Entrez Gene

Basic Information
Gene ID	57758
Name	SCUBE2
Synonymous	signal peptide, CUB domain, EGF-like 2;SCUBE2;signal peptide, CUB domain, EGF-like 2
Definition	signal peptide, CUB and EGF-like domain-containing protein 2
Position	11p15.3
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.04.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1637G>A; p.R546Q; 11:9048014-9048014	skin	malignant_melanoma	Substitution - Missense
c.1610G>A; p.G537D; 11:9048041-9048041	skin	malignant_melanoma	Substitution - Missense
c.1972C>T; p.P658S; 11:9033740-9033740	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2547C>T; p.I849I; 11:9027431-9027431	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2547C>T; p.I849I; 11:9027431-9027431	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2612C>T; p.T871I; 11:9027366-9027366	skin	malignant_melanoma	Substitution - Missense
c.204C>A; p.S68S; 11:9089759-9089759	prostate	carcinoma	Substitution - coding silent
c.843G>C; p.L281L; 11:9065898-9065898	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.763C>T; p.R255*; 11:9065978-9065978	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1850C>T; p.P617L; 11:9047421-9047421	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1476C>A; p.T492T; 11:9050682-9050682	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.65_67delTGC; p.L22delL; 11:9091462-9091464	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.1249G>A; p.V417I; 11:9053718-9053718	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1732G>A; p.V578I; 11:9047539-9047539	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.329G>A; p.R110H; 11:9079437-9079437	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.169C>A; p.H57N; 11:9089794-9089794	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.329G>A; p.R110H; 11:9079437-9079437	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1207+2T>C; p.?; 11:9055791-9055791	stomach	carcinoma; adenocarcinoma	Unknown
c.2607G>T; p.R869R; 11:9027371-9027371	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.545A>T; p.H182L; 11:9069468-9069468	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2671G>A; p.A891T; 11:9025798-9025798	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2671G>A; p.A891T; 11:9025798-9025798	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.74T>C; p.L25P; 11:9091455-9091455	liver	carcinoma	Substitution - Missense
c.2671G>A; p.A891T; 11:9025798-9025798	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1772C>T; p.T591M; 11:9047499-9047499	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.366C>T; p.D122D; 11:9079400-9079400	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1772C>T; p.T591M; 11:9047499-9047499	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1772C>T; p.T591M; 11:9047499-9047499	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.366C>T; p.D122D; 11:9079400-9079400	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1768C>T; p.R590C; 11:9047503-9047503	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1768C>T; p.R590C; 11:9047503-9047503	skin	malignant_melanoma	Substitution - Missense
c.1768C>T; p.R590C; 11:9047503-9047503	skin	malignant_melanoma	Substitution - Missense
c.2284A>C; p.T762P; 11:9030016-9030016	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.589G>A; p.A197T; 11:9069424-9069424	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.591C>A; p.A197A; 11:9069422-9069422	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2372C>G; p.T791S; 11:9029928-9029928	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1757G>A; p.R586H; 11:9047514-9047514	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2408A>G; p.Q803R; 11:9029892-9029892	breast	carcinoma	Substitution - Missense
c.369T>C; p.G123G; 11:9079397-9079397	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1528G>A; p.E510K; 11:9050630-9050630	prostate	carcinoma	Substitution - Missense
c.814G>A; p.D272N; 11:9065927-9065927	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.65T>C; p.L22P; 11:9091464-9091464	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.65T>C; p.L22P; 11:9091464-9091464	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1068A>C; p.L356F; 11:9059325-9059325	skin	malignant_melanoma	Substitution - Missense
c.2460T>C; p.I820I; 11:9027518-9027518	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1769G>A; p.R590H; 11:9047502-9047502	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1769G>A; p.R590H; 11:9047502-9047502	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2606G>A; p.R869Q; 11:9027372-9027372	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1537C>T; p.R513*; 11:9050621-9050621	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.454T>C; p.C152R; 11:9074544-9074544	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2448C>A; p.F816L; 11:9027530-9027530	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.408T>C; p.N136N; 11:9074590-9074590	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.668G>A; p.G223E; 11:9066789-9066789	skin	malignant_melanoma	Substitution - Missense
c.1091-1G>A; p.?; 11:9055910-9055910	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1587C>T; p.Y529Y; 11:9048064-9048064	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1221C>A; p.C407*; 11:9053746-9053746	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.954G>A; p.G318G; 11:9060421-9060421	breast	carcinoma	Substitution - coding silent
c.1477T>C; p.F493L; 11:9050681-9050681	skin; upper_arm	malignant_melanoma	Substitution - Missense
c.2101G>T; p.G701C; 11:9030911-9030911	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1197C>T; p.T399T; 11:9055803-9055803	skin	malignant_melanoma	Substitution - coding silent
c.2546T>G; p.I849S; 11:9027432-9027432	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2973G>A; p.V991V; 11:9021072-9021072	liver	carcinoma	Substitution - coding silent
c.835C>T; p.R279W; 11:9065906-9065906	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2973G>A; p.V991V; 11:9021072-9021072	liver	carcinoma	Substitution - coding silent
c.2973G>A; p.V991V; 11:9021072-9021072	liver	carcinoma	Substitution - coding silent
c.1751G>T; p.R584L; 11:9047520-9047520	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2406C>T; p.T802T; 11:9029894-9029894	skin	malignant_melanoma	Substitution - coding silent
c.2930A>T; p.E977V; 11:9021115-9021115	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1738C>T; p.R580*; 11:9047533-9047533	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.688G>T; p.D230Y; 11:9066769-9066769	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.261C>T; p.I87I; 11:9079505-9079505	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.836G>A; p.R279Q; 11:9065905-9065905	stomach	adenocarcinoma	Substitution - Missense
c.1172G>A; p.R391Q; 11:9055828-9055828	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2507C>T; p.T836M; 11:9027471-9027471	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1830C>T; p.L610L; 11:9047441-9047441	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1830C>T; p.L610L; 11:9047441-9047441	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1830C>T; p.L610L; 11:9047441-9047441	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2296C>A; p.R766R; 11:9030004-9030004	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1126C>T; p.H376Y; 11:9055874-9055874	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.458G>T; p.C153F; 11:9074540-9074540	liver	carcinoma	Substitution - Missense
c.2534G>A; p.R845H; 11:9027444-9027444	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1744G>A; p.E582K; 11:9047527-9047527	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1744G>A; p.E582K; 11:9047527-9047527	breast	carcinoma	Substitution - Missense
c.1786G>A; p.V596I; 11:9047485-9047485	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1831G>A; p.D611N; 11:9047440-9047440	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.830T>G; p.V277G; 11:9065911-9065911	breast	carcinoma	Substitution - Missense
c.616C>T; p.L206L; 11:9069397-9069397	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2000G>A; p.G667E; 11:9033712-9033712	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.229T>C; p.Y77H; 11:9089734-9089734	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1538G>A; p.R513Q; 11:9050620-9050620	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1451T>C; p.V484A; 11:9050707-9050707	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2679C>T; p.T893T; 11:9025790-9025790	skin	malignant_melanoma	Substitution - coding silent
c.2357C>A; p.S786Y; 11:9029943-9029943	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1146T>C; p.P382P; 11:9055854-9055854	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1366C>A; p.R456S; 11:9053180-9053180	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.527G>A; p.S176N; 11:9069486-9069486	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1366C>T; p.R456C; 11:9053180-9053180	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1404C>T; p.D468D; 11:9053142-9053142	breast	carcinoma	Substitution - coding silent
c.1404C>T; p.D468D; 11:9053142-9053142	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2800C>A; p.R934R; 11:9021923-9021923	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1276G>A; p.E426K; 11:9053691-9053691	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2231C>T; p.S744F; 11:9030781-9030781	skin	malignant_melanoma	Substitution - Missense
c.884G>A; p.R295H; 11:9060491-9060491	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2174G>A; p.R725Q; 11:9030838-9030838	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.547G>A; p.G183S; 11:9069466-9069466	liver	carcinoma	Substitution - Missense
c.2236C>T; p.Q746*; 11:9030776-9030776	skin	malignant_melanoma	Substitution - Nonsense
c.2305C>T; p.R769C; 11:9029995-9029995	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2305C>T; p.R769C; 11:9029995-9029995	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2711A>G; p.K904R; 11:9025758-9025758	skin	malignant_melanoma	Substitution - Missense
c.2800C>T; p.R934*; 11:9021923-9021923	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.246G>A; p.R82R; 11:9089717-9089717	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.411C>T; p.G137G; 11:9074587-9074587	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2380G>A; p.D794N; 11:9029920-9029920	urinary_tract; bladder	carcinoma	Substitution - Missense
c.390C>G; p.D130E; 11:9074608-9074608	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1605C>A; p.S535R; 11:9048046-9048046	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.701G>T; p.G234V; 11:9066756-9066756	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1198C>G; p.H400D; 11:9055802-9055802	liver	carcinoma	Substitution - Missense
c.2184C>T; p.C728C; 11:9030828-9030828	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1104C>T; p.C368C; 11:9055896-9055896	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.662A>C; p.N221T; 11:9066795-9066795	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2500G>A; p.E834K; 11:9027478-9027478	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2500G>A; p.E834K; 11:9027478-9027478	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1989A>C; p.Q663H; 11:9033723-9033723	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1583G>A; p.R528H; 11:9048068-9048068	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.882C>A; p.D294E; 11:9060493-9060493	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1383C>T; p.C461C; 11:9053163-9053163	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.464A>C; p.K155T; 11:9074534-9074534	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1024G>A; p.V342M; 11:9059369-9059369	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1794G>A; p.R598R; 11:9047477-9047477	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1024G>A; p.V342M; 11:9059369-9059369	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2624A>G; p.N875S; 11:9025845-9025845	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.697G>A; p.D233N; 11:9066760-9066760	breast	carcinoma	Substitution - Missense
c.2376G>A; p.T792T; 11:9029924-9029924	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1749G>A; p.K583K; 11:9047522-9047522	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2013T>G; p.C671W; 11:9033699-9033699	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1349C>T; p.P450L; 11:9053197-9053197	skin	malignant_melanoma	Substitution - Missense
c.1759A>G; p.K587E; 11:9047512-9047512	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2762A>G; p.Y921C; 11:9025707-9025707	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.902C>T; p.S301L; 11:9060473-9060473	pancreas	other; adenoma	Substitution - Missense
c.1753C>T; p.L585F; 11:9047518-9047518	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2559G>T; p.E853D; 11:9027419-9027419	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2254+1G>T; p.?; 11:9030757-9030757	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.2157C>G; p.F719L; 11:9030855-9030855	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.519G>A; p.E173E; 11:9069494-9069494	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2658C>T; p.Y886Y; 11:9025811-9025811	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.139G>C; p.D47H; 11:9089824-9089824	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2945C>T; p.S982L; 11:9021100-9021100	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2283C>A; p.N761K; 11:9030017-9030017	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.781G>C; p.E261Q; 11:9065960-9065960	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2366G>T; p.G789V; 11:9029934-9029934	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2655C>A; p.T885T; 11:9025814-9025814	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.189G>A; p.Q63Q; 11:9089774-9089774	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.189G>A; p.Q63Q; 11:9089774-9089774	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1739G>A; p.R580Q; 11:9047532-9047532	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1634G>A; p.G545D; 11:9048017-9048017	liver	carcinoma	Substitution - Missense
c.1634G>A; p.G545D; 11:9048017-9048017	liver	carcinoma	Substitution - Missense
c.235G>A; p.G79R; 11:9089728-9089728	skin	malignant_melanoma	Substitution - Missense
c.2962C>G; p.R988G; 11:9021083-9021083	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.177C>T; p.D59D; 11:9089786-9089786	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1834G>A; p.V612M; 11:9047437-9047437	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.721C>G; p.P241A; 11:9066736-9066736	pancreas	carcinoma	Substitution - Missense
c.513G>A; p.S171S; 11:9074485-9074485	skin	malignant_melanoma	Substitution - coding silent
c.2032G>A; p.G678R; 11:9033680-9033680	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2893C>T; p.Q965*; 11:9021152-9021152	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.513G>A; p.S171S; 11:9074485-9074485	skin	malignant_melanoma	Substitution - coding silent
c.2846A>G; p.K949R; 11:9021877-9021877	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2594A>G; p.Y865C; 11:9027384-9027384	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1163C>T; p.A388V; 11:9055837-9055837	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1849C>T; p.P617S; 11:9047422-9047422	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.523C>A; p.L175M; 11:9069490-9069490	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1582C>T; p.R528C; 11:9048069-9048069	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2537G>A; p.R846H; 11:9027441-9027441	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.567G>A; p.K189K; 11:9069446-9069446	skin	malignant_melanoma	Substitution - coding silent
c.1561A>G; p.S521G; 11:9048090-9048090	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2781A>T; p.E927D; 11:9021942-9021942	breast	carcinoma	Substitution - Missense
c.2422A>G; p.R808G; 11:9027556-9027556	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1056A>G; p.G352G; 11:9059337-9059337	breast	carcinoma	Substitution - coding silent
c.2670C>T; p.I890I; 11:9025799-9025799	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1117A>T; p.T373S; 11:9055883-9055883	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1374C>T; p.S458S; 11:9053172-9053172	skin	malignant_melanoma	Substitution - coding silent
c.512C>T; p.S171L; 11:9074486-9074486	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.461G>A; p.C154Y; 11:9074537-9074537	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]