Entrez Gene

Basic Information
Gene ID	65268
Name	WNK2
Synonymous	WNK lysine deficient protein kinase 2;WNK2;WNK lysine deficient protein kinase 2
Definition	antigen NY-CO-43\|mitogen-activated protein kinase kinase kinase\|protein kinase lysine-deficient 2\|protein kinase with no lysine 2\|protein kinase, lysine deficient 2\|serine/threonine-protein kinase WNK2\|serologically defined colon cancer antigen 43
Position	9q22.3
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.15.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1922delC; p.P641fs*2; 9:93253007-93253007	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1922delC; p.P641fs*2; 9:93253007-93253007	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.3111G>C; p.S1037S; 9:93261900-93261900	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.3111G>C; p.S1037S; 9:93261900-93261900	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.4432G>A; p.A1478T; 9:93289228-93289228	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.5463C>T; p.F1821F; 9:93292973-93292973	skin	malignant_melanoma	Substitution - coding silent
c.4432G>A; p.A1478T; 9:93289228-93289228	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2809C>G; p.P937A; 9:93259399-93259399	central_nervous_system; brain	glioma; astrocytoma_Grade_II	Substitution - Missense
c.2399C>T; p.P800L; 9:93258989-93258989	skin	malignant_melanoma	Substitution - Missense
c.5085A>G; p.T1695T; 9:93292595-93292595	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.5061G>T; p.E1687D; 9:93292571-93292571	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.3016G>T; p.G1006W; 9:93259606-93259606	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.6548C>T; p.P2183L; 9:93317596-93317596	skin	malignant_melanoma	Substitution - Missense
c.3316G>C; p.E1106Q; 9:93262105-93262105	liver	carcinoma	Substitution - Missense
c.3673C>A; p.L1225M; 9:93267764-93267764	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.813A>G; p.T271T; 9:93230888-93230888	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.3316G>C; p.E1106Q; 9:93262105-93262105	liver	carcinoma	Substitution - Missense
c.2638G>A; p.V880M; 9:93259228-93259228	skin; trunk	malignant_melanoma	Substitution - Missense
c.1313_1317delTCTTC; p.F438fs*56; 9:93239789-93239793	breast	carcinoma	Deletion - Frameshift
c.4346C>A; p.A1449D; 9:93289142-93289142	central_nervous_system; brain	glioma	Substitution - Missense
c.6021G>T; p.S2007S; 9:93299212-93299212	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.6730C>A; p.R2244S; 9:93318019-93318019	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1337G>A; p.R446K; 9:93239813-93239813	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4972G>A; p.V1658I; 9:93292388-93292388	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.4972G>A; p.V1658I; 9:93292388-93292388	central_nervous_system; thalamus	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.5555C>T; p.T1852M; 9:93293065-93293065	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.6179T>C; p.L2060P; 9:93306786-93306786	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1092C>T; p.D364D; 9:93234866-93234866	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.3480C>T; p.S1160S; 9:93263677-93263677	skin	malignant_melanoma	Substitution - coding silent
c.2224_2225insC; p.H744fs*166; 9:93257023-93257024	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.5534G>A; p.R1845K; 9:93293044-93293044	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.5088delG; p.G1698fs*53; 9:93292598-93292598	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.5088delG; p.G1698fs*53; 9:93292598-93292598	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2629C>T; p.P877S; 9:93259219-93259219	skin	malignant_melanoma	Substitution - Missense
c.1842G>A; p.S614S; 9:93252932-93252932	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2332C>T; p.P778S; 9:93257131-93257131	skin	malignant_melanoma	Substitution - Missense
c.4359C>T; p.D1453D; 9:93289155-93289155	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.5579C>T; p.S1860F; 9:93293089-93293089	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2213T>C; p.L738P; 9:93257012-93257012	thyroid	other; neoplasm	Substitution - Missense
c.5484C>T; p.F1828F; 9:93292994-93292994	skin	malignant_melanoma	Substitution - coding silent
c.720C>T; p.I240I; 9:93229776-93229776	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.5755G>A; p.V1919M; 9:93297944-93297944	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.4739G>T; p.R1580L; 9:93289535-93289535	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2213T>C; p.L738P; 9:93257012-93257012	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.5070G>A; p.P1690P; 9:93292580-93292580	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2299delC; p.P767fs*58; 9:93257098-93257098	autonomic_ganglia	neuroblastoma	Deletion - Frameshift
c.5999C>T; p.S2000F; 9:93299190-93299190	skin	malignant_melanoma	Substitution - Missense
c.6472-2A>G; p.?; 9:93317518-93317518	skin	malignant_melanoma	Unknown
c.5999C>T; p.S2000F; 9:93299190-93299190	skin	malignant_melanoma	Substitution - Missense
c.4752_4753insG; p.D1587fs*9; 9:93289548-93289549	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.5778C>G; p.P1926P; 9:93297967-93297967	kidney	other; neoplasm	Substitution - coding silent
c.4752_4753insG; p.D1587fs*9; 9:93289548-93289549	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1819G>T; p.G607C; 9:93252909-93252909	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4719C>T; p.P1573P; 9:93289515-93289515	skin	malignant_melanoma	Substitution - coding silent
c.3270C>T; p.I1090I; 9:93262059-93262059	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.4112delC; p.S1373fs*5; 9:93288908-93288908	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.3270C>T; p.I1090I; 9:93262059-93262059	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.5906C>T; p.P1969L; 9:93299097-93299097	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.4112delC; p.S1373fs*5; 9:93288908-93288908	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.968C>A; p.S323Y; 9:93231043-93231043	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.6212G>A; p.S2071N; 9:93306819-93306819	thyroid	carcinoma	Substitution - Missense
c.4993T>C; p.F1665L; 9:93292503-93292503	prostate	carcinoma	Substitution - Missense
c.2626G>A; p.A876T; 9:93259216-93259216	skin	malignant_melanoma	Substitution - Missense
c.2910C>T; p.P970P; 9:93259500-93259500	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2269G>A; p.A757T; 9:93257068-93257068	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2021delC; p.A676fs*15; 9:93256327-93256327	autonomic_ganglia	neuroblastoma	Deletion - Frameshift
c.6642delC; p.T2215fs*31; 9:93317925-93317925	ovary	carcinoma; mucinous_carcinoma	Deletion - Frameshift
c.6642delC; p.T2215fs*31; 9:93317925-93317925	ovary	carcinoma; mucinous_carcinoma	Deletion - Frameshift
c.5361C>G; p.G1787G; 9:93292871-93292871	thyroid	other; neoplasm	Substitution - coding silent
c.2372C>T; p.T791M; 9:93258962-93258962	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.5713G>A; p.E1905K; 9:93297902-93297902	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1380C>T; p.I460I; 9:93239856-93239856	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.4305C>T; p.L1435L; 9:93289101-93289101	skin	malignant_melanoma	Substitution - coding silent
c.6007G>A; p.A2003T; 9:93299198-93299198	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.582G>A; p.T194T; 9:93185553-93185553	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.6608G>A; p.R2203K; 9:93317897-93317897	skin	malignant_melanoma	Substitution - Missense
c.2798A>T; p.Q933L; 9:93259388-93259388	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.4510C>G; p.P1504A; 9:93289306-93289306	thyroid	carcinoma	Substitution - Missense
c.2875A>G; p.T959A; 9:93259465-93259465	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2875A>G; p.T959A; 9:93259465-93259465	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.804G>A; p.T268T; 9:93229860-93229860	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.6420G>C; p.L2140L; 9:93308533-93308533	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.3648G>A; p.T1216T; 9:93264027-93264027	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.6365T>C; p.V2122A; 9:93308478-93308478	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1584G>A; p.R528R; 9:93247626-93247626	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1052C>T; p.A351V; 9:93234826-93234826	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.4327A>T; p.T1443S; 9:93289123-93289123	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1052C>T; p.A351V; 9:93234826-93234826	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4431C>T; p.P1477P; 9:93289227-93289227	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2987C>T; p.P996L; 9:93259577-93259577	skin	malignant_melanoma	Substitution - Missense
c.5434C>T; p.P1812S; 9:93292944-93292944	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2868G>A; p.P956P; 9:93259458-93259458	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.6560C>T; p.P2187L; 9:93317608-93317608	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1349C>A; p.A450E; 9:93239825-93239825	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.5119G>A; p.G1707S; 9:93292629-93292629	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3064G>A; p.A1022T; 9:93261853-93261853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4340A>C; p.E1447A; 9:93289136-93289136	breast	carcinoma	Substitution - Missense
c.3064G>A; p.A1022T; 9:93261853-93261853	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.5829G>A; p.K1943K; 9:93298018-93298018	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.4661C>T; p.S1554F; 9:93289457-93289457	pancreas	carcinoma	Substitution - Missense
c.600C>T; p.D200D; 9:93185571-93185571	thyroid	other; neoplasm	Substitution - coding silent
c.4524C>T; p.T1508T; 9:93289320-93289320	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1920C>T; p.P640P; 9:93253010-93253010	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3261G>A; p.G1087G; 9:93262050-93262050	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.6724C>T; p.P2242S; 9:93318013-93318013	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1576C>T; p.Q526*; 9:93247618-93247618	skin	malignant_melanoma	Substitution - Nonsense
c.2307G>A; p.A769A; 9:93257106-93257106	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.5459A>T; p.D1820V; 9:93292969-93292969	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2398C>T; p.P800S; 9:93258988-93258988	skin	malignant_melanoma	Substitution - Missense
c.225C>T; p.A75A; 9:93185196-93185196	thyroid	other; neoplasm	Substitution - coding silent
c.225C>T; p.A75A; 9:93185196-93185196	thyroid	other; neoplasm	Substitution - coding silent
c.1544C>A; p.A515D; 9:93247586-93247586	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.6541G>A; p.V2181I; 9:93317589-93317589	skin	malignant_melanoma	Substitution - Missense
c.5067G>A; p.P1689P; 9:93292577-93292577	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1228C>A; p.P410T; 9:93238269-93238269	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.4436T>C; p.L1479S; 9:93289232-93289232	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3581C>T; p.T1194M; 9:93263960-93263960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3581C>T; p.T1194M; 9:93263960-93263960	liver	carcinoma	Substitution - Missense
c.3581C>T; p.T1194M; 9:93263960-93263960	liver	carcinoma	Substitution - Missense
c.3319G>A; p.E1107K; 9:93262670-93262670	skin	malignant_melanoma	Substitution - Missense
c.1564G>A; p.V522M; 9:93247606-93247606	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.5181C>A; p.A1727A; 9:93292691-93292691	liver	carcinoma	Substitution - coding silent
c.6459C>T; p.G2153G; 9:93308572-93308572	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.4915C>A; p.L1639I; 9:93292331-93292331	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.664C>T; p.R222W; 9:93229720-93229720	ovary	other; neoplasm	Substitution - Missense
c.1564G>A; p.V522M; 9:93247606-93247606	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.6372C>T; p.A2124A; 9:93308485-93308485	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.5271C>T; p.D1757D; 9:93292781-93292781	thyroid	other; neoplasm	Substitution - coding silent
c.5271C>T; p.D1757D; 9:93292781-93292781	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.5271C>T; p.D1757D; 9:93292781-93292781	breast	carcinoma	Substitution - coding silent
c.3690A>C; p.E1230D; 9:93267781-93267781	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.5143C>T; p.R1715W; 9:93292653-93292653	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.4628G>A; p.R1543Q; 9:93289424-93289424	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3686G>A; p.R1229Q; 9:93267777-93267777	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.3871G>A; p.V1291I; 9:93268065-93268065	skin	malignant_melanoma	Substitution - Missense
c.5998T>G; p.S2000A; 9:93299189-93299189	pancreas	carcinoma	Substitution - Missense
c.6363G>C; p.T2121T; 9:93308476-93308476	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.5229C>T; p.T1743T; 9:93292739-93292739	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1794G>A; p.S598S; 9:93252884-93252884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.5305G>A; p.V1769M; 9:93292815-93292815	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.5149C>T; p.R1717C; 9:93292659-93292659	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.3345C>T; p.P1115P; 9:93262696-93262696	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.5065_5066CC>TT; p.P1689L; 9:93292575-93292576	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4644G>A; p.Q1548Q; 9:93289440-93289440	skin	malignant_melanoma	Substitution - coding silent
c.3968C>T; p.S1323F; 9:93268723-93268723	skin	malignant_melanoma	Substitution - Missense
c.5270A>G; p.D1757G; 9:93292780-93292780	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.2733T>C; p.P911P; 9:93259323-93259323	skin	malignant_melanoma	Substitution - coding silent
c.3968C>T; p.S1323F; 9:93268723-93268723	skin	malignant_melanoma	Substitution - Missense
c.4272G>A; p.E1424E; 9:93289068-93289068	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2077G>A; p.A693T; 9:93256383-93256383	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.5758G>A; p.G1920S; 9:93297947-93297947	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.936T>C; p.C312C; 9:93231011-93231011	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2359G>A; p.V787M; 9:93258949-93258949	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.5933G>T; p.S1978I; 9:93299124-93299124	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.5933G>T; p.S1978I; 9:93299124-93299124	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1133C>T; p.S378L; 9:93234907-93234907	skin	malignant_melanoma	Substitution - Missense
c.2578C>T; p.R860W; 9:93259168-93259168	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2627C>T; p.A876V; 9:93259217-93259217	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5541C>T; p.G1847G; 9:93293051-93293051	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1712G>A; p.G571E; 9:93247754-93247754	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.4860C>G; p.A1620A; 9:93290013-93290013	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.4417G>A; p.G1473R; 9:93289213-93289213	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.811A>G; p.T271A; 9:93229867-93229867	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.2529G>A; p.Q843Q; 9:93259119-93259119	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.4728G>A; p.G1576G; 9:93289524-93289524	skin	malignant_melanoma	Substitution - coding silent
c.4417G>A; p.G1473R; 9:93289213-93289213	prostate	carcinoma	Substitution - Missense
c.3757G>A; p.A1253T; 9:93267848-93267848	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1993-8C>A; p.?; 9:93256291-93256291	liver	carcinoma	Unknown
c.1361A>G; p.H454R; 9:93239837-93239837	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.3951C>G; p.P1317P; 9:93268706-93268706	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.3047C>T; p.P1016L; 9:93261836-93261836	skin	malignant_melanoma	Substitution - Missense
c.1518C>T; p.F506F; 9:93247560-93247560	skin	malignant_melanoma	Substitution - coding silent
c.100G>T; p.E34*; 9:93185071-93185071	central_nervous_system; thalamus	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.6121A>T; p.S2041C; 9:93300101-93300101	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.599A>G; p.D200G; 9:93185570-93185570	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4695C>T; p.G1565G; 9:93289491-93289491	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1828G>A; p.V610M; 9:93252918-93252918	prostate	carcinoma	Substitution - Missense
c.3379T>G; p.S1127A; 9:93263576-93263576	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.6062G>A; p.R2021H; 9:93299253-93299253	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.5260G>T; p.A1754S; 9:93292770-93292770	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.801G>A; p.G267G; 9:93229857-93229857	skin	malignant_melanoma	Substitution - coding silent
c.6692G>T; p.G2231V; 9:93317981-93317981	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1522G>A; p.E508K; 9:93247564-93247564	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5651G>A; p.S1884N; 9:93293161-93293161	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.6686G>A; p.R2229Q; 9:93317975-93317975	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2040C>T; p.S680S; 9:93256346-93256346	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.949A>T; p.I317F; 9:93231024-93231024	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2911A>G; p.M971V; 9:93259501-93259501	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1841C>T; p.S614L; 9:93252931-93252931	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1287G>A; p.E429E; 9:93239763-93239763	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.6595G>A; p.G2199R; 9:93317884-93317884	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.3325G>A; p.A1109T; 9:93262676-93262676	urinary_tract; bladder	carcinoma	Substitution - Missense
c.5750C>G; p.P1917R; 9:93297939-93297939	stomach	carcinoma	Substitution - Missense
c.2404G>A; p.A802T; 9:93258994-93258994	skin	malignant_melanoma	Substitution - Missense
c.5750C>G; p.P1917R; 9:93297939-93297939	stomach	carcinoma	Substitution - Missense
c.3654G>T; p.M1218I; 9:93264033-93264033	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3991+7G>A; p.?; 9:93268753-93268753	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Unknown
c.5103C>T; p.S1701S; 9:93292613-93292613	kidney	other; neoplasm	Substitution - coding silent
c.6539C>T; p.T2180M; 9:93317587-93317587	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.6539C>T; p.T2180M; 9:93317587-93317587	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.697delA; p.G234fs*27; 9:93229753-93229753	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2224delC; p.H744fs*18; 9:93257023-93257023	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.6519G>A; p.A2173A; 9:93317567-93317567	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1106_1107GG>AA; p.G369E; 9:93234880-93234881	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4253C>T; p.T1418M; 9:93289049-93289049	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2224delC; p.H744fs*18; 9:93257023-93257023	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2560C>G; p.P854A; 9:93259150-93259150	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.5789G>A; p.R1930H; 9:93297978-93297978	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.4116delC; p.S1373fs*5; 9:93288912-93288912	stomach	carcinoma; adenocarcinoma	Deletion - Frameshift
c.4116delC; p.S1373fs*5; 9:93288912-93288912	stomach	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2467G>A; p.A823T; 9:93259057-93259057	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.6493G>A; p.V2165M; 9:93317541-93317541	urinary_tract; bladder	carcinoma	Substitution - Missense
c.3651T>C; p.Y1217Y; 9:93264030-93264030	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3703C>T; p.Q1235*; 9:93267794-93267794	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.4122C>T; p.S1374S; 9:93288918-93288918	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3703C>T; p.Q1235*; 9:93267794-93267794	breast	carcinoma	Substitution - Nonsense
c.5437G>A; p.V1813M; 9:93292947-93292947	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3995C>A; p.S1332*; 9:93288791-93288791	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1939G>A; p.V647I; 9:93253029-93253029	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.6033C>T; p.S2011S; 9:93299224-93299224	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1163C>T; p.A388V; 9:93234937-93234937	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1061T>C; p.M354T; 9:93234835-93234835	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.5269G>A; p.D1757N; 9:93292779-93292779	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.6196G>A; p.G2066S; 9:93306803-93306803	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4771C>T; p.P1591S; 9:93289567-93289567	skin	malignant_melanoma	Substitution - Missense
c.2821G>A; p.V941M; 9:93259411-93259411	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1604C>T; p.A535V; 9:93247646-93247646	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2301A>G; p.P767P; 9:93257100-93257100	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.426delG; p.A144fs*89; 9:93185397-93185397	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2025C>T; p.P675P; 9:93256331-93256331	central_nervous_system; brain	glioma	Substitution - coding silent
c.3947C>T; p.S1316L; 9:93268702-93268702	skin	malignant_melanoma	Substitution - Missense
c.2611C>A; p.P871T; 9:93259201-93259201	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3947C>T; p.S1316L; 9:93268702-93268702	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3947C>T; p.S1316L; 9:93268702-93268702	skin	malignant_melanoma	Substitution - Missense
c.4729G>C; p.D1577H; 9:93289525-93289525	breast	carcinoma	Substitution - Missense
c.3582G>A; p.T1194T; 9:93263961-93263961	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.782C>T; p.T261M; 9:93229838-93229838	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3582G>A; p.T1194T; 9:93263961-93263961	thyroid	other; neoplasm	Substitution - coding silent
c.3582G>A; p.T1194T; 9:93263961-93263961	thyroid	other; neoplasm	Substitution - coding silent
c.2682C>A; p.G894G; 9:93259272-93259272	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.878A>C; p.K293T; 9:93230953-93230953	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1560C>T; p.D520D; 9:93247602-93247602	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1164G>A; p.A388A; 9:93234938-93234938	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.4527C>T; p.V1509V; 9:93289323-93289323	skin	malignant_melanoma	Substitution - coding silent
c.2647C>T; p.L883L; 9:93259237-93259237	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.489G>C; p.E163D; 9:93185460-93185460	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.489G>C; p.E163D; 9:93185460-93185460	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3145C>T; p.P1049S; 9:93261934-93261934	skin	malignant_melanoma	Substitution - Missense
c.1561C>T; p.R521C; 9:93247603-93247603	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1561C>T; p.R521C; 9:93247603-93247603	pancreas	carcinoma	Substitution - Missense
c.2440G>A; p.V814M; 9:93259030-93259030	thyroid	other; neoplasm	Substitution - Missense
c.2440G>A; p.V814M; 9:93259030-93259030	breast	carcinoma	Substitution - Missense
c.2440G>A; p.V814M; 9:93259030-93259030	thyroid	other; neoplasm	Substitution - Missense
c.6225C>T; p.T2075T; 9:93308338-93308338	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1825A>G; p.T609A; 9:93252915-93252915	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.4647G>A; p.E1549E; 9:93289443-93289443	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.812C>T; p.T271I; 9:93229868-93229868	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.5883C>A; p.H1961Q; 9:93299074-93299074	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.824G>T; p.R275L; 9:93230899-93230899	skin	malignant_melanoma	Substitution - Missense
c.1501-6T>A; p.?; 9:93247537-93247537	liver	carcinoma	Unknown
c.3473G>A; p.R1158H; 9:93263670-93263670	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.4578C>T; p.P1526P; 9:93289374-93289374	skin	malignant_melanoma	Substitution - coding silent
c.2105C>A; p.P702H; 9:93256411-93256411	skin; trunk	malignant_melanoma	Substitution - Missense
c.5069C>T; p.P1690L; 9:93292579-93292579	skin	malignant_melanoma	Substitution - Missense
c.4575_4576CC>TT; p.P1526S; 9:93289371-93289372	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4478T>C; p.V1493A; 9:93289274-93289274	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2169G>A; p.P723P; 9:93256968-93256968	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.3283C>T; p.P1095S; 9:93262072-93262072	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5776delC; p.T1928fs*12; 9:93297965-93297965	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1431G>A; p.K477K; 9:93239907-93239907	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - coding silent
c.3662A>G; p.H1221R; 9:93267753-93267753	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3756C>T; p.D1252D; 9:93267847-93267847	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.5357T>G; p.V1786G; 9:93292867-93292867	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5357T>G; p.V1786G; 9:93292867-93292867	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5357T>G; p.V1786G; 9:93292867-93292867	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5357T>G; p.V1786G; 9:93292867-93292867	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5357T>G; p.V1786G; 9:93292867-93292867	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5357T>G; p.V1786G; 9:93292867-93292867	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5357T>G; p.V1786G; 9:93292867-93292867	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5357T>G; p.V1786G; 9:93292867-93292867	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5357T>G; p.V1786G; 9:93292867-93292867	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5357T>G; p.V1786G; 9:93292867-93292867	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5357T>G; p.V1786G; 9:93292867-93292867	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5357T>G; p.V1786G; 9:93292867-93292867	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5357T>G; p.V1786G; 9:93292867-93292867	thyroid	other; neoplasm	Substitution - Missense
c.5357T>G; p.V1786G; 9:93292867-93292867	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5357T>G; p.V1786G; 9:93292867-93292867	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1480G>A; p.D494N; 9:93239956-93239956	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.6477C>T; p.T2159T; 9:93317525-93317525	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1053G>A; p.A351A; 9:93234827-93234827	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.6005G>T; p.R2002L; 9:93299196-93299196	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.6600C>T; p.T2200T; 9:93317889-93317889	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.3700G>A; p.E1234K; 9:93267791-93267791	skin	malignant_melanoma	Substitution - Missense
c.2699C>T; p.A900V; 9:93259289-93259289	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3700G>A; p.E1234K; 9:93267791-93267791	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1225G>A; p.D409N; 9:93238266-93238266	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.4355G>T; p.R1452M; 9:93289151-93289151	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1056C>T; p.P352P; 9:93234830-93234830	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.6515C>T; p.P2172L; 9:93317563-93317563	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1236C>G; p.I412M; 9:93238277-93238277	breast	carcinoma	Substitution - Missense
c.2523T>G; p.P841P; 9:93259113-93259113	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.3773A>C; p.D1258A; 9:93267864-93267864	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.4099C>G; p.P1367A; 9:93288895-93288895	liver	carcinoma	Substitution - Missense
c.4099C>G; p.P1367A; 9:93288895-93288895	liver	carcinoma	Substitution - Missense
c.1874C>T; p.S625F; 9:93252964-93252964	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4287G>A; p.P1429P; 9:93289083-93289083	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.4967_4968CC>AT; p.P1656H; 9:93292383-93292384	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5637G>T; p.K1879N; 9:93293147-93293147	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1319_1327delCAGAGGACA; p.E441_T443delEDT; 9:93239795-93239803	breast	carcinoma	Deletion - In frame
c.3118C>T; p.L1040L; 9:93261907-93261907	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2023C>T; p.P675S; 9:93256329-93256329	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5862C>T; p.V1954V; 9:93298051-93298051	breast	carcinoma	Substitution - coding silent
c.1540G>A; p.V514M; 9:93247582-93247582	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2403G>C; p.P801P; 9:93258993-93258993	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.6604C>A; p.R2202R; 9:93317893-93317893	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.5909C>T; p.P1970L; 9:93299100-93299100	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2956delG; p.V986fs*114; 9:93259546-93259546	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.3096G>T; p.P1032P; 9:93261885-93261885	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.6147T>G; p.S2049R; 9:93300127-93300127	thyroid	other; neoplasm	Substitution - Missense
c.5613G>A; p.S1871S; 9:93293123-93293123	skin	malignant_melanoma	Substitution - coding silent
c.1459G>T; p.D487Y; 9:93239935-93239935	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3113C>T; p.P1038L; 9:93261902-93261902	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.4943T>A; p.V1648E; 9:93292359-93292359	liver	carcinoma	Substitution - Missense
c.5505C>T; p.A1835A; 9:93293015-93293015	liver	carcinoma	Substitution - coding silent
c.5090G>A; p.G1697E; 9:93292600-93292600	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.6391C>T; p.L2131F; 9:93308504-93308504	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.5505C>T; p.A1835A; 9:93293015-93293015	liver	carcinoma	Substitution - coding silent
c.3046C>T; p.P1016S; 9:93261835-93261835	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - Missense
c.2551C>T; p.P851S; 9:93259141-93259141	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1486G>T; p.V496L; 9:93239962-93239962	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1486G>T; p.V496L; 9:93239962-93239962	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.549C>T; p.F183F; 9:93185520-93185520	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.502G>A; p.D168N; 9:93185473-93185473	skin	malignant_melanoma	Substitution - Missense
c.1119G>A; p.L373L; 9:93234893-93234893	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2861_2896del36; p.T959_P970del12; 9:93259451-93259486	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.5430C>T; p.S1810S; 9:93292940-93292940	skin	malignant_melanoma	Substitution - coding silent
c.6130C>T; p.R2044C; 9:93300110-93300110	skin	malignant_melanoma	Substitution - Missense
c.5430C>T; p.S1810S; 9:93292940-93292940	skin	malignant_melanoma	Substitution - coding silent
c.3647C>T; p.T1216M; 9:93264026-93264026	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3497G>T; p.R1166L; 9:93263694-93263694	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.4572G>A; p.P1524P; 9:93289368-93289368	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.4278C>T; p.H1426H; 9:93289074-93289074	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1469A>G; p.K490R; 9:93239945-93239945	liver	carcinoma	Substitution - Missense
c.1469A>G; p.K490R; 9:93239945-93239945	liver	carcinoma	Substitution - Missense
c.4753delG; p.D1587fs*35; 9:93289549-93289549	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.6606G>A; p.R2202R; 9:93317895-93317895	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1469A>G; p.K490R; 9:93239945-93239945	liver	carcinoma	Substitution - Missense
c.3808G>T; p.G1270C; 9:93267899-93267899	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.4106C>G; p.P1369R; 9:93288902-93288902	urinary_tract; bladder	carcinoma	Substitution - Missense
c.6375G>A; p.A2125A; 9:93308488-93308488	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.4249G>A; p.E1417K; 9:93289045-93289045	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3080C>T; p.T1027I; 9:93261869-93261869	skin	malignant_melanoma	Substitution - Missense
c.1381G>A; p.A461T; 9:93239857-93239857	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3328T>A; p.S1110T; 9:93262679-93262679	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.3682G>A; p.E1228K; 9:93267773-93267773	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.3114G>A; p.P1038P; 9:93261903-93261903	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1667C>T; p.P556L; 9:93247709-93247709	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2960G>A; p.R987H; 9:93259550-93259550	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4978C>T; p.Q1660*; 9:93292394-93292394	skin	malignant_melanoma	Substitution - Nonsense
c.2514A>C; p.P838P; 9:93259104-93259104	thyroid	other; neoplasm	Substitution - coding silent
c.4338A>G; p.P1446P; 9:93289134-93289134	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.3871+1G>A; p.?; 9:93268066-93268066	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.3184G>A; p.V1062M; 9:93261973-93261973	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2727C>T; p.D909D; 9:93259317-93259317	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.813-3C>A; p.?; 9:93230885-93230885	liver	carcinoma	Unknown
c.3248C>T; p.P1083L; 9:93262037-93262037	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2986C>T; p.P996S; 9:93259576-93259576	skin	malignant_melanoma	Substitution - Missense
c.1661C>T; p.P554L; 9:93247703-93247703	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.813-3C>A; p.?; 9:93230885-93230885	liver	carcinoma	Unknown
c.510G>A; p.K170K; 9:93185481-93185481	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.4924G>A; p.D1642N; 9:93292340-93292340	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2612C>A; p.P871H; 9:93259202-93259202	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.4973T>C; p.V1658A; 9:93292389-93292389	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.4806C>T; p.V1602V; 9:93289602-93289602	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.4856G>A; p.G1619E; 9:93290009-93290009	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.4856G>A; p.G1619E; 9:93290009-93290009	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.976A>T; p.I326F; 9:93231051-93231051	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.673T>C; p.F225L; 9:93229729-93229729	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3245C>G; p.P1082R; 9:93262034-93262034	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.783G>T; p.T261T; 9:93229839-93229839	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.3890G>A; p.R1297K; 9:93268645-93268645	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2708C>T; p.P903L; 9:93259298-93259298	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4573delC; p.R1527fs*48; 9:93289369-93289369	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2635G>T; p.G879C; 9:93259225-93259225	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.6355A>G; p.S2119G; 9:93308468-93308468	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.994G>A; p.A332T; 9:93231069-93231069	skin	malignant_melanoma	Substitution - Missense
c.5199C>A; p.F1733L; 9:93292709-93292709	thyroid	other; neoplasm	Substitution - Missense
c.5263C>T; p.P1755S; 9:93292773-93292773	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]