Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

5655

Name

KLK10

Synonymous

kallikrein-related peptidase 10;KLK10;kallikrein-related peptidase 10

Definition

breast normal epithelial cell associated serine protease|kallikrein 10 protein 1|kallikrein 10 protein 12|kallikrein 10 protein 2|kallikrein 10 protein 3|kallikrein 10 protein 4|kallikrein 10 protein 7|kallikrein 10 protein 8|kallikrein 10 protein 9|kalli

Position

19q13

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.03.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.54G>T; p.A18A; 19:51019077-51019077

 lungcarcinoma; small_cell_carcinomaSubstitution - coding silent

c.751G>A; p.G251S; 19:51014880-51014880

 skinmalignant_melanomaSubstitution - Missense

c.778A>T; p.T260S; 19:51014853-51014853

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.318A>C; p.G106G; 19:51016108-51016108

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.729C>A; p.L243L; 19:51014902-51014902

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.317G>T; p.G106V; 19:51016109-51016109

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.317G>T; p.G106V; 19:51016109-51016109

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.158C>T; p.A53V; 19:51017221-51017221

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.172C>T; p.P58S; 19:51017207-51017207

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.349G>T; p.V117F; 19:51016077-51016077

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.349G>T; p.V117F; 19:51016077-51016077

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.803G>A; p.W268*; 19:51014828-51014828

 large_intestine; rectumNSSubstitution - Nonsense

c.429G>A; p.L143L; 19:51015997-51015997

 livercarcinomaSubstitution - coding silent

c.368A>G; p.Q123R; 19:51016058-51016058

 breastcarcinomaSubstitution - Missense

c.3G>A; p.M1I; 19:51019128-51019128

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.804G>C; p.W268C; 19:51014827-51014827

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.814G>T; p.V272F; 19:51014817-51014817

 oesophaguscarcinomaSubstitution - Missense

c.780C>T; p.T260T; 19:51014851-51014851

 skinmalignant_melanomaSubstitution - coding silent

c.617C>T; p.P206L; 19:51015478-51015478

 skinmalignant_melanomaSubstitution - Missense

c.316G>A; p.G106R; 19:51016110-51016110

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.316G>A; p.G106R; 19:51016110-51016110

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.619G>T; p.G207C; 19:51015476-51015476

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.591C>A; p.S197R; 19:51015504-51015504

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.802T>C; p.W268R; 19:51014829-51014829

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.35C>G; p.S12C; 19:51019096-51019096

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.802T>C; p.W268R; 19:51014829-51014829

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.213C>T; p.C71C; 19:51017166-51017166

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.805A>G; p.I269V; 19:51014826-51014826

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.417G>A; p.M139I; 19:51016009-51016009

 ovaryother; neoplasmSubstitution - Missense

c.163G>T; p.G55C; 19:51017216-51017216

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.447G>A; p.L149L; 19:51015979-51015979

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.108C>T; p.L36L; 19:51017271-51017271

 skinmalignant_melanomaSubstitution - coding silent

c.423G>A; p.L141L; 19:51016003-51016003

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.804G>A; p.W268*; 19:51014827-51014827

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.34T>A; p.S12T; 19:51019097-51019097

 prostatecarcinomaSubstitution - Missense

c.341G>A; p.R114H; 19:51016085-51016085

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.658C>T; p.R220W; 19:51015437-51015437

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.821G>A; p.R274H; 19:51014810-51014810

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.394C>T; p.R132*; 19:51016032-51016032

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.408C>T; p.H136H; 19:51016018-51016018

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.731C>T; p.S244L; 19:51014900-51014900

 skin; neckmalignant_melanomaSubstitution - Missense

c.216G>T; p.A72A; 19:51017163-51017163

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - coding silent

c.163G>A; p.G55S; 19:51017216-51017216

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; plasma_cell_myelomaSubstitution - Missense

c.303_308delGCTGCT; p.L103_L104delLL; 19:51016118-51016123

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaDeletion - In frame

c.786C>A; p.I262I; 19:51014845-51014845

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.329G>A; p.R110H; 19:51016097-51016097

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.746C>T; p.P249L; 19:51014885-51014885

 skinmalignant_melanomaSubstitution - Missense

c.746C>T; p.P249L; 19:51014885-51014885

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.803G>T; p.W268L; 19:51014828-51014828

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.803G>T; p.W268L; 19:51014828-51014828

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.585C>A; p.I195I; 19:51015510-51015510

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - coding silent

c.314A>G; p.Q105R; 19:51016112-51016112

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.314A>G; p.Q105R; 19:51016112-51016112

 large_intestine; coloncarcinomaSubstitution - Missense

c.314A>G; p.Q105R; 19:51016112-51016112

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.659G>A; p.R220Q; 19:51015436-51015436

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.727C>T; p.L243F; 19:51014904-51014904

 skinmalignant_melanomaSubstitution - Missense

c.762G>A; p.Q254Q; 19:51014869-51014869

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.682G>A; p.D228N; 19:51014949-51014949

 breastcarcinomaSubstitution - Missense

c.609C>T; p.V203V; 19:51015486-51015486

 central_nervous_system; braingliomaSubstitution - coding silent

c.336C>G; p.T112T; 19:51016090-51016090

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.336C>G; p.T112T; 19:51016090-51016090

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - coding silent

c.336C>G; p.T112T; 19:51016090-51016090

 thyroidother; neoplasmSubstitution - coding silent

c.148T>G; p.S50A; 19:51017231-51017231

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.148T>G; p.S50A; 19:51017231-51017231

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.148T>G; p.S50A; 19:51017231-51017231

 thyroidother; neoplasmSubstitution - Missense

c.148T>G; p.S50A; 19:51017231-51017231

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.148T>G; p.S50A; 19:51017231-51017231

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.108C>A; p.L36L; 19:51017271-51017271

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

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