Entrez Gene

Basic Information
Gene ID	57863
Name	CADM3
Synonymous	cell adhesion molecule 3;CADM3;cell adhesion molecule 3
Definition	TSLC1-like 1\|TSLC1-like protein 1\|brain immunoglobulin receptor\|dendritic cell nectin-like protein 1 short isoform\|immunoglobulin superfamily member 4B\|immunoglobulin superfamily, member 4B\|nectin-like 1\|nectin-like protein 1\|synaptic cell adhesion molecu
Position	1q21.2-q22
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.09.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.717G>A; p.A239A; 1:159193964-159193964	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.717G>A; p.A239A; 1:159193964-159193964	skin	malignant_melanoma	Substitution - coding silent
c.928C>A; p.L310M; 1:159196934-159196934	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1099A>G; p.I367V; 1:159199795-159199795	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.885-6C>A; p.?; 1:159196885-159196885	oesophagus	carcinoma; adenocarcinoma	Unknown
c.375C>T; p.H125H; 1:159192621-159192621	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.484G>C; p.G162R; 1:159192730-159192730	prostate	adenoma	Substitution - Missense
c.666C>T; p.F222F; 1:159193913-159193913	skin	malignant_melanoma	Substitution - coding silent
c.368C>T; p.T123M; 1:159192614-159192614	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.368C>T; p.T123M; 1:159192614-159192614	skin; trunk	malignant_melanoma	Substitution - Missense
c.680C>T; p.S227L; 1:159193927-159193927	skin	malignant_melanoma	Substitution - Missense
c.680C>T; p.S227L; 1:159193927-159193927	skin	malignant_melanoma	Substitution - Missense
c.680C>T; p.S227L; 1:159193927-159193927	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1140C>G; p.I380M; 1:159199836-159199836	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.515A>G; p.Y172C; 1:159193453-159193453	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.92A>G; p.Y31C; 1:159189774-159189774	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.67G>A; p.G23R; 1:159171832-159171832	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.894G>T; p.Q298H; 1:159196900-159196900	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.327G>A; p.K109K; 1:159192072-159192072	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.226G>T; p.A76S; 1:159191971-159191971	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1051A>C; p.N351H; 1:159197057-159197057	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.347G>A; p.R116Q; 1:159192593-159192593	skin	malignant_melanoma	Substitution - Missense
c.347G>A; p.R116Q; 1:159192593-159192593	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.418G>A; p.G140S; 1:159192664-159192664	pancreas	carcinoma	Substitution - Missense
c.1257C>T; p.G419G; 1:159200880-159200880	breast	carcinoma	Substitution - coding silent
c.347G>A; p.R116Q; 1:159192593-159192593	skin	malignant_melanoma	Substitution - Missense
c.1161C>A; p.H387Q; 1:159199857-159199857	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1257C>T; p.G419G; 1:159200880-159200880	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.661A>G; p.T221A; 1:159193908-159193908	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.547A>T; p.T183S; 1:159193485-159193485	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.586C>A; p.R196R; 1:159193524-159193524	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.719G>A; p.S240N; 1:159193966-159193966	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.472G>A; p.V158I; 1:159192718-159192718	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1065G>T; p.P355P; 1:159199761-159199761	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1276G>A; p.D426N; 1:159200899-159200899	skin	malignant_melanoma	Substitution - Missense
c.876C>A; p.G292G; 1:159196446-159196446	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.158T>C; p.V53A; 1:159189840-159189840	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.499C>T; p.P167S; 1:159193437-159193437	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1092C>G; p.H364Q; 1:159199788-159199788	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1270G>T; p.G424W; 1:159200893-159200893	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.454C>T; p.R152*; 1:159192700-159192700	liver	carcinoma	Substitution - Nonsense
c.454C>T; p.R152*; 1:159192700-159192700	liver	carcinoma	Substitution - Nonsense
c.15C>T; p.A5A; 1:159171780-159171780	skin	malignant_melanoma	Substitution - coding silent
c.1271G>A; p.G424E; 1:159200894-159200894	skin	malignant_melanoma	Substitution - Missense
c.824C>A; p.P275H; 1:159196394-159196394	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.100G>A; p.E34K; 1:159189782-159189782	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1235C>T; p.T412M; 1:159200858-159200858	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1041C>A; p.T347T; 1:159197047-159197047	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.588G>T; p.R196R; 1:159193526-159193526	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1299G>A; p.433; 1:159200922-159200922	skin	malignant_melanoma	Substitution - coding silent
c.1275C>T; p.D425D; 1:159200898-159200898	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.169C>T; p.P57S; 1:159189851-159189851	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1256G>A; p.G419D; 1:159200879-159200879	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.729C>T; p.C243C; 1:159193976-159193976	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.701G>T; p.R234L; 1:159193948-159193948	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.268G>A; p.E90K; 1:159192013-159192013	skin	malignant_melanoma	Substitution - Missense
c.268G>A; p.E90K; 1:159192013-159192013	skin	malignant_melanoma	Substitution - Missense
c.741T>A; p.H247Q; 1:159193988-159193988	prostate	carcinoma	Substitution - Missense
c.729C>T; p.C243C; 1:159193976-159193976	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.346C>T; p.R116*; 1:159192592-159192592	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.995G>A; p.G332D; 1:159197001-159197001	skin	malignant_melanoma	Substitution - Missense
c.1156G>A; p.G386S; 1:159199852-159199852	large_intestine; colon	adenoma	Substitution - Missense
c.889C>T; p.Q297*; 1:159196895-159196895	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1157G>A; p.G386D; 1:159199853-159199853	liver	carcinoma	Substitution - Missense
c.793+5G>T; p.?; 1:159194045-159194045	liver	carcinoma	Unknown
c.1101C>T; p.I367I; 1:159199797-159199797	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1101C>T; p.I367I; 1:159199797-159199797	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.383G>A; p.S128N; 1:159192629-159192629	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.287G>C; p.W96S; 1:159192032-159192032	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.532G>A; p.E178K; 1:159193470-159193470	skin	malignant_melanoma	Substitution - Missense
c.613G>T; p.E205*; 1:159193551-159193551	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1159C>A; p.H387N; 1:159199855-159199855	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.621C>T; p.H207H; 1:159193559-159193559	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.587G>A; p.R196Q; 1:159193525-159193525	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.621C>T; p.H207H; 1:159193559-159193559	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.799C>T; p.P267S; 1:159196369-159196369	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.20_21insGCTCCT; p.L14_F15insLL; 1:159171785-159171786	large_intestine	carcinoma; adenocarcinoma	Insertion - In frame
c.258G>A; p.V86V; 1:159192003-159192003	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.530G>T; p.R177L; 1:159193468-159193468	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.767C>T; p.S256F; 1:159194014-159194014	skin	malignant_melanoma	Substitution - Missense
c.767C>T; p.S256F; 1:159194014-159194014	skin	malignant_melanoma	Substitution - Missense
c.764G>A; p.R255K; 1:159194011-159194011	skin	malignant_melanoma	Substitution - Missense
c.1113G>A; p.V371V; 1:159199809-159199809	skin	malignant_melanoma	Substitution - coding silent
c.884+1G>T; p.?; 1:159196455-159196455	lung	carcinoma; small_cell_carcinoma	Unknown
c.534A>C; p.E178D; 1:159193472-159193472	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.656G>T; p.G219V; 1:159193903-159193903	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.92A>T; p.Y31F; 1:159189774-159189774	thyroid	other; neoplasm	Substitution - Missense
c.778C>T; p.R260C; 1:159194025-159194025	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.706G>A; p.D236N; 1:159193953-159193953	skin	malignant_melanoma	Substitution - Missense
c.884+5G>C; p.?; 1:159196459-159196459	NS	NS	Unknown
c.703G>A; p.E235K; 1:159193950-159193950	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1285G>A; p.E429K; 1:159200908-159200908	skin	malignant_melanoma	Substitution - Missense
c.703G>A; p.E235K; 1:159193950-159193950	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1284G>A; p.K428K; 1:159200907-159200907	skin	malignant_melanoma	Substitution - coding silent
c.135C>T; p.L45L; 1:159189817-159189817	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1227C>T; p.D409D; 1:159200850-159200850	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1227C>T; p.D409D; 1:159200850-159200850	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.806C>T; p.A269V; 1:159196376-159196376	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1213G>C; p.D405H; 1:159200836-159200836	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.543A>C; p.T181T; 1:159193481-159193481	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.764G>C; p.R255T; 1:159194011-159194011	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.746C>T; p.S249F; 1:159193993-159193993	haematopoietic_and_lymphoid_tissue; abdomen	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.746C>T; p.S249F; 1:159193993-159193993	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.903G>A; p.W301*; 1:159196909-159196909	skin	malignant_melanoma	Substitution - Nonsense
c.1248T>C; p.N416N; 1:159200871-159200871	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.716C>T; p.A239V; 1:159193963-159193963	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.716C>T; p.A239V; 1:159193963-159193963	breast	carcinoma	Substitution - Missense
c.885C>G; p.V295V; 1:159196891-159196891	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1003G>T; p.A335S; 1:159197009-159197009	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1171C>T; p.R391W; 1:159199867-159199867	bone; humerus	other; chondroblastoma	Substitution - Missense
c.774T>A; p.S258S; 1:159194021-159194021	lung; left_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1042C>T; p.L348F; 1:159197048-159197048	skin	malignant_melanoma	Substitution - Missense
c.1153C>A; p.L385I; 1:159199849-159199849	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1185C>A; p.T395T; 1:159200808-159200808	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.523T>G; p.S175A; 1:159193461-159193461	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.252C>T; p.C84C; 1:159191997-159191997	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1059C>T; p.P353P; 1:159199755-159199755	skin	malignant_melanoma	Substitution - coding silent
c.1229C>T; p.A410V; 1:159200852-159200852	skin	malignant_melanoma	Substitution - Missense
c.912G>C; p.E304D; 1:159196918-159196918	skin	malignant_melanoma	Substitution - Missense
c.979G>A; p.D327N; 1:159196985-159196985	skin	malignant_melanoma	Substitution - Missense
c.337C>T; p.R113*; 1:159192583-159192583	skin	malignant_melanoma	Substitution - Nonsense
c.337C>T; p.R113*; 1:159192583-159192583	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1016T>C; p.M339T; 1:159197022-159197022	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1222C>A; p.P408T; 1:159200845-159200845	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1056C>A; p.D352E; 1:159199752-159199752	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.929T>C; p.L310P; 1:159196935-159196935	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1172G>T; p.R391L; 1:159199868-159199868	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.455G>A; p.R152Q; 1:159192701-159192701	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.455G>A; p.R152Q; 1:159192701-159192701	skin	malignant_melanoma	Substitution - Missense
c.455G>A; p.R152Q; 1:159192701-159192701	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.1228G>A; p.A410T; 1:159200851-159200851	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.471C>T; p.L157L; 1:159192717-159192717	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.471C>T; p.L157L; 1:159192717-159192717	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1079C>T; p.S360F; 1:159199775-159199775	skin	malignant_melanoma	Substitution - Missense
c.710A>G; p.D237G; 1:159193957-159193957	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1216G>A; p.D406N; 1:159200839-159200839	skin	malignant_melanoma	Substitution - Missense
c.57G>T; p.W19C; 1:159171822-159171822	thyroid	other; neoplasm	Substitution - Missense
c.504C>A; p.I168I; 1:159193442-159193442	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.685A>G; p.T229A; 1:159193932-159193932	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1110C>T; p.I370I; 1:159199806-159199806	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1110C>T; p.I370I; 1:159199806-159199806	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1107G>A; p.G369G; 1:159199803-159199803	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1110C>T; p.I370I; 1:159199806-159199806	skin	malignant_melanoma	Substitution - coding silent
c.1110C>T; p.I370I; 1:159199806-159199806	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.755G>A; p.G252E; 1:159194002-159194002	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1041C>T; p.T347T; 1:159197047-159197047	skin	malignant_melanoma	Substitution - coding silent
c.554A>G; p.N185S; 1:159193492-159193492	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.742G>A; p.E248K; 1:159193989-159193989	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1106G>A; p.G369E; 1:159199802-159199802	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.772T>C; p.S258P; 1:159194019-159194019	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.695T>G; p.V232G; 1:159193942-159193942	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.640C>A; p.Q214K; 1:159193887-159193887	prostate	adenoma	Substitution - Missense
c.415G>T; p.E139*; 1:159192661-159192661	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1213G>A; p.D405N; 1:159200836-159200836	breast	carcinoma	Substitution - Missense
c.954G>A; p.L318L; 1:159196960-159196960	breast	carcinoma	Substitution - coding silent
c.225G>A; p.V75V; 1:159191970-159191970	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.842G>C; p.G281A; 1:159196412-159196412	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.320G>A; p.G107E; 1:159192065-159192065	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.855G>C; p.L285F; 1:159196425-159196425	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.701G>A; p.R234Q; 1:159193948-159193948	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.698C>T; p.T233I; 1:159193945-159193945	liver	carcinoma	Substitution - Missense
c.670G>A; p.V224I; 1:159193917-159193917	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.698C>T; p.T233I; 1:159193945-159193945	liver	carcinoma	Substitution - Missense
c.338G>T; p.R113L; 1:159192584-159192584	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.389G>A; p.S130N; 1:159192635-159192635	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.190+1G>T; p.?; 1:159189873-159189873	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1242C>T; p.I414I; 1:159200865-159200865	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.817C>T; p.P273S; 1:159196387-159196387	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.817C>T; p.P273S; 1:159196387-159196387	breast	carcinoma	Substitution - Missense
c.787G>A; p.V263I; 1:159194034-159194034	skin	malignant_melanoma	Substitution - Missense
c.331G>A; p.A111T; 1:159192076-159192076	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.742G>C; p.E248Q; 1:159193989-159193989	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.609C>T; p.D203D; 1:159193547-159193547	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.941A>C; p.Q314P; 1:159196947-159196947	pancreas	carcinoma	Substitution - Missense
c.941A>C; p.Q314P; 1:159196947-159196947	pancreas	carcinoma	Substitution - Missense
c.785A>C; p.E262A; 1:159194032-159194032	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.648T>A; p.D216E; 1:159193895-159193895	skin	malignant_melanoma	Substitution - Missense
c.835C>T; p.R279C; 1:159196405-159196405	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.835C>T; p.R279C; 1:159196405-159196405	skin	malignant_melanoma	Substitution - Missense
c.1247A>T; p.N416I; 1:159200870-159200870	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1211C>T; p.S404F; 1:159200834-159200834	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1165T>G; p.L389V; 1:159199861-159199861	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.873C>T; p.R291R; 1:159196443-159196443	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1285G>T; p.E429*; 1:159200908-159200908	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Nonsense
c.370C>T; p.P124S; 1:159192616-159192616	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.634C>T; p.R212C; 1:159193881-159193881	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.396C>T; p.S132S; 1:159192642-159192642	oesophagus	carcinoma	Substitution - coding silent
c.723C>T; p.I241I; 1:159193970-159193970	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.595T>C; p.W199R; 1:159193533-159193533	stomach	adenocarcinoma	Substitution - Missense
c.573C>A; p.S191R; 1:159193511-159193511	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1151T>G; p.F384C; 1:159199847-159199847	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.544G>A; p.A182T; 1:159193482-159193482	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.511G>T; p.G171C; 1:159193449-159193449	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.376G>A; p.E126K; 1:159192622-159192622	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.376G>A; p.E126K; 1:159192622-159192622	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.376G>A; p.E126K; 1:159192622-159192622	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1173G>A; p.R391R; 1:159199869-159199869	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.376G>A; p.E126K; 1:159192622-159192622	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1064_1065insT; p.V356fs*45; 1:159199760-159199761	lung	carcinoma; small_cell_carcinoma	Insertion - Frameshift
c.1173G>A; p.R391R; 1:159199869-159199869	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.397A>G; p.N133D; 1:159192643-159192643	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1173G>A; p.R391R; 1:159199869-159199869	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.686C>T; p.T229I; 1:159193933-159193933	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.840G>A; p.E280E; 1:159196410-159196410	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]