Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

64866

Name

CDCP1

Synonymous

CUB domain containing protein 1;CDCP1;CUB domain containing protein 1

Definition

CUB domain-containing protein 1|membrane glycoprotein gp140|subtractive immunization M plus HEp3-associated 135 kDa protein|transmembrane and associated with src kinases

Position

3p21.31

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.06.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1919T>A; p.I640N; 3:45091247-45091247

 livercarcinomaSubstitution - Missense

c.2177G>A; p.R726Q; 3:45085972-45085972

 skinmalignant_melanomaSubstitution - Missense

c.1296G>T; p.V432V; 3:45093608-45093608

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.2488G>T; p.E830*; 3:45085661-45085661

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1125C>T; p.F375F; 3:45095468-45095468

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.2339G>A; p.C780Y; 3:45085810-45085810

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1275G>A; p.R425R; 3:45093629-45093629

 skinmalignant_melanomaSubstitution - coding silent

c.1275G>A; p.R425R; 3:45093629-45093629

 skinmalignant_melanomaSubstitution - coding silent

c.2307G>A; p.M769I; 3:45085842-45085842

 skin; neckmalignant_melanomaSubstitution - Missense

c.1025-7G>A; p.?; 3:45095575-45095575

 livercarcinomaUnknown

c.2130C>T; p.N710N; 3:45086019-45086019

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.674C>T; p.S225F; 3:45110823-45110823

 skinmalignant_melanomaSubstitution - Missense

c.473G>A; p.G158E; 3:45112265-45112265

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1498C>T; p.P500S; 3:45093406-45093406

 skinmalignant_melanomaSubstitution - Missense

c.571G>T; p.G191*; 3:45112167-45112167

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.747C>T; p.L249L; 3:45110750-45110750

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1760G>T; p.C587F; 3:45091406-45091406

 breastcarcinomaSubstitution - Missense

c.1572C>T; p.F524F; 3:45093332-45093332

 skinmalignant_melanomaSubstitution - coding silent

c.341C>T; p.S114L; 3:45112397-45112397

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.492C>T; p.S164S; 3:45112246-45112246

 thyroidcarcinomaSubstitution - coding silent

c.2096A>G; p.N699S; 3:45086053-45086053

 skinmalignant_melanomaSubstitution - Missense

c.2148G>A; p.P716P; 3:45086001-45086001

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1084C>T; p.R362W; 3:45095509-45095509

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1627G>A; p.E543K; 3:45093277-45093277

 skin; extremitymalignant_melanomaSubstitution - Missense

c.794C>T; p.S265F; 3:45110703-45110703

 skinmalignant_melanomaSubstitution - Missense

c.1756G>A; p.A586T; 3:45091410-45091410

 skin; legmalignant_melanoma; superficial_spreadingSubstitution - Missense

c.979C>T; p.R327W; 3:45110518-45110518

 skin; trunkmalignant_melanomaSubstitution - Missense

c.2487G>T; p.Q829H; 3:45085662-45085662

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1315C>T; p.L439L; 3:45093589-45093589

 thyroidcarcinomaSubstitution - coding silent

c.384T>C; p.D128D; 3:45112354-45112354

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.916G>A; p.A306T; 3:45110581-45110581

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1844C>T; p.A615V; 3:45091322-45091322

 skinmalignant_melanomaSubstitution - Missense

c.269T>C; p.V90A; 3:45118435-45118435

 breastcarcinomaSubstitution - Missense

c.742G>A; p.E248K; 3:45110755-45110755

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1841G>T; p.R614L; 3:45091325-45091325

 skinmalignant_melanomaSubstitution - Missense

c.522C>T; p.I174I; 3:45112216-45112216

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.827G>A; p.R276K; 3:45110670-45110670

 skinmalignant_melanomaSubstitution - Missense

c.534C>T; p.C178C; 3:45112204-45112204

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1684C>T; p.P562S; 3:45091482-45091482

 skinmalignant_melanomaSubstitution - Missense

c.170A>G; p.Y57C; 3:45118534-45118534

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1586C>T; p.S529F; 3:45093318-45093318

 skinmalignant_melanomaSubstitution - Missense

c.2321C>T; p.P774L; 3:45085828-45085828

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.479C>T; p.T160I; 3:45112259-45112259

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.599G>A; p.W200*; 3:45112139-45112139

 skinmalignant_melanomaSubstitution - Nonsense

c.1738G>A; p.V580M; 3:45091428-45091428

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1089C>T; p.P363P; 3:45095504-45095504

 skinmalignant_melanomaSubstitution - coding silent

c.2173G>A; p.G725R; 3:45085976-45085976

 skinmalignant_melanomaSubstitution - Missense

c.1581G>A; p.E527E; 3:45093323-45093323

 skinmalignant_melanomaSubstitution - coding silent

c.1141C>T; p.R381W; 3:45095452-45095452

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1500G>A; p.P500P; 3:45093404-45093404

 stomachadenocarcinomaSubstitution - coding silent

c.1416C>T; p.H472H; 3:45093488-45093488

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1417G>A; p.E473K; 3:45093487-45093487

 skinmalignant_melanomaSubstitution - Missense

c.694T>C; p.S232P; 3:45110803-45110803

 skinmalignant_melanomaSubstitution - Missense

c.1922C>T; p.S641F; 3:45091244-45091244

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.2165T>G; p.F722C; 3:45085984-45085984

 skinmalignant_melanomaSubstitution - Missense

c.258G>A; p.E86E; 3:45118446-45118446

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.921G>T; p.G307G; 3:45110576-45110576

 breastcarcinomaSubstitution - coding silent

c.1623C>T; p.F541F; 3:45093281-45093281

 breastcarcinomaSubstitution - coding silent

c.779T>A; p.L260Q; 3:45110718-45110718

 skinmalignant_melanomaSubstitution - Missense

c.502G>A; p.D168N; 3:45112236-45112236

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.502G>A; p.D168N; 3:45112236-45112236

 skinmalignant_melanomaSubstitution - Missense

c.1722G>T; p.V574V; 3:45091444-45091444

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.2457G>T; p.K819N; 3:45085692-45085692

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.890T>C; p.L297P; 3:45110607-45110607

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.2181G>A; p.K727K; 3:45085968-45085968

 skinmalignant_melanomaSubstitution - coding silent

c.31G>T; p.A11S; 3:45146257-45146257

 livercarcinomaSubstitution - Missense

c.31G>T; p.A11S; 3:45146257-45146257

 livercarcinomaSubstitution - Missense

c.2062A>T; p.I688F; 3:45089073-45089073

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1747G>C; p.D583H; 3:45091419-45091419

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1162A>G; p.T388A; 3:45095431-45095431

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.2395_2402delCCTGAGTC; p.P799fs*1; 3:45085747-45085754

 breastcarcinomaDeletion - Frameshift

c.839G>A; p.R280Q; 3:45110658-45110658

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1595G>A; p.G532D; 3:45093309-45093309

 skinmalignant_melanomaSubstitution - Missense

c.524G>A; p.G175E; 3:45112214-45112214

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1038G>A; p.V346V; 3:45095555-45095555

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.401G>A; p.S134N; 3:45112337-45112337

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.2146C>G; p.P716A; 3:45086003-45086003

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.2404G>C; p.E802Q; 3:45085745-45085745

 breastcarcinomaSubstitution - Missense

c.2210T>C; p.I737T; 3:45085939-45085939

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2348C>T; p.A783V; 3:45085801-45085801

 skinmalignant_melanomaSubstitution - Missense

c.2107G>A; p.A703T; 3:45086042-45086042

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2146C>T; p.P716S; 3:45086003-45086003

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2146C>T; p.P716S; 3:45086003-45086003

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1964T>A; p.F655Y; 3:45091202-45091202

 skinmalignant_melanomaSubstitution - Missense

c.2362T>C; p.L788L; 3:45085787-45085787

 skinmalignant_melanomaSubstitution - coding silent

c.848A>G; p.Y283C; 3:45110649-45110649

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.703C>T; p.L235L; 3:45110794-45110794

 skinmalignant_melanomaSubstitution - coding silent

c.2322C>T; p.P774P; 3:45085827-45085827

 skinmalignant_melanomaSubstitution - coding silent

c.2054G>A; p.G685E; 3:45089081-45089081

 skinmalignant_melanomaSubstitution - Missense

c.2009T>C; p.L670P; 3:45089126-45089126

 livercarcinomaSubstitution - Missense

c.2212G>A; p.E738K; 3:45085937-45085937

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.2009T>C; p.L670P; 3:45089126-45089126

 livercarcinomaSubstitution - Missense

c.1809C>T; p.R603R; 3:45091357-45091357

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.765C>T; p.V255V; 3:45110732-45110732

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.1809C>T; p.R603R; 3:45091357-45091357

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.741T>G; p.D247E; 3:45110756-45110756

 skinmalignant_melanomaSubstitution - Missense

c.101T>C; p.L34P; 3:45118603-45118603

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2485C>G; p.Q829E; 3:45085664-45085664

 pancreascarcinomaSubstitution - Missense

c.1569C>A; p.S523R; 3:45093335-45093335

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.1569C>A; p.S523R; 3:45093335-45093335

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.140G>A; p.G47E; 3:45118564-45118564

 bone; extraskeletalEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.1816A>G; p.M606V; 3:45091350-45091350

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1866C>T; p.D622D; 3:45091300-45091300

 NSNSSubstitution - coding silent

c.1866C>T; p.D622D; 3:45091300-45091300

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1486G>C; p.G496R; 3:45093418-45093418

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1548C>A; p.T516T; 3:45093356-45093356

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.2193C>T; p.S731S; 3:45085956-45085956

 skinmalignant_melanomaSubstitution - coding silent

c.1975C>T; p.L659F; 3:45091191-45091191

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1421A>C; p.K474T; 3:45093483-45093483

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.2020G>A; p.V674M; 3:45089115-45089115

 central_nervous_system; medullaprimitive_neuroectodermal_tumour-medulloblastoma; large_cellSubstitution - Missense

c.902A>T; p.Q301L; 3:45110595-45110595

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.511G>A; p.V171M; 3:45112227-45112227

 thyroidcarcinoma; anaplastic_carcinomaSubstitution - Missense

c.1077C>T; p.I359I; 3:45095516-45095516

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.324G>T; p.E108D; 3:45112414-45112414

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.2043G>C; p.L681L; 3:45089092-45089092

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.622G>A; p.G208S; 3:45112116-45112116

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1818G>A; p.M606I; 3:45091348-45091348

 skinmalignant_melanomaSubstitution - Missense

c.523G>A; p.G175R; 3:45112215-45112215

 skinmalignant_melanomaSubstitution - Missense

c.2082G>A; p.K694K; 3:45086067-45086067

 skinmalignant_melanomaSubstitution - coding silent

c.2429A>G; p.H810R; 3:45085720-45085720

 central_nervous_system; braingliomaSubstitution - Missense

c.2384C>T; p.P795L; 3:45085765-45085765

 skinmalignant_melanomaSubstitution - Missense

c.1108T>C; p.F370L; 3:45095485-45095485

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.553C>T; p.R185W; 3:45112185-45112185

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1113C>T; p.V371V; 3:45095480-45095480

 skinmalignant_melanomaSubstitution - coding silent

c.921G>A; p.G307G; 3:45110576-45110576

 skinmalignant_melanomaSubstitution - coding silent

c.405C>T; p.I135I; 3:45112333-45112333

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.405C>T; p.I135I; 3:45112333-45112333

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.425C>T; p.S142F; 3:45112313-45112313

 skinmalignant_melanomaSubstitution - Missense

c.302C>T; p.S101L; 3:45112436-45112436

 skinmalignant_melanomaSubstitution - Missense

c.2182G>A; p.D728N; 3:45085967-45085967

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1840C>T; p.R614W; 3:45091326-45091326

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1840C>T; p.R614W; 3:45091326-45091326

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - Missense

c.2069G>T; p.C690F; 3:45089066-45089066

 livercarcinomaSubstitution - Missense

c.2069G>T; p.C690F; 3:45089066-45089066

 livercarcinomaSubstitution - Missense

c.2069G>T; p.C690F; 3:45089066-45089066

 livercarcinomaSubstitution - Missense

c.2407_2408delAG; p.S803fs*1; 3:45085741-45085742

 breastcarcinomaDeletion - Frameshift

c.2291C>A; p.P764Q; 3:45085858-45085858

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.2390C>T; p.S797F; 3:45085759-45085759

 skinmalignant_melanomaSubstitution - Missense

c.1343G>T; p.W448L; 3:45093561-45093561

 adrenal_gland; adrenal_glandadrenal_cortical_carcinoma; functioningSubstitution - Missense

c.1171T>G; p.S391A; 3:45095422-45095422

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.440G>A; p.R147K; 3:45112298-45112298

 skinmalignant_melanomaSubstitution - Missense

c.362T>G; p.L121R; 3:45112376-45112376

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1810G>A; p.A604T; 3:45091356-45091356

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.235A>G; p.T79A; 3:45118469-45118469

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.533G>T; p.C178F; 3:45112205-45112205

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.2112G>C; p.V704V; 3:45086037-45086037

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.2470C>A; p.P824T; 3:45085679-45085679

 breastcarcinomaSubstitution - Missense

c.1553G>A; p.R518H; 3:45093351-45093351

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1878C>T; p.L626L; 3:45091288-45091288

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1330C>T; p.H444Y; 3:45093574-45093574

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.501C>T; p.I167I; 3:45112237-45112237

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.721C>T; p.P241S; 3:45110776-45110776

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.568G>C; p.E190Q; 3:45112170-45112170

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.314C>T; p.P105L; 3:45112424-45112424

 skinmalignant_melanomaSubstitution - Missense

c.2412A>G; p.E804E; 3:45085737-45085737

 skinmalignant_melanomaSubstitution - coding silent

c.1547C>T; p.T516I; 3:45093357-45093357

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1879C>T; p.P627S; 3:45091287-45091287

 skin; armmalignant_melanomaSubstitution - Missense

c.2000C>G; p.T667S; 3:45089135-45089135

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

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