Entrez Gene

Basic Information
Gene ID	49860
Name	CRNN
Synonymous	cornulin;CRNN;cornulin
Definition	53 kDa putative calcium-binding protein\|53 kDa squamous epithelial-induced stress protein\|58 kDa heat shock protein\|squamous epithelial heat shock protein 53\|tumor-related protein
Position	1q21
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.

The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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The ratio of the loss-of-function mutations over missense mutations is 0.10.

The copy number variations for various cancers

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There is no record for CRNN

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.137T>A; p.V46E; 1:152412097-152412097	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.50G>A; p.R17H; 1:152412184-152412184	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.50G>A; p.R17H; 1:152412184-152412184	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1035A>G; p.G345G; 1:152410047-152410047	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1035A>G; p.G345G; 1:152410047-152410047	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.246C>A; p.A82A; 1:152410836-152410836	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.377C>T; p.A126V; 1:152410705-152410705	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.906G>A; p.V302V; 1:152410176-152410176	skin	malignant_melanoma	Substitution - coding silent
c.1394C>A; p.S465Y; 1:152409688-152409688	breast	carcinoma	Substitution - Missense
c.377C>T; p.A126V; 1:152410705-152410705	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.377C>T; p.A126V; 1:152410705-152410705	central_nervous_system; brain	glioma	Substitution - Missense
c.457C>T; p.Q153*; 1:152410625-152410625	skin	malignant_melanoma	Substitution - Nonsense
c.457C>T; p.Q153*; 1:152410625-152410625	skin	malignant_melanoma	Substitution - Nonsense
c.457C>T; p.Q153*; 1:152410625-152410625	skin	malignant_melanoma	Substitution - Nonsense
c.920G>T; p.S307I; 1:152410162-152410162	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.858T>C; p.H286H; 1:152410224-152410224	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.413G>A; p.R138K; 1:152410669-152410669	skin	malignant_melanoma	Substitution - Missense
c.182T>A; p.L61Q; 1:152410900-152410900	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1357C>T; p.L453F; 1:152409725-152409725	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.77C>A; p.T26K; 1:152412157-152412157	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1270C>T; p.R424C; 1:152409812-152409812	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.223C>T; p.L75L; 1:152410859-152410859	skin	malignant_melanoma	Substitution - coding silent
c.622C>A; p.P208T; 1:152410460-152410460	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.651G>A; p.Q217Q; 1:152410431-152410431	skin	malignant_melanoma	Substitution - coding silent
c.329C>T; p.S110L; 1:152410753-152410753	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1431G>T; p.E477D; 1:152409651-152409651	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.329C>T; p.S110L; 1:152410753-152410753	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1291G>A; p.G431R; 1:152409791-152409791	skin	malignant_melanoma	Substitution - Missense
c.365A>C; p.E122A; 1:152410717-152410717	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.809C>T; p.T270I; 1:152410273-152410273	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.184G>A; p.D62N; 1:152410898-152410898	skin	malignant_melanoma	Substitution - Missense
c.541C>T; p.P181S; 1:152410541-152410541	skin	malignant_melanoma	Substitution - Missense
c.93G>A; p.G31G; 1:152412141-152412141	skin	malignant_melanoma	Substitution - coding silent
c.344A>G; p.E115G; 1:152410738-152410738	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.211T>C; p.F71L; 1:152410871-152410871	liver	carcinoma	Substitution - Missense
c.1001G>A; p.G334D; 1:152410081-152410081	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.211T>C; p.F71L; 1:152410871-152410871	liver	carcinoma	Substitution - Missense
c.247C>G; p.Q83E; 1:152410835-152410835	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.94G>C; p.E32Q; 1:152412140-152412140	breast	carcinoma	Substitution - Missense
c.1004G>A; p.R335K; 1:152410078-152410078	skin	malignant_melanoma	Substitution - Missense
c.820_821GG>AA; p.G274N; 1:152410261-152410262	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.413G>T; p.R138I; 1:152410669-152410669	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1325G>T; p.W442L; 1:152409757-152409757	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1325G>T; p.W442L; 1:152409757-152409757	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1340C>A; p.S447*; 1:152409742-152409742	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1464C>T; p.S488S; 1:152409618-152409618	skin	malignant_melanoma	Substitution - coding silent
c.171C>T; p.V57V; 1:152410911-152410911	skin	malignant_melanoma	Substitution - coding silent
c.1403A>G; p.Q468R; 1:152409679-152409679	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.522G>C; p.Q174H; 1:152410560-152410560	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.486G>A; p.A162A; 1:152410596-152410596	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.340G>A; p.G114S; 1:152410742-152410742	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.882C>T; p.H294H; 1:152410200-152410200	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.882C>T; p.H294H; 1:152410200-152410200	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.486G>A; p.A162A; 1:152410596-152410596	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.397G>A; p.E133K; 1:152410685-152410685	skin	malignant_melanoma	Substitution - Missense
c.606G>A; p.Q202Q; 1:152410476-152410476	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.606G>A; p.Q202Q; 1:152410476-152410476	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.397G>A; p.E133K; 1:152410685-152410685	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.920G>A; p.S307N; 1:152410162-152410162	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1086A>C; p.R362S; 1:152409996-152409996	breast	carcinoma	Substitution - Missense
c.502G>C; p.D168H; 1:152410580-152410580	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1221G>A; p.G407G; 1:152409861-152409861	skin	malignant_melanoma	Substitution - coding silent
c.1373delG; p.G458fs*33; 1:152409709-152409709	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1297A>C; p.R433R; 1:152409785-152409785	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.282G>T; p.E94D; 1:152410800-152410800	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.107T>C; p.L36P; 1:152412127-152412127	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.837C>T; p.S279S; 1:152410245-152410245	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.990C>T; p.I330I; 1:152410092-152410092	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.990C>T; p.I330I; 1:152410092-152410092	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.778G>A; p.A260T; 1:152410304-152410304	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1156A>T; p.R386*; 1:152409926-152409926	pancreas	carcinoma; ductal_carcinoma	Substitution - Nonsense
c.1153C>T; p.Q385*; 1:152409929-152409929	skin	malignant_melanoma	Substitution - Nonsense
c.271G>A; p.E91K; 1:152410811-152410811	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.766C>T; p.Q256*; 1:152410316-152410316	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.292G>A; p.G98S; 1:152410790-152410790	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.538A>G; p.S180G; 1:152410544-152410544	skin	malignant_melanoma	Substitution - Missense
c.538A>G; p.S180G; 1:152410544-152410544	skin	malignant_melanoma	Substitution - Missense
c.1105G>T; p.G369*; 1:152409977-152409977	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.62C>T; p.T21M; 1:152412172-152412172	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.62C>T; p.T21M; 1:152412172-152412172	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1333G>A; p.D445N; 1:152409749-152409749	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1081G>A; p.D361N; 1:152410001-152410001	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.555C>A; p.L185L; 1:152410527-152410527	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.716C>A; p.T239N; 1:152410366-152410366	breast	carcinoma	Substitution - Missense
c.1120C>A; p.Q374K; 1:152409962-152409962	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.81G>A; p.A27A; 1:152412153-152412153	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.81G>A; p.A27A; 1:152412153-152412153	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.81G>A; p.A27A; 1:152412153-152412153	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.625G>A; p.E209K; 1:152410457-152410457	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.858_859TG>CA; p.A287T; 1:152410223-152410224	urinary_tract; bladder	carcinoma	Substitution - Missense
c.936C>T; p.S312S; 1:152410146-152410146	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.670G>A; p.G224S; 1:152410412-152410412	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.199G>T; p.G67W; 1:152410883-152410883	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.838C>A; p.Q280K; 1:152410244-152410244	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1266A>G; p.P422P; 1:152409816-152409816	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1177C>T; p.P393S; 1:152409905-152409905	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1438G>A; p.G480S; 1:152409644-152409644	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1033G>A; p.G345R; 1:152410049-152410049	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1074G>A; p.V358V; 1:152410008-152410008	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.401G>A; p.G134E; 1:152410681-152410681	breast	carcinoma	Substitution - Missense
c.589G>A; p.E197K; 1:152410493-152410493	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.980G>A; p.G327E; 1:152410102-152410102	skin	malignant_melanoma	Substitution - Missense
c.125C>T; p.A42V; 1:152412109-152412109	skin	malignant_melanoma	Substitution - Missense
c.39G>C; p.E13D; 1:152412195-152412195	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.972G>C; p.Q324H; 1:152410110-152410110	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1039A>G; p.T347A; 1:152410043-152410043	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1039A>G; p.T347A; 1:152410043-152410043	skin	malignant_melanoma	Substitution - Missense
c.166G>A; p.E56K; 1:152410916-152410916	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1215G>A; p.Q405Q; 1:152409867-152409867	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.55G>C; p.A19P; 1:152412179-152412179	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.99G>A; p.L33L; 1:152412135-152412135	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.216G>A; p.K72K; 1:152410866-152410866	skin; upper_back	malignant_melanoma	Substitution - coding silent
c.218A>G; p.E73G; 1:152410864-152410864	skin	malignant_melanoma	Substitution - Missense
c.216G>A; p.K72K; 1:152410866-152410866	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.1376A>G; p.N459S; 1:152409706-152409706	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.520C>T; p.Q174*; 1:152410562-152410562	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1316G>T; p.G439V; 1:152409766-152409766	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.437G>A; p.G146E; 1:152410645-152410645	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.686G>A; p.G229E; 1:152410396-152410396	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.568G>A; p.E190K; 1:152410514-152410514	liver	carcinoma	Substitution - Missense
c.1271G>A; p.R424H; 1:152409811-152409811	breast	carcinoma	Substitution - Missense
c.1271G>A; p.R424H; 1:152409811-152409811	central_nervous_system; brain	glioma	Substitution - Missense
c.939C>T; p.T313T; 1:152410143-152410143	skin	malignant_melanoma	Substitution - coding silent
c.519C>T; p.S173S; 1:152410563-152410563	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.564G>A; p.Q188Q; 1:152410518-152410518	skin	malignant_melanoma	Substitution - coding silent
c.36C>T; p.I12I; 1:152412198-152412198	breast	carcinoma	Substitution - coding silent
c.1429G>T; p.E477*; 1:152409653-152409653	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.36C>T; p.I12I; 1:152412198-152412198	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.36C>T; p.I12I; 1:152412198-152412198	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.167A>G; p.E56G; 1:152410915-152410915	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.902C>T; p.T301I; 1:152410180-152410180	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.549A>G; p.I183M; 1:152410533-152410533	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.600G>A; p.R200R; 1:152410482-152410482	skin	malignant_melanoma	Substitution - coding silent
c.552delA; p.Q184fs*23; 1:152410530-152410530	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelofibrosis	Deletion - Frameshift
c.600G>A; p.R200R; 1:152410482-152410482	skin	malignant_melanoma	Substitution - coding silent
c.284G>A; p.G95E; 1:152410798-152410798	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1223C>A; p.A408E; 1:152409859-152409859	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.528G>T; p.Q176H; 1:152410554-152410554	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1359C>T; p.L453L; 1:152409723-152409723	skin	malignant_melanoma	Substitution - coding silent
c.760A>C; p.S254R; 1:152410322-152410322	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.324G>A; p.G108G; 1:152410758-152410758	skin	malignant_melanoma	Substitution - coding silent
c.343G>A; p.E115K; 1:152410739-152410739	skin	malignant_melanoma	Substitution - Missense
c.1199C>T; p.P400L; 1:152409883-152409883	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1199C>T; p.P400L; 1:152409883-152409883	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.249G>T; p.Q83H; 1:152410833-152410833	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1431G>A; p.E477E; 1:152409651-152409651	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1071T>C; p.T357T; 1:152410011-152410011	breast	carcinoma	Substitution - coding silent
c.788A>G; p.D263G; 1:152410294-152410294	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.993C>T; p.H331H; 1:152410089-152410089	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.993C>T; p.H331H; 1:152410089-152410089	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1246G>A; p.E416K; 1:152409836-152409836	breast	carcinoma	Substitution - Missense
c.1195G>T; p.V399L; 1:152409887-152409887	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.981G>T; p.G327G; 1:152410101-152410101	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.645G>A; p.R215R; 1:152410437-152410437	skin	malignant_melanoma	Substitution - coding silent
c.1366G>A; p.D456N; 1:152409716-152409716	skin	malignant_melanoma	Substitution - Missense
c.1220G>A; p.G407E; 1:152409862-152409862	skin	malignant_melanoma	Substitution - Missense
c.1136C>T; p.T379M; 1:152409946-152409946	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.747G>A; p.Q249Q; 1:152410335-152410335	skin	malignant_melanoma	Substitution - coding silent
c.1219G>T; p.G407W; 1:152409863-152409863	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.542C>T; p.P181L; 1:152410540-152410540	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.717C>A; p.T239T; 1:152410365-152410365	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.346G>A; p.G116R; 1:152410736-152410736	skin	malignant_melanoma	Substitution - Missense
c.346G>A; p.G116R; 1:152410736-152410736	skin	malignant_melanoma	Substitution - Missense
c.485C>T; p.A162V; 1:152410597-152410597	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.844G>T; p.V282L; 1:152410238-152410238	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1202G>A; p.G401E; 1:152409880-152409880	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.381G>A; p.G127G; 1:152410701-152410701	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.330G>A; p.S110S; 1:152410752-152410752	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.99G>T; p.L33L; 1:152412135-152412135	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.709G>T; p.G237C; 1:152410373-152410373	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1436G>A; p.R479Q; 1:152409646-152409646	skin	malignant_melanoma	Substitution - Missense
c.1436G>A; p.R479Q; 1:152409646-152409646	skin	malignant_melanoma	Substitution - Missense
c.1286G>A; p.G429E; 1:152409796-152409796	skin	malignant_melanoma	Substitution - Missense

Mutation summary in protein domains

Top

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

Loss of Function mutations compare to missense mutations

Top

The copy number variations for various cancers

Top

COSMIC somatic mutation [Top]