Entrez Gene

Basic Information
Gene ID	55717
Name	WDR11
Synonymous	WD repeat domain 11;WDR11;WD repeat domain 11
Definition	WD repeat domain 15\|WD repeat-containing protein 11\|WD repeat-containing protein 15\|bromodomain and WD repeat-containing protein 2
Position	10q26
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.10.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.3132C>T; p.G1044G; 10:120904750-120904750	skin	malignant_melanoma	Substitution - coding silent
c.1803_1804CC>TT; p.L602F; 10:120883843-120883844	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1A>T; p.M1L; 10:120851421-120851421	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.869C>T; p.P290L; 10:120865202-120865202	skin	malignant_melanoma	Substitution - Missense
c.3181G>A; p.G1061S; 10:120904799-120904799	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.3469G>A; p.V1157M; 10:120906807-120906807	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2024C>T; p.A675V; 10:120886739-120886739	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.8C>T; p.P3L; 10:120851428-120851428	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2561C>A; p.A854D; 10:120900074-120900074	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2422A>G; p.K808E; 10:120890794-120890794	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2483C>T; p.A828V; 10:120890855-120890855	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.360G>A; p.Q120Q; 10:120860116-120860116	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.3384C>T; p.L1128L; 10:120905968-120905968	skin	malignant_melanoma	Substitution - coding silent
c.416A>G; p.N139S; 10:120860172-120860172	thyroid	carcinoma	Substitution - Missense
c.1662A>G; p.T554T; 10:120878458-120878458	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2232A>G; p.G744G; 10:120889898-120889898	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1634A>G; p.N545S; 10:120878430-120878430	liver	carcinoma	Substitution - Missense
c.1553T>G; p.V518G; 10:120873920-120873920	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1024G>C; p.D342H; 10:120866598-120866598	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.709C>T; p.P237S; 10:120862917-120862917	skin	malignant_melanoma	Substitution - Missense
c.1146A>G; p.I382M; 10:120866720-120866720	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2289T>C; p.N763N; 10:120889955-120889955	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1030C>T; p.R344*; 10:120866604-120866604	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1526A>T; p.K509I; 10:120873893-120873893	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.930T>C; p.G310G; 10:120865680-120865680	skin	malignant_melanoma	Substitution - coding silent
c.1119C>T; p.L373L; 10:120866693-120866693	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3363C>G; p.V1121V; 10:120905947-120905947	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1502A>G; p.H501R; 10:120873869-120873869	prostate	carcinoma	Substitution - Missense
c.1987G>A; p.A663T; 10:120886702-120886702	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.714-9delT; p.?; 10:120865038-120865038	stomach	adenocarcinoma	Unknown
c.3345C>T; p.H1115H; 10:120905929-120905929	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1328G>A; p.R443K; 10:120871203-120871203	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.683T>C; p.V228A; 10:120862891-120862891	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.944G>A; p.R315H; 10:120865694-120865694	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2663A>G; p.Q888R; 10:120901074-120901074	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2123G>A; p.G708E; 10:120889079-120889079	urinary_tract; bladder	carcinoma	Substitution - Missense
c.141T>G; p.D47E; 10:120852578-120852578	thyroid	carcinoma	Substitution - Missense
c.3088G>C; p.D1030H; 10:120904706-120904706	central_nervous_system; brain	glioma	Substitution - Missense
c.275A>G; p.N92S; 10:120858719-120858719	breast	carcinoma	Substitution - Missense
c.1191-8C>A; p.?; 10:120867058-120867058	liver	carcinoma	Unknown
c.89G>A; p.G30D; 10:120852526-120852526	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1191-8C>A; p.?; 10:120867058-120867058	liver	carcinoma	Unknown
c.465G>C; p.K155N; 10:120860221-120860221	urinary_tract; bladder	carcinoma	Substitution - Missense
c.834G>A; p.T278T; 10:120865167-120865167	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2297T>G; p.L766*; 10:120889963-120889963	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2297T>G; p.L766*; 10:120889963-120889963	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.939_940delTT; p.L314fs*7; 10:120865689-120865690	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.3592C>T; p.L1198F; 10:120908630-120908630	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2999G>A; p.C1000Y; 10:120904114-120904114	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1844C>A; p.A615D; 10:120883884-120883884	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2390G>A; p.R797H; 10:120890762-120890762	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3318C>T; p.A1106A; 10:120905902-120905902	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.552C>T; p.F184F; 10:120862760-120862760	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2252G>C; p.W751S; 10:120889918-120889918	breast	carcinoma	Substitution - Missense
c.1770A>G; p.K590K; 10:120883810-120883810	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2414C>T; p.T805M; 10:120890786-120890786	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3393C>T; p.L1131L; 10:120905977-120905977	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2430C>A; p.I810I; 10:120890802-120890802	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2430C>A; p.I810I; 10:120890802-120890802	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.898C>T; p.R300C; 10:120865648-120865648	pancreas	carcinoma	Substitution - Missense
c.898C>T; p.R300C; 10:120865648-120865648	pancreas	carcinoma	Substitution - Missense
c.898C>T; p.R300C; 10:120865648-120865648	pancreas	carcinoma	Substitution - Missense
c.1066G>A; p.V356I; 10:120866640-120866640	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.276T>C; p.N92N; 10:120858720-120858720	skin	malignant_melanoma	Substitution - coding silent
c.2164A>G; p.T722A; 10:120889120-120889120	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.25A>G; p.K9E; 10:120851445-120851445	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1305A>T; p.A435A; 10:120871180-120871180	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.156A>C; p.Q52H; 10:120852593-120852593	pancreas	carcinoma	Substitution - Missense
c.686A>G; p.K229R; 10:120862894-120862894	breast	carcinoma	Substitution - Missense
c.1442T>A; p.I481N; 10:120871317-120871317	liver	carcinoma	Substitution - Missense
c.703G>C; p.E235Q; 10:120862911-120862911	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.343C>T; p.P115S; 10:120858787-120858787	skin	malignant_melanoma	Substitution - Missense
c.3382C>T; p.L1128F; 10:120905966-120905966	skin	malignant_melanoma	Substitution - Missense
c.3382C>T; p.L1128F; 10:120905966-120905966	skin	malignant_melanoma	Substitution - Missense
c.3343C>A; p.H1115N; 10:120905927-120905927	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.343C>T; p.P115S; 10:120858787-120858787	skin	malignant_melanoma	Substitution - Missense
c.2731C>T; p.Q911*; 10:120902300-120902300	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1837A>G; p.I613V; 10:120883877-120883877	breast	carcinoma	Substitution - Missense
c.2731C>T; p.Q911*; 10:120902300-120902300	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.609A>G; p.I203M; 10:120862817-120862817	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.609A>G; p.I203M; 10:120862817-120862817	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3234C>T; p.D1078D; 10:120905359-120905359	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.282G>C; p.K94N; 10:120858726-120858726	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.797G>C; p.R266P; 10:120865130-120865130	liver	carcinoma	Substitution - Missense
c.2095A>T; p.K699*; 10:120886810-120886810	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1997_2007del11; p.L669fs*13; 10:120886712-120886722	breast	carcinoma	Deletion - Frameshift
c.3429G>A; p.T1143T; 10:120906013-120906013	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.3429G>A; p.T1143T; 10:120906013-120906013	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1654C>T; p.L552F; 10:120878450-120878450	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2931+1G>T; p.?; 10:120903233-120903233	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.3331C>T; p.R1111W; 10:120905915-120905915	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3331C>T; p.R1111W; 10:120905915-120905915	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2716G>T; p.E906*; 10:120902285-120902285	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.337G>A; p.A113T; 10:120858781-120858781	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1794G>T; p.R598S; 10:120883834-120883834	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1052G>T; p.R351M; 10:120866626-120866626	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.6G>A; p.L2L; 10:120851426-120851426	liver	carcinoma	Substitution - coding silent
c.6G>A; p.L2L; 10:120851426-120851426	liver	carcinoma	Substitution - coding silent
c.2160T>G; p.G720G; 10:120889116-120889116	breast	carcinoma	Substitution - coding silent
c.132A>T; p.V44V; 10:120852569-120852569	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.132A>T; p.V44V; 10:120852569-120852569	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3661C>T; p.P1221S; 10:120908699-120908699	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.887C>T; p.P296L; 10:120865637-120865637	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.199-7G>C; p.?; 10:120858636-120858636	stomach	carcinoma; adenocarcinoma	Unknown
c.3028-1G>A; p.?; 10:120904645-120904645	kidney	carcinoma; papillary_renal_cell_carcinoma	Unknown
c.40A>G; p.T14A; 10:120851460-120851460	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1607C>T; p.T536I; 10:120878403-120878403	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1868A>G; p.N623S; 10:120885833-120885833	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1174C>A; p.R392R; 10:120866748-120866748	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.958T>C; p.Y320H; 10:120865708-120865708	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.494C>A; p.S165Y; 10:120860250-120860250	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.584C>T; p.S195L; 10:120862792-120862792	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.15A>T; p.T5T; 10:120851435-120851435	ovary	other; neoplasm	Substitution - coding silent
c.3592C>A; p.L1198I; 10:120908630-120908630	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1681C>T; p.R561C; 10:120880843-120880843	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2266C>T; p.R756C; 10:120889932-120889932	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.759G>T; p.L253L; 10:120865092-120865092	large_intestine; colon	NS	Substitution - coding silent
c.1899A>T; p.A633A; 10:120885864-120885864	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1945C>A; p.L649M; 10:120885910-120885910	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1882A>G; p.R628G; 10:120885847-120885847	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.871delT; p.L292fs*3; 10:120865204-120865204	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.871delT; p.L292fs*3; 10:120865204-120865204	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.439G>A; p.D147N; 10:120860195-120860195	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1713C>T; p.I571I; 10:120880875-120880875	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.439G>A; p.D147N; 10:120860195-120860195	prostate	carcinoma	Substitution - Missense
c.585A>G; p.S195S; 10:120862793-120862793	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.3499G>T; p.E1167*; 10:120906837-120906837	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.387C>T; p.R129R; 10:120860143-120860143	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1500C>T; p.Y500Y; 10:120873867-120873867	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3397T>A; p.S1133T; 10:120905981-120905981	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.2661_2662CC>TT; p.Q888*; 10:120901072-120901073	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.823G>C; p.V275L; 10:120865156-120865156	urinary_tract; bladder	carcinoma	Substitution - Missense
c.823G>C; p.V275L; 10:120865156-120865156	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2821C>T; p.Q941*; 10:120903122-120903122	ovary	other; neoplasm	Substitution - Nonsense
c.295G>C; p.D99H; 10:120858739-120858739	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1198G>T; p.G400C; 10:120867073-120867073	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.411G>A; p.P137P; 10:120860167-120860167	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.603T>G; p.V201V; 10:120862811-120862811	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.243A>G; p.P81P; 10:120858687-120858687	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1372G>C; p.G458R; 10:120871247-120871247	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1634A>T; p.N545I; 10:120878430-120878430	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1282G>A; p.D428N; 10:120867157-120867157	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1291A>T; p.I431F; 10:120867166-120867166	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.3472G>A; p.E1158K; 10:120906810-120906810	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1393G>A; p.A465T; 10:120871268-120871268	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.705G>A; p.E235E; 10:120862913-120862913	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.3194-1G>A; p.?; 10:120905318-120905318	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1574delG; p.S525fs*2; 10:120878370-120878370	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.3351T>C; p.C1117C; 10:120905935-120905935	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2331G>T; p.W777C; 10:120889997-120889997	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.755A>G; p.Y252C; 10:120865088-120865088	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2808G>A; p.L936L; 10:120903109-120903109	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.A372A; 10:120866690-120866690	skin	malignant_melanoma	Substitution - coding silent
c.1542C>T; p.H514H; 10:120873909-120873909	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.191T>C; p.V64A; 10:120852628-120852628	skin	malignant_melanoma	Substitution - Missense
c.1411C>T; p.R471C; 10:120871286-120871286	skin	malignant_melanoma	Substitution - Missense
c.1411C>T; p.R471C; 10:120871286-120871286	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.759G>A; p.L253L; 10:120865092-120865092	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; follicular_lymphoma	Substitution - coding silent
c.1411C>T; p.R471C; 10:120871286-120871286	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2898C>T; p.C966C; 10:120903199-120903199	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1554C>A; p.V518V; 10:120873921-120873921	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1827C>T; p.N609N; 10:120883867-120883867	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2932A>C; p.K978Q; 10:120904047-120904047	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2944G>C; p.E982Q; 10:120904059-120904059	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.212G>A; p.R71K; 10:120858656-120858656	liver	carcinoma	Substitution - Missense
c.212G>A; p.R71K; 10:120858656-120858656	liver	carcinoma	Substitution - Missense
c.3203A>G; p.Q1068R; 10:120905328-120905328	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2304A>G; p.A768A; 10:120889970-120889970	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2304A>G; p.A768A; 10:120889970-120889970	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.3203A>G; p.Q1068R; 10:120905328-120905328	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2958G>A; p.L986L; 10:120904073-120904073	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2958G>A; p.L986L; 10:120904073-120904073	thyroid	other; neoplasm	Substitution - coding silent
c.2148C>T; p.I716I; 10:120889104-120889104	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.3292-1G>T; p.?; 10:120905875-120905875	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.1664-10G>T; p.?; 10:120880816-120880816	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.1783T>A; p.W595R; 10:120883823-120883823	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1783T>A; p.W595R; 10:120883823-120883823	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1783T>A; p.W595R; 10:120883823-120883823	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1783T>A; p.W595R; 10:120883823-120883823	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1783T>A; p.W595R; 10:120883823-120883823	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1783T>A; p.W595R; 10:120883823-120883823	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]