Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

55233

Name

MOB1A

Synonymous

MOB kinase activator 1A;MOB1A;MOB kinase activator 1A

Definition

MOB1 Mps One Binder homolog A|MOB1, Mps One Binder kinase activator-like 1B|mob1 alpha|mob1 homolog 1B|mps one binder kinase activator-like 1B

Position

2p13.1

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.48G>T; p.K16N; 2:74172719-74172719

 breastcarcinomaSubstitution - Missense

c.426G>A; p.S142S; 2:74165201-74165201

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.426G>A; p.S142S; 2:74165201-74165201

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.142C>T; p.P48S; 2:74172625-74172625

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.208A>G; p.M70V; 2:74167081-74167081

 livercarcinomaSubstitution - Missense

c.426G>T; p.S142S; 2:74165201-74165201

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.426G>T; p.S142S; 2:74165201-74165201

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

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