Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

6135

Name

RPL11

Synonymous

ribosomal protein L11;RPL11;ribosomal protein L11

Definition

60S ribosomal protein L11|CLL-associated antigen KW-12|cell growth-inhibiting protein 34

Position

1p36.1-p35

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.22.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.87T>C; p.S29S; 1:23692689-23692689

 livercarcinomaSubstitution - coding silent

c.97C>A; p.L33M; 1:23692699-23692699

 skinmalignant_melanomaSubstitution - Missense

c.386A>T; p.D129V; 1:23694781-23694781

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.375C>G; p.I125M; 1:23694770-23694770

 pancreascarcinomaSubstitution - Missense

c.375C>G; p.I125M; 1:23694770-23694770

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.375C>G; p.I125M; 1:23694770-23694770

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.223C>T; p.R75*; 1:23693872-23693872

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.223C>T; p.R75*; 1:23693872-23693872

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Nonsense

c.519C>T; p.I173I; 1:23696355-23696355

 large_intestine; rectumNSSubstitution - coding silent

c.353A>C; p.K118T; 1:23694748-23694748

 skinmalignant_melanomaSubstitution - Missense

c.146T>A; p.V49E; 1:23692748-23692748

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.6+1G>C; p.?; 1:23691830-23691830

 central_nervous_system; brainglioma; astrocytoma_Grade_IVUnknown

c.380G>A; p.G127D; 1:23694775-23694775

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.424G>A; p.A142T; 1:23695825-23695825

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.424G>A; p.A142T; 1:23695825-23695825

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.437G>A; p.R146H; 1:23695838-23695838

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.43C>T; p.L15F; 1:23692645-23692645

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.513T>C; p.D171D; 1:23696349-23696349

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.70A>G; p.I24V; 1:23692672-23692672

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.297C>T; p.F99F; 1:23694692-23694692

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.46C>T; p.R16C; 1:23692648-23692648

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.46C>T; p.R16C; 1:23692648-23692648

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.197A>G; p.E66G; 1:23693846-23693846

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.299C>T; p.S100L; 1:23694694-23694694

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.508_509delTA; p.Y170fs*1; 1:23696344-23696345

 biliary_tract; bile_ductcarcinoma; adenocarcinomaDeletion - Frameshift

c.103C>T; p.R35*; 1:23692705-23692705

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.451A>T; p.I151F; 1:23695852-23695852

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.128T>A; p.L43H; 1:23692730-23692730

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.128T>A; p.L43H; 1:23692730-23692730

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.128T>A; p.L43H; 1:23692730-23692730

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.496T>C; p.F166L; 1:23695897-23695897

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.128T>G; p.L43R; 1:23692730-23692730

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.319T>G; p.F107V; 1:23694714-23694714

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.176C>T; p.S59F; 1:23693825-23693825

 skinmalignant_melanomaSubstitution - Missense

c.436C>T; p.R146C; 1:23695837-23695837

 prostateadenomaSubstitution - Missense

c.66C>G; p.L22L; 1:23692668-23692668

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.37C>T; p.R13W; 1:23692639-23692639

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.37C>T; p.R13W; 1:23692639-23692639

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.6+1G>T; p.?; 1:23691830-23691830

 stomachcarcinoma; adenocarcinomaUnknown

c.67A>G; p.N23D; 1:23692669-23692669

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

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