Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

56925

Name

LXN

Synonymous

latexin;LXN;latexin

Definition

MUM|endogenous carboxypeptidase inhibitor|tissue carboxypeptidase inhibitor

Position

3q25.32

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.158A>G; p.H53R; 3:158670991-158670991

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.571G>A; p.E191K; 3:158666744-158666744

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.278G>C; p.G93A; 3:158669525-158669525

 pancreascarcinoma; acinar_carcinomaSubstitution - Missense

c.623A>C; p.K208T; 3:158666692-158666692

 livercarcinomaSubstitution - Missense

c.194A>G; p.Q65R; 3:158669609-158669609

 skinmalignant_melanomaSubstitution - Missense

c.335C>G; p.S112C; 3:158669468-158669468

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.335C>G; p.S112C; 3:158669468-158669468

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.587A>G; p.Q196R; 3:158666728-158666728

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.189A>C; p.Q63H; 3:158670960-158670960

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.83C>A; p.P28Q; 3:158672396-158672396

 skinmalignant_melanomaSubstitution - Missense

c.356C>T; p.A119V; 3:158669447-158669447

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.11C>T; p.P4L; 3:158672468-158672468

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.640C>A; p.R214S; 3:158666675-158666675

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.338T>C; p.M113T; 3:158669465-158669465

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.54G>A; p.Q18Q; 3:158672425-158672425

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.595G>C; p.V199L; 3:158666720-158666720

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.508-1G>A; p.?; 3:158667075-158667075

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.508-1G>A; p.?; 3:158667075-158667075

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.508-1G>A; p.?; 3:158667075-158667075

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.508-1G>A; p.?; 3:158667075-158667075

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.508-1G>A; p.?; 3:158667075-158667075

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.508-1G>A; p.?; 3:158667075-158667075

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.508-1G>A; p.?; 3:158667075-158667075

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.508-1G>A; p.?; 3:158667075-158667075

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.280G>T; p.E94*; 3:158669523-158669523

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.405C>T; p.L135L; 3:158669098-158669098

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.405C>T; p.L135L; 3:158669098-158669098

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.250G>A; p.A84T; 3:158669553-158669553

 breastcarcinomaSubstitution - Missense

c.104A>T; p.Q35L; 3:158672375-158672375

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.241C>T; p.Q81*; 3:158669562-158669562

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.651G>T; p.K217N; 3:158666664-158666664

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.76G>T; p.G26W; 3:158672403-158672403

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.328C>T; p.L110F; 3:158669475-158669475

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.401C>T; p.T134M; 3:158669102-158669102

 thyroidcarcinoma; medullary_carcinomaSubstitution - Missense

c.67T>C; p.Y23H; 3:158672412-158672412

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.196G>A; p.V66I; 3:158669607-158669607

 skinmalignant_melanomaSubstitution - Missense

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