Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

54979

Name

HRASLS2

Synonymous

HRAS-like suppressor 2;HRASLS2;HRAS-like suppressor 2

Definition

-

Position

11q12.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.13.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.141G>C; p.A47A; 11:63558638-63558638

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.141G>C; p.A47A; 11:63558638-63558638

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.405G>A; p.T135T; 11:63553048-63553048

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.155C>T; p.S52F; 11:63558624-63558624

 skinmalignant_melanomaSubstitution - Missense

c.75C>T; p.A25A; 11:63560128-63560128

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.140C>T; p.A47V; 11:63558639-63558639

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.307G>T; p.E103*; 11:63558472-63558472

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.392C>T; p.T131I; 11:63553061-63553061

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.140C>T; p.A47V; 11:63558639-63558639

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.292G>A; p.E98K; 11:63558487-63558487

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.31G>A; p.G11R; 11:63560172-63560172

 skinmalignant_melanomaSubstitution - Missense

c.121G>A; p.E41K; 11:63558658-63558658

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.209G>T; p.G70V; 11:63558570-63558570

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.452G>T; p.G151V; 11:63553001-63553001

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.210G>T; p.G70G; 11:63558569-63558569

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.361C>T; p.R121C; 11:63558418-63558418

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.440C>T; p.A147V; 11:63553013-63553013

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.351G>A; p.V117V; 11:63558428-63558428

 skinmalignant_melanomaSubstitution - coding silent

c.151C>T; p.L51L; 11:63558628-63558628

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.164_165CC>TT; p.T55I; 11:63558614-63558615

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.16C>T; p.P6S; 11:63560187-63560187

 skinmalignant_melanomaSubstitution - Missense

c.192G>T; p.L64L; 11:63558587-63558587

 autonomic_ganglianeuroblastomaSubstitution - coding silent

c.43G>T; p.E15*; 11:63560160-63560160

 skinmalignant_melanomaSubstitution - Nonsense

c.248G>A; p.R83K; 11:63558531-63558531

 skinmalignant_melanomaSubstitution - Missense

c.113C>T; p.P38L; 11:63560090-63560090

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.476G>A; p.R159Q; 11:63552977-63552977

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.50C>A; p.S17Y; 11:63560153-63560153

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.151C>A; p.L51M; 11:63558628-63558628

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.478G>A; p.E160K; 11:63552975-63552975

 skinmalignant_melanomaSubstitution - Missense

c.478G>A; p.E160K; 11:63552975-63552975

 skinmalignant_melanomaSubstitution - Missense

c.348C>T; p.F116F; 11:63558431-63558431

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.12C>G; p.A4A; 11:63560191-63560191

 ovaryother; neoplasmSubstitution - coding silent

c.93C>G; p.G31G; 11:63560110-63560110

 breastcarcinoma; ductal_carcinomaSubstitution - coding silent

c.372C>T; p.V124V; 11:63558407-63558407

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.405G>C; p.T135T; 11:63553048-63553048

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.405G>C; p.T135T; 11:63553048-63553048

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - coding silent

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