Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

6425

Name

SFRP5

Synonymous

secreted frizzled-related protein 5;SFRP5;secreted frizzled-related protein 5

Definition

FRP-1b|SARP-3|frizzled-related protein 1b|sFRP-5|secreted apoptosis related protein 3|secreted apoptosis-related protein 3

Position

10q24.1

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.10.

The copy number variations for various cancers

Top

There is no record for SFRP5

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.921C>G; p.Y307*; 10:97767547-97767547

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.619C>T; p.R207C; 10:97767849-97767849

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.619C>T; p.R207C; 10:97767849-97767849

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.483C>T; p.L161L; 10:97771351-97771351

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.323T>C; p.L108P; 10:97771511-97771511

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.731T>G; p.V244G; 10:97767737-97767737

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.908G>A; p.C303Y; 10:97767560-97767560

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.902A>C; p.Y301S; 10:97767566-97767566

 thyroidother; neoplasmSubstitution - Missense

c.410C>T; p.P137L; 10:97771424-97771424

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.20G>C; p.G7A; 10:97771814-97771814

 thyroidother; neoplasmSubstitution - Missense

c.714G>A; p.K238K; 10:97767754-97767754

 skinmalignant_melanomaSubstitution - coding silent

c.847C>A; p.R283S; 10:97767621-97767621

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.45G>T; p.L15L; 10:97771789-97771789

 autonomic_ganglianeuroblastomaSubstitution - coding silent

c.624C>A; p.I208I; 10:97767844-97767844

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.514G>A; p.A172T; 10:97771320-97771320

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.240G>A; p.E80E; 10:97771594-97771594

 breastcarcinomaSubstitution - coding silent

c.168C>T; p.I56I; 10:97771666-97771666

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.834C>T; p.L278L; 10:97767634-97767634

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.364T>A; p.Y122N; 10:97771470-97771470

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.709C>T; p.R237C; 10:97767759-97767759

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.709C>T; p.R237C; 10:97767759-97767759

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.214C>T; p.R72W; 10:97771620-97771620

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.559G>A; p.E187K; 10:97769716-97769716

 skin; mucosalmalignant_melanomaSubstitution - Missense

c.573C>T; p.D191D; 10:97769702-97769702

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.95A>G; p.Y32C; 10:97771739-97771739

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.95A>G; p.Y32C; 10:97771739-97771739

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.805G>A; p.G269S; 10:97767663-97767663

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.247G>A; p.A83T; 10:97771587-97771587

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.418G>A; p.E140K; 10:97771416-97771416

 skinmalignant_melanomaSubstitution - Missense

c.575G>A; p.G192D; 10:97769700-97769700

 biliary_tract; bile_ductcarcinoma; adenocarcinomaSubstitution - Missense

c.695C>A; p.P232Q; 10:97767773-97767773

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.804G>A; p.M268I; 10:97767664-97767664

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.648G>A; p.G216G; 10:97767820-97767820

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.326G>T; p.C109F; 10:97771508-97771508

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

')