Entrez Gene

Basic Information
Gene ID	54778
Name	RNF111
Synonymous	ring finger protein 111;RNF111;ring finger protein 111
Definition	Arkadia\|E3 ubiquitin-protein ligase Arkadia
Position	15q21
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.26.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1548C>T; p.H516H; 15:59066945-59066945	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2172T>C; p.L724L; 15:59081159-59081159	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.27C>G; p.N9K; 15:59030849-59030849	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.27C>G; p.N9K; 15:59030849-59030849	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2683C>T; p.R895C; 15:59091098-59091098	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.27C>G; p.N9K; 15:59030849-59030849	thyroid	other; neoplasm	Substitution - Missense
c.1716T>C; p.S572S; 15:59075983-59075983	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2683C>T; p.R895C; 15:59091098-59091098	skin	malignant_melanoma	Substitution - Missense
c.2088A>T; p.I696I; 15:59081075-59081075	skin	malignant_melanoma	Substitution - coding silent
c.2072C>T; p.A691V; 15:59081059-59081059	skin	malignant_melanoma	Substitution - Missense
c.2882T>G; p.V961G; 15:59094821-59094821	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2034G>A; p.P678P; 15:59081021-59081021	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2034G>A; p.P678P; 15:59081021-59081021	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1835G>A; p.S612N; 15:59076102-59076102	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2034G>A; p.P678P; 15:59081021-59081021	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1960A>G; p.T654A; 15:59080947-59080947	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2582G>A; p.R861H; 15:59089698-59089698	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1575T>C; p.A525A; 15:59066972-59066972	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.37A>G; p.T13A; 15:59030859-59030859	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1655A>C; p.N552T; 15:59067052-59067052	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1027C>T; p.H343Y; 15:59055701-59055701	breast	carcinoma	Substitution - Missense
c.121G>C; p.E41Q; 15:59030943-59030943	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1575T>A; p.A525A; 15:59066972-59066972	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2062C>T; p.P688S; 15:59081049-59081049	skin	malignant_melanoma	Substitution - Missense
c.128T>C; p.I43T; 15:59030950-59030950	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2581C>T; p.R861C; 15:59089697-59089697	pancreas	carcinoma	Substitution - Missense
c.837T>C; p.V279V; 15:59031659-59031659	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2653C>T; p.H885Y; 15:59091068-59091068	skin	malignant_melanoma	Substitution - Missense
c.578C>T; p.S193L; 15:59031400-59031400	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1094G>A; p.R365H; 15:59055768-59055768	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1056C>A; p.S352S; 15:59055730-59055730	prostate	adenoma	Substitution - coding silent
c.1056C>A; p.S352S; 15:59055730-59055730	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.284G>A; p.R95H; 15:59031106-59031106	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1056C>A; p.S352S; 15:59055730-59055730	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.662C>T; p.S221F; 15:59031484-59031484	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1978C>T; p.Q660*; 15:59080965-59080965	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1165G>T; p.E389*; 15:59055839-59055839	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1868C>T; p.S623L; 15:59076135-59076135	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1993C>T; p.P665S; 15:59080980-59080980	skin	malignant_melanoma	Substitution - Missense
c.790G>T; p.E264*; 15:59031612-59031612	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.352C>T; p.L118L; 15:59031174-59031174	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.795C>A; p.S265S; 15:59031617-59031617	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2313delC; p.P773fs*44; 15:59084144-59084144	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.2313delC; p.P773fs*44; 15:59084144-59084144	pancreas	carcinoma; acinar_carcinoma	Deletion - Frameshift
c.2313delC; p.P773fs*44; 15:59084144-59084144	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2313delC; p.P773fs*44; 15:59084144-59084144	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1007+2T>C; p.?; 15:59052433-59052433	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.2313delC; p.P773fs*44; 15:59084144-59084144	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2313delC; p.P773fs*44; 15:59084144-59084144	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1557C>T; p.H519H; 15:59066954-59066954	skin	malignant_melanoma	Substitution - coding silent
c.1352G>A; p.G451D; 15:59058536-59058536	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.772G>A; p.E258K; 15:59031594-59031594	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1545_1546insCAC; p.H520_T521insH; 15:59066942-59066943	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - In frame
c.1612C>G; p.P538A; 15:59067009-59067009	pancreas	carcinoma	Substitution - Missense
c.2047T>C; p.Y683H; 15:59081034-59081034	skin	malignant_melanoma	Substitution - Missense
c.948A>C; p.E316D; 15:59052372-59052372	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1987G>C; p.A663P; 15:59080974-59080974	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2173C>T; p.P725S; 15:59081160-59081160	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.259A>C; p.K87Q; 15:59031081-59031081	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1088G>A; p.R363Q; 15:59055762-59055762	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.2740-5C>A; p.?; 15:59092532-59092532	liver	carcinoma	Unknown
c.1679A>T; p.H560L; 15:59067076-59067076	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2740-5C>A; p.?; 15:59092532-59092532	liver	carcinoma	Unknown
c.1881G>A; p.A627A; 15:59076148-59076148	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.883A>G; p.S295G; 15:59052307-59052307	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.2297+2T>C; p.?; 15:59081286-59081286	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.683_684delAA; p.K229fs*23; 15:59031505-59031506	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.256G>T; p.E86*; 15:59031078-59031078	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.683delA; p.E230fs*4; 15:59031505-59031505	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2605G>C; p.G869R; 15:59089721-59089721	skin	malignant_melanoma	Substitution - Missense
c.1849T>C; p.S617P; 15:59076116-59076116	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1337_1351del15; p.N447_G451delNSTTG; 15:59058521-59058535	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Deletion - In frame
c.1337_1351del15; p.N447_G451delNSTTG; 15:59058521-59058535	breast	carcinoma	Deletion - In frame
c.1358C>T; p.S453F; 15:59058542-59058542	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.711G>T; p.K237N; 15:59031533-59031533	breast	carcinoma	Substitution - Missense
c.1813C>T; p.Q605*; 15:59076080-59076080	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Nonsense
c.2801G>T; p.C934F; 15:59092598-59092598	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.981G>T; p.E327D; 15:59052405-59052405	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1813C>T; p.Q605*; 15:59076080-59076080	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_therapy_related	Substitution - Nonsense
c.267C>T; p.L89L; 15:59031089-59031089	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1801A>G; p.I601V; 15:59076068-59076068	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1008G>A; p.R336R; 15:59055682-59055682	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.731G>A; p.R244Q; 15:59031553-59031553	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1959G>C; p.L653F; 15:59080946-59080946	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1911_1914delCTCT; p.L639fs*14; 15:59076178-59076181	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1911_1914delCTCT; p.L639fs*14; 15:59076178-59076181	breast	carcinoma	Deletion - Frameshift
c.881-1G>A; p.?; 15:59052304-59052304	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1268C>T; p.S423F; 15:59058452-59058452	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2164C>T; p.Q722*; 15:59081151-59081151	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2848C>A; p.L950I; 15:59094787-59094787	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2734delA; p.K913fs*29; 15:59091149-59091149	stomach	adenocarcinoma	Deletion - Frameshift
c.2033C>T; p.P678L; 15:59081020-59081020	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1255T>C; p.S419P; 15:59058439-59058439	pancreas	carcinoma	Substitution - Missense
c.2710A>G; p.R904G; 15:59091125-59091125	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1358C>G; p.S453C; 15:59058542-59058542	urinary_tract; bladder	carcinoma	Substitution - Missense
c.238_239GG>AA; p.G80N; 15:59031060-59031061	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1819G>A; p.A607T; 15:59076086-59076086	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1701G>A; p.V567V; 15:59075968-59075968	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.250G>T; p.E84*; 15:59031072-59031072	liver	carcinoma	Substitution - Nonsense
c.892G>A; p.E298K; 15:59052316-59052316	urinary_tract; bladder	carcinoma	Substitution - Missense
c.250G>T; p.E84*; 15:59031072-59031072	liver	carcinoma	Substitution - Nonsense
c.1007+1G>T; p.?; 15:59052432-59052432	ovary	carcinoma; serous_carcinoma	Unknown
c.1345A>C; p.T449P; 15:59058529-59058529	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2712A>T; p.R904S; 15:59091127-59091127	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1345A>C; p.T449P; 15:59058529-59058529	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.246G>A; p.Q82Q; 15:59031068-59031068	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2038C>G; p.Q680E; 15:59081025-59081025	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1322C>T; p.S441L; 15:59058506-59058506	urinary_tract; bladder	carcinoma	Substitution - Missense
c.565A>G; p.T189A; 15:59031387-59031387	liver	carcinoma	Substitution - Missense
c.565A>G; p.T189A; 15:59031387-59031387	liver	carcinoma	Substitution - Missense
c.1487C>T; p.A496V; 15:59066884-59066884	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.988A>C; p.T330P; 15:59052412-59052412	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2845C>T; p.R949C; 15:59094784-59094784	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2437G>T; p.E813*; 15:59085672-59085672	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1793G>A; p.R598Q; 15:59076060-59076060	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1793G>A; p.R598Q; 15:59076060-59076060	breast	carcinoma	Substitution - Missense
c.655A>C; p.N219H; 15:59031477-59031477	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2306A>G; p.H769R; 15:59084137-59084137	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1322delC; p.S441fs*1; 15:59058506-59058506	lung	carcinoma; large_cell_carcinoma	Deletion - Frameshift
c.2110C>T; p.P704S; 15:59081097-59081097	skin	malignant_melanoma	Substitution - Missense
c.2801G>A; p.C934Y; 15:59092598-59092598	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.2403G>A; p.Q801Q; 15:59084234-59084234	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.644G>T; p.R215I; 15:59031466-59031466	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1724G>T; p.R575I; 15:59075991-59075991	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2225_2226delCA; p.Q743fs*6; 15:59081212-59081213	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1915C>A; p.L639I; 15:59076182-59076182	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.104G>A; p.G35E; 15:59030926-59030926	skin	malignant_melanoma	Substitution - Missense
c.2860C>T; p.H954Y; 15:59094799-59094799	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1326T>C; p.A442A; 15:59058510-59058510	pancreas	carcinoma	Substitution - coding silent
c.2860C>T; p.H954Y; 15:59094799-59094799	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1326T>C; p.A442A; 15:59058510-59058510	pancreas	carcinoma	Substitution - coding silent
c.1739G>A; p.G580D; 15:59076006-59076006	liver	carcinoma	Substitution - Missense
c.1300C>A; p.P434T; 15:59058484-59058484	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1983T>C; p.A661A; 15:59080970-59080970	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1373C>G; p.S458*; 15:59066770-59066770	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.874C>T; p.P292S; 15:59031696-59031696	skin	malignant_melanoma	Substitution - Missense
c.2424G>C; p.W808C; 15:59085659-59085659	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.2424G>C; p.W808C; 15:59085659-59085659	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2864T>G; p.L955R; 15:59094803-59094803	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1871G>T; p.S624I; 15:59076138-59076138	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.758C>G; p.S253C; 15:59031580-59031580	urinary_tract; bladder	carcinoma	Substitution - Missense
c.730C>T; p.R244*; 15:59031552-59031552	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.730C>T; p.R244*; 15:59031552-59031552	skin	malignant_melanoma	Substitution - Nonsense
c.2300G>A; p.R767Q; 15:59084131-59084131	stomach	adenocarcinoma	Substitution - Missense
c.1792C>T; p.R598*; 15:59076059-59076059	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1792C>T; p.R598*; 15:59076059-59076059	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1792C>T; p.R598*; 15:59076059-59076059	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.128T>A; p.I43N; 15:59030950-59030950	breast	carcinoma	Substitution - Missense
c.2010delC; p.P672fs*42; 15:59080997-59080997	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2311C>T; p.R771C; 15:59084142-59084142	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2187G>T; p.Q729H; 15:59081174-59081174	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2187G>T; p.Q729H; 15:59081174-59081174	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.277delA; p.K94fs*23; 15:59031099-59031099	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.568G>T; p.E190*; 15:59031390-59031390	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2712A>G; p.R904R; 15:59091127-59091127	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2712A>G; p.R904R; 15:59091127-59091127	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2712A>G; p.R904R; 15:59091127-59091127	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1681G>T; p.E561*; 15:59067078-59067078	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2672G>C; p.G891A; 15:59091087-59091087	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1184T>C; p.V395A; 15:59058368-59058368	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1667G>A; p.G556D; 15:59067064-59067064	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1288A>C; p.T430P; 15:59058472-59058472	breast	carcinoma	Substitution - Missense
c.2187G>C; p.Q729H; 15:59081174-59081174	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.214C>G; p.Q72E; 15:59031036-59031036	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.214C>G; p.Q72E; 15:59031036-59031036	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2468C>T; p.P823L; 15:59085703-59085703	breast	carcinoma	Substitution - Missense
c.2687G>A; p.G896E; 15:59091102-59091102	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.2687G>A; p.G896E; 15:59091102-59091102	urinary_tract; bladder	carcinoma	Substitution - Missense
c.698T>G; p.L233*; 15:59031520-59031520	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2056C>T; p.P686S; 15:59081043-59081043	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1531C>T; p.H511Y; 15:59066928-59066928	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2297+1G>A; p.?; 15:59081285-59081285	breast	carcinoma	Unknown
c.1909C>T; p.P637S; 15:59076176-59076176	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2705T>C; p.I902T; 15:59091120-59091120	breast	carcinoma	Substitution - Missense
c.2705T>C; p.I902T; 15:59091120-59091120	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.1327A>C; p.T443P; 15:59058511-59058511	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2744A>T; p.K915I; 15:59092541-59092541	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.703C>T; p.Q235*; 15:59031525-59031525	prostate	carcinoma	Substitution - Nonsense
c.536C>T; p.A179V; 15:59031358-59031358	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2488T>C; p.L830L; 15:59085723-59085723	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2177C>T; p.P726L; 15:59081164-59081164	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.617C>T; p.S206L; 15:59031439-59031439	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1545T>C; p.H515H; 15:59066942-59066942	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1416T>C; p.P472P; 15:59066813-59066813	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2670A>C; p.L890F; 15:59091085-59091085	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2512C>T; p.R838*; 15:59085747-59085747	stomach	adenocarcinoma	Substitution - Nonsense
c.189A>C; p.E63D; 15:59031011-59031011	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2512C>T; p.R838*; 15:59085747-59085747	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.478G>T; p.E160*; 15:59031300-59031300	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]