| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 57727 |
Name | NCOA5 |
Synonymous | nuclear receptor coactivator 5;NCOA5;nuclear receptor coactivator 5 |
Definition | NCoA-5|coactivator independent of AF-2 |
Position | 20q13.12 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.11. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.184G>C; p.D62H; 20:46070391-46070391 |
kidney | other; neoplasm | Substitution - Missense |
c.607A>G; p.I203V; 20:46067077-46067077 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.181C>T; p.R61W; 20:46070394-46070394 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.290G>A; p.R97K; 20:46070285-46070285 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.8C>T; p.T3M; 20:46079417-46079417 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.523C>T; p.R175W; 20:46067161-46067161 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.460G>T; p.G154*; 20:46068544-46068544 |
skin; ear | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |
c.1118G>T; p.R373L; 20:46063392-46063392 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1179G>A; p.A393A; 20:46062861-46062861 |
stomach | carcinoma; diffuse_adenocarcinoma | Substitution - coding silent |
c.1358C>T; p.P453L; 20:46062682-46062682 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.936G>T; p.Q312H; 20:46063574-46063574 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1546C>T; p.L516L; 20:46062494-46062494 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.355C>T; p.P119S; 20:46070220-46070220 |
skin | malignant_melanoma | Substitution - Missense |
c.244C>T; p.R82W; 20:46070331-46070331 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.35G>A; p.R12Q; 20:46079390-46079390 |
breast | carcinoma | Substitution - Missense |
c.35G>A; p.R12Q; 20:46079390-46079390 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.462A>G; p.G154G; 20:46068542-46068542 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1367C>T; p.A456V; 20:46062673-46062673 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1150G>T; p.G384C; 20:46063360-46063360 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.233T>C; p.V78A; 20:46070342-46070342 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1174G>T; p.G392W; 20:46062866-46062866 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.291G>A; p.R97R; 20:46070284-46070284 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - coding silent |
c.1257C>A; p.P419P; 20:46062783-46062783 |
thyroid | other; neoplasm | Substitution - coding silent |
c.556G>C; p.E186Q; 20:46067128-46067128 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.556G>C; p.E186Q; 20:46067128-46067128 |
lung | carcinoma; bronchioloalveolar_adenocarcinoma | Substitution - Missense |
c.629+4A>G; p.?; 20:46067051-46067051 |
liver | carcinoma | Unknown |
c.1656T>G; p.P552P; 20:46062384-46062384 |
skin | malignant_melanoma | Substitution - coding silent |
c.875G>A; p.R292K; 20:46063635-46063635 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.544C>T; p.R182C; 20:46067140-46067140 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.544C>T; p.R182C; 20:46067140-46067140 |
skin | malignant_melanoma | Substitution - Missense |
c.1434G>T; p.Q478H; 20:46062606-46062606 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.1136C>T; p.T379I; 20:46063374-46063374 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.961A>G; p.I321V; 20:46063549-46063549 |
oesophagus; middle_third | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1138G>A; p.D380N; 20:46063372-46063372 |
liver | carcinoma | Substitution - Missense |
c.752C>T; p.P251L; 20:46065106-46065106 |
skin | malignant_melanoma | Substitution - Missense |
c.1138G>A; p.D380N; 20:46063372-46063372 |
bone | Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour | Substitution - Missense |
c.1138G>A; p.D380N; 20:46063372-46063372 |
liver | carcinoma | Substitution - Missense |
c.269_270delTT; p.F90fs*2; 20:46070305-46070306 |
endometrium | carcinoma; endometrioid_carcinoma | Deletion - Frameshift |
c.1004G>A; p.R335H; 20:46063506-46063506 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.1004G>A; p.R335H; 20:46063506-46063506 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1359delC; p.S454fs*69; 20:46062681-46062681 |
pancreas | carcinoma; acinar_carcinoma | Deletion - Frameshift |
c.1359delC; p.S454fs*69; 20:46062681-46062681 |
large_intestine | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.576T>G; p.F192L; 20:46067108-46067108 |
breast | carcinoma | Substitution - Missense |
c.1682C>T; p.T561I; 20:46062358-46062358 |
skin | malignant_melanoma | Substitution - Missense |
c.1022C>T; p.A341V; 20:46063488-46063488 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1397C>T; p.S466F; 20:46062643-46062643 |
skin | malignant_melanoma | Substitution - Missense |
c.1332G>C; p.V444V; 20:46062708-46062708 |
oesophagus | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1525T>G; p.F509V; 20:46062515-46062515 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.82C>T; p.R28*; 20:46070493-46070493 |
stomach | carcinoma; intestinal_adenocarcinoma | Substitution - Nonsense |
c.82C>T; p.R28*; 20:46070493-46070493 |
stomach | adenocarcinoma | Substitution - Nonsense |
c.1712C>T; p.P571L; 20:46062328-46062328 |
skin | malignant_melanoma | Substitution - Missense |
c.1258A>T; p.T420S; 20:46062782-46062782 |
thyroid | other; neoplasm | Substitution - Missense |
c.1606G>C; p.D536H; 20:46062434-46062434 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.1162C>T; p.R388C; 20:46062878-46062878 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.238G>T; p.D80Y; 20:46070337-46070337 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1427G>C; p.R476T; 20:46062613-46062613 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.1362G>A; p.S454S; 20:46062678-46062678 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.95G>A; p.R32Q; 20:46070480-46070480 |
pancreas | carcinoma | Substitution - Missense |
c.95G>A; p.R32Q; 20:46070480-46070480 |
pancreas | carcinoma | Substitution - Missense |
c.904C>T; p.R302W; 20:46063606-46063606 |
oesophagus; lower_third | carcinoma; adenocarcinoma | Substitution - Missense |
c.290G>T; p.R97M; 20:46070285-46070285 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1117C>A; p.R373R; 20:46063393-46063393 |
oesophagus | carcinoma | Substitution - coding silent |
c.642G>C; p.E214D; 20:46065216-46065216 |
breast | carcinoma | Substitution - Missense |
c.64C>T; p.R22*; 20:46070511-46070511 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.1240C>T; p.L414F; 20:46062800-46062800 |
large_intestine; colon | adenoma | Substitution - Missense |
c.650G>T; p.G217V; 20:46065208-46065208 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.959C>T; p.A320V; 20:46063551-46063551 |
skin | malignant_melanoma | Substitution - Missense |
c.583G>A; p.E195K; 20:46067101-46067101 |
breast | carcinoma | Substitution - Missense |
c.250G>A; p.V84M; 20:46070325-46070325 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.788A>T; p.H263L; 20:46065070-46065070 |
lung | carcinoma; small_cell_carcinoma | Substitution - Missense |
c.1297G>A; p.A433T; 20:46062743-46062743 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.610G>A; p.V204M; 20:46067074-46067074 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.395G>A; p.R132Q; 20:46068609-46068609 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.514C>T; p.R172C; 20:46067170-46067170 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.629A>G; p.K210R; 20:46067055-46067055 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.474A>T; p.P158P; 20:46068530-46068530 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - coding silent |
c.506G>A; p.R169H; 20:46067178-46067178 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1163G>T; p.R388L; 20:46062877-46062877 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.208C>T; p.R70W; 20:46070367-46070367 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.298C>T; p.R100*; 20:46070277-46070277 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.1242C>T; p.L414L; 20:46062798-46062798 |
skin | malignant_melanoma | Substitution - coding silent |
c.570A>G; p.R190R; 20:46067114-46067114 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.437A>T; p.D146V; 20:46068567-46068567 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.94C>T; p.R32*; 20:46070481-46070481 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.1335G>T; p.T445T; 20:46062705-46062705 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.719A>G; p.Q240R; 20:46065139-46065139 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.4A>C; p.N2H; 20:46079421-46079421 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1357C>T; p.P453S; 20:46062683-46062683 |
skin | malignant_melanoma | Substitution - Missense |
c.991G>A; p.E331K; 20:46063519-46063519 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.785T>C; p.I262T; 20:46065073-46065073 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1612C>T; p.P538S; 20:46062428-46062428 |
skin | malignant_melanoma | Substitution - Missense |
c.1359C>T; p.P453P; 20:46062681-46062681 |
breast | carcinoma | Substitution - coding silent |
c.1037T>C; p.I346T; 20:46063473-46063473 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.38+6G>A; p.?; 20:46079381-46079381 |
pancreas | carcinoma | Unknown |
c.703G>C; p.E235Q; 20:46065155-46065155 |
breast | carcinoma | Substitution - Missense |
c.1035C>T; p.L345L; 20:46063475-46063475 |
breast | carcinoma | Substitution - coding silent |
c.963C>T; p.I321I; 20:46063547-46063547 |
skin | malignant_melanoma | Substitution - coding silent |
c.1528G>T; p.G510C; 20:46062512-46062512 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma | Substitution - Missense |
c.963C>T; p.I321I; 20:46063547-46063547 |
skin | malignant_melanoma | Substitution - coding silent |
c.1018C>T; p.P340S; 20:46063492-46063492 |
liver | carcinoma | Substitution - Missense |
c.1018C>T; p.P340S; 20:46063492-46063492 |
liver | carcinoma | Substitution - Missense |
c.587G>A; p.R196K; 20:46067097-46067097 |
oesophagus; lower_third | carcinoma; adenocarcinoma | Substitution - Missense |
c.330C>T; p.Y110Y; 20:46070245-46070245 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1589C>G; p.S530C; 20:46062451-46062451 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1732C>T; p.H578Y; 20:46062308-46062308 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1633G>C; p.D545H; 20:46062407-46062407 |
breast | carcinoma | Substitution - Missense |
c.238G>A; p.D80N; 20:46070337-46070337 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1102C>T; p.R368*; 20:46063408-46063408 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; acute_lymphoblastic_leukaemia | Substitution - Nonsense |
c.238G>A; p.D80N; 20:46070337-46070337 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1329A>C; p.T443T; 20:46062711-46062711 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.1275delC; p.T426fs*19; 20:46062765-46062765 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.193C>T; p.H65Y; 20:46070382-46070382 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1275delC; p.T426fs*19; 20:46062765-46062765 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.1275delC; p.T426fs*19; 20:46062765-46062765 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.186C>T; p.D62D; 20:46070389-46070389 |
skin | malignant_melanoma | Substitution - coding silent |
c.1261C>A; p.P421T; 20:46062779-46062779 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.7A>G; p.T3A; 20:46079418-46079418 |
skin | malignant_melanoma | Substitution - Missense |
c.1678C>G; p.Q560E; 20:46062362-46062362 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |