9:91757502-91757502	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1920G>A; p.V640V; 9:91724574-91724574	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1707G>A; p.S569S; 9:91724787-91724787	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1450T>A; p.F484I; 9:91725044-91725044	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1177T>A; p.S393T; 9:91730916-91730916	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1244C>T; p.P415L; 9:91726683-91726683	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2680G>A; p.A894T; 9:91723814-91723814	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1739A>G; p.D580G; 9:91724755-91724755	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1137G>A; p.T379T; 9:91730956-91730956	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2367C>A; p.P789P; 9:91724127-91724127	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.651G>A; p.T217T; 9:91733408-91733408	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1416G>A; p.A472A; 9:91725078-91725078	skin	malignant_melanoma	Substitution - coding silent
c.2117G>A; p.R706Q; 9:91724377-91724377	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2155G>A; p.A719T; 9:91724339-91724339	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.137C>T; p.P46L; 9:91775779-91775779	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.2395C>T; p.P799S; 9:91724099-91724099	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.151G>A; p.D51N; 9:91775765-91775765	ovary	other; neoplasm	Substitution - Missense
c.2482C>A; p.P828T; 9:91724012-91724012	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2395C>T; p.P799S; 9:91724099-91724099	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2442G>A; p.P814P; 9:91724052-91724052	pancreas	carcinoma	Substitution - coding silent
c.1153C>T; p.R385C; 9:91730940-91730940	large_intestine	adenoma	Substitution - Missense
c.1821C>T; p.S607S; 9:91724673-91724673	skin	malignant_melanoma	Substitution - coding silent
c.671C>T; p.S224L; 9:91733388-91733388	breast	carcinoma	Substitution - Missense
c.671C>T; p.S224L; 9:91733388-91733388	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.824C>T; p.P275L; 9:91733235-91733235	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1885G>A; p.V629M; 9:91724609-91724609	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.569C>T; p.T190I; 9:91737444-91737444	skin	malignant_melanoma	Substitution - Missense
c.2003A>C; p.K668T; 9:91724491-91724491	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.526C>A; p.P176T; 9:91737487-91737487	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1964C>T; p.P655L; 9:91724530-91724530	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.761A>G; p.D254G; 9:91733298-91733298	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1571A>C; p.E524A; 9:91724923-91724923	kidney	other; neoplasm	Substitution - Missense
c.2304G>A; p.T768T; 9:91724190-91724190	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1523C>T; p.T508M; 9:91724971-91724971	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2203C>T; p.R735W; 9:91724291-91724291	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2203C>T; p.R735W; 9:91724291-91724291	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2388C>T; p.F796F; 9:91724106-91724106	skin	malignant_melanoma	Substitution - coding silent
c.482A>T; p.N161I; 9:91756083-91756083	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.508G>A; p.E170K; 9:91737505-91737505	skin	malignant_melanoma	Substitution - Missense
c.1639C>A; p.Q547K; 9:91724855-91724855	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.743C>T; p.P248L; 9:91733316-91733316	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.295G>A; p.D99N; 9:91757440-91757440	skin	malignant_melanoma	Substitution - Missense
c.2357A>G; p.Y786C; 9:91724137-91724137	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1448G>A; p.R483Q; 9:91725046-91725046	breast	carcinoma	Substitution - Missense
c.2183G>C; p.C728S; 9:91724311-91724311	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.548C>T; p.A183V; 9:91737465-91737465	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.417C>A; p.N139K; 9:91757318-91757318	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1538C>A; p.A513E; 9:91724956-91724956	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1101C>T; p.N367N; 9:91730992-91730992	skin	malignant_melanoma	Substitution - coding silent
c.1623C>T; p.G541G; 9:91724871-91724871	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.339G>A; p.K113K; 9:91757396-91757396	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.982G>A; p.A328T; 9:91731111-91731111	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1623C>T; p.G541G; 9:91724871-91724871	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.763G>A; p.E255K; 9:91733296-91733296	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2134C>T; p.P712S; 9:91724360-91724360	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1842G>A; p.K614K; 9:91724652-91724652	skin	malignant_melanoma	Substitution - coding silent
c.1738G>T; p.D580Y; 9:91724756-91724756	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2134C>T; p.P712S; 9:91724360-91724360	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2725G>A; p.V909M; 9:91723769-91723769	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1399G>A; p.E467K; 9:91725095-91725095	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.317C>T; p.P106L; 9:91757418-91757418	stomach	carcinoma	Substitution - Missense
c.1545G>T; p.G515G; 9:91724949-91724949	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.323G>A; p.R108Q; 9:91757412-91757412	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1331T>C; p.L444P; 9:91726596-91726596	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.838C>T; p.R280W; 9:91733221-91733221	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1027C>A; p.Q343K; 9:91731066-91731066	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.2453A>T; p.Y818F; 9:91724041-91724041	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.838C>T; p.R280W; 9:91733221-91733221	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1300G>A; p.A434T; 9:91726627-91726627	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2567T>C; p.V856A; 9:91723927-91723927	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.574T>C; p.Y192H; 9:91737439-91737439	skin; shoulder	malignant_melanoma	Substitution - Missense
c.323G>T; p.R108L; 9:91757412-91757412	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.303G>A; p.P101P; 9:91757432-91757432	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2064C>T; p.Y688Y; 9:91724430-91724430	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.823C>T; p.P275S; 9:91733236-91733236	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1614C>T; p.C538C; 9:91724880-91724880	liver	carcinoma	Substitution - coding silent
c.457C>T; p.R153W; 9:91757278-91757278	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1687G>A; p.E563K; 9:91724807-91724807	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.457C>T; p.R153W; 9:91757278-91757278	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2068C>A; p.L690M; 9:91724426-91724426	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.534G>A; p.R178R; 9:91737479-91737479	skin	malignant_melanoma	Substitution - coding silent
c.2091C>T; p.S697S; 9:91724403-91724403	skin	malignant_melanoma	Substitution - coding silent
c.2644T>G; p.S882A; 9:91723850-91723850	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2377G>T; p.A793S; 9:91724117-91724117	skin; arm	malignant_melanoma	Substitution - Missense
c.1624G>A; p.V542M; 9:91724870-91724870	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1624G>A; p.V542M; 9:91724870-91724870	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2408C>T; p.P803L; 9:91724086-91724086	skin	malignant_melanoma	Substitution - Missense
c.2315C>T; p.S772F; 9:91724179-91724179	skin	malignant_melanoma	Substitution - Missense
c.2577C>T; p.P859P; 9:91723917-91723917	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1588C>T; p.R530W; 9:91724906-91724906	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1588C>T; p.R530W; 9:91724906-91724906	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2766G>T; p.E922D; 9:91723728-91723728	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1330C>A; p.L444M; 9:91726597-91726597	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1670C>T; p.S557L; 9:91724824-91724824	skin	malignant_melanoma	Substitution - Missense
c.2018C>G; p.S673*; 9:91724476-91724476	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.98-1G>T; p.?; 9:91775819-91775819	stomach	carcinoma; adenocarcinoma	Unknown
c.1670C>T; p.S557L; 9:91724824-91724824	skin; abdomen	malignant_melanoma	Substitution - Missense
c.1969C>T; p.R657C; 9:91724525-91724525	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1254C>T; p.I418I; 9:91726673-91726673	skin	malignant_melanoma	Substitution - coding silent
c.1969C>T; p.R657C; 9:91724525-91724525	central_nervous_system; brain	glioma	Substitution - Missense
c.2327G>A; p.S776N; 9:91724167-91724167	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1800G>C; p.A600A; 9:91724694-91724694	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2678G>A; p.G893D; 9:91723816-91723816	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2250C>T; p.G750G; 9:91724244-91724244	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2335A>G; p.S779G; 9:91724159-91724159	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2632C>T; p.P878S; 9:91723862-91723862	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.158C>A; p.P53Q; 9:91775758-91775758	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.158C>A; p.P53Q; 9:91775758-91775758	liver	carcinoma	Substitution - Missense
c.1172T>C; p.V391A; 9:91730921-91730921	skin; back	malignant_melanoma	Substitution - Missense
c.1999G>A; p.G667S; 9:91724495-91724495	large_intestine; colon	adenoma	Substitution - Missense
c.1890G>T; p.K630N; 9:91724604-91724604	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.663C>T; p.D221D; 9:91733396-91733396	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1625T>C; p.V542A; 9:91724869-91724869	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2622C>T; p.V874V; 9:91723872-91723872	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1625T>C; p.V542A; 9:91724869-91724869	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1228C>T; p.P410S; 9:91726699-91726699	skin	malignant_melanoma	Substitution - Missense
c.2413A>G; p.K805E; 9:91724081-91724081	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1082G>C; p.G361A; 9:91731011-91731011	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1659C>T; p.F553F; 9:91724835-91724835	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1105G>A; p.G369R; 9:91730988-91730988	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2172C>T; p.L724L; 9:91724322-91724322	breast	carcinoma	Substitution - coding silent
c.815G>A; p.R272H; 9:91733244-91733244	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2249G>A; p.G750D; 9:91724245-91724245	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2249G>A; p.G750D; 9:91724245-91724245	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.169C>T; p.L57L; 9:91775747-91775747	skin	malignant_melanoma	Substitution - coding silent
c.815G>A; p.R272H; 9:91733244-91733244	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1820C>T; p.S607F; 9:91724674-91724674	skin	malignant_melanoma	Substitution - Missense
c.1101C>A; p.N367K; 9:91730992-91730992	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1758C>T; p.A586A; 9:91724736-91724736	skin	malignant_melanoma	Substitution - coding silent
c.1149C>T; p.N383N; 9:91730944-91730944	pancreas	carcinoma	Substitution - coding silent
c.1149C>T; p.N383N; 9:91730944-91730944	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1873G>A; p.D625N; 9:91724621-91724621	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.231G>T; p.Q77H; 9:91757504-91757504	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2710G>T; p.G904W; 9:91723784-91723784	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1023C>T; p.A341A; 9:91731070-91731070	skin	malignant_melanoma	Substitution - coding silent
c.1010G>A; p.C337Y; 9:91731083-91731083	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.628T>C; p.F210L; 9:91733431-91733431	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.350G>A; p.G117D; 9:91757385-91757385	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.733A>G; p.T245A; 9:91733326-91733326	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.733A>G; p.T245A; 9:91733326-91733326	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.733A>G; p.T245A; 9:91733326-91733326	thyroid	other; neoplasm	Substitution - Missense
c.2778G>A; p.L926L; 9:91723716-91723716	skin	malignant_melanoma	Substitution - coding silent
c.153C>A; p.D51E; 9:91775763-91775763	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1547C>T; p.P516L; 9:91724947-91724947	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2221G>A; p.D741N; 9:91724273-91724273	skin	malignant_melanoma	Substitution - Missense
c.153C>A; p.D51E; 9:91775763-91775763	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1741C>G; p.R581G; 9:91724753-91724753	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1764G>A; p.E588E; 9:91724730-91724730	skin	malignant_melanoma	Substitution - coding silent
c.2517G>T; p.P839P; 9:91723977-91723977	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1692C>T; p.F564F; 9:91724802-91724802	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1971C>T; p.R657R; 9:91724523-91724523	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1860T>C; p.N620N; 9:91724634-91724634	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1855C>T; p.R619C; 9:91724639-91724639	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1247T>A; p.L416Q; 9:91726680-91726680	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1321C>T; p.R441W; 9:91726606-91726606	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1747G>A; p.V583M; 9:91724747-91724747	skin	malignant_melanoma	Substitution - Missense
c.2124G>A; p.R708R; 9:91724370-91724370	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1855C>T; p.R619C; 9:91724639-91724639	large_intestine	adenoma	Substitution - Missense
c.1256C>T; p.A419V; 9:91726671-91726671	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1991T>C; p.I664T; 9:91724503-91724503	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2634delC; p.S879fs*>65; 9:91723860-91723860	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.821A>G; p.N274S; 9:91733238-91733238	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1538C>T; p.A513V; 9:91724956-91724956	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.488A>C; p.N163T; 9:91756077-91756077	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2724C>A; p.T908T; 9:91723770-91723770	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2516C>T; p.P839L; 9:91723978-91723978	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2516C>T; p.P839L; 9:91723978-91723978	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1417G>T; p.V473L; 9:91725077-91725077	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2516C>T; p.P839L; 9:91723978-91723978	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2014G>A; p.D672N; 9:91724480-91724480	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2014G>A; p.D672N; 9:91724480-91724480	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2173A>G; p.M725V; 9:91724321-91724321	prostate	carcinoma	Substitution - Missense
c.1553G>A; p.R518Q; 9:91724941-91724941	breast	carcinoma	Substitution - Missense
c.1015C>T; p.P339S; 9:91731078-91731078	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1015C>T; p.P339S; 9:91731078-91731078	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1942C>A; p.L648M; 9:91724552-91724552	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.2197C>T; p.P733S; 9:91724297-91724297	skin	malignant_melanoma	Substitution - Missense
c.2672C>T; p.S891L; 9:91723822-91723822	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.436G>A; p.A146T; 9:91757299-91757299	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.722C>A; p.A241E; 9:91733337-91733337	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1479C>A; p.F493L; 9:91725015-91725015	breast	carcinoma	Substitution - Missense
c.1178C>T; p.S393L; 9:91730915-91730915	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2517G>C; p.P839P; 9:91723977-91723977	prostate	carcinoma	Substitution - coding silent
c.1178C>T; p.S393L; 9:91730915-91730915	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.977G>T; p.G326V; 9:91731116-91731116	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.977G>T; p.G326V; 9:91731116-91731116	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2698G>A; p.A900T; 9:91723796-91723796	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1709C>T; p.P570L; 9:91724785-91724785	prostate	carcinoma	Substitution - Missense
c.1770C>A; p.P590P; 9:91724724-91724724	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1041_1042CC>AG; p.S347>?; 9:91731051-91731052	large_intestine; caecum	carcinoma; adenocarcinoma	Complex
c.2122C>A; p.R708R; 9:91724372-91724372	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1716G>A; p.S572S; 9:91724778-91724778	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1480G>A; p.G494S; 9:91725014-91725014	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1480G>A; p.G494S; 9:91725014-91725014	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.520T>A; p.C174S; 9:91737493-91737493	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2680G>T; p.A894S; 9:91723814-91723814	pancreas	carcinoma	Substitution - Missense
c.2204G>A; p.R735Q; 9:91724290-91724290	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.157C>T; p.P53S; 9:91775759-91775759	skin	malignant_melanoma	Substitution - Missense
c.1415C>T; p.A472V; 9:91725079-91725079	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.814C>T; p.R272C; 9:91733245-91733245	pancreas	carcinoma	Substitution - Missense
c.814C>T; p.R272C; 9:91733245-91733245	pancreas	carcinoma	Substitution - Missense
c.1486G>T; p.A496S; 9:91725008-91725008	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2036G>A; p.G679D; 9:91724458-91724458	pancreas	carcinoma	Substitution - Missense
c.2036G>A; p.G679D; 9:91724458-91724458	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.2349C>T; p.N783N; 9:91724145-91724145	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.814C>T; p.R272C; 9:91733245-91733245	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.2191G>A; p.E731K; 9:91724303-91724303	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2191G>A; p.E731K; 9:91724303-91724303	skin	malignant_melanoma	Substitution - Missense
c.1372A>G; p.N458D; 9:91726555-91726555	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2382G>A; p.P794P; 9:91724112-91724112	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.108G>A; p.E36E; 9:91775808-91775808	skin	malignant_melanoma	Substitution - coding silent
c.1872C>T; p.Y624Y; 9:91724622-91724622	skin	malignant_melanoma	Substitution - coding silent
c.1171G>A; p.V391I; 9:91730922-91730922	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1310C>A; p.S437Y; 9:91726617-91726617	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2433G>A; p.M811I; 9:91724061-91724061	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2539G>A; p.A847T; 9:91723955-91723955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.298G>A; p.A100T; 9:91757437-91757437	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1745C>T; p.T582M; 9:91724749-91724749	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1700T>C; p.M567T; 9:91724794-91724794	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1547C>A; p.P516H; 9:91724947-91724947	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1776C>T; p.F592F; 9:91724718-91724718	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1776C>T; p.F592F; 9:91724718-91724718	skin	malignant_melanoma	Substitution - coding silent
c.744G>A; p.P248P; 9:91733315-91733315	breast	carcinoma	Substitution - coding silent
c.2065G>A; p.G689S; 9:91724429-91724429	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1167T>G; p.C389W; 9:91730926-91730926	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1546C>A; p.P516T; 9:91724948-91724948	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.762C>T; p.D254D; 9:91733297-91733297	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.762C>T; p.D254D; 9:91733297-91733297	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1359A>G; p.E453E; 9:91726568-91726568	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.405C>A; p.C135*; 9:91757330-91757330	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2343G>A; p.V781V; 9:91724151-91724151	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.935G>T; p.R312L; 9:91733124-91733124	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1391A>T; p.K464I; 9:91725103-91725103	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1255G>A; p.A419T; 9:91726672-91726672	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1635G>T; p.K545N; 9:91724859-91724859	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2088C>T; p.Y696Y; 9:91724406-91724406	thyroid	other; neoplasm	Substitution - coding silent
c.2088C>T; p.Y696Y; 9:91724406-91724406	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1286G>A; p.R429Q; 9:91726641-91726641	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1357G>A; p.E453K; 9:91726570-91726570	skin	malignant_melanoma	Substitution - Missense
c.685C>T; p.P229S; 9:91733374-91733374	skin; ankle	malignant_melanoma; acral_lentiginous	Substitution - Missense
c.2748_2750delGGA; p.E917delE; 9:91723744-91723746	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.2156C>T; p.A719V; 9:91724338-91724338	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2748_2750delGGA; p.E917delE; 9:91723744-91723746	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.1992C>T; p.I664I; 9:91724502-91724502	skin	malignant_melanoma	Substitution - coding silent
c.2376G>A; p.K792K; 9:91724118-91724118	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.298G>T; p.A100S; 9:91757437-91757437	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2694G>A; p.Q898Q; 9:91723800-91723800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2694G>A; p.Q898Q; 9:91723800-91723800	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2387T>C; p.F796S; 9:91724107-91724107	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1975A>G; p.M659V; 9:91724519-91724519	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1373A>G; p.N458S; 9:91726554-91726554	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.599G>A; p.G200E; 9:91737414-91737414	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.405C>T; p.C135C; 9:91757330-91757330	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2466C>T; p.N822N; 9:91724028-91724028	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.320G>A; p.R107Q; 9:91757415-91757415	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.154G>A; p.G52S; 9:91775762-91775762	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1608C>T; p.V536V; 9:91724886-91724886	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1179G>A; p.S393S; 9:91730914-91730914	pancreas	carcinoma	Substitution - coding silent
c.1179G>A; p.S393S; 9:91730914-91730914	liver	carcinoma	Substitution - coding silent
c.1179G>A; p.S393S; 9:91730914-91730914	liver	carcinoma	Substitution - coding silent
c.1179G>A; p.S393S; 9:91730914-91730914	skin	malignant_melanoma	Substitution - coding silent
c.2362G>T; p.G788W; 9:91724132-91724132	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.639C>T; p.I213I; 9:91733420-91733420	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1539G>T; p.A513A; 9:91724955-91724955	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1495delG; p.E499fs*11; 9:91724999-91724999	NS	malignant_melanoma	Deletion - Frameshift
c.1949G>A; p.G650E; 9:91724545-91724545	skin	malignant_melanoma	Substitution - Missense
c.1514C>T; p.A505V; 9:91724980-91724980	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1934A>G; p.Y645C; 9:91724560-91724560	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1116G>T; p.M372I; 9:91730977-91730977	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1103C>A; p.P368H; 9:91730990-91730990	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.661G>T; p.D221Y; 9:91733398-91733398	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.434delC; p.A146fs*67; 9:91757301-91757301	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.2351C>T; p.A784V; 9:91724143-91724143	skin	malignant_melanoma	Substitution - Missense
c.2170C>T; p.L724F; 9:91724324-91724324	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2633C>T; p.P878L; 9:91723861-91723861	skin	malignant_melanoma	Substitution - Missense
c.263A>G; p.N88S; 9:91757472-91757472	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1225G>T; p.V409F; 9:91726702-91726702	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.980C>T; p.T327M; 9:91731113-91731113	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1207G>T; p.G403W; 9:91726720-91726720	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.980C>T; p.T327M; 9:91731113-91731113	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.265C>A; p.P89T; 9:91757470-91757470	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.362G>A; p.R121Q; 9:91757373-91757373	skin	malignant_melanoma	Substitution - Missense
c.362G>A; p.R121Q; 9:91757373-91757373	skin	malignant_melanoma	Substitution - Missense
c.2474_2475insC; p.Q825fs*71; 9:91724019-91724020	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Insertion - Frameshift
c.533G>A; p.R178Q; 9:91737480-91737480	skin	malignant_melanoma	Substitution - Missense
c.533G>A; p.R178Q; 9:91737480-91737480	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1017G>A; p.P339P; 9:91731076-91731076	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1387G>A; p.A463T; 9:91725107-91725107	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.905G>A; p.R302H; 9:91733154-91733154	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.538A>G; p.I180V; 9:91737475-91737475	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2603C>T; p.S868F; 9:91723891-91723891	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.905G>A; p.R302H; 9:91733154-91733154	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2153C>T; p.P718L; 9:91724341-91724341	skin	malignant_melanoma	Substitution - Missense
c.2186G>A; p.W729*; 9:91724308-91724308	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2674G>C; p.E892Q; 9:91723820-91723820	breast	carcinoma	Substitution - Missense
c.1078_1079GG>AT; p.G360M; 9:91731014-91731015	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.622+1G>A; p.?; 9:91737390-91737390	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.1830C>T; p.H610H; 9:91724664-91724664	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1069G>T; p.E357*; 9:91731024-91731024	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.1069G>T; p.E357*; 9:91731024-91731024	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.1069G>T; p.E357*; 9:91731024-91731024	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.2213G>A; p.R738H; 9:91724281-91724281	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1402A>T; p.I468F; 9:91725092-91725092	skin; mucosal	malignant_melanoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]