Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

51364

Name

ZMYND10

Synonymous

zinc finger, MYND-type containing 10;ZMYND10;zinc finger, MYND-type containing 10

Definition

protein BLu|zinc finger MYND domain-containing protein 10|zinc finger, MYND domain containing 10

Position

3p21.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.09.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1295T>A; p.L432Q; 3:50341438-50341438

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.104A>G; p.Q35R; 3:50345221-50345221

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_leukaemiaSubstitution - Missense

c.928T>G; p.L310V; 3:50342086-50342086

 endometriumcarcinoma; serous_carcinomaSubstitution - Missense

c.275T>G; p.V92G; 3:50343777-50343777

 breastcarcinomaSubstitution - Missense

c.475G>A; p.E159K; 3:50343342-50343342

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.601C>T; p.L201F; 3:50343017-50343017

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1309G>T; p.D437Y; 3:50341424-50341424

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1116G>A; p.A372A; 3:50341815-50341815

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.128A>G; p.N43S; 3:50345197-50345197

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.862C>T; p.R288W; 3:50342408-50342408

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1171C>T; p.R391W; 3:50341650-50341650

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.108T>C; p.H36H; 3:50345217-50345217

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.108T>C; p.H36H; 3:50345217-50345217

 livercarcinomaSubstitution - coding silent

c.108T>C; p.H36H; 3:50345217-50345217

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1309G>C; p.D437H; 3:50341424-50341424

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.622C>T; p.R208C; 3:50342996-50342996

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.622C>T; p.R208C; 3:50342996-50342996

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.178G>C; p.E60Q; 3:50345147-50345147

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.178G>C; p.E60Q; 3:50345147-50345147

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.178G>C; p.E60Q; 3:50345147-50345147

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.689G>A; p.R230Q; 3:50342929-50342929

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.613A>C; p.T205P; 3:50343005-50343005

 breastcarcinomaSubstitution - Missense

c.1249G>T; p.E417*; 3:50341484-50341484

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.1177C>T; p.R393C; 3:50341644-50341644

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1235G>A; p.W412*; 3:50341586-50341586

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Nonsense

c.1074G>A; p.Q358Q; 3:50341857-50341857

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.623G>C; p.R208P; 3:50342995-50342995

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.230C>T; p.A77V; 3:50343822-50343822

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1193G>C; p.S398T; 3:50341628-50341628

 breastcarcinomaSubstitution - Missense

c.522G>A; p.K174K; 3:50343195-50343195

 skinmalignant_melanomaSubstitution - coding silent

c.886C>A; p.L296I; 3:50342128-50342128

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.513G>T; p.E171D; 3:50343204-50343204

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.660G>A; p.V220V; 3:50342958-50342958

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.229G>A; p.A77T; 3:50343823-50343823

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.623G>A; p.R208H; 3:50342995-50342995

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.107A>G; p.H36R; 3:50345218-50345218

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.934A>C; p.S312R; 3:50342080-50342080

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.574C>T; p.R192C; 3:50343143-50343143

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.877C>T; p.R293W; 3:50342137-50342137

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.448G>A; p.A150T; 3:50343369-50343369

 breastcarcinomaSubstitution - Missense

c.164delG; p.G55fs*21; 3:50345161-50345161

 endometriumcarcinoma; endometrioid_carcinomaDeletion - Frameshift

c.1210C>T; p.R404C; 3:50341611-50341611

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.793G>A; p.A265T; 3:50342477-50342477

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.793G>A; p.A265T; 3:50342477-50342477

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.525G>A; p.Q175Q; 3:50343192-50343192

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1118G>C; p.R373P; 3:50341813-50341813

 skinmalignant_melanomaSubstitution - Missense

c.693G>A; p.R231R; 3:50342925-50342925

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.922G>A; p.A308T; 3:50342092-50342092

 livercarcinomaSubstitution - Missense

c.922G>A; p.A308T; 3:50342092-50342092

 livercarcinomaSubstitution - Missense

c.1019G>A; p.R340Q; 3:50341912-50341912

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.280G>A; p.D94N; 3:50343772-50343772

 breastcarcinomaSubstitution - Missense

c.437C>T; p.T146I; 3:50343380-50343380

 thyroidcarcinoma; anaplastic_carcinomaSubstitution - Missense

c.1295T>C; p.L432P; 3:50341438-50341438

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.467G>C; p.G156A; 3:50343350-50343350

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1047G>A; p.W349*; 3:50341884-50341884

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_leukaemiaSubstitution - Nonsense

c.1247G>T; p.R416M; 3:50341574-50341574

 pancreascarcinomaSubstitution - Missense

c.3G>A; p.M1I; 3:50345577-50345577

 skinmalignant_melanomaSubstitution - Missense

c.717C>T; p.F239F; 3:50342553-50342553

 breastcarcinomaSubstitution - coding silent

c.717C>T; p.F239F; 3:50342553-50342553

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1195G>A; p.A399T; 3:50341626-50341626

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1143G>A; p.L381L; 3:50341678-50341678

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.492G>A; p.Q164Q; 3:50343325-50343325

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.559G>A; p.A187T; 3:50343158-50343158

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

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